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DK1432431T3 - Fremgangsmåder og sammensætninger til modulering af interleukin-21-aktivitet - Google Patents

Fremgangsmåder og sammensætninger til modulering af interleukin-21-aktivitet Download PDF

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Publication number
DK1432431T3
DK1432431T3 DK02766319.4T DK02766319T DK1432431T3 DK 1432431 T3 DK1432431 T3 DK 1432431T3 DK 02766319 T DK02766319 T DK 02766319T DK 1432431 T3 DK1432431 T3 DK 1432431T3
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Denmark
Prior art keywords
cells
cell
antigen
seq
ser
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DK02766319.4T
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English (en)
Inventor
Laura Carter
Matthew J Whitters
Mary Collins
Deborah A Young
Glenn Larsen
Debra D Donaldson
Leslie D Lowe
Kyri Dunussi
Margery Ma
Joann S Witek
Marion T Kasaian
Michelle Ungar
Beatriz Carreno
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Genetics Inst Llc
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Priority claimed from US09/972,218 external-priority patent/US7189400B2/en
Application filed by Genetics Inst Llc filed Critical Genetics Inst Llc
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Publication of DK1432431T3 publication Critical patent/DK1432431T3/da

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Claims (13)

1. Anti-IL-21 antistof eller et antigen-bindende fragment deraf til anvendelse til behandling eller forebyggelse af en arthritis-lidelse hos en patient.
2. Antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anti-IL-21 antistoffet eller det antigen-bindende fragment deraf indgives i kombination med et yderligere terapeutisk middel.
3. Antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 2, hvor det yderligere terapeutiske middel er valgt fra gruppen bestående af en cytokininhibitor, en vækstfaktorinhibitor, et immunosuppressivt stof, et anti-inflammatorisk middel, en stofskifteinhibitor, en enzyminhibitor, et cytotoksisk middel og et cytostatisk middel.
4. Farmaceutisk sammensætning til anvendelse til behandling eller forebyggelse afen arthritis-lidelse hos en patient, hvor den farmaceutiske sammensætning omfatter (i) et anti-IL-21 antistof eller et antigen-bindende fragment deraf i en farmaceutisk acceptabel bærer, eller (ii) et anti-IL-21 antistof eller et antigen-bindende fragment deraf og et yderligere terapeutisk middel valgt fra gruppen bestående afen cytokininhibitor, en vækstfaktorinhibitor, et immunosuppressivt stof, et anti-inflammatorisk middel, en stofskifteinhibitor, en enzyminhibitor, et cytotoksisk middel, og et cytostatisk middel, i en farmaceutisk acceptabel bærer.
5. Farmaceutisk sammensætning til anvendelse ifølge krav 4, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 2, hvor det yderligere terapeutiske middel er valgt fra gruppen bestående af en TNF-antagonist, en IL-12-antagonist, en IL-15-antagonist, en IL-17-antagonist, en IL-18-antagonist, en IL-22-antagonist, et T-celle-depleterende middel, et B-celle-depleterende middel, methotrexat, leflunomid, sirolimus (rapamycin) eller en analog deraf, en Cox-2-inhibitor, en cPLA2-inhibitor, et NSAID og en p38-inhibitor.
6. Farmaceutisk sammensætning til anvendelse ifølge krav 5, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 5, hvor TNF-antagonisten er et opløseligt fragment af en TNF-receptor.
7. Farmaceutisk sammensætning til anvendelse ifølge krav 5 eller krav 6, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 5 eller krav 6, hvor TNF-antagonisten er et p75-humant TNF-receptor-IgG-fusionsprotein.
8. Farmaceutisk sammensætning til anvendelse ifølge krav 5, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 5, hvor det yderligere terapeutiske middel er en IL-15-antagonist.
9. Farmaceutisk sammensætning til anvendelse ifølge krav 5, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 5, hvor det yderligere terapeutiske middel er methotrexat eller leflunomid.
10. Farmaceutisk sammensætning til anvendelse ifølge krav 5, eller anti-IL-21 antistoffet eller det antigen-bindende fragment deraf til anvendelse ifølge krav 5, hvor rapamycin-analogen er CCI-779.
11. Anti-IL-21 antistof eller antigen-bindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-3, 5-10, eller den farmaceutiske sammensætning til anvendelse ifølge et hvilket som helst af kravene 4-10, hvor arthritis-lidelsen er valgt fra gruppen bestående af rheumatoid arthritis, juvenil rheumatoid arthritis, osteoarthritis, psoriasisarthritis og Bechterew's sygdom.
12. Anti-IL-21 antistof eller antigen-bindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-3, 5-11, eller den farmaceutiske sammensætning til anvendelse ifølge et hvilket som helst af kravene 4-11, hvor anti-IL-21 antistoffet er et monoklonalt eller et enkelt-specificitets antistof.
13. Anti-IL-21 antistof eller antigen-bindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-3, 5-12, eller den farmaceutiske sammensætning til anvendelse ifølge et hvilket som helst af kravene 4-12, hvor anti-IL-21 antistoffet er et humant, humaniseret, kimært eller neutraliserende antistof.
DK02766319.4T 2001-10-04 2002-10-04 Fremgangsmåder og sammensætninger til modulering af interleukin-21-aktivitet DK1432431T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/972,218 US7189400B2 (en) 1998-03-17 2001-10-04 Methods of treatment with antagonists of MU-1
US37374602P 2002-04-17 2002-04-17
PCT/US2002/029839 WO2003028630A2 (en) 2001-10-04 2002-10-04 Methods and compositions for modulating interleukin-21 receptor activity

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DK1432431T3 true DK1432431T3 (da) 2017-07-10

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EP (2) EP3254687A1 (da)
JP (2) JP2005508915A (da)
CA (1) CA2460916A1 (da)
DK (1) DK1432431T3 (da)
ES (1) ES2629395T3 (da)
NZ (1) NZ532021A (da)
WO (1) WO2003028630A2 (da)

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US6610286B2 (en) 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
CA2481304A1 (en) * 2002-03-27 2003-10-09 Patrick Hwu Method for treating cancer in humans
CA2526950C (en) * 2002-05-27 2012-06-26 Leif Hakansson Method for determining immune system affecting compounds
PT1531850E (pt) 2002-06-07 2012-05-07 Zymogenetics Inc Utilização de il-21 e anticorpo monoclonal para tratar cancros sólidos
CN1688340A (zh) 2002-07-15 2005-10-26 韦思公司 调节t辅助(th)细胞发育和功能的方法和组合物
EP1731163A2 (en) * 2002-10-11 2006-12-13 Novo Nordisk A/S Treatment of allergic conditions by use of IL 21
CA2501807A1 (en) * 2002-10-11 2004-04-22 Novo Nordisk A/S Treatment of allergic conditions by use of il 21
EP1603949B9 (en) * 2003-03-14 2011-02-02 Wyeth LLC Antibodies against human il-21 receptor and uses therefor
WO2004084835A2 (en) * 2003-03-21 2004-10-07 Wyeth Treating immunological disorder using agonists of interleukin-21/ interleukin-21 receptor
CA2542179A1 (en) * 2003-10-10 2005-04-21 Novo Nordisk A/S Il-21 derivatives
US20060228331A1 (en) * 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
ES2428358T3 (es) * 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
CA2542662A1 (en) * 2003-10-17 2005-04-28 Novo Nordisk A/S Pharmaceutical combinations comprising il-21
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