DK124081B - Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf.

Info

Publication number: DK124081B
Authority: DK; Denmark
Prior art keywords: racemic; preparation; acid addition; addition salts; optically active
Prior art date: 1966-09-03

Application number

DK441867AA

Other languages

Danish (da)

English (en)

Inventor

A Mentrup

K Zeile

P Danneberg

K Schromm

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-09-03

Filing date

1967-09-01

Publication date

1972-09-11

1966-09-03 Priority claimed from DE1966B0088772 external-priority patent/DE1670144B2/de

1967-09-01 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1972-09-11 Publication of DK124081B publication Critical patent/DK124081B/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK441867AA 1966-09-03 1967-09-01 Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf. DK124081B (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE1966B0088772 DE1670144B2 (de)	1966-09-03	1966-09-03	Substituierte n- eckige klammer auf l-arylpropyl-(2) eckige klammer zu -n'- phenyl-piperazine, verfahren zu deren herstellung und daraus hergestellte zentraldepressiv wirkende pharmazeutische praeparate
DEB0093758		1967-08-01

Publications (1)

Publication Number	Publication Date
DK124081B true DK124081B (da)	1972-09-11

Family

ID=25968081

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK441867AA DK124081B (da)	1966-09-03	1967-09-01	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf.

Country Status (14)

Country	Link
US (1)	US3729474A (fr)
AT (7)	AT280301B (fr)
BE (1)	BE703407A (fr)
CH (8)	CH505841A (fr)
DE (1)	DE1670254A1 (fr)
DK (1)	DK124081B (fr)
ES (8)	ES344693A1 (fr)
FI (1)	FI49969C (fr)
FR (2)	FR1550188A (fr)
GB (1)	GB1176672A (fr)
IL (1)	IL28589A (fr)
NL (2)	NL6712054A (fr)
SE (1)	SE350260B (fr)
YU (9)	YU33749B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2037852C3 (de) *	1970-07-30	1980-06-26	Boehringer Sohn Ingelheim	Neue Piperazinderivate und Verfahren zu ihrer Herstellung
US3859438A (en) *	1971-07-08	1975-01-07	Boehringer Sohn Ingelheim	Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl-2)-n-bicyclic aryl-piperazine and method of use
DE2325633A1 (de) *	1973-05-21	1974-12-12	Boehringer Sohn Ingelheim	Piperazinderivate
US4094980A (en) *	1974-09-03	1978-06-13	Boehringer Ingelheim Gmbh	N-[1-(3',4'-methylenedioxy-phenyl)-propyl-(2)]-N'-phenyl-piperazines and salts thereof
FR2285883A1 (fr) *	1974-09-30	1976-04-23	Cerm Cent Europ Rech Mauvernay	Nouveaux composes