DK150512C - Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf

Info

Publication number: DK150512C
Authority: DK; Denmark
Prior art keywords: quino; analogue; preparation; addition salts; lincarboxylic
Prior art date: 1976-02-11

Application number

DK056077A

Other languages

Danish (da)

English (en)

Other versions

DK56077A (da

DK150512B (da

Inventor

Andre Allais

Francois Clemence

Roger Deraedt

Odile Le Martret

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-02-11

Filing date

1977-02-10

Publication date

1987-11-16

1977-02-10 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1977-08-12 Publication of DK56077A publication Critical patent/DK56077A/da

1987-03-16 Publication of DK150512B publication Critical patent/DK150512B/da

1987-11-16 Application granted granted Critical

1987-11-16 Publication of DK150512C publication Critical patent/DK150512C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

DK056077A 1976-02-11 1977-02-10 Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf DK150512C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7603754A FR2340735A1 (fr)	1976-02-11	1976-02-11	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR7603754		1976-02-11

Publications (3)

Publication Number	Publication Date
DK56077A DK56077A (da)	1977-08-12
DK150512B DK150512B (da)	1987-03-16
DK150512C true DK150512C (da)	1987-11-16

Family

ID=9168994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK056077A DK150512C (da)	1976-02-11	1977-02-10	Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf

Country Status (19)

