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DK1319669T3 - Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder - Google Patents

Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder

Info

Publication number
DK1319669T3
DK1319669T3 DK03005363T DK03005363T DK1319669T3 DK 1319669 T3 DK1319669 T3 DK 1319669T3 DK 03005363 T DK03005363 T DK 03005363T DK 03005363 T DK03005363 T DK 03005363T DK 1319669 T3 DK1319669 T3 DK 1319669T3
Authority
DK
Denmark
Prior art keywords
timp
metalloproteinase
methods
type
composition
Prior art date
Application number
DK03005363T
Other languages
English (en)
Inventor
Raymond A Koski
Scott M Silbiger
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22462365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1319669(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK1319669T3 publication Critical patent/DK1319669T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK03005363T 1993-10-06 1994-10-04 Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder DK1319669T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/134,231 US6562596B1 (en) 1993-10-06 1993-10-06 Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
PCT/US1994/011241 WO1995009918A1 (en) 1993-10-06 1994-10-04 Tissue inhibitor metalloproteinase type three (timp-3)

Publications (1)

Publication Number Publication Date
DK1319669T3 true DK1319669T3 (da) 2009-02-09

Family

ID=22462365

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94115578T DK0648838T3 (da) 1993-10-06 1994-10-04 Vævsinhibitor af metalloproteinase type tre (TIMP-3)
DK03005363T DK1319669T3 (da) 1993-10-06 1994-10-04 Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK94115578T DK0648838T3 (da) 1993-10-06 1994-10-04 Vævsinhibitor af metalloproteinase type tre (TIMP-3)

Country Status (13)

