[go: up one dir, main page]

DK1636348T3 - Fremgangsmåde til generering af beta-öceller ud fra eksokrine pankreatiske celler - Google Patents

Fremgangsmåde til generering af beta-öceller ud fra eksokrine pankreatiske celler

Info

Publication number
DK1636348T3
DK1636348T3 DK04737673T DK04737673T DK1636348T3 DK 1636348 T3 DK1636348 T3 DK 1636348T3 DK 04737673 T DK04737673 T DK 04737673T DK 04737673 T DK04737673 T DK 04737673T DK 1636348 T3 DK1636348 T3 DK 1636348T3
Authority
DK
Denmark
Prior art keywords
cells
exocrine pancreatic
generating beta
islet
pancreatic cells
Prior art date
Application number
DK04737673T
Other languages
English (en)
Inventor
Luc Bouwens
Luc Baeyens
Original Assignee
Vrije Universiteit Brussel Vub
Opus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vrije Universiteit Brussel Vub, Opus Nv filed Critical Vrije Universiteit Brussel Vub
Application granted granted Critical
Publication of DK1636348T3 publication Critical patent/DK1636348T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/235Leukemia inhibitory factor [LIF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04737673T 2003-06-20 2004-06-21 Fremgangsmåde til generering af beta-öceller ud fra eksokrine pankreatiske celler DK1636348T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03447164 2003-06-20
PCT/BE2004/000089 WO2004113512A2 (en) 2003-06-20 2004-06-21 Method of generating islet beta-cells from exocrine pancreatic cells

Publications (1)

Publication Number Publication Date
DK1636348T3 true DK1636348T3 (da) 2009-11-23

Family

ID=33522524

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04737673T DK1636348T3 (da) 2003-06-20 2004-06-21 Fremgangsmåde til generering af beta-öceller ud fra eksokrine pankreatiske celler

Country Status (13)

Country Link
US (1) US7604991B2 (da)
EP (1) EP1636348B1 (da)
JP (1) JP2007520194A (da)
AT (1) ATE437941T1 (da)
CA (1) CA2527626A1 (da)
CY (1) CY1109474T1 (da)
DE (1) DE602004022292D1 (da)
DK (1) DK1636348T3 (da)
ES (1) ES2330438T3 (da)
PL (1) PL1636348T3 (da)
PT (1) PT1636348E (da)
SI (1) SI1636348T1 (da)
WO (1) WO2004113512A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2262890A1 (en) * 2008-02-22 2010-12-22 Vrije Universiteit Brussel Method for generating islet beta cells from dedifferentiated exocrine pancreatic cells
SG11201408717XA (en) 2012-06-26 2015-02-27 Seraxis Inc Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus
US9988605B2 (en) * 2013-12-11 2018-06-05 Korea Advanced Institute Of Science And Technology Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells
EP3289073A4 (en) * 2015-05-01 2019-07-17 University of Miami METHOD AND COMPOSITIONS FOR THE CONVERSION OF NON-ENDOCRINE PANCREATIC TISSUE IN INSULIN-PRODUCING CELLS
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739771B2 (en) * 1995-10-25 2001-10-18 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of langerhans and in vivo uses thereof
ES2553108T3 (es) * 1998-08-10 2015-12-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diferenciación de células no productoras de insulina en células productoras de insulina mediante GLP-1 o exendina-4 y utilizaciones de las mismas
KR19990014353A (ko) * 1998-10-17 1999-02-25 윤태욱 췌도의 대량 배양증식방법
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
MXPA02004268A (es) * 1999-10-29 2003-01-28 Univ Mcgill Medio para preparar celulas dediferenciadas.
US6610535B1 (en) * 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
ES2299417T3 (es) 2000-04-12 2008-06-01 Beta-Cell N.V. Metodo para producir preparaciones de celulas endocrinas pancreaticas madura e inmaduras, preparacion de las celulas y su utilizacion para el tratamiento de la diabetes mellitus.
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
CN1662643A (zh) * 2002-05-28 2005-08-31 贝克顿·迪金森公司 人腺泡细胞的扩增和转分化

Also Published As

Publication number Publication date
PT1636348E (pt) 2009-10-21
CY1109474T1 (el) 2014-08-13
ATE437941T1 (de) 2009-08-15
WO2004113512A2 (en) 2004-12-29
US20070292388A1 (en) 2007-12-20
EP1636348B1 (en) 2009-07-29
SI1636348T1 (sl) 2010-01-29
CA2527626A1 (en) 2004-12-29
ES2330438T3 (es) 2009-12-10
DE602004022292D1 (de) 2009-09-10
US7604991B2 (en) 2009-10-20
WO2004113512A3 (en) 2005-03-31
PL1636348T3 (pl) 2010-01-29
JP2007520194A (ja) 2007-07-26
EP1636348A2 (en) 2006-03-22

Similar Documents

Publication Publication Date Title
ATE542553T1 (de) Dezellularisierte omentummatrix und ihre verwendung
IL250313B (en) Expansion of renewable stem cell populations
UY28005A1 (es) Indol -3-carboxamidas como activadores de glucoquinasa (gk)
MX2009011484A (es) Proceso para la preparacion de etenilfenil alcoholes opticamente activos.
MX2007003589A (es) Metodos y dispositivos para inhibir la iclinacion de un espejo en un modulador interferometrico.
MX2021013219A (es) Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos.
CY1109474T1 (el) Μεθοδος δημιουργιας β-κυτταρων νησιδιων απο ενδοκρινη παγκρεατικα κυτταρα
DK1725660T3 (da) Ekspressionskassetter med multiple promotorer til samtidig afgivelse af RNAi-midler
WO2007002385A3 (en) Mesoderm and definitive endoderm cell populations
ATE508747T1 (de) C-kit kinase-hemmer
PE20090888A1 (es) Compuestos heterociclicos como agentes moduladores del receptor acoplado a la proteina g gpr119
EP2054360A4 (en) AROMATIC COMPOUND WITH FUSED CORES AND ORGANIC LIGHT-EMITTING DEVICE USING THE SAME
MXPA05000655A (es) Metodos y composiciones para modular el desarrollo y la funcion de las celulas t helper (th).
MX2010002338A (es) Compuesto de organoazufre con fluor y composicion pesticida que lo comprende.
NO20072302L (no) Modulatorer av hepatocyttvekstfaktoraktivator
MX2009006315A (es) Compuesto heterociclico fusionado.
SA522432641B1 (ar) T تركيبة لزراعة الخلية التنظيمية واستخدامها
GEP20237572B (en) Polyheterocyclic modulators of sting (stimulator of interferon genes)
DK1720979T3 (da) Anvendelse af et serumfrit celledyrkningsmedium til fremstilling af IL-18BP I pattedyrceller
DE602005011780D1 (de) Triazinderivate mit carbamatfunktion
WO2005094353A3 (en) Methods for production of regulatory t cells and uses thereof
MX2010012730A (es) Metodo para diferenciacion de celulas progenitoras de mamifero en celulas de islote pancreaticas que producen insulina.
TW200602044A (en) Compounds
WO2009062260A8 (en) Therapy for multiple sclerosis
DK1165113T3 (da) Anvendelse af ErbB-receptorligander i behandling af diabetes