Country	Link
US (1)	US4107310A (xx)
JP (1)	JPS52116479A (xx)
AU (1)	AU508345B2 (xx)
BE (1)	BE851306A (xx)
CA (1)	CA1089464A (xx)
CH (1)	CH620437A5 (xx)
DD (1)	DD129552A5 (xx)
DE (1)	DE2705446A1 (xx)
DK (1)	DK150512C (xx)
ES (1)	ES455804A1 (xx)
FR (1)	FR2340735A1 (xx)
GB (1)	GB1572482A (xx)
IE (1)	IE44879B1 (xx)
IL (1)	IL51413A (xx)
LU (1)	LU76742A1 (xx)
NL (1)	NL7701398A (xx)
SE (1)	SE441528B (xx)
SU (1)	SU867299A3 (xx)
ZA (1)	ZA77787B (xx)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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US4190659A (en) *	1973-08-27	1980-02-26	Sandoz, Inc.	Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4281131A (en)	1977-06-20	1981-07-28	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4273930A (en) *	1977-06-20	1981-06-16	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acid esters
US4187309A (en) *	1977-06-20	1980-02-05	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4221797A (en) *	1978-08-14	1980-09-09	Sandoz, Inc.	Dihydroquinoline-one derivatives
FR2443467A1 (fr) *	1978-12-08	1980-07-04	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) *	1980-05-19	1981-11-20	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament
US4266050A (en) *	1980-07-02	1981-05-05	American Home Products Corporation	1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives
IE52670B1 (en) *	1981-03-03	1988-01-20	Leo Ab	Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
HU190796B (en) *	1981-06-12	1986-11-28	Roussel Uclaf,Fr	Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2523130A1 (fr) *	1982-03-15	1983-09-16	Roussel Uclaf	Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2507602A1 (fr) *	1981-06-12	1982-12-17	Roussel Uclaf	Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2509728A1 (fr) *	1981-07-17	1983-01-21	Roussel Uclaf	Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2537139B2 (fr) *	1982-03-15	1985-09-20	Roussel Uclaf	Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant
FR2551437B2 (fr) *	1982-06-03	1985-10-25	Roussel Uclaf	Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation
FR2530633A1 (fr) *	1982-06-03	1984-01-27	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2532939A1 (fr) *	1982-09-13	1984-03-16	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2537140B1 (fr) *	1982-12-07	1986-07-18	Roussel Uclaf	Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
SE452170B (sv) *	1983-10-03	1987-11-16	Boliden Ab	Forfarande for utvinning av metall ur koppar och/eller edelmetall innehallande material som innehaller antimon och vismut
FR2566405B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) *	1984-07-09	1986-07-22	Ciba-Geigy Corporation	Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
JPH0358559A (ja) *	1989-07-26	1991-03-13	Sekisui Chem Co Ltd	電話システム
US5175151A (en) *	1990-09-07	1992-12-29	Schering Corporation	Antiviral compounds and antihypertensive compounds
EP0549729B1 (en) *	1990-09-07	1997-12-17	Schering Corporation	Antiviral compounds and antihypertensive compounds
US5179093A (en) *	1991-05-10	1993-01-12	Schering Corporation	Quinoline-diones
DE4138820A1 (de) *	1991-11-26	1993-05-27	Basf Ag	Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
SE9201076L (sv) *	1992-04-06	1993-10-07	Shimon Slavin	Användningen av gamla läkemedel för behandling av diabetes
SE9400809D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of quinoline-3-carboxamide compounds
SE9400810D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of Quinoline-3-carboxamide compounds
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US8314124B2 (en) *	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv) *	2004-02-06	2004-02-06	Active Biotech Ab	New composition containing quinoline compounds
PT2489659T (pt)	2004-06-24	2018-03-07	Vertex Pharma	Moduladores de transportadores de cassete de ligação a atp
RU2556984C2 (ru) *	2004-06-24	2015-07-20	Вертекс Фармасьютикалз Инкорпорейтед	Модуляторы транспортеров атф-связывающей кассеты
US8354427B2 (en) *	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
WO2006087830A1 (ja) *	2005-02-18	2006-08-24	Kanebo, Ltd.	帯状織物構造体およびその製法
CA2625287C (en) *	2005-10-19	2016-07-26	Teva Pharmaceutical Industries Ltd.	Crystals of laquinimod sodium, and process for the manufacture thereof
CN101374849A (zh) *	2005-12-24	2009-02-25	沃泰克斯药物股份有限公司	作为abc转运蛋白调控剂的喹啉-4-酮衍生物
SI3219705T1 (sl)	2005-12-28	2020-08-31	Vertex Pharmaceuticals Incorporated	Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid
EA018031B1 (ru)	2006-06-12	2013-05-30	Тева Фармасьютикал Индастриз, Лтд.	Стабильные препараты лаквинимода
US20080221161A1 (en) *	2007-02-09	2008-09-11	Kalypsys, Inc.	Heterocyclic modulators of tgr5 for treatment of disease
PL2682120T3 (pl) *	2007-12-20	2017-02-28	Teva Pharmaceutical Industries, Ltd.	Stabilne preparaty lakwinimodu
EP2337779B1 (en) *	2008-09-03	2017-04-19	Teva Pharmaceutical Industries Ltd.	2-oxo-1,2-dihydro-quinoline modulators of immune function
SG193156A1 (en)	2009-03-20	2013-09-30	Vertex Pharma	Process for making modulators of cystic fibrosis transmembrane conductance regulator
KR20160148050A (ko) *	2009-07-30	2016-12-23	테바 파마슈티컬 인더스트리즈 리미티드	라퀴니모드를 이용한 크론병의 치료
PL3064206T3 (pl) *	2009-08-10	2020-02-28	Active Biotech Ab	Leczenie choroby Huntingtona z zastosowaniem lakwinimodu
EA201290860A1 (ru) *	2010-03-03	2013-04-30	Тева Фармасьютикал Индастриз Лтд.	Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата
WO2011109536A1 (en) *	2010-03-03	2011-09-09	Teva Pharmaceutical Industries Ltd.	Treatment of lupus arthritis using laquinimod
JP2013521303A (ja) *	2010-03-03	2013-06-10	テバファーマシューティカルインダストリーズリミティド	ラキニモドを使用したループス腎炎の治療
CN102267984B (zh) *	2010-06-04	2014-07-30	中国人民解放军军事医学科学院毒物药物研究所	4-羟基喹啉-3-酰胺衍生物及其制备方法和用途
US8962598B2 (en)	2010-10-14	2015-02-24	Immunahr Ab	1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
EP2537517A1 (en) *	2011-06-22	2012-12-26	Active Biotech AB	Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
CA2851525A1 (en)	2011-10-12	2013-04-18	Teva Pharmaceutical Industries Ltd.	Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN106063787A (zh)	2012-02-03	2016-11-02	泰华制药工业有限公司	拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
CN109966264A (zh)	2012-02-27	2019-07-05	沃泰克斯药物股份有限公司	药物组合物及其施用
TW201400117A (zh)	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
CN104955522A (zh)	2012-11-07	2015-09-30	梯瓦制药工业有限公司	拉喹莫德胺盐
TWI631105B (zh) *	2013-01-31	2018-08-01	維泰克斯製藥公司	作爲鈉通道調節劑之喹啉及喹噁啉醯胺
WO2014153145A2 (en)	2013-03-14	2014-09-25	Teva Pharmaceutical Industries Ltd.	Crystals of laquinimod sodium and improved process for the manufacture thereof
AU2015253330A1 (en)	2014-04-29	2016-12-01	Teva Pharmaceutical Industries Ltd.	Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status
ES2702288T3 (es)	2014-10-07	2019-02-28	Vertex Pharma	Co-cristales de moduladores de regulador de conductancia transmembrana de la fibrosis quística

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL289475A (xx) *	1962-03-01
US3749731A (en) *	1971-07-08	1973-07-31	Warner Lambert Co	2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
FR2281761A1 (fr) *	1974-08-13	1976-03-12	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

1976
- 1976-02-11 FR FR7603754A patent/FR2340735A1/fr active Granted
1977
- 1977-01-26 SE SE7700804A patent/SE441528B/xx not_active IP Right Cessation
- 1977-02-07 US US05/766,487 patent/US4107310A/en not_active Expired - Lifetime
- 1977-02-09 DD DD7700197299A patent/DD129552A5/xx not_active IP Right Cessation
- 1977-02-09 DE DE19772705446 patent/DE2705446A1/de active Granted
- 1977-02-09 CA CA271,429A patent/CA1089464A/fr not_active Expired
- 1977-02-10 GB GB5556/77A patent/GB1572482A/en not_active Expired
- 1977-02-10 IE IE289/77A patent/IE44879B1/en unknown
- 1977-02-10 LU LU76742A patent/LU76742A1/xx unknown
- 1977-02-10 SU SU772450451A patent/SU867299A3/ru active
- 1977-02-10 IL IL51413A patent/IL51413A/xx unknown
- 1977-02-10 BE BE174832A patent/BE851306A/xx not_active IP Right Cessation
- 1977-02-10 JP JP1313977A patent/JPS52116479A/ja active Granted
- 1977-02-10 ES ES455804A patent/ES455804A1/es not_active Expired
- 1977-02-10 ZA ZA00770787A patent/ZA77787B/xx unknown
- 1977-02-10 DK DK056077A patent/DK150512C/da not_active IP Right Cessation
- 1977-02-10 NL NL7701398A patent/NL7701398A/xx not_active Application Discontinuation
- 1977-02-11 CH CH172177A patent/CH620437A5/fr not_active IP Right Cessation
- 1977-02-11 AU AU22218/77A patent/AU508345B2/en not_active Expired

Also Published As

Publication number	Publication date
JPS52116479A (en)	1977-09-29
DE2705446A1 (de)	1977-08-18
SE7700804L (sv)	1977-08-12
DE2705446C2 (xx)	1989-10-12
AU2221877A (en)	1978-08-17
NL7701398A (nl)	1977-08-15
AU508345B2 (en)	1980-03-20
DK56077A (da)	1977-08-12
CH620437A5 (xx)	1980-11-28
IL51413A0 (en)	1977-04-29
GB1572482A (en)	1980-07-30
SE441528B (sv)	1985-10-14
US4107310A (en)	1978-08-15
FR2340735A1 (fr)	1977-09-09
DD129552A5 (de)	1978-01-25
CA1089464A (fr)	1980-11-11
IL51413A (en)	1980-09-16
IE44879B1 (en)	1982-05-05
ES455804A1 (es)	1978-01-16
FR2340735B1 (xx)	1978-11-03
BE851306A (fr)	1977-08-10
LU76742A1 (xx)	1977-08-19
SU867299A3 (ru)	1981-09-23
DK150512B (da)	1987-03-16
IE44879L (en)	1977-08-11
ZA77787B (en)	1978-03-29
JPS623152B2 (xx)	1987-01-23

Publication	Publication Date	Title
DK150512C (da)	1987-11-16	Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf
DK144010C (da)	1982-04-26	Analogifremgangsmaade til fremstilling af 2-piperazinyl-6,7-dimethoxyquinazoliner eller syreadditionssalte deraf
DK149111C (da)	1986-06-09	Analogifremgangsmaade til fremstilling af histidinderivater eller syreadditionssalte deraf
DK143275C (da)	1982-01-18	Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
DK145119C (da)	1983-02-14	Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf
DK147362C (da)	1988-06-27	Analogifremgangsmaade til fremstilling af ergolen- eller ergolin-derivater eller syreadditionssalte deraf
DK149594C (da)	1987-03-16	Analogifremgangsmaade til fremstilling af dipeptidderivater eller syreadditionssalte heraf
DK462380A (da)	1981-05-02	Analogifremgangsmaade til fremstilling af 2,4-diaminoquinazolin-forbindelser eller syreadditionssalte deraf
DK145260C (da)	1983-03-14	Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK149609C (da)	1987-02-09	Analogifremgangsmaade til fremstilling af hydroxyamino-alkan- eller -alkenphosphonsyrederivater eller estere eller salte deraf
DK147858C (da)	1985-06-10	Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera
DK146592C (da)	1984-06-12	Analogifremgangsmaade til fremstilling af n-substituerede benzensulfonamider eller syreadditionssalte deraf
DK392877A (da)	1978-03-04	Fremgangsmaade til fremstilling af phenylethylaminer eller syreadditionssalte heraf
DK146281C (da)	1984-01-30	Analogifremgangsmaade til fremstilling af 2-brom-6-fluor-n-2-imidazolidinyliden-benzamin eller syreadditionssalte heraf
DK147942C (da)	1985-09-02	Analogifremgangsmaade til fremstilling af kanamycin a- eller kanamycin b-derivater eller syreadditionssalte deraf
DK144127C (da)	1982-06-01	Analogifremgangsmaade til fremstilling af lysergsyre- eller 9,10-dihydrolysergsyreamider eller syreadditionssalte deraf
DK159079A (da)	1979-11-19	Fremgangsmaade til fremstilling af derivater af 4-amino-2-piperidinoquinazolin eller syreadditionssalte deraf
DK140695B (da)	1979-10-29	Analogifremgangsmaade til fremstilling af 2,4-diamo-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf
DK149077C (da)	1986-06-16	Analogifremgangsmaade til fremstilling af encephalin-analoge pentapeptidamidderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK149841C (da)	1987-04-21	Analogifremgangsmaade til fremstilling af alfa-fluor-methyl-alfa-aminoalkansyrer eller farmaceutisk acceptable syreadditionssalte deraf
DK148281C (da)	1985-11-11	Analogifremgangsmaade til fremstilling af 8a-substituerede 8,8a-desoxy-8,8a-dihydrooleandomycin-forbindelser eller farmaceutiskacceptable syreadditionssalte deraf
DK144793C (da)	1982-11-01	Analogifremgangsmaade til fremstilling af dihydro- eller tetrahydroiminothiaziner eller farmaceutisk acceptable syreadditionssalte deraf
DK146886C (da)	1984-07-09	Analogifremgangsmaade til fremstilling af basisk substituerede o-propylerede oximer eller fysiologisk acceptable syreadditionssalte deraf
DK149628C (da)	1987-02-02	Analogifremgangsmaade til fremstilling af 8-substitueret-4ae-amino-makrolider eller syreadditionssalte deraf
DK151629C (da)	1988-06-20	Analogifremgangsmaade til fremstilling af 3-amino-1-benzoxepin-5(2h)-on-derivater eller syreadditionssalte deraf

Legal Events

Date	Code	Title	Description
1990-10-15	PBP	Patent lapsed