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DK1283265T3 - Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved - Google Patents

Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved

Info

Publication number
DK1283265T3
DK1283265T3 DK01930179T DK01930179T DK1283265T3 DK 1283265 T3 DK1283265 T3 DK 1283265T3 DK 01930179 T DK01930179 T DK 01930179T DK 01930179 T DK01930179 T DK 01930179T DK 1283265 T3 DK1283265 T3 DK 1283265T3
Authority
DK
Denmark
Prior art keywords
sugar chain
reduction
protein
glycoprotein
mannose phosphate
Prior art date
Application number
DK01930179T
Other languages
English (en)
Inventor
Masami Miura
Masaaki Hirose
Taeko Miwa
Hiroyuki Irie
Shinobu Kuwae
Kenmi Miyano
Wataru Otani
Hideyuki Ohi
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Application granted granted Critical
Publication of DK1283265T3 publication Critical patent/DK1283265T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK01930179T 2000-05-17 2001-05-16 Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved DK1283265T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000144643 2000-05-17
PCT/JP2001/004070 WO2001088143A1 (fr) 2000-05-17 2001-05-16 Procede d'elaboration de proteine avec reduction de chaine saccharose acide, et glycoproteine resultante

Publications (1)

Publication Number Publication Date
DK1283265T3 true DK1283265T3 (da) 2009-11-09

Family

ID=18651270

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01930179T DK1283265T3 (da) 2000-05-17 2001-05-16 Fremgangsmåde til fremstilling af protein med reduktion af mannosephosphat i sukkerkæden og glycoprotein fremstillet derved

Country Status (9)

Country Link
US (3) US7198921B2 (da)
EP (1) EP1283265B1 (da)
JP (2) JP4969011B2 (da)
AT (1) ATE438722T1 (da)
AU (1) AU2001256762A1 (da)
DE (1) DE60139467D1 (da)
DK (1) DK1283265T3 (da)
ES (1) ES2328106T3 (da)
WO (1) WO2001088143A1 (da)

