DK169339B1 - Farmaceutiske præparater omfattende et alkali- eller jordalkalimetalsalt af glycerophosphoryl-O-serin til behandling af cerebral involutive syndromer, anvendelse af glycerophosphoryl-O-serin og alkali- eller jordalkalimetalsalte deraf til fremstilling af sådanne præparater, alkali- eller jordalkalimetalsalte af glycerophosphoryl-O-serin samt fremgangsmåde til fremstilling af sådanne salte - Google Patents
Farmaceutiske præparater omfattende et alkali- eller jordalkalimetalsalt af glycerophosphoryl-O-serin til behandling af cerebral involutive syndromer, anvendelse af glycerophosphoryl-O-serin og alkali- eller jordalkalimetalsalte deraf til fremstilling af sådanne præparater, alkali- eller jordalkalimetalsalte af glycerophosphoryl-O-serin samt fremgangsmåde til fremstilling af sådanne salte Download PDFInfo
- Publication number
- DK169339B1 DK169339B1 DK532087A DK532087A DK169339B1 DK 169339 B1 DK169339 B1 DK 169339B1 DK 532087 A DK532087 A DK 532087A DK 532087 A DK532087 A DK 532087A DK 169339 B1 DK169339 B1 DK 169339B1
- Authority
- DK
- Denmark
- Prior art keywords
- serine
- glycerophosphoryl
- alkaline earth
- earth metal
- salts
- Prior art date
Links
- 230000002490 cerebral effect Effects 0.000 title claims abstract description 15
- 229910052784 alkaline earth metal Inorganic materials 0.000 title claims description 31
- 150000003839 salts Chemical class 0.000 title claims description 15
- -1 alkaline earth metal salt Chemical class 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 7
- 208000011580 syndromic disease Diseases 0.000 title claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title description 2
- 229910052783 alkali metal Inorganic materials 0.000 title 3
- 150000001340 alkali metals Chemical class 0.000 title 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 239000003513 alkali Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 8
- 159000000007 calcium salts Chemical class 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
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- 238000004108 freeze drying Methods 0.000 claims description 3
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- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 230000003143 atherosclerotic effect Effects 0.000 claims description 2
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- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 45
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- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1938286 | 1986-02-12 | ||
| IT8619382A IT1213034B (it) | 1986-02-12 | 1986-02-12 | Composizioni farmaceutiche per la terapia di cerebropatie su base organica e funzionale. |
| EP8700068 | 1987-02-12 | ||
| PCT/EP1987/000068 WO1987005024A1 (en) | 1986-02-12 | 1987-02-12 | Pharmaceutical compositions for the therapy of cerebropathies on functional and organic base |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK532087D0 DK532087D0 (da) | 1987-10-12 |
| DK532087A DK532087A (da) | 1987-10-12 |
| DK169339B1 true DK169339B1 (da) | 1994-10-10 |
Family
ID=11157215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK532087A DK169339B1 (da) | 1986-02-12 | 1987-10-12 | Farmaceutiske præparater omfattende et alkali- eller jordalkalimetalsalt af glycerophosphoryl-O-serin til behandling af cerebral involutive syndromer, anvendelse af glycerophosphoryl-O-serin og alkali- eller jordalkalimetalsalte deraf til fremstilling af sådanne præparater, alkali- eller jordalkalimetalsalte af glycerophosphoryl-O-serin samt fremgangsmåde til fremstilling af sådanne salte |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4950776A (no) |
| EP (1) | EP0256069B1 (no) |
| JP (1) | JPH0780775B2 (no) |
| KR (1) | KR940011187B1 (no) |
| AT (1) | ATE71385T1 (no) |
| AU (1) | AU601403B2 (no) |
| CA (1) | CA1291766C (no) |
| DE (1) | DE3775854D1 (no) |
| DK (1) | DK169339B1 (no) |
| FI (1) | FI874450A (no) |
| HU (1) | HU199148B (no) |
| IE (1) | IE59283B1 (no) |
| IL (1) | IL81549A0 (no) |
| IT (1) | IT1213034B (no) |
| NO (1) | NO874241L (no) |
| NZ (1) | NZ219259A (no) |
| PH (1) | PH24445A (no) |
| WO (1) | WO1987005024A1 (no) |
| ZA (1) | ZA871032B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0348859A1 (en) * | 1988-07-01 | 1990-01-03 | MAGIS FARMACEUTICI S.p.A. | 1,2-di-O-acyl glycero(DI)phosphate of L-carnitine and its derivatives, a process for their preparation and pharmaceutical formulations which contain them |
