DK1566635T3 - Chip med array af mikrobrønde til påvisning af antigenspecifik lymfocyt, fremgangsmåde til påvisning af antigenspecifik lymfocyt og fremgangsmåde til kloning af antigenspecifik lymfocyt-antigenreceptorgen - Google Patents
Chip med array af mikrobrønde til påvisning af antigenspecifik lymfocyt, fremgangsmåde til påvisning af antigenspecifik lymfocyt og fremgangsmåde til kloning af antigenspecifik lymfocyt-antigenreceptorgenInfo
- Publication number
- DK1566635T3 DK1566635T3 DK03812277.6T DK03812277T DK1566635T3 DK 1566635 T3 DK1566635 T3 DK 1566635T3 DK 03812277 T DK03812277 T DK 03812277T DK 1566635 T3 DK1566635 T3 DK 1566635T3
- Authority
- DK
- Denmark
- Prior art keywords
- antigen
- specific lymphocyte
- detecting
- lymphocyte
- array chip
- Prior art date
Links
- 210000004698 lymphocyte Anatomy 0.000 title abstract 8
- 239000000427 antigen Substances 0.000 title abstract 7
- 108091007433 antigens Proteins 0.000 title abstract 7
- 102000036639 antigens Human genes 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 title 1
- 238000010367 cloning Methods 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002331031 | 2002-11-14 | ||
| JP2002346728 | 2002-11-29 | ||
| PCT/JP2003/012500 WO2004051266A1 (ja) | 2002-11-14 | 2003-09-30 | 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法、並びに抗原特異的リンパ球抗原受容体遺伝子のクローニング方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1566635T3 true DK1566635T3 (da) | 2012-03-19 |
Family
ID=32473638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03812277.6T DK1566635T3 (da) | 2002-11-14 | 2003-09-30 | Chip med array af mikrobrønde til påvisning af antigenspecifik lymfocyt, fremgangsmåde til påvisning af antigenspecifik lymfocyt og fremgangsmåde til kloning af antigenspecifik lymfocyt-antigenreceptorgen |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060134704A1 (da) |
| EP (2) | EP1566635B1 (da) |
| AT (1) | ATE536548T1 (da) |
| AU (1) | AU2003266712A1 (da) |
| DK (1) | DK1566635T3 (da) |
| WO (1) | WO2004051266A1 (da) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1566635B1 (en) * | 2002-11-14 | 2011-12-07 | Vivalis | Microwell array chip for detecting antigen-specific lymphocyte, method of detecting antigen-specific lymphocyte and method of cloning antigen-specific lymphocyte antigen receptor gene |
| IL154677A0 (en) | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
| WO2004087911A1 (ja) * | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
| US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
| DK1691196T3 (da) * | 2003-09-25 | 2013-04-15 | Vivalis | Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf |
| JP2006061023A (ja) * | 2004-08-24 | 2006-03-09 | Suntory Ltd | マイクロチャンバーアレイを用いたスクリーニング方法およびスクリーニング装置 |
| JP3927978B2 (ja) * | 2004-11-02 | 2007-06-13 | キヤノン株式会社 | 生化学反応カートリッジおよび生化学処理装置システム |
| ES2352344T3 (es) | 2005-01-25 | 2011-02-17 | Seng Enterprises Limited | Dispositivo de microfluido para estudio de células. |
| US7776553B2 (en) | 2005-09-16 | 2010-08-17 | Presidents And Fellows Of Harvard College | Screening assays and methods |
| JP4025916B2 (ja) | 2005-09-30 | 2007-12-26 | 富山県 | 感熱応答性高分子を用いた穴パタン付き膜を有するチップ及びその製造方法 |
| WO2007052245A1 (en) | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
| US7724373B2 (en) * | 2005-12-16 | 2010-05-25 | Indiana University Research & Technology Corporation | Sub-micron surface plasmon resonance sensor systems |
| US8355136B2 (en) | 2005-12-16 | 2013-01-15 | Indiana University Research And Technology Corporation | Sub-micron surface plasmon resonance sensor systems |
