DK151341C - Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat - Google Patents

Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat

Info

Publication number: DK151341C
Authority: DK; Denmark
Prior art keywords: argininaldehyde; phenylalanyl; prolyl; sulfate; preparation
Prior art date: 1981-01-13

Application number

DK009382A

Other languages

English (en)

Other versions

DK9382A (da

DK151341B (da

Inventor

Sandor Bajusz

Erzsebet Szell

Eva Barabas

Daniel Bagdy

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-01-13

Filing date

1982-01-12

Publication date

1988-05-09

1982-01-12 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1982-07-14 Publication of DK9382A publication Critical patent/DK9382A/da

1987-11-23 Publication of DK151341B publication Critical patent/DK151341B/da

1988-05-09 Application granted granted Critical

1988-05-09 Publication of DK151341C publication Critical patent/DK151341C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK009382A 1981-01-13 1982-01-12 Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat DK151341C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU7081		1981-01-13
HU8170A HU184368B (en)	1981-01-13	1981-01-13	Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

Publications (3)

Publication Number	Publication Date
DK9382A DK9382A (da)	1982-07-14
DK151341B DK151341B (da)	1987-11-23
DK151341C true DK151341C (da)	1988-05-09

Family

ID=10947750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK009382A DK151341C (da)	1981-01-13	1982-01-12	Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat

Country Status (23)

Country	Link
US (2)	US4399065A (da)
JP (1)	JPS57181046A (da)
AT (1)	AT383352B (da)
AU (1)	AU544492B2 (da)
BE (1)	BE891708A (da)
CA (1)	CA1182111A (da)
CH (1)	CH649305A5 (da)
DE (1)	DE3200812C2 (da)
DK (1)	DK151341C (da)
ES (1)	ES8301205A1 (da)
FI (1)	FI74024C (da)
FR (1)	FR2497799B1 (da)
GB (1)	GB2091270B (da)
HU (1)	HU184368B (da)
IL (1)	IL64761A (da)
IT (1)	IT1210842B (da)
MX (1)	MX156383A (da)
NL (1)	NL8200105A (da)
NO (1)	NO158021C (da)
PL (1)	PL133451B1 (da)
PT (1)	PT74268B (da)
SE (1)	SE453509B (da)
SU (1)	SU1442078A3 (da)

Families Citing this family (65)

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HU184368B (en) *	1981-01-13	1984-08-28	Gyogyszerkutato Intezet	Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
EP0316965A3 (en) *	1983-02-07	1989-08-09	Aktiebolaget Hässle	Enzyme inhibitors
DE3481913D1 (de) *	1983-04-27	1990-05-17	Ici America Inc	Prolin-derivate.
HU192646B (en) *	1984-12-21	1987-06-29	Gyogyszerkutato Intezet	Process for preparing new n-alkyl-peptide aldehydes
DE3505555A1 (de) *	1985-02-18	1986-09-11	Behringwerke Ag, 3550 Marburg	Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
DE3606480A1 (de) *	1986-02-28	1987-09-03	Behringwerke Ag	Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5023236A (en) *	1988-04-07	1991-06-11	Corvas, Inc.	Factor VII/VIIA active site inhibitors
US5332726A (en) *	1989-09-29	1994-07-26	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Antithrombotic peptides and pseudopeptides
US5064814A (en) *	1990-04-05	1991-11-12	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Anti-thrombotic peptide and pseudopeptide derivatives
GB2244994B (en) *	1990-06-12	1994-01-19	Richter Gedeon Vegyeszet	Improved process for the preparation of tripeptide aldehydes
US5430023A (en) *	1990-09-28	1995-07-04	Eli Lilly And Company	Tripeptide antithrombotic agents
CA2075154A1 (en) *	1991-08-06	1993-02-07	Neelakantan Balasubramanian	Peptide aldehydes as antithrombotic agents
US5250660A (en) *	1991-11-12	1993-10-05	Eli Lilly And Company	Peptide purification process
US5252566A (en) *	1991-11-12	1993-10-12	Eli Lilly And Company	Antithrombotic agents
US5416093A (en) *	1991-11-12	1995-05-16	Eli Lilly And Company	Antithrombotic agents
US5492895A (en) *	1992-02-14	1996-02-20	Corvas International, Inc.	Inhibitors of thrombosis
ATE159030T1 (de) *	1992-03-04	1997-10-15	Gyogyszerkutato Intezet	Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
ATE149562T1 (de) *	1992-08-14	1997-03-15	Procter & Gamble	Peptidaldehydhaltige flüssige waschmittel
US5576283A (en) *	1992-08-14	1996-11-19	The Procter & Gamble Company	Liquid detergents containing a peptide aldehyde
US5582762A (en) *	1992-08-14	1996-12-10	The Procter & Gamble Company	Liquid detergents containing a peptide trifluoromethyl ketone
US5371072A (en) *	1992-10-16	1994-12-06	Corvas International, Inc.	Asp-Pro-Arg α-keto-amide enzyme inhibitors
IL108031A0 (en) *	1992-12-22	1994-04-12	Procter & Gamble	Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5705487A (en) *	1994-03-04	1998-01-06	Eli Lilly And Company	Antithrombotic agents
US5602101A (en) *	1994-03-04	1997-02-11	Eli Lilly And Company	Antithrombotic agents
US5488037A (en) *	1994-03-04	1996-01-30	Eli Lilly And Company	Antithrombotic agents
CA2143533A1 (en) *	1994-03-04	1995-09-05	Kenneth D. Kurz	Antithrombotic agents
US5885967A (en) *	1994-03-04	1999-03-23	Eli Lilly And Company	Antithrombotic agents
US5707966A (en) *	1994-03-04	1998-01-13	Eli Lilly And Company	Antithrombotic agents
US5439888A (en) *	1994-03-04	1995-08-08	Eli Lilly And Company	Antithrombotic agents
ZA951618B (en) *	1994-03-04	1996-08-27	Lilly Co Eli	Antithrombotic agents
US5436229A (en) *	1994-03-04	1995-07-25	Eli Lilly And Company	Bisulfite adducts of arginine aldehydes
US5726159A (en) *	1994-03-04	1998-03-10	Eli Lilly And Company	Antithrombotic agents
US5484772A (en) *	1994-03-04	1996-01-16	Eli Lilly And Company	Antithrombotic agents
US5932733A (en) *	1994-06-17	1999-08-03	Corvas International, Inc.	3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5658930A (en) *	1994-12-13	1997-08-19	Corvas International, Inc.	Aromatic heterocyclic derivatives as enzyme inhibitors
US5656645A (en) *	1994-12-13	1997-08-12	Corvas International, Inc.	Aromatic heterocyclic derivatives as enzyme inhibitors
US5914319A (en) *	1995-02-27	1999-06-22	Eli Lilly And Company	Antithrombotic agents
US5710130A (en) *	1995-02-27	1998-01-20	Eli Lilly And Company	Antithrombotic agents
US6046169A (en) *	1995-06-07	2000-04-04	Cor Therapeutics, Inc.	Inhibitors of factor XA
US5919765A (en) *	1995-06-07	1999-07-06	Cor Therapeutics, Inc.	Inhibitors of factor XA
US5721214A (en) *	1995-06-07	1998-02-24	Cor Therapeutics, Inc.	Inhibitors of factor Xa
US6022861A (en) *	1995-06-07	2000-02-08	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6069130A (en)	1995-06-07	2000-05-30	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6069232A (en) *	1995-10-02	2000-05-30	Hoechst Marion Roussel, Inc.	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
DE19605039A1 (de)	1996-02-12	1997-08-14	Hoechst Ag	Verfahren zur Herstellung von Oligopeptid-Aldehyden
US5739354A (en) *	1996-03-26	1998-04-14	Hoechst Marion Roussel, Inc.	Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
US6245743B1 (en)	1996-06-05	2001-06-12	Cor Therapeutics, Inc.	Inhibitors of factor Xa
IT1283467B1 (it) *	1996-07-19	1998-04-21	Menarini Farma Ind	Derivati di cicloalcani 1,2 sostituiti come inibitori della trombina, procedimento per la loro preparazione e loro impiego in formulazioni
US6165966A (en) *	1996-09-24	2000-12-26	The Procter & Gamble Company	Liquid detergents containing proteolytic enzyme and protease inhibitors
US6180586B1 (en)	1996-09-24	2001-01-30	The Procter & Gamble Company	Liquid laundry detergent compositions containing proteolytic enzyme and protease inhibitors
BR9712111A (pt) *	1996-09-24	1999-08-31	Procter & Gamble	Detergentes líquidos contendo enzima proteolítica e inibidores da protease.
US7090455B2 (en) *	1998-11-13	2006-08-15	Pneutools, Incorporated	Stacked assembly of roofing caps
WO2009068926A1 (en) *	2007-11-30	2009-06-04	University Of Debrecen	Use of urokinase type plasminogen activator inhibitors for the treatment of corneal disorders
EP2343310A1 (en) *	2010-01-08	2011-07-13	Novozymes A/S	Serine hydrolase formulation
JP6334396B2 (ja)	2011-07-01	2018-05-30	ノボザイムスアクティーゼルスカブ	安定化スブチリシン組成物
WO2016001319A1 (en)	2014-07-03	2016-01-07	Novozymes A/S	Improved stabilization of non-protease enzyme
DE102015208655A1 (de)	2015-05-11	2016-11-17	Henkel Ag & Co. Kgaa	Enzymstabilisatoren
DE102015210828A1 (de)	2015-06-12	2016-12-15	Henkel Ag & Co. Kgaa	Phosphatfreies flüssiges Geschirrspülmittel
DE102016209406A1 (de)	2016-05-31	2017-11-30	Henkel Ag & Co. Kgaa	Stabilisierte Enzym-haltige Wasch- und Reinigungsmittel
DE102017219993A1 (de)	2017-11-09	2019-05-09	Henkel Ag & Co. Kgaa	Enzymhaltiges Wasch- oder Reinigungsmittel
DE102018129277A1 (de)	2018-11-21	2020-05-28	Henkel Ag & Co. Kgaa	Mehrkomponenten Wasch- oder Reinigungsmittel enthaltend eine Chinon-Oxidoreduktase
JP2022538360A (ja)	2019-07-01	2022-09-01	ビーエーエスエフソシエタス・ヨーロピア	酵素を安定化するためのペプチドアセタール
EP3770237A1 (de)	2019-07-22	2021-01-27	Henkel AG & Co. KGaA	Wasch- und reinigungsmittel mit verbesserter enzym-stabilität
JP2023544111A (ja)	2020-09-22	2023-10-20	ビーエーエスエフソシエタス・ヨーロピア	第二の酵素を含む、プロテアーゼとプロテアーゼ阻害薬との改善された組合せ
DE102023204055A1 (de)	2023-05-03	2024-11-07	Henkel Ag & Co. Kgaa	Leistungsverbesserte protease-varianten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3826793A (en) *	1968-10-21	1974-07-30	Bofors Ab	Anticoagulant peptides related to fibrino peptides
HU169870B (da) *	1974-06-14	1977-02-28
HU177098B (en) *	1979-01-04	1981-07-28	Gyogyszerkutato Intezet	Process for producing new peptidyl-n-carboxy-l-arginin-a
HU184368B (en) *	1981-01-13	1984-08-28	Gyogyszerkutato Intezet	Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

1981
- 1981-01-13 HU HU8170A patent/HU184368B/hu not_active IP Right Cessation
1982
- 1982-01-05 US US06/337,288 patent/US4399065A/en not_active Expired - Lifetime
- 1982-01-07 BE BE1/10391A patent/BE891708A/fr not_active IP Right Cessation
- 1982-01-12 MX MX190944A patent/MX156383A/es unknown
- 1982-01-12 GB GB8200800A patent/GB2091270B/en not_active Expired
- 1982-01-12 SE SE8200135A patent/SE453509B/sv not_active IP Right Cessation
- 1982-01-12 IT IT8219074A patent/IT1210842B/it active
- 1982-01-12 ES ES508637A patent/ES8301205A1/es not_active Expired
- 1982-01-12 AU AU79446/82A patent/AU544492B2/en not_active Ceased
- 1982-01-12 NO NO820083A patent/NO158021C/no unknown
- 1982-01-12 CH CH148/82A patent/CH649305A5/de not_active IP Right Cessation
- 1982-01-12 PT PT74268A patent/PT74268B/pt not_active IP Right Cessation
- 1982-01-12 CA CA000393981A patent/CA1182111A/en not_active Expired
- 1982-01-12 FR FR8200361A patent/FR2497799B1/fr not_active Expired
- 1982-01-12 DK DK009382A patent/DK151341C/da not_active IP Right Cessation
- 1982-01-12 IL IL64761A patent/IL64761A/xx not_active IP Right Cessation
- 1982-01-12 FI FI820086A patent/FI74024C/fi not_active IP Right Cessation
- 1982-01-12 PL PL1982234696A patent/PL133451B1/pl unknown
- 1982-01-13 NL NL8200105A patent/NL8200105A/nl not_active Application Discontinuation
- 1982-01-13 SU SU823374350A patent/SU1442078A3/ru active
- 1982-01-13 AT AT0009782A patent/AT383352B/de not_active IP Right Cessation
- 1982-01-13 JP JP57002886A patent/JPS57181046A/ja active Granted
- 1982-01-13 DE DE3200812A patent/DE3200812C2/de not_active Expired
1983
- 1983-04-14 US US06/484,888 patent/US4478745A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US4399065A (en)	1983-08-16
DK9382A (da)	1982-07-14
AT383352B (de)	1987-06-25
HU184368B (en)	1984-08-28
JPH0251920B2 (da)	1990-11-08
FR2497799B1 (fr)	1985-06-28
CH649305A5 (de)	1985-05-15
AU544492B2 (en)	1985-05-30
GB2091270A (en)	1982-07-28
SU1442078A3 (ru)	1988-11-30
PT74268A (en)	1982-02-01
CA1182111A (en)	1985-02-05
FI74024B (fi)	1987-08-31
JPS57181046A (en)	1982-11-08
SE453509B (sv)	1988-02-08
SE8200135L (sv)	1982-07-14
DK151341B (da)	1987-11-23
IL64761A0 (en)	1982-03-31
NL8200105A (nl)	1982-08-02
MX156383A (es)	1988-08-16
PL234696A1 (da)	1982-09-13
US4478745A (en)	1984-10-23
NO158021B (no)	1988-03-21
PL133451B1 (en)	1985-06-29
FI820086L (fi)	1982-07-14
NO820083L (no)	1982-07-14
ATA9782A (de)	1986-11-15
DE3200812A1 (de)	1982-08-12
IT1210842B (it)	1989-09-29
FI74024C (fi)	1987-12-10
DE3200812C2 (de)	1986-09-18
ES508637A0 (es)	1982-11-16
NO158021C (no)	1988-06-29
BE891708A (fr)	1982-07-07
IT8219074A0 (it)	1982-01-12
AU7944682A (en)	1982-07-22
FR2497799A1 (fr)	1982-07-16
PT74268B (en)	1983-06-27
GB2091270B (en)	1984-08-22
IL64761A (en)	1985-01-31
ES8301205A1 (es)	1982-11-16

