DK1625153T3 - Acylerede nonadepsipeptider af typen Lysobactin - Google Patents

Acylerede nonadepsipeptider af typen Lysobactin

Info

Publication number: DK1625153T3
Authority: DK; Denmark
Prior art keywords: nonadepsipeptides; lysobactin; acylated; type; lysobactin type
Prior art date: 2003-05-09

Application number

DK04729639T

Other languages

English (en)

Inventor

Rainer Endermann

Chantal Fuerstner

Elke Hartmann

Johannes Koebberling

Guido Schiffer

Joachim Schuhmacher

Joachim Telser

Nussbaum Franz Von

Nina Brunner

Sonja Anlauf

Jacques Ragot

Niels Svenstrup

Michael-Alexander Bruening

Original Assignee

Aicuris Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-09

Filing date

2004-04-27

Publication date

2009-12-14

2004-04-27 Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg

2009-12-14 Application granted granted Critical

2009-12-14 Publication of DK1625153T3 publication Critical patent/DK1625153T3/da

Links

KQMKBWMQSNKASI-AVSFGBOWSA-N lysobactin Chemical compound O1C(=O)[C@H](CO)NC(=O)[C@H]([C@H](O)C(N)=O)NC(=O)CNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@H](O)C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)CC(C)C)[C@H]1C1=CC=CC=C1 KQMKBWMQSNKASI-AVSFGBOWSA-N 0.000 title 1
KQMKBWMQSNKASI-UHFFFAOYSA-N lysobactin Natural products O1C(=O)C(CO)NC(=O)C(C(O)C(N)=O)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(C(C)CC)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C(O)C(C)C)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C)C1C1=CC=CC=C1 KQMKBWMQSNKASI-UHFFFAOYSA-N 0.000 title 1
108010011530 lysobactin Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK04729639T 2003-05-09 2004-04-27 Acylerede nonadepsipeptider af typen Lysobactin DK1625153T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10320781A DE10320781A1 (de)	2003-05-09	2003-05-09	Acylierte Nonadepsipeptide
PCT/EP2004/004416 WO2004099239A1 (de)	2003-05-09	2004-04-27	Acylierte nonadepsipeptide vom lysobactin-typ

Publications (1)

Publication Number	Publication Date
DK1625153T3 true DK1625153T3 (da)	2009-12-14

Family

ID=33394366

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04729639T DK1625153T3 (da)	2003-05-09	2004-04-27	Acylerede nonadepsipeptider af typen Lysobactin

Country Status (16)

Country	Link
US (1)	US7368424B2 (da)
EP (1)	EP1625153B1 (da)
JP (1)	JP4557232B2 (da)
AR (1)	AR044256A1 (da)
AT (1)	ATE440859T1 (da)
CA (1)	CA2524722A1 (da)
CL (1)	CL2004000979A1 (da)
DE (2)	DE10320781A1 (da)
DK (1)	DK1625153T3 (da)
ES (1)	ES2330221T3 (da)
GT (1)	GT200400090A (da)
PL (1)	PL1625153T3 (da)
PT (1)	PT1625153E (da)
TW (1)	TW200510449A (da)
UY (1)	UY28313A1 (da)
WO (1)	WO2004099239A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10320781A1 (de) *	2003-05-09	2004-11-25	Bayer Healthcare Ag	Acylierte Nonadepsipeptide
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
EA200700243A1 (ru)	2004-07-14	2007-08-31	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Способы лечения гепатита с
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
MX2007000762A (es)	2004-07-22	2007-04-02	Ptc Therapeutics Inc	Tienopiridinas para tratamientode hepatitis c.
DE102004051025A1 (de)	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004051023A1 (de)	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102004053409A1 (de)	2004-11-05	2006-05-11	Bayer Healthcare Ag	Verfahren zur gezielten Herstellung von Lysobactinfragmenten
DE102004053407A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Acylierte Nonadepsipeptide II
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
JP5564570B2 (ja) *	2009-09-25	2014-07-30	カディラ・ヘルスケア・リミテッド	ラコサミドおよびその中間体の調製方法
TW201717991A (zh) *	2015-08-17	2017-06-01	拜耳動物保健有限公司	用於治療牛乳房炎之溶桿菌素
EP3363452A1 (en)	2017-02-17	2018-08-22	Bayer Animal Health GmbH	Combinations of lysobactin and aminogylcosides against diseases caused by gram-positive and gram-negative bacteria in non-human animals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1266247C (en)	1985-03-25	1990-02-27		ANTIBIOTIC PREPARED BY LYSOBACTER SP. SC14.067
JPH01132600A (ja)	1987-11-17	1989-05-25	Shionogi & Co Ltd	カタノシンａおよびｂならびにその製造法
DE10320781A1 (de) *	2003-05-09	2004-11-25	Bayer Healthcare Ag	Acylierte Nonadepsipeptide

