DK1265605T3 - Farmaceutiske sammensætninger omfattende peptidmimetisk, cyklisk beta-drejningsforbindelse - Google Patents
Farmaceutiske sammensætninger omfattende peptidmimetisk, cyklisk beta-drejningsforbindelseInfo
- Publication number
- DK1265605T3 DK1265605T3 DK01942551T DK01942551T DK1265605T3 DK 1265605 T3 DK1265605 T3 DK 1265605T3 DK 01942551 T DK01942551 T DK 01942551T DK 01942551 T DK01942551 T DK 01942551T DK 1265605 T3 DK1265605 T3 DK 1265605T3
- Authority
- DK
- Denmark
- Prior art keywords
- trka
- extracellular domain
- pharmaceutical compositions
- compounds
- peptide mimetic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 125000004122 cyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 101150111783 NTRK1 gene Proteins 0.000 abstract 4
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 abstract 2
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 230000001537 neural effect Effects 0.000 abstract 2
- 239000000816 peptidomimetic Substances 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000001228 trophic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17648200P | 2000-01-18 | 2000-01-18 | |
| PCT/CA2001/000043 WO2001052843A1 (en) | 2000-01-18 | 2001-01-18 | β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1265605T3 true DK1265605T3 (da) | 2007-02-12 |
Family
ID=22644525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01942551T DK1265605T3 (da) | 2000-01-18 | 2001-01-18 | Farmaceutiske sammensætninger omfattende peptidmimetisk, cyklisk beta-drejningsforbindelse |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6881719B2 (da) |
| EP (1) | EP1265605B1 (da) |
| AT (1) | ATE340571T1 (da) |
| AU (1) | AU2001228212A1 (da) |
| CA (1) | CA2397670C (da) |
| DE (1) | DE60123399T2 (da) |
| DK (1) | DK1265605T3 (da) |
| ES (1) | ES2273849T3 (da) |
| WO (1) | WO2001052843A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7923216B2 (en) | 1997-08-14 | 2011-04-12 | Institut Pasteur | In vivo modulation of neuronal transport |
| US7923015B2 (en) | 1997-08-14 | 2011-04-12 | Institut Pasteur | Methods for direct visualization of active synapses |
| US7566765B2 (en) * | 2000-03-06 | 2009-07-28 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds containing a nine-membered carbon-nitrogen ring |
| ATE554784T1 (de) | 2001-05-25 | 2012-05-15 | Cornell Res Foundation Inc | Hochaffiner ligand für p75 neurotrophin-rezeptor |
| AUPR604401A0 (en) | 2001-06-29 | 2001-07-26 | University Of Wollongong, The | Peptoid compounds |
| AU2003304238A1 (en) | 2002-10-08 | 2005-01-13 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| MXPA05003502A (es) | 2002-10-08 | 2005-09-30 | Rinat Neuroscience Corp | Metodo para tratar dolor post-quirurgico al administrar un antagonista del factor de crecimiento de nervios y composiciones que contienen el mismo. |
| PT2263692T (pt) | 2002-12-24 | 2018-11-28 | Rinat Neuroscience Corp | Anticorpos anti-ngf e métodos de utilização dos mesmos |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| GEP20094629B (en) | 2003-03-19 | 2009-03-10 | Biogen Idec Inc | Nogo receptor binding protein |
| ATE457995T1 (de) | 2003-06-18 | 2010-03-15 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| KR101637908B1 (ko) | 2004-04-07 | 2016-07-11 | 리나트 뉴로사이언스 코프. | 신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법 |
| PT1776136E (pt) | 2004-06-24 | 2012-12-05 | Biogen Idec Inc | Tratamento de estados que envolvem desmielinização |
| WO2006005740A2 (en) * | 2004-07-14 | 2006-01-19 | Janssen Pharmaceutica N.V. | P75ntr screening assay for indentifying modulators of apoptosis |
| WO2006052391A2 (en) * | 2004-10-14 | 2006-05-18 | Rigel Pharmaceuticals, Inc. | Heterocyclic inhibitors of ires-mediated translation and methods of use thereof |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ES2569881T3 (es) | 2005-06-08 | 2016-05-12 | The University Of North Carolina At Chapel Hill | Procedimientos para facilitar la supervivencia de células neuronales usando miméticos de neurotrofina BDNF peptídicos y no peptídicos |
| BRPI0613387A2 (pt) | 2005-07-08 | 2011-01-11 | Biogen Idec Inc | anticorpo isolado ou fragmento de ligação de antìgeno deste e o seu uso, polinucleotìdeo isolado, composição, vetor, célula hospedeira, anticorpo anti-sp35 e método para a produção do mesmo, polipeptìdeo isolado, método in vitro para redução da inibição do crescimento axonal e método in vitro para inibição do crescimento do colapso do cone |