| IT1230140B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della serina, loro processo di preparazione e impiego in terapia umana |
| IT1231776B (it) * | 1989-08-07 | 1991-12-21 | Magis Farmaceutici | Processo per preparare i derivati acetilati della l alfa glicerofosforil serina. |
| IT1254471B (it) * | 1992-02-27 | 1995-09-25 | Magis Farmaceutici | Derivati ammidici della (r)-glicerofosforil-(s)-serina o del suo diacil derivato, un processo per la loro preparazione e relative composizioni farmaceutiche per il potenziamento dei processi di apprendimento |
| IT1265647B1 (it) * | 1992-11-18 | 1996-11-22 | Farmin Srl | Composizione farmaceutiche topiche per le allergie respiratorie |
| JP6195949B2 (ja) | 2016-02-26 | 2017-09-13 | 株式会社リケン | ピストンリング |
| CN108558937B (zh) * | 2018-04-19 | 2019-05-24 | 厦门大学 | 一种L-α-甘油磷脂酰丝氨酸及其合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55115824A (en) * | 1979-02-28 | 1980-09-06 | Nippon Shoji Kk | Remedy for clouding of consciousness and sensomobile disorder |
| IT1123142B (it) * | 1979-09-14 | 1986-04-30 | Lpb Ist Farm | Uso di glicerilfosforil derivati nella terapia di dislipemie ed epatiti,e composizioni farmaceutiche relative |
| DE3212387A1 (de) * | 1982-04-02 | 1983-10-13 | Bayer Ag, 5090 Leverkusen | Glycerinphosphatide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US4624852A (en) * | 1983-05-16 | 1986-11-25 | Massachusetts Institute Of Technology | Process and composition for treating neurological disorders and aging |
| JPS6081193A (ja) * | 1983-10-11 | 1985-05-09 | Takeda Chem Ind Ltd | リン脂質 |
| IT1212900B (it) * | 1983-11-17 | 1989-11-30 | Valle Francesco Della | Uso terapeutico della fosfatidilserina in malattie del sistema nervoso centrale senza effetti sulla coagulazione sanguigna |
| IT1199972B (it) * | 1985-05-08 | 1989-01-05 | Lpb Ist Farm | Composizioni farmaceutiche per la terapia di sindromi cerebrali involutive e del decadimento mentale |
-
1986
- 1986-02-12 IT IT8619382A patent/IT1213034B/it active
-
1987
- 1987-02-12 ZA ZA871032A patent/ZA871032B/xx unknown
- 1987-02-12 WO PCT/EP1987/000068 patent/WO1987005024A1/en active IP Right Grant
- 1987-02-12 DE DE8787901055T patent/DE3775854D1/de not_active Expired - Fee Related
- 1987-02-12 US US07/112,000 patent/US4950776A/en not_active Expired - Fee Related
- 1987-02-12 IE IE36187A patent/IE59283B1/en not_active IP Right Cessation
- 1987-02-12 CA CA000529554A patent/CA1291766C/en not_active Expired - Lifetime
- 1987-02-12 EP EP87901055A patent/EP0256069B1/en not_active Expired - Lifetime
- 1987-02-12 PH PH34851A patent/PH24445A/en unknown
- 1987-02-12 JP JP62501166A patent/JPH0780775B2/ja not_active Expired - Lifetime
- 1987-02-12 AT AT87901055T patent/ATE71385T1/de not_active IP Right Cessation
- 1987-02-12 NZ NZ219259A patent/NZ219259A/xx unknown
- 1987-02-12 KR KR1019870700914A patent/KR940011187B1/ko not_active IP Right Cessation
- 1987-02-12 IL IL81549A patent/IL81549A0/xx not_active IP Right Cessation
- 1987-02-12 AU AU70250/87A patent/AU601403B2/en not_active Ceased
- 1987-02-12 HU HU871033A patent/HU199148B/hu not_active IP Right Cessation
- 1987-10-09 NO NO874241A patent/NO874241L/no unknown
- 1987-10-09 FI FI874450A patent/FI874450A/fi not_active IP Right Cessation
- 1987-10-12 DK DK532087A patent/DK169339B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8619382A0 (it) | 1986-02-12 |
| IE59283B1 (en) | 1994-02-09 |
| DK532087D0 (da) | 1987-10-12 |
| ATE71385T1 (de) | 1992-01-15 |
| KR880700805A (ko) | 1988-04-12 |
| JPS63502893A (ja) | 1988-10-27 |
| NZ219259A (en) | 1989-04-26 |
| ZA871032B (en) | 1987-08-04 |
| CA1291766C (en) | 1991-11-05 |
| US4950776A (en) | 1990-08-21 |
| DE3775854D1 (de) | 1992-02-20 |
| IE870361L (en) | 1987-08-12 |
| EP0256069B1 (en) | 1992-01-08 |
| FI874450A0 (fi) | 1987-10-09 |
| NO874241L (no) | 1987-12-09 |
| FI874450A (fi) | 1987-10-09 |
| PH24445A (en) | 1990-06-25 |
| HUT47299A (en) | 1989-02-28 |
| HU199148B (en) | 1990-01-29 |
| IL81549A0 (en) | 1987-09-16 |
| DK532087A (da) | 1987-10-12 |
| JPH0780775B2 (ja) | 1995-08-30 |
| AU601403B2 (en) | 1990-09-13 |
| EP0256069A1 (en) | 1988-02-24 |
| NO874241D0 (no) | 1987-10-09 |
| KR940011187B1 (ko) | 1994-11-26 |
| AU7025087A (en) | 1987-09-09 |
| WO1987005024A1 (en) | 1987-08-27 |
| IT1213034B (it) | 1989-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |