DK1438289T3 - Indolderivater som cox II-inhibitorer - Google Patents

Indolderivater som cox II-inhibitorer

Info

Publication number: DK1438289T3
Authority: DK; Denmark
Prior art keywords: cox; inhibitors; indole derivatives; indole; derivatives
Prior art date: 2001-09-27

Application number

DK02779382T

Other languages

English (en)

Inventor

Chris Allen Broka

Jeffrey Allen Campbell

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-27

Filing date

2002-09-20

Publication date

2005-08-08

2002-09-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-08-08 Application granted granted Critical

2005-08-08 Publication of DK1438289T3 publication Critical patent/DK1438289T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Pregnancy & Childbirth (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

DK02779382T 2001-09-27 2002-09-20 Indolderivater som cox II-inhibitorer DK1438289T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32538901P	2001-09-27	2001-09-27
PCT/EP2002/010557 WO2003029212A1 (en)	2001-09-27	2002-09-20	Indole derivatives as cox ii inhibitors

Publications (1)

Publication Number	Publication Date
DK1438289T3 true DK1438289T3 (da)	2005-08-08

Family

ID=23267681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02779382T DK1438289T3 (da)	2001-09-27	2002-09-20	Indolderivater som cox II-inhibitorer

Country Status (25)

Country	Link
US (3)	US6872744B2 (da)
EP (1)	EP1438289B1 (da)
JP (1)	JP4141954B2 (da)
KR (1)	KR20040047862A (da)
CN (1)	CN1261412C (da)
AR (1)	AR036624A1 (da)
AT (1)	ATE292115T1 (da)
BR (1)	BR0212925A (da)
CA (1)	CA2461670A1 (da)
CO (1)	CO5560557A2 (da)
DE (1)	DE60203529T2 (da)
DK (1)	DK1438289T3 (da)
ES (1)	ES2238616T3 (da)
HR (1)	HRPK20040271B3 (da)
HU (1)	HUP0401499A3 (da)
IL (1)	IL160752A0 (da)
MX (1)	MXPA04002824A (da)
NO (1)	NO20041237L (da)
NZ (1)	NZ531577A (da)
PL (1)	PL370342A1 (da)
PT (1)	PT1438289E (da)
RU (1)	RU2004113111A (da)
SI (1)	SI1438289T1 (da)
WO (1)	WO2003029212A1 (da)
ZA (1)	ZA200402360B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2238616T3 (es) *	2001-09-27	2005-09-01	F. Hoffmann-La Roche Ag	Derivados de indol como inhibidores de cox ii.
SE0202241D0 (sv) *	2002-07-17	2002-07-17	Astrazeneca Ab	Novel Compounds
WO2004014364A1 (en) *	2002-08-07	2004-02-19	Idenix (Cayman) Limited	Substituted phenylindoles for the treatment of hiv
MXPA06007054A (es) *	2003-12-19	2007-04-17	Elixir Pharmaceuticals Inc	Metodos para tratar una enfermedad.
EP1589016A1 (en) *	2004-04-13	2005-10-26	Cephalon France	Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7119214B2 (en)	2004-04-13	2006-10-10	Cephalon France	Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7423176B2 (en)	2004-04-13	2008-09-09	Cephalon, Inc.	Bicyclic aromatic sulfinyl derivatives
AU2005254782A1 (en)	2004-06-18	2005-12-29	Biolipox Ab	Indoles useful in the treatment of inflammation
WO2006041961A1 (en) *	2004-10-05	2006-04-20	GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES	Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
CN101142185A (zh)	2005-01-19	2008-03-12	比奥里波克斯公司	用于炎症治疗的吲哚
US7622495B2 (en) *	2006-10-03	2009-11-24	Neurim Pharmaceuticals (1991) Ltd.	Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
CA2668959A1 (en)	2006-11-09	2008-05-15	F. Hoffmann-La Roche Ag	Indole and benzofuran 2-carboxamide derivatives
WO2012024620A2 (en)	2010-08-20	2012-02-23	Amira Pharmaceuticals, Inc.	Autotaxin inhibitors and uses thereof
EP2714680B1 (en)	2011-05-27	2015-11-25	Amira Pharmaceuticals, Inc.	Heterocyclic autotaxin inhibitors and uses thereof
US9951026B2 (en)	2013-09-17	2018-04-24	Pharmakea, Inc.	Heterocyclic vinyl autotaxin inhibitor compounds
EP3046905A4 (en)	2013-09-17	2017-03-22	Pharmakea Inc.	Vinyl autotaxin inhibitor compounds
EP3049405A4 (en)	2013-09-26	2017-03-08	Pharmakea Inc.	Autotaxin inhibitor compounds
CN110372671B (zh)	2013-11-22	2023-02-21	赛博治疗有限责任公司	自分泌运动因子抑制剂化合物
AU2016268250B2 (en)	2015-05-27	2020-08-27	Sabre Therapeutics Llc	Autotaxin inhibitors and uses thereof
KR102241064B1 (ko)	2019-07-30	2021-04-16	부산대학교 산학협력단	신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물
CN113004187B (zh) *	2021-03-16	2022-09-20	沈阳药科大学	一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4654360A (en)	1984-06-01	1987-03-31	Syntex (U.S.A.) Inc.	1,2,3-trisubstituted indoles for treatment of inflammation
JPH0347123A (ja)	1989-05-05	1991-02-28	G D Searle & Co	インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
DE4338770A1 (de)	1993-11-12	1995-05-18	Matthias Dr Lehr	Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
AU717430B2 (en)	1996-08-26	2000-03-23	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
AU7237998A (en) *	1997-05-16	1998-12-08	Chugai Seiyaku Kabushiki Kaisha	Indole derivatives and mono- and diazaindole derivatives
JP2002504551A (ja)	1998-02-25	2002-02-12	ジェネティックス・インスチチュート・インコーポレーテッド	ホスホリパーゼａ２の阻害剤
MXPA00006605A (es) *	1999-07-02	2004-12-09	Pfizer	Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
US6306890B1 (en) *	1999-08-30	2001-10-23	Vanderbilt University	Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6376708B1 (en) *	2000-04-11	2002-04-23	Monsanto Technology Llc	Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts
ES2238616T3 (es) *	2001-09-27	2005-09-01	F. Hoffmann-La Roche Ag	Derivados de indol como inhibidores de cox ii.
TW200400177A (en) *	2002-06-04	2004-01-01	Wyeth Corp	1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands

2002
- 2002-09-20 ES ES02779382T patent/ES2238616T3/es not_active Expired - Lifetime
- 2002-09-20 HU HU0401499A patent/HUP0401499A3/hu unknown
- 2002-09-20 CA CA002461670A patent/CA2461670A1/en not_active Abandoned
- 2002-09-20 PL PL02370342A patent/PL370342A1/xx not_active Application Discontinuation
- 2002-09-20 AT AT02779382T patent/ATE292115T1/de not_active IP Right Cessation
- 2002-09-20 KR KR10-2004-7004428A patent/KR20040047862A/ko not_active Application Discontinuation
- 2002-09-20 RU RU2004113111/04A patent/RU2004113111A/ru not_active Application Discontinuation
- 2002-09-20 MX MXPA04002824A patent/MXPA04002824A/es unknown
- 2002-09-20 EP EP02779382A patent/EP1438289B1/en not_active Expired - Lifetime
- 2002-09-20 DE DE60203529T patent/DE60203529T2/de not_active Expired - Fee Related
- 2002-09-20 PT PT02779382T patent/PT1438289E/pt unknown
- 2002-09-20 WO PCT/EP2002/010557 patent/WO2003029212A1/en active IP Right Grant
- 2002-09-20 DK DK02779382T patent/DK1438289T3/da active
- 2002-09-20 JP JP2003532462A patent/JP4141954B2/ja not_active Expired - Fee Related
- 2002-09-20 CN CNB028191900A patent/CN1261412C/zh not_active Expired - Fee Related
- 2002-09-20 IL IL16075202A patent/IL160752A0/xx unknown
- 2002-09-20 NZ NZ531577A patent/NZ531577A/en unknown
- 2002-09-20 SI SI200230116T patent/SI1438289T1/xx unknown
- 2002-09-20 BR BR0212925-6A patent/BR0212925A/pt not_active IP Right Cessation
- 2002-09-25 AR ARP020103595A patent/AR036624A1/es not_active Application Discontinuation
- 2002-09-26 US US10/255,891 patent/US6872744B2/en not_active Expired - Fee Related
2004
- 2004-03-19 HR HR20040271A patent/HRPK20040271B3/xx not_active IP Right Cessation
- 2004-03-24 CO CO04027740A patent/CO5560557A2/es not_active Application Discontinuation
- 2004-03-24 NO NO20041237A patent/NO20041237L/no unknown
- 2004-03-25 ZA ZA200402360A patent/ZA200402360B/en unknown
2005
- 2005-02-25 US US11/065,841 patent/US7074939B2/en not_active Expired - Fee Related
2006
- 2006-03-02 US US11/391,655 patent/US7410994B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4141954B2 (ja)	2008-08-27
HRP20040271A2 (en)	2004-08-31
ATE292115T1 (de)	2005-04-15
CO5560557A2 (es)	2005-09-30
CN1261412C (zh)	2006-06-28
MXPA04002824A (es)	2004-07-05
KR20040047862A (ko)	2004-06-05
DE60203529T2 (de)	2006-03-16
PT1438289E (pt)	2005-06-30
WO2003029212A1 (en)	2003-04-10
CA2461670A1 (en)	2003-04-10
NO20041237L (no)	2004-03-24
SI1438289T1 (da)	2005-08-31
HRPK20040271B3 (en)	2006-02-28
US7410994B2 (en)	2008-08-12
JP2005510474A (ja)	2005-04-21
BR0212925A (pt)	2004-10-13
AR036624A1 (es)	2004-09-22
ES2238616T3 (es)	2005-09-01
CN1561334A (zh)	2005-01-05
ZA200402360B (en)	2005-04-26
HUP0401499A3 (en)	2007-05-02
HUP0401499A2 (hu)	2004-12-28
RU2004113111A (ru)	2005-06-27
EP1438289A1 (en)	2004-07-21
IL160752A0 (en)	2004-08-31
US7074939B2 (en)	2006-07-11
US20060178420A1 (en)	2006-08-10
US6872744B2 (en)	2005-03-29
EP1438289B1 (en)	2005-03-30
US20030130337A1 (en)	2003-07-10
PL370342A1 (en)	2005-05-16
US20050176803A1 (en)	2005-08-11
DE60203529D1 (de)	2005-05-04
NZ531577A (en)	2005-09-30

Publication	Publication Date	Title
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1438289T3 (da)	2005-08-08	Indolderivater som cox II-inhibitorer
NO20030867L (no)	2003-02-25	Hydroksamderivater anvendelig som deacetylaseinhibitorer
DK1501826T3 (da)	2007-01-29	Substituerede indoler som alpha-1-agonister
NO20034307D0 (no)	2003-09-26	Cyklopropylindol-derivater som selektive serotonin- gjenopptaksinhibitorer
DK1436271T6 (da)	2022-06-27	Phenylpiperazinderivater som serotonin-genoptagelseshæmmere
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
DK1370554T3 (da)	2006-02-06	3-(4-Amidopyrrol-2-ylmethyliden)-2-indolinon-derivater som proteinkinaseinhibitorer
DE60336314D1 (de)	2011-04-21	Substituierte indole
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NO20033618D0 (no)	2003-08-14	Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
DK1585749T3 (da)	2008-09-22	Diazepinoindol-derivater som kinaseinhibitorer
NO20050665L (no)	2005-04-18	Pyrrolidonderivater som MAOE inhibitoere
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NO20055680D0 (no)	2005-12-01	Heksahydropyridoisokinoliner som DPP-IV-inhibitorer
NO20014483D0 (no)	2001-09-14	Aminderivater som proteaseinhibitorer
NO20015065D0 (no)	2001-10-18	Pyrazolobenzodiazepiner som CDK2-inhibitorer
NO20030842L (no)	2003-04-28	Fenoksybenzylaminderivater som selektive serotonin- gjenopptaksinhibitorer
NO20035440D0 (no)	2003-12-05	Pyrrolidinderivater som faktor-XA-inhibitorer
DK1442026T3 (da)	2009-07-06	Triazolderivater som cyclooxygenase (COX)-inhibitorer
NO20021959D0 (no)	2002-04-25	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
IS7022A (is)	2003-11-10	Nýjar indólafleiður
DK1487802T3 (da)	2011-04-04	2,3-diaryl-pyrazolidin-derivater som neurotensin-nedbrydende enzyminhibitorer
DE60323130D1 (de)	2008-10-02	Indolderivaten
DK1377550T3 (da)	2005-02-07	Phenyl-heterocyclyletherderivater som serotonin-re-uptakeinhibitorer