DK1608671T3 - Østrogenderivater som inhibitorer af steroidsulfatase - Google Patents

Østrogenderivater som inhibitorer af steroidsulfatase

Info

Publication number: DK1608671T3
Authority: DK; Denmark
Prior art keywords: group; inhibitors; steroid sulfatase; ring system; estrogen derivatives
Prior art date: 2003-03-24

Application number

DK04713124.8T

Other languages

English (en)

Inventor

Michael John Reed

Surinder K Chander

Fabrice Jourdan

Barry V L Potter

Mathew Leese

Alan Purohit

Simon Paul Newman

Original Assignee

Sterix Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-24

Filing date

2004-02-20

Publication date

2010-05-10

2003-03-24 Priority claimed from GB0306717A external-priority patent/GB0306717D0/en

2003-07-07 Priority claimed from GB0315885A external-priority patent/GB0315885D0/en

2004-02-20 Application filed by Sterix Ltd filed Critical Sterix Ltd

2010-05-10 Application granted granted Critical

2010-05-10 Publication of DK1608671T3 publication Critical patent/DK1608671T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Psychiatry (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Enzymes And Modification Thereof (AREA)

DK04713124.8T 2003-03-24 2004-02-20 Østrogenderivater som inhibitorer af steroidsulfatase DK1608671T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0306717A GB0306717D0 (en)	2003-03-24	2003-03-24	Compound
GB0315885A GB0315885D0 (en)	2003-07-07	2003-07-07	Compound
PCT/GB2004/000705 WO2004085459A1 (en)	2003-03-24	2004-02-20	Oestrogen derivatives as inhibitors of steroid sulphatase

Publications (1)

Publication Number	Publication Date
DK1608671T3 true DK1608671T3 (da)	2010-05-10

Family

ID=33099976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04713124.8T DK1608671T3 (da)	2003-03-24	2004-02-20	Østrogenderivater som inhibitorer af steroidsulfatase

Country Status (15)