| US20080227664A1 (en) * | 2007-03-16 | 2008-09-18 | Canon Kabushiki Kaisha | Cell array structural body and cell array |
| JP4148367B1 (ja) | 2007-08-02 | 2008-09-10 | 富山県 | 細胞のスクリーニング方法 |
| WO2009045898A2 (en) * | 2007-09-28 | 2009-04-09 | Mayo Foundation For Medical Education And Research | Assessing t cell repertoires |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| EP2237887A2 (en) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Device for the study of living cells |
| EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| JP5749156B2 (ja) * | 2008-04-05 | 2015-07-15 | シングル セル テクノロジー, インコーポレイテッドSingle Cell Technology, Inc. | 生理活性物質の生産のための単一細胞を選抜する方法 |
| EP2336348B1 (en) * | 2008-09-02 | 2014-11-05 | National Institute of Advanced Industrial Science And Technology | Cell detection method, and microarray chip for use in the method |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| EP3699296A1 (en) * | 2008-11-07 | 2020-08-26 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| DK2387627T3 (da) | 2009-01-15 | 2016-07-04 | Adaptive Biotechnologies Corp | Adaptiv immunitetsprofilering og fremgangsmåder til at frembringe monoklonale antistoffer |
| RU2539032C2 (ru) | 2009-06-25 | 2015-01-10 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения искусственного иммунитета |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| US20130115606A1 (en) | 2010-07-07 | 2013-05-09 | The University Of British Columbia | System and method for microfluidic cell culture |
| US10087408B2 (en) | 2010-07-07 | 2018-10-02 | The University Of British Columbia | System and method for microfluidic cell culture |
| EP2724157B1 (en) | 2011-06-27 | 2017-03-08 | Valneva | Method for screening cells |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| US9279159B2 (en) | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3388535B1 (en) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| US8790907B2 (en) | 2012-01-27 | 2014-07-29 | Japan Agency For Marine-Earth Science And Technology | Method for detachment and preparation of living microorganisms |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| JP6327734B2 (ja) * | 2012-03-07 | 2018-05-23 | 国立大学法人富山大学 | T細胞の刺激方法およびその利用 |
| US9150905B2 (en) | 2012-05-08 | 2015-10-06 | Adaptive Biotechnologies Corporation | Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions |
| EP3330384B1 (en) | 2012-10-01 | 2019-09-25 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
| JP6210004B2 (ja) * | 2013-04-09 | 2017-10-11 | 株式会社Jvcケンウッド | 試料分析用デバイス及びエクソソームの捕捉方法 |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| CA2941612A1 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
| WO2015182749A1 (ja) | 2014-05-30 | 2015-12-03 | 国立大学法人富山大学 | TCR cDNAの増幅方法 |
| ES2784343T3 (es) | 2014-10-29 | 2020-09-24 | Adaptive Biotechnologies Corp | Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras |
| JP6812797B2 (ja) * | 2014-11-04 | 2021-01-13 | 凸版印刷株式会社 | 核酸導入方法、核酸検出方法、生体成分解析方法、生体成分定量用アレイデバイス、及び生体成分解析キット |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| EP3591074B1 (en) | 2015-02-24 | 2024-10-23 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| US10488321B2 (en) | 2015-03-19 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| EP3408288A2 (en) | 2016-01-29 | 2018-12-05 | Achaogen, Inc. | Screening methods for identifying antibodies that bind cell surface epitopes |
| CN109563539A (zh) | 2016-06-15 | 2019-04-02 | 慕尼黑路德维希马克西米利安斯大学 | 使用dna纳米技术的单分子检测或定量 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US10724089B2 (en) | 2016-10-06 | 2020-07-28 | The Board Of Trustees Of The University Of Illinois | Spatial molecular analysis of tissue |