| WO2008013782A2 (en) | 2006-07-24 | 2008-01-31 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of sp35 or trka antagonists |
| EP2099468B1 (en) * | 2006-12-05 | 2018-07-11 | The Royal Institution for the Advancement of Learning/McGill University | Methods of use of trk receptor modulators |
| AU2011253937B2 (en) * | 2006-12-05 | 2012-09-27 | The Royal Institution For The Advancement Of Learning/ Mcgill University | Methods of use of TRK receptor modulators |
| EP2205071B1 (en) * | 2007-10-11 | 2015-07-22 | Biogen MA Inc. | Lingo-1 antagonists and trkb agonists for use in the treatment of glaucoma |
| WO2009061500A1 (en) * | 2007-11-08 | 2009-05-14 | Biogen Idec Ma Inc. | Use of lingo-4 antagonists in the treatment of conditions involving demyelination |
| ES2521515T3 (es) * | 2008-04-04 | 2014-11-12 | Mimetogen Pharmaceuticals Inc. | Compuestos cíclicos peptidomiméticos con giro beta para tratar el ojo seco |
| CA2729961C (en) | 2008-07-09 | 2018-05-01 | Biogen Idec Ma Inc. | Li113, li62 variant co2, anti-lingo antibodies |
| US8653036B2 (en) | 2009-02-27 | 2014-02-18 | Mimetogen Pharmaceuticals Inc. | Methods of treating retinitis pigmentosa |
| AU2010319349B2 (en) | 2009-11-12 | 2015-07-16 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US9796780B2 (en) | 2012-05-14 | 2017-10-24 | Biogen Ma Inc. | LINGO-2 antagonists for treatment of conditions involving motor neurons |
| US9115179B2 (en) | 2012-06-22 | 2015-08-25 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
| BR112015022832A2 (pt) | 2013-03-15 | 2017-07-18 | Pharmatrophix Inc | miméticos de neurotrofina bdnf não peptídicos |
| RU2015141933A (ru) | 2013-03-15 | 2017-04-26 | Фарматрофикс, Инк. | Непептидные миметики нейротрофина bdnf |
| JP6886816B2 (ja) | 2013-09-09 | 2021-06-16 | カニムガイド セラピューティックス アーベー | 免疫系調節薬 |
| WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
| US10881709B2 (en) | 2015-03-06 | 2021-01-05 | Canimguide Therapeutics Ab | Immune system modulators and compositions |
| CN107849089B (zh) | 2015-07-09 | 2022-07-05 | 米梅奥亨制药公司 | β-转角环状模拟肽盐的溶液相合成和结晶 |
| JPWO2022009992A1 (da) * | 2020-07-10 | 2022-01-13 | ||
| EP4347617A4 (en) * | 2021-06-02 | 2025-09-03 | Texas A & M Univ Sys | SELECTIVE SMALL MOLECULE AGONISTS AND PARTIAL AGONISTS OF TRK RECEPTORS |
| IL318654A (en) * | 2022-08-05 | 2025-03-01 | The Texas A& M Univ System | Compositions and methods for dye-bound cyclic peptides for medical use |
| FR3148027A1 (fr) * | 2023-04-24 | 2024-10-25 | Peptinov | Composition vaccinale anti-ngf |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034224A (en) * | 1989-05-30 | 1991-07-23 | American Cyanamid Company | Method and composition for treating protozoal infections |
| JP3042713B2 (ja) * | 1990-12-21 | 2000-05-22 | マイクロカーブ インコーポレイティド | 微生物のコロニー化を阻害するためへの宿主細胞リン脂質の使用 |
| GB9402331D0 (en) * | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
-
2001
- 2001-01-18 DK DK01942551T patent/DK1265605T3/da active
- 2001-01-18 EP EP01942551A patent/EP1265605B1/en not_active Expired - Lifetime
- 2001-01-18 DE DE60123399T patent/DE60123399T2/de not_active Expired - Lifetime
- 2001-01-18 WO PCT/CA2001/000043 patent/WO2001052843A1/en not_active Ceased
- 2001-01-18 CA CA2397670A patent/CA2397670C/en not_active Expired - Lifetime
- 2001-01-18 AT AT01942551T patent/ATE340571T1/de not_active IP Right Cessation
- 2001-01-18 US US10/181,546 patent/US6881719B2/en not_active Expired - Lifetime
- 2001-01-18 ES ES01942551T patent/ES2273849T3/es not_active Expired - Lifetime
- 2001-01-18 AU AU2001228212A patent/AU2001228212A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE340571T1 (de) | 2006-10-15 |
| US6881719B2 (en) | 2005-04-19 |
| WO2001052843A1 (en) | 2001-07-26 |
| EP1265605A1 (en) | 2002-12-18 |
| EP1265605B1 (en) | 2006-09-27 |
| DE60123399T2 (de) | 2007-08-23 |
| DE60123399D1 (de) | 2006-11-09 |
| US20030211982A1 (en) | 2003-11-13 |
| CA2397670C (en) | 2010-06-08 |
| ES2273849T3 (es) | 2007-05-16 |
| AU2001228212A1 (en) | 2001-07-31 |
| CA2397670A1 (en) | 2001-07-26 |
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