Country	Link
US (1)	US7893284B2 (da)
EP (1)	EP1608671B1 (da)
JP (1)	JP4719144B2 (da)
AT (1)	ATE454395T1 (da)
AU (1)	AU2004224053B2 (da)
BR (1)	BRPI0408703A (da)
CA (1)	CA2520142C (da)
DE (1)	DE602004024966D1 (da)
DK (1)	DK1608671T3 (da)
EA (1)	EA011123B1 (da)
ES (1)	ES2339450T3 (da)
HK (1)	HK1082258A1 (da)
MX (1)	MXPA05010339A (da)
PL (1)	PL378577A1 (da)
WO (1)	WO2004085459A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0113920D0 (en)	2001-06-07	2001-08-01	Sterix Ltd	Composition
US8030298B2 (en)	2005-05-26	2011-10-04	Abbott Products Gmbh	17β-HSD1 and STS inhibitors
US8288367B2 (en)	2006-11-30	2012-10-16	Solvay Pharmaceuticals Gmbh	Substituted estratriene derivatives as 17BETA HSD inhibitors
WO2008090517A2 (en) *	2007-01-26	2008-07-31	Piramal Life Sciences Limited	Enriched plant extract, compound, and methods for the treatment of proliferative disorders
EP2149371A1 (en)	2008-07-28	2010-02-03	PregLem S.A.	Use of steroid sulfatase inhibitors for the treatment of preterm labor
WO2010024930A2 (en)	2008-08-28	2010-03-04	President And Fellows Of Harvard College	Cortistatin analogues and syntheses therof
US20120190659A1 (en) *	2009-04-22	2012-07-26	Children's Medical Center Corporation	Angiogenesis inhibitors
WO2012116290A2 (en) *	2011-02-25	2012-08-30	Washington University	Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
PT2766380T (pt)	2011-10-14	2019-07-29	Sage Therapeutics Inc	Compostos de 19-nor pregnano 3,3-dissubstituídos, composições e seus usos
CN105026415B (zh)	2012-12-18	2019-02-01	华盛顿大学	神经活性的19-烷氧基-17-取代的甾族化合物、其前药以及利用所述化合物的治疗方法
US9512170B2 (en)	2013-03-01	2016-12-06	Washington University	Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en)	2013-03-11	2016-06-14	Washington University	Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en)	2013-03-14	2017-02-07	Washington University	Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
HUE051403T2 (hu)	2013-04-17	2021-03-01	Sage Therapeutics Inc	Neuroaktív 19-nor-szteroidok kezelési eljárásokhoz
KR102396328B1 (ko)	2013-04-17	2022-05-10	세이지 테라퓨틱스, 인크.	19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
PL3021852T3 (pl)	2013-07-19	2021-07-05	Sage Therapeutics, Inc.	Neuroaktywne steroidy, kompozycje i ich zastosowania
LT3488852T (lt)	2013-08-23	2021-02-25	Sage Therapeutics, Inc.	Neuroaktyvūs steroidai, kompozicijos, ir jų naudojimas
SG11201605178WA (en)	2013-12-24	2016-07-28	Harvard College	Cortistatin analogues and syntheses and uses thereof
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
US20170233433A1 (en)	2014-10-16	2017-08-17	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
SG10202009859YA (en)	2014-10-16	2020-11-27	Sage Therapeutics Inc	Compositions and methods for treating cns disorders
PL3224269T3 (pl)	2014-11-27	2020-08-24	Sage Therapeutics, Inc.	Kompozycje i sposoby leczenia zaburzeń OUN
LT3250210T (lt)	2015-01-26	2021-04-12	Sage Therapeutics, Inc.	Kompozicijos ir būdai, skirti gydyti cns sutrikimus
EP4155314A1 (en)	2015-02-20	2023-03-29	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
EP3294298A4 (en)	2015-05-08	2018-10-17	President and Fellows of Harvard College	Cortistatin analogues, syntheses, and uses thereof
EP3316889A4 (en)	2015-07-01	2018-11-14	President and Fellows of Harvard College	Cortistatin analogues and syntheses and uses thereof
AU2017283878A1 (en) *	2016-06-15	2019-01-03	Sony Corporation	Information processing device, observation system, observation method, and program
US20190233465A1 (en)	2016-07-11	2019-08-01	Sage Therapeutics, Inc.	C7, c12, and c16 substituted neuroactive steroids and their methods of use
JP7049313B2 (ja)	2016-07-11	2022-04-06	セージセラピューティクス，インコーポレイテッド	Ｃ１７、ｃ２０、およびｃ２１置換神経刺激性ステロイドおよびそれらの使用方法
CR20240234A (es)	2019-05-31	2024-07-09	Sage Therapeutics Inc	ESTEROIDES NEUROACTIVOS Y COMPOSICIONES DE ESTOS (Divisional 2021-629)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4994439A (en) *	1989-01-19	1991-02-19	California Biotechnology Inc.	Transmembrane formulations for drug administration
DE19723794A1 (de) *	1997-06-06	1998-12-10	Jenapharm Gmbh	Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
US6288050B1 (en) *	1997-07-18	2001-09-11	Duquesne University Of The Holy Ghost	Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) *	1997-12-04	2002-11-27	Imperial College	Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) *	1997-12-24	2000-04-04	Sri International	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
ATE401896T1 (de) *	1998-06-10	2008-08-15	Sterix Ltd	Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
EP1173182A2 (en) *	1999-04-30	2002-01-23	Sterix Limited	Use of estrone derivatives as antitumour agents
AU2001248849A1 (en) *	2000-04-24	2001-11-07	Kyowa Hakko Kogyo Co. Ltd.	Estra-1,3,5(10)-triene derivatives
CA2408751A1 (en) *	2000-05-11	2001-11-15	Robert Henry Hesse	2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity
CA2418479C (en) *	2000-08-18	2007-12-18	The Board Of Trustees Of The University Of Illinois	Prodrugs of betulinic acid derivatives for the treatment of cancer
GB0020498D0 (en) *	2000-08-18	2000-10-11	Sterix Ltd	Compound
WO2002062347A1 (en)	2001-02-05	2002-08-15	Oncology Sciences Corporation	Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
GB0421106D0 (en) *	2004-09-22	2004-10-27	Sterix Ltd	Compound