| WO2018140827A1 (en) | 2017-01-27 | 2018-08-02 | Achaogen, Inc. | Reporter microorganisms and uses thereof |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| AU2019398307A1 (en) | 2018-12-13 | 2021-06-10 | Dna Script | Direct oligonucleotide synthesis on cells and biomolecules |
| EP4232542A4 (en) * | 2020-10-22 | 2024-10-09 | The Board of Regents of the University of Texas System | HIGH THROUGHPUT MICROWELL ARRAY PLATES AND METHODS OF MANUFACTURE |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68507A (en) | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
| US5310674A (en) | 1982-05-10 | 1994-05-10 | Bar-Ilan University | Apertured cell carrier |
| US5272081A (en) * | 1982-05-10 | 1993-12-21 | Bar-Ilan University | System and methods for cell selection |
| US6410252B1 (en) * | 1995-12-22 | 2002-06-25 | Case Western Reserve University | Methods for measuring T cell cytokines |
| AU727541B2 (en) * | 1996-09-06 | 2000-12-14 | Ortho-Mcneil Pharmaceutical, Inc. | Purification of antigen-specific T cells |
| US6548263B1 (en) * | 1997-05-29 | 2003-04-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
| US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| EP1060022A1 (en) | 1998-02-04 | 2000-12-20 | Merck & Co., Inc. | Virtual wells for use in high throughput screening assays |
| US6210910B1 (en) * | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| US6087103A (en) * | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
| US20030027214A1 (en) * | 1999-02-17 | 2003-02-06 | Kamb Carl Alexander | Methods for substrate-ligand interaction screening |
| JP2003504657A (ja) * | 1999-07-02 | 2003-02-04 | トムソン ライセンシング ソシエテ アノニム | テレビジョン用の投写型スクリーン |
| US7211209B2 (en) * | 2000-11-08 | 2007-05-01 | Surface Logix, Inc. | Method of making device for arraying biomolecules and for monitoring cell motility in real-time |
| US20020141906A1 (en) | 2001-03-30 | 2002-10-03 | American Type Culture Collection | Microtiter plate sealing cover with well identifiers |
| US6777187B2 (en) * | 2001-05-02 | 2004-08-17 | Rubicon Genomics, Inc. | Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates |
| JP4754746B2 (ja) | 2001-09-28 | 2011-08-24 | オリンパス株式会社 | 棒状担体およびこれを具備するシリンダー反応容器 |
| EP1566635B1 (en) * | 2002-11-14 | 2011-12-07 | Vivalis | Microwell array chip for detecting antigen-specific lymphocyte, method of detecting antigen-specific lymphocyte and method of cloning antigen-specific lymphocyte antigen receptor gene |
| WO2004087911A1 (ja) | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
-
2003
- 2003-09-30 EP EP03812277A patent/EP1566635B1/en not_active Revoked
- 2003-09-30 AT AT03812277T patent/ATE536548T1/de active
- 2003-09-30 EP EP10184204.5A patent/EP2365331B1/en not_active Expired - Lifetime
- 2003-09-30 US US10/534,800 patent/US20060134704A1/en not_active Abandoned
- 2003-09-30 AU AU2003266712A patent/AU2003266712A1/en not_active Abandoned
- 2003-09-30 DK DK03812277.6T patent/DK1566635T3/da active
- 2003-09-30 WO PCT/JP2003/012500 patent/WO2004051266A1/ja not_active Ceased
-
2008
- 2008-12-17 US US12/337,481 patent/US8445193B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2365331B1 (en) | 2015-11-04 |
| ATE536548T1 (de) | 2011-12-15 |
| US20090181859A1 (en) | 2009-07-16 |
| EP1566635A1 (en) | 2005-08-24 |
| US20060134704A1 (en) | 2006-06-22 |
| EP1566635B1 (en) | 2011-12-07 |
| EP2365331A3 (en) | 2011-11-23 |
| EP1566635A4 (en) | 2006-12-27 |
| AU2003266712A1 (en) | 2004-06-23 |
| WO2004051266A1 (ja) | 2004-06-17 |
| US8445193B2 (en) | 2013-05-21 |
| EP2365331A2 (en) | 2011-09-14 |
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