DK1648899T3 - Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander - Google Patents
Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorliganderInfo
- Publication number
- DK1648899T3 DK1648899T3 DK04779031T DK04779031T DK1648899T3 DK 1648899 T3 DK1648899 T3 DK 1648899T3 DK 04779031 T DK04779031 T DK 04779031T DK 04779031 T DK04779031 T DK 04779031T DK 1648899 T3 DK1648899 T3 DK 1648899T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazopyrimidines
- triazolopyrimidines
- receptor ligands
- benzodiazepine receptor
- benzodiazepine
- Prior art date
Links
- 102000004300 GABA-A Receptors Human genes 0.000 title 1
- 108090000839 GABA-A Receptors Proteins 0.000 title 1
- 150000005237 imidazopyrimidines Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49000603P | 2003-07-25 | 2003-07-25 | |
| US54308304P | 2004-02-09 | 2004-02-09 | |
| PCT/US2004/023794 WO2005012306A2 (en) | 2003-07-25 | 2004-07-23 | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1648899T3 true DK1648899T3 (da) | 2007-04-02 |
Family
ID=34118813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04779031T DK1648899T3 (da) | 2003-07-25 | 2004-07-23 | Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7271170B2 (da) |
| EP (1) | EP1648899B1 (da) |
| JP (1) | JP2007500130A (da) |
| KR (1) | KR20060098425A (da) |
| AR (1) | AR045117A1 (da) |
| AT (1) | ATE350382T1 (da) |
| AU (1) | AU2004261591A1 (da) |
| BR (1) | BRPI0412908A (da) |
| CA (1) | CA2537331A1 (da) |
| CY (1) | CY1107565T1 (da) |
| DE (1) | DE602004004143T2 (da) |
| DK (1) | DK1648899T3 (da) |
| ES (1) | ES2278345T3 (da) |
| IL (1) | IL173265A0 (da) |
| MX (1) | MXPA06000887A (da) |
| NZ (1) | NZ544262A (da) |
| PL (1) | PL1648899T3 (da) |
| PT (1) | PT1648899E (da) |
| TW (1) | TW200524937A (da) |
| WO (1) | WO2005012306A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1619948A4 (en) * | 2003-05-05 | 2007-02-14 | Neurogen Corp | SUBSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS |
| US20080167324A1 (en) * | 2005-03-02 | 2008-07-10 | Yuelian Xu | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives |
| CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| EP2146576A4 (en) * | 2007-04-11 | 2013-01-16 | Cypress Bioscience Inc | TREATMENT OF DOWN SYNDROME WITH BENZODIAZEPINE REACTANT AGONISTS |
| US8546394B2 (en) | 2007-04-17 | 2013-10-01 | Bristol-Myers Squibb Company | Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US20090270373A1 (en) * | 2008-04-11 | 2009-10-29 | Cypress Biosciences, Inc. | Treatment of down syndrom with benzodiazepine receptor antagonists |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US544057A (en) * | 1895-08-06 | Bill and letter file | ||
| AU4058000A (en) * | 1999-04-02 | 2000-10-23 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulatorsof gabaa receptors |
| US6737242B1 (en) * | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
| GB9929687D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| WO2002002557A2 (en) | 2000-06-30 | 2002-01-10 | Neurogen Corporation | 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands |
| GB0027561D0 (en) | 2000-11-10 | 2000-12-27 | Merck Sharp & Dohme | Therapeutic agents |
| US6900215B2 (en) * | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| TWI248936B (en) * | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| AU2002241139B2 (en) * | 2001-03-23 | 2007-09-20 | Merck Sharp & Dohme Limited | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003245259A1 (en) * | 2002-05-02 | 2003-11-17 | Neurogen Corporation | Substituted imidazole derivatives: gabaa receptor ligands |
| AU2003301864A1 (en) * | 2002-05-08 | 2004-06-07 | Neurogen Corporation | Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands |
| EP1506194B1 (en) * | 2002-05-17 | 2006-07-19 | Neurogen Corporation | SUBSTITUTED RING-FUSED IMIDAZOLE DERIVATES: GABA sb A /sb RECEPTOR LIGANDS |
| CN100579579C (zh) * | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