Country Link
US (5) US6562596B1 (da)
EP (3) EP0648838B1 (da)
AT (2) ATE412749T1 (da)
AU (1) AU7928194A (da)
DE (2) DE69432581T2 (da)
DK (2) DK0648838T3 (da)
ES (2) ES2194852T3 (da)
HK (2) HK1009287A1 (da)
IL (4) IL162152A (da)
PT (2) PT648838E (da)
SI (2) SI1319669T1 (da)
WO (1) WO1995009918A1 (da)
ZA (1) ZA947781B (da)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
DE19524720A1 (de) * 1995-07-12 1997-01-16 Hoechst Ag Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3"
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AU3759100A (en) * 1999-03-24 2000-10-09 B.F. Goodrich Company, The Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
GB9921418D0 (en) * 1999-09-11 1999-11-10 Univ Sheffield Cell transfection
WO2001042438A2 (en) * 1999-12-13 2001-06-14 Regents Of The University Of Minnesota Leukolysin/mmp25/mt6-mmp
KR100774796B1 (ko) * 2000-01-19 2007-11-07 가부시키가이샤 디나벡크 겐큐쇼 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도
US6562955B2 (en) * 2000-03-17 2003-05-13 Tosoh Corporation Oligonucleotides for detection of Vibrio parahaemolyticus and detection method for Vibrio parahaemolyticus using the same oligonucleotides
GB0015761D0 (en) * 2000-06-27 2000-08-16 Univ Bristol Polypeptide
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
DE10102784A1 (de) * 2001-01-22 2002-08-01 Henkel Kgaa Kosmetische oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
EP2305284A3 (en) * 2002-03-08 2012-11-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of EGFR transactivation inhibitors in human cancer
AUPS282002A0 (en) * 2002-06-06 2002-06-27 Gropep Limited Metalloproteinase inhibitors
ATE432347T1 (de) * 2002-06-24 2009-06-15 Exiqon As Methoden und systeme zur detektion und isolation von nucleinsäuresequenzen
US7060795B2 (en) * 2002-12-19 2006-06-13 Kimberly-Clark Worldwide, Inc. Wound care compositions
WO2004085617A2 (en) * 2003-03-21 2004-10-07 The Cleveland Clinic Foundation Timp3 as vegf inhibitor
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
EP2287326A1 (en) 2003-08-08 2011-02-23 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
WO2005086915A2 (en) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
CA2600177C (en) * 2005-03-01 2011-06-14 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
CA2617138A1 (en) * 2005-07-29 2007-02-08 Imperial Innovations Limited Mutant timp-3
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
EP2136831B1 (en) 2007-03-02 2012-09-12 The Cleveland Clinic Foundation Anti-angiogenic peptides
AU2010278959A1 (en) * 2009-07-31 2012-02-02 Amgen Inc. Polypeptides that bind tissue inhibitor of metalloproteinase type three (TIMP-3), compositions and methods
WO2012048291A2 (en) 2010-10-08 2012-04-12 Proteapex Therapeutics Llc Compositions and methods for inhibition of mmp:mmp-substrate interactions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US8911734B2 (en) 2010-12-01 2014-12-16 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
WO2013030362A1 (en) 2011-08-31 2013-03-07 Universität Zürich Prorektorat Mnw Modulators of mir-323-3p for the prevention or treatment of rheumatoid arthritis
CA3095010A1 (en) 2012-02-21 2013-08-29 Cytonics Corporation Systems, compositions, and methods for transplantation
AU2014236683B2 (en) 2013-03-14 2018-09-27 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (TIMP-3), compositions and methods
JP2016528236A (ja) * 2013-08-07 2016-09-15 アスチュート メディカル,インコーポレイテッド 生物学的試料において改善された性能を有するtimp2のためのアッセイ
US9352021B2 (en) 2013-08-28 2016-05-31 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
AU2014324094B2 (en) * 2013-09-18 2019-03-14 James Cook University Modified anti-inflammatory proteins and method of use
WO2015039188A1 (en) * 2013-09-18 2015-03-26 James Cook University Anti-inflammatory proteins and methods of use
EP3421066B1 (en) 2013-10-24 2021-03-03 Amgen Inc. Injector and method of assembly
MX2016005315A (es) 2013-10-24 2016-08-11 Amgen Inc Sistema de administracion de farmacos con control sensible a la temperatura.
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
AU2015256082C1 (en) 2014-05-07 2020-09-10 Amgen Inc. Autoinjector with shock reducing elements
SG11201609963PA (en) 2014-06-03 2016-12-29 Amgen Inc Devices and methods for assisting a user of a drug delivery device
WO2016025850A1 (en) 2014-08-15 2016-02-18 Amgen Inc. Pericardial drug delivery device and method of use
WO2016033212A1 (en) * 2014-08-27 2016-03-03 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
EP3943135A3 (en) 2014-10-14 2022-06-29 Amgen Inc. Drug injection device with visual and audible indicators
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
EP3233163B1 (en) 2014-12-19 2021-10-13 Amgen Inc. Drug delivery device with proximity sensor
ES2748750T3 (es) 2015-02-17 2020-03-17 Amgen Inc Dispositivo de administración de fármacos con sujeción asistida por vacío y/o realimentación
EP3981450A1 (en) 2015-02-27 2022-04-13 Amgen, Inc Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement
WO2017011336A1 (en) 2015-07-10 2017-01-19 E.&J. Gallo Winery System and method for dispensing a beverage
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
ES2755717T3 (es) 2015-12-09 2020-04-23 Amgen Inc Autoinyector con tapa de señalización
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
WO2017160799A1 (en) 2016-03-15 2017-09-21 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
WO2017189089A1 (en) 2016-04-29 2017-11-02 Amgen Inc. Drug delivery device with messaging label
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