2004
- 2004-02-20 PL PL378577A patent/PL378577A1/pl not_active Application Discontinuation
- 2004-02-20 BR BRPI0408703-8A patent/BRPI0408703A/pt not_active IP Right Cessation
- 2004-02-20 EP EP04713124A patent/EP1608671B1/en not_active Expired - Lifetime
- 2004-02-20 DK DK04713124.8T patent/DK1608671T3/da active
- 2004-02-20 CA CA2520142A patent/CA2520142C/en not_active Expired - Fee Related
- 2004-02-20 JP JP2006505892A patent/JP4719144B2/ja not_active Expired - Fee Related
- 2004-02-20 DE DE602004024966T patent/DE602004024966D1/de not_active Expired - Lifetime
- 2004-02-20 WO PCT/GB2004/000705 patent/WO2004085459A1/en active Application Filing
- 2004-02-20 MX MXPA05010339A patent/MXPA05010339A/es active IP Right Grant
- 2004-02-20 AU AU2004224053A patent/AU2004224053B2/en not_active Ceased
- 2004-02-20 ES ES04713124T patent/ES2339450T3/es not_active Expired - Lifetime
- 2004-02-20 AT AT04713124T patent/ATE454395T1/de not_active IP Right Cessation
- 2004-02-20 EA EA200501426A patent/EA011123B1/ru not_active IP Right Cessation
2005
- 2005-09-23 US US11/233,945 patent/US7893284B2/en not_active Expired - Fee Related
2006
- 2006-03-29 HK HK06103924.9A patent/HK1082258A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2006521335A (ja)	2006-09-21
US20060094696A1 (en)	2006-05-04
HK1082258A1 (en)	2006-06-02
DE602004024966D1 (de)	2010-02-25
BRPI0408703A (pt)	2006-03-07
EA200501426A1 (ru)	2006-06-30
CA2520142A1 (en)	2004-10-07
EP1608671A1 (en)	2005-12-28
EA011123B1 (ru)	2008-12-30
US7893284B2 (en)	2011-02-22
AU2004224053A1 (en)	2004-10-07
PL378577A1 (pl)	2006-05-02
MXPA05010339A (es)	2005-12-14
ATE454395T1 (de)	2010-01-15
EP1608671B1 (en)	2010-01-06
JP4719144B2 (ja)	2011-07-06
AU2004224053B2 (en)	2011-06-09
ES2339450T3 (es)	2010-05-20
WO2004085459A1 (en)	2004-10-07
CA2520142C (en)	2011-01-04

Publication	Publication Date	Title
DK1608671T3 (da)	2010-05-10	Østrogenderivater som inhibitorer af steroidsulfatase
DOP2011000301A (es)	2011-10-31	Derivados de azaadamantano y metodos de uso de los mismos
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GT200100007A (es)	2001-10-19	Antagonistas del factor liberador de corticotropina.
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TR200000447T2 (tr)	2000-07-21	5-Alkil-2-arilaminofenilasetik asitler ve türevleri.
RS52168B (en)	2012-08-31	PIPERIDINSKI GPCR AGONIST
CU23834B1 (es)	2012-10-15	Compuestos de pirazolo [3,4-d] pirimidinona y sus derivados para la inhibición pde9
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AR067613A1 (es)	2009-10-14	Inhibidores de adn-pk, uso y sintesis de los mismos
NO20061317L (no)	2006-03-23	Imidazopyridinderivater som induserbare NO-syntaseinhibatorer
DK1311619T3 (da)	2007-01-29	Anvendelse af en bitumen/vokssammensætning
HN2001000235A (es)	2001-11-07	Derivados puentes de piperazina
ECSP034531A (es)	2003-05-26	Derivados sustituidos de c-ciclohexilmetilamina
NO20061344L (no)	2006-03-24	Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer
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AR028743A1 (es)	2003-05-21	DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA
AR042404A2 (es)	2005-06-22	Compuestos derivados de anilina
PA8519801A1 (es)	2002-04-25	Nuevo procedimiento para la preparacion de pirazolopirimidinonas
MX2008011292A (es)	2008-09-10	Compuestos esteroidales como inhibidores de esteroide sulfatasa.
HN2000000056A (es)	2001-02-02	Nuevas formas cristalinas de un antibiotico macrolido