| EP1560822B1 (en) | 2002-11-08 | 2006-08-09 | Neurogen Corporation | 4-imidazol-1-ylmethyl-pyrimidine derivatives as ligands for gabaa receptors |
| EP1619948A4 (en) | 2003-05-05 | 2007-02-14 | Neurogen Corp | SUBSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS |
-
2004
- 2004-07-23 AU AU2004261591A patent/AU2004261591A1/en not_active Abandoned
- 2004-07-23 DE DE602004004143T patent/DE602004004143T2/de not_active Expired - Lifetime
- 2004-07-23 NZ NZ544262A patent/NZ544262A/xx unknown
- 2004-07-23 PL PL04779031T patent/PL1648899T3/pl unknown
- 2004-07-23 ES ES04779031T patent/ES2278345T3/es not_active Expired - Lifetime
- 2004-07-23 CA CA002537331A patent/CA2537331A1/en not_active Abandoned
- 2004-07-23 KR KR1020067001782A patent/KR20060098425A/ko not_active Ceased
- 2004-07-23 EP EP04779031A patent/EP1648899B1/en not_active Expired - Lifetime
- 2004-07-23 DK DK04779031T patent/DK1648899T3/da active
- 2004-07-23 WO PCT/US2004/023794 patent/WO2005012306A2/en active IP Right Grant
- 2004-07-23 MX MXPA06000887A patent/MXPA06000887A/es active IP Right Grant
- 2004-07-23 US US10/898,690 patent/US7271170B2/en not_active Expired - Lifetime
- 2004-07-23 BR BRPI0412908-3A patent/BRPI0412908A/pt not_active IP Right Cessation
- 2004-07-23 AT AT04779031T patent/ATE350382T1/de not_active IP Right Cessation
- 2004-07-23 PT PT04779031T patent/PT1648899E/pt unknown
- 2004-07-23 JP JP2006521278A patent/JP2007500130A/ja active Pending
- 2004-07-26 AR ARP040102649A patent/AR045117A1/es unknown
- 2004-07-26 TW TW093122247A patent/TW200524937A/zh unknown
-
2006
- 2006-01-19 IL IL173265A patent/IL173265A0/en unknown
-
2007
- 2007-02-26 CY CY20071100262T patent/CY1107565T1/el unknown
- 2007-09-14 US US11/855,386 patent/US20080139580A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2278345T3 (es) | 2007-08-01 |
| WO2005012306A2 (en) | 2005-02-10 |
| PL1648899T3 (pl) | 2007-06-29 |
| IL173265A0 (en) | 2006-06-11 |
| WO2005012306A3 (en) | 2005-04-14 |
| EP1648899A2 (en) | 2006-04-26 |
| PT1648899E (pt) | 2007-03-30 |
| AR045117A1 (es) | 2005-10-19 |
| CY1107565T1 (el) | 2013-03-13 |
| BRPI0412908A (pt) | 2006-09-26 |
| CA2537331A1 (en) | 2005-02-10 |
| HK1089446A1 (en) | 2006-12-01 |
| TW200524937A (en) | 2005-08-01 |
| US20050038043A1 (en) | 2005-02-17 |
| MXPA06000887A (es) | 2006-04-19 |
| DE602004004143T2 (de) | 2007-10-11 |
| KR20060098425A (ko) | 2006-09-18 |
| US7271170B2 (en) | 2007-09-18 |
| JP2007500130A (ja) | 2007-01-11 |
| US20080139580A1 (en) | 2008-06-12 |
| AU2004261591A1 (en) | 2005-02-10 |
| NZ544262A (en) | 2009-06-26 |
| EP1648899B1 (en) | 2007-01-03 |
| DE602004004143D1 (de) | 2007-02-15 |
| ATE350382T1 (de) | 2007-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL175773A0 (en) | Anti-igfr1 antibody therapeutic combinations | |
| DE60336044D1 (de) | Sitzgleitschiene | |
| DE602004007220D1 (de) | Verbinder | |
| DE602004031798D1 (de) | Verbinder | |
| IS8054A (is) | Kannabinóíð viðtaka bindlar og notkun þeirra | |
| GB0416511D0 (en) | Pyrrolobenzodiazepines | |
| IS8137A (is) | Kannabinóíð viðtaka bindlar og notkun þeirra | |
| DE602004022898D1 (de) | Verbinder | |
| DE60327986D1 (de) | Sitzstruktur | |
| DE60314931D1 (de) | Sitzstruktur | |
| IS8526A (is) | CRF viðtakamótlyf og aðferðir tengdar þeim | |
| IS8575A (is) | 3-ß-D-ríbófúranósýlþíasóló [4,5-d]pýridímínnúkleósíð og notkun þeirra | |
| ATE512148T1 (de) | Pyrazolo- und imidazopyrimidinderivate | |
| DE502004011106D1 (de) | 6-arylmethyl-substituierte pyrazolopyrimidine | |
| DE50308359D1 (de) | Armlehne | |
| DE50308343D1 (de) | Armlehne | |
| IL173265A0 (en) | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazcpine receptor ligands | |
| DE602004026397D1 (de) | Verbinder | |
| DE602004003978D1 (de) | Verbinder | |
| DE602004001059D1 (de) | Sicherheitsgurtsystem | |
| DE602004009500D1 (de) | Verbinder | |
| ATA19412003A (de) | Stützkörpermatte | |
| DE60316553D1 (de) | Verbinder | |
| DE602004029309D1 (de) | Verbinder | |
| DE602004000496D1 (de) | Verbinder |