2003
- 2003-05-09 DE DE10320781A patent/DE10320781A1/de not_active Withdrawn
2004
- 2004-04-27 EP EP04729639A patent/EP1625153B1/de not_active Expired - Lifetime
- 2004-04-27 PT PT04729639T patent/PT1625153E/pt unknown
- 2004-04-27 ES ES04729639T patent/ES2330221T3/es not_active Expired - Lifetime
- 2004-04-27 JP JP2006505280A patent/JP4557232B2/ja not_active Expired - Fee Related
- 2004-04-27 PL PL04729639T patent/PL1625153T3/pl unknown
- 2004-04-27 DE DE502004009971T patent/DE502004009971D1/de not_active Expired - Lifetime
- 2004-04-27 WO PCT/EP2004/004416 patent/WO2004099239A1/de active Application Filing
- 2004-04-27 AT AT04729639T patent/ATE440859T1/de active
- 2004-04-27 CA CA002524722A patent/CA2524722A1/en not_active Abandoned
- 2004-04-27 DK DK04729639T patent/DK1625153T3/da active
- 2004-05-05 GT GT200400090A patent/GT200400090A/es unknown
- 2004-05-06 US US10/840,749 patent/US7368424B2/en not_active Expired - Fee Related
- 2004-05-06 AR ARP040101548A patent/AR044256A1/es unknown
- 2004-05-07 UY UY28313A patent/UY28313A1/es not_active Application Discontinuation
- 2004-05-07 CL CL200400979A patent/CL2004000979A1/es unknown
- 2004-05-07 TW TW093112838A patent/TW200510449A/zh unknown

Also Published As

Publication number	Publication date
UY28313A1 (es)	2004-12-31
EP1625153B1 (de)	2009-08-26
AR044256A1 (es)	2005-09-07
CA2524722A1 (en)	2004-11-18
JP4557232B2 (ja)	2010-10-06
TW200510449A (en)	2005-03-16
WO2004099239A1 (de)	2004-11-18
PL1625153T3 (pl)	2010-02-26
ATE440859T1 (de)	2009-09-15
GT200400090A (es)	2004-12-23
US7368424B2 (en)	2008-05-06
EP1625153A1 (de)	2006-02-15
DE10320781A1 (de)	2004-11-25
JP2007535469A (ja)	2007-12-06
PT1625153E (pt)	2009-11-03
CL2004000979A1 (es)	2005-05-06
US20050075281A1 (en)	2005-04-07
DE502004009971D1 (de)	2009-10-08
ES2330221T3 (es)	2009-12-07

Publication	Publication Date	Title
DE502004003292D1 (de)	2007-05-03	Flugzeug
EP1515583A4 (en)	2009-12-30	LOUD SPEAKER
ITMI20041123A1 (it)	2004-09-03	Fissaggio
DE602004002987D1 (de)	2006-12-14	Linseneinführsystem
DE602004002062D1 (de)	2006-10-05	Vibrationsgeschütztes Hitzeschield
DE502004011058D1 (de)	2010-05-27	Fallhäufigkeit
DK1625153T3 (da)	2009-12-14	Acylerede nonadepsipeptider af typen Lysobactin
DE602004015185D1 (de)	2008-09-04	Lautsprecher
DE602004018602D1 (de)	2009-02-05	Mikrospiegel
AT502792A5 (de)	2007-05-15	Düsenanpressvorrichtung
DE502004009754D1 (de)	2009-08-27	Tourbillon
NO20034599D0 (no)	2003-10-14	Brokonstruksjon
DK1633719T3 (da)	2010-01-04	Substituerede spirobenzazepiner
NO20040868L (no)	2004-08-26	Ruting av meldinger
NO20034600D0 (no)	2003-10-14	Brokonstruksjon
DE502004009022D1 (de)	2009-04-02	Pendelstütze
ATA5212002A (de)	2004-08-15	Teleskop
DK1592417T3 (da)	2007-08-06	Kombinationen af antidiabetiske lægemidler
FR2856381B1 (fr)	2006-04-14	Barquette multi-alveolaire
DE10394324D2 (de)	2006-06-29	Schmuckstück
DE10394322D2 (de)	2006-06-29	Schmuckstück
DE50307365D1 (de)	2007-07-12	Etui
DE10390040D2 (de)	2004-12-23	Fernglas
FIU20030431U0 (fi)	2003-11-17	Peili
SE0300011D0 (sv)	2003-01-08	Blandninganordning