Publication	Publication Date	Title
DK151341C (da)	1988-05-09	Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat
DK149949C (da)	1987-06-15	Analogifremgangsmaade til fremstilling af n-aryl-piperazinalkanamider
DK65882A (da)	1982-08-18	Fremgangsmaade til fremstilling af substituerede phosphonamider
DK260682A (da)	1982-12-13	Fremgangsmaade til fremstilling af partikelformige geler
DK570482A (da)	1983-06-25	Fremgangsmaade til fremstilling af antiinflammatorisk oftalmisk oploesning
DK1183D0 (da)	1983-01-04	Fremgangsmade til fremstilling af tiazolidinderivater
DK354382A (da)	1983-02-08	Fremgangsmaade til fremstilling af aminopyridazinforbindelser
DK150903C (da)	1988-01-25	Analogifremgangsmaade til fremstilling af benzisoselenazoloner
DK159824C (da)	1991-04-29	Analogifremgangsmaade til fremstilling af succinylferroproteiner
DK153282A (da)	1982-10-07	Fremgangsmaade til fremstilling af bismethinisoindoliner
DK127482A (da)	1982-09-24	Fremgangsmaade til fremstilling af dipeptidforbindelser
DK372283D0 (da)	1983-08-15	Fremgangsmade til fremstilling af desoxyuridinderivater
DK239382A (da)	1982-11-29	Fremgangsmaade til fremstilling af anthracyclinglycosider
DK150986C (da)	1988-02-15	Fremgangsmaade til fremstilling af azopigmentpraeparater
DK305982A (da)	1983-01-09	Fremgangsmaade til fremstilling af amidobenzamider
DK309783D0 (da)	1983-07-05	Fremgangsmade til fremstilling af organoglykosider
DK108783D0 (da)	1983-03-04	Fremgangsmade til fremstilling af triglycerider
DK119083D0 (da)	1983-03-14	Fremgangsmade til fremstilling af alkanoylpyridinoner
DK32082A (da)	1982-07-31	Fremgangsmaade til fremstilling af bicycliske forbindelser
DK157873C (da)	1990-08-06	Analogifremgangsmaade til fremstilling af azinorifamycin-forbindelser
DK424083A (da)	1984-03-29	Fremgangsmaade til fremstilling af anthracyclinglycosider
DK296383D0 (da)	1983-06-28	Fremgangsmade til fremstilling af fenaetylaminer
DK535482A (da)	1983-06-04	Fremgangsmaade til fremstilling af thioalkanoylcarnitiner
DK151881C (da)	1988-07-04	Analogifremgangsmaade til fremstilling af 2-oxazoliner
DK157853C (da)	1990-08-06	Analogifremgangsmaade til fremstilling af 4-benzyloxypiperidinderivater

Legal Events

Date	Code	Title	Description
2000-09-04	PBP	Patent lapsed