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US7198921B2 (en) * 2000-05-17 2007-04-03 Mitsubishi Pharma Corporation Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
US20040214273A1 (en) 2001-01-19 2004-10-28 Kazuhito Fujiyama Method for secretory production of glycoprotein having human-type sugar chain using plant cell
EP2341128A1 (en) * 2003-12-24 2011-07-06 GlycoFi, Inc. Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
EP1747280B1 (en) * 2004-04-29 2018-01-17 GlycoFi, Inc. Methods for reducing or eliminating alpha-mannosidase resistant glycans in the production of glycoproteins
CA2623197A1 (en) * 2005-09-22 2007-03-29 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
US20100028951A1 (en) * 2007-03-07 2010-02-04 Stephen Hamilton Production of glycoproteins with modified fucosylation
WO2008120107A2 (en) 2007-04-03 2008-10-09 Oxyrane (Uk) Limited Glycosylation of molecules
US8829276B2 (en) 2007-04-17 2014-09-09 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
CN101903531B (zh) * 2007-12-19 2013-09-18 格利科菲公司 用于蛋白质生产的酵母菌株
CA2714166A1 (en) 2008-02-20 2009-08-27 Glycofi, Inc. Vectors and yeast strains for protein production
JP5731827B2 (ja) * 2008-03-03 2015-06-10 グライコフィ， インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
US8067339B2 (en) * 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
JP2011530311A (ja) 2008-08-12 2011-12-22 グライコフィ， インコーポレイテッド タンパク質製造のための改良されたベクターおよび酵母株：Ｃａ２＋ＡＴＰアーゼ過剰発現
SG173796A1 (en) 2009-02-25 2011-09-29 Merck Sharp & Dohme Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
WO2011039634A2 (en) 2009-09-29 2011-04-07 Universiteit Gent Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
CN104031961A (zh) 2009-10-16 2014-09-10 默沙东公司 生产成熟的人促红细胞生成素的方法以及包含获自该方法的人促红细胞生成素的组合物
RU2012122166A (ru) 2009-10-30 2013-12-10 Мерк Шарп И Доум Корп. Способы получения рекомбинантных белков с увеличенными эффективностями секреции
WO2011053612A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Method for producing therapeutic proteins in pichia pastoris lacking dipeptidyl aminopeptidase activity
JP2013511272A (ja) 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合ｎ−グリカンを生成する酵母株
JP5976549B2 (ja) 2010-02-24 2016-08-24 メルク・シャープ・エンド・ドーム・コーポレイション ピチア・パストリスにおいて産生される治療用糖タンパク質上のｎ−グリコシル化部位占拠を増加させるための方法
CN103080130B (zh) 2010-05-27 2016-08-17 默沙东公司 制备具有改进特性的抗体的方法
KR101979220B1 (ko) 2010-09-29 2019-05-16 옥시레인 유케이 리미티드 인산화된 n-글리칸들의 탈-만노실화
KR101983572B1 (ko) 2010-09-29 2019-05-29 옥시레인 유케이 리미티드 만노스-1-포스포-6-만노스 결합의 캡핑제거 및 인산화 n-글리칸의 탈만노실이 가능한 만노시다제 및 당단백질의 활용을 통한 포유류 세포의 촉진방법
CN107459577A (zh) 2010-12-01 2017-12-12 默沙东公司 表面锚定的fc‑诱饵抗体展示系统
JP2014518608A (ja) 2011-02-25 2014-08-07 メルク・シャープ・アンド・ドーム・コーポレーション 修飾ｏ−グリコシル化を有するタンパク質の製造のための酵母株
WO2012162277A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES
IN2014CN02963A (da) 2011-10-28 2015-07-03 Merck Sharp & Dohme
EP3628326B1 (en) 2012-03-15 2024-02-28 Oxyrane UK Limited Methods and materials for treatment of pompe's disease
CN104271816A (zh) 2012-05-11 2015-01-07 默沙东公司 表面锚定的轻链诱饵抗体展示系统
WO2013174927A1 (en) 2012-05-23 2013-11-28 Novartis International Pharmaceutical Limited Production of fucosylated glycoproteins
EP2909306B1 (en) 2012-10-22 2019-12-11 Merck Sharp & Dohme Corp. Crz1 mutant fungal cells
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
CN108064266A (zh) 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备

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IL82935A0 (en) * 1986-08-12 1987-12-20 Phillips Petroleum Co Secretion of heterologous proteins from yeast
JPH093097A (ja) * 1995-06-16 1997-01-07 Green Cross Corp:The ピキア属酵母由来の糖鎖伸長タンパク、該蛋白質をコードするｄｎａ、修飾該ｄｎａおよび形質転換体
JP2770010B2 (ja) 1996-03-29 1998-06-25 工業技術院長 酵母のマンノース−１−リン酸転移を正に制御する遺伝子ならびにこの遺伝子の欠損変異株を利用する高マンノース型中性糖鎖の製造方法
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
US7198921B2 (en) * 2000-05-17 2007-04-03 Mitsubishi Pharma Corporation Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
EP1522590B1 (en) * 2000-06-28 2009-08-26 Glycofi, Inc. Methods for producing modified glycoproteins

Also Published As

Publication number Publication date
US7488591B2 (en) 2009-02-10
US7198921B2 (en) 2007-04-03
US20040014170A1 (en) 2004-01-22
US20090004725A1 (en) 2009-01-01
US20070202569A1 (en) 2007-08-30
WO2001088143A1 (fr) 2001-11-22
DE60139467D1 (de) 2009-09-17
EP1283265B1 (en) 2009-08-05
ATE438722T1 (de) 2009-08-15
JP2012105652A (ja) 2012-06-07
EP1283265A4 (en) 2004-10-20
ES2328106T3 (es) 2009-11-10
AU2001256762A1 (en) 2001-11-26
US7872111B2 (en) 2011-01-18
EP1283265A1 (en) 2003-02-12
JP4969011B2 (ja) 2012-07-04

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