WO2017197222A1 (en) 2016-05-13 2017-11-16 Amgen Inc. Vial sleeve assembly
EP3458988B1 (en) 2016-05-16 2023-10-18 Amgen Inc. Data encryption in medical devices with limited computational capability
EP3465124A1 (en) 2016-06-03 2019-04-10 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
US11285266B2 (en) 2016-07-01 2022-03-29 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
WO2018034784A1 (en) 2016-08-17 2018-02-22 Amgen Inc. Drug delivery device with placement detection
WO2018081234A1 (en) 2016-10-25 2018-05-03 Amgen Inc. On-body injector
WO2018136398A1 (en) 2017-01-17 2018-07-26 Amgen Inc. Injection devices and related methods of use and assembly
JP7280189B2 (ja) 2017-02-17 2023-05-23 アムジエン・インコーポレーテツド 薬物送達装置用の挿入機構
JP7064501B2 (ja) 2017-02-17 2022-05-10 アムジエン・インコーポレーテツド 無菌流体流路を備える薬物送達デバイスおよび関連する組立方法
EP3592403A1 (en) 2017-03-06 2020-01-15 Amgen Inc. Drug delivery device with activation prevention feature
WO2018164829A1 (en) 2017-03-07 2018-09-13 Amgen Inc. Needle insertion by overpressure
IL303449B2 (en) 2017-03-09 2024-08-01 Amgen Inc Insertion mechanism for a drug delivery device
ES2959935T3 (es) 2017-03-28 2024-02-29 Amgen Inc Sistema y método de vástago de émbolo y conjunto de jeringa
CN110709103B (zh) 2017-04-05 2024-02-02 机敏医药股份有限公司 用于生物学样品中具有改善的性能的timp2的测定法
EP3634539A1 (en) 2017-06-08 2020-04-15 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
US11904143B2 (en) 2017-06-08 2024-02-20 Amgen Inc. Torque driven drug delivery device
EP3641857A1 (en) 2017-06-22 2020-04-29 Amgen Inc. Device activation impact/shock reduction
WO2018237225A1 (en) 2017-06-23 2018-12-27 Amgen Inc. Electronic drug delivery device comprising a cap activated by a switch assembly
ES2972207T3 (es) 2017-07-14 2024-06-11 Amgen Inc Sistema de inserción-retracción de agujas con sistema de resorte de torsión doble
MA49626A (fr) 2017-07-21 2020-05-27 Amgen Inc Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage
US11617837B2 (en) 2017-07-25 2023-04-04 Amgen Inc. Drug delivery device with gear module and related method of assembly
WO2019022950A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF
US20200164155A1 (en) 2017-08-09 2020-05-28 Amgen Inc. Hydraulic-pneumatic pressurized chamber drug delivery system
EP3668567A1 (en) 2017-08-18 2020-06-24 Amgen Inc. Wearable injector with sterile adhesive patch
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
WO2019070472A1 (en) 2017-10-04 2019-04-11 Amgen Inc. FLOW ADAPTER FOR MEDICATION DELIVERY DEVICE
WO2019070552A1 (en) 2017-10-06 2019-04-11 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD
IL273323B2 (en) 2017-10-09 2024-10-01 Amgen Inc Drug delivery device with drive assembly and related assembly method
EP3703779A1 (en) 2017-11-03 2020-09-09 Amgen Inc. Systems and approaches for sterilizing a drug delivery device
US20200261648A1 (en) 2017-11-06 2020-08-20 Amgen Inc. Drug delivery device with placement and flow sensing
MA50569A (fr) 2017-11-06 2020-09-16 Amgen Inc Ensembles de remplissage-finition et procédés associés
SG11202002966QA (en) 2017-11-10 2020-05-28 Amgen Inc Plungers for drug delivery devices
JP7370969B2 (ja) 2017-11-16 2023-10-30 アムジエン・インコーポレーテツド 薬物送達デバイスの扉ラッチ機構
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
US20210260279A1 (en) 2018-07-24 2021-08-26 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
CN112351804A (zh) 2018-07-24 2021-02-09 安进公司 用于施用药物的输送装置
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
MA53379A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
WO2020028009A1 (en) 2018-07-31 2020-02-06 Amgen Inc. Fluid path assembly for a drug delivery device
JP2022500095A (ja) 2018-09-24 2022-01-04 アムジエン・インコーポレーテツド インターベンション投薬システム及び方法
EP3856283A1 (en) 2018-09-28 2021-08-04 Amgen Inc. Muscle wire escapement activation assembly for a drug delivery device
US12156991B2 (en) 2018-10-02 2024-12-03 Amgen Inc. Injection systems for drug delivery with internal force transmission
EP3860686A1 (en) 2018-10-05 2021-08-11 Amgen Inc. Drug delivery device having dose indicator
TWI846741B (zh) 2018-10-15 2024-07-01 美商安進公司 用於藥物遞送裝置之平台組裝方法
BR112021007016A2 (pt) 2018-10-15 2021-07-13 Amgen Inc. dispositivo de administração de fármaco tendo mecanismo de amortecimento
EP3873566B1 (en) 2018-11-01 2024-11-27 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
EP3873563A1 (en) 2018-11-01 2021-09-08 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
US20220160972A1 (en) 2019-04-24 2022-05-26 Amgen Inc. Syringe sterilization verification assemblies and methods
US20220273887A1 (en) 2019-08-23 2022-09-01 Amgen Inc. Drug delivery device with configurable needle shield engagement components and related methods
CN117320964A (zh) 2021-05-21 2023-12-29 美国安进公司 优化药物容器的灌装方案的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2726981C2 (de) * 1977-06-15 1984-11-22 Fried. Krupp Gmbh, 4300 Essen Vorrichtung zur Zeitmessung zwischen Impulsen
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
DE3666826D1 (en) 1985-01-18 1989-12-14 Searle & Co Human natural inhibitor of collagenases
ATE219776T1 (de) * 1989-03-21 2002-07-15 Us Secretary United States Dep Matrizenmetalloproteinase-inhibitor-peptide
WO1990014363A1 (en) 1989-05-19 1990-11-29 Amgen Inc. Metalloproteinase inhibitor
GEP20002145B (en) 1989-10-16 2000-06-25 Amgen Inc Us Stem Cell Factor
EP0512071B1 (en) * 1990-01-25 1996-10-30 Children's Hospital Method and compositions for inhibiting angiogenesis
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Also Published As

Publication number Publication date
DK0648838T3 (da) 2003-08-25
DE69432581D1 (de) 2003-06-05
PT648838E (pt) 2003-08-29
ES2194852T3 (es) 2003-12-01
EP0648838B1 (en) 2003-05-02
IL111171A0 (en) 1994-12-29
WO1995009918A1 (en) 1995-04-13
US6562596B1 (en) 2003-05-13
EP0648838A1 (en) 1995-04-19
US6683155B1 (en) 2004-01-27
DE69435162D1 (de) 2008-12-11
EP1319669B1 (en) 2008-10-29
US7842788B2 (en) 2010-11-30
EP1319669A3 (en) 2003-10-01
US7071317B2 (en) 2006-07-04
DE69432581T2 (de) 2004-04-08
ATE239079T1 (de) 2003-05-15
EP2011875A1 (en) 2009-01-07
PT1319669E (pt) 2009-01-07
US20100010201A1 (en) 2010-01-14
IL162152A (en) 2008-11-03
ES2315438T3 (es) 2009-04-01
IL191890A0 (en) 2009-05-04
US20030143693A1 (en) 2003-07-31
SI1319669T1 (sl) 2009-02-28
EP1319669A2 (en) 2003-06-18
AU7928194A (en) 1995-05-01
HK1009287A1 (en) 1999-05-28
ZA947781B (en) 1995-05-17
US20060286085A1 (en) 2006-12-21
HK1055977A1 (en) 2004-01-30
IL162152A0 (en) 2005-11-20
ATE412749T1 (de) 2008-11-15
US7435719B2 (en) 2008-10-14
IL111171A (en) 2006-07-05
SI0648838T1 (en) 2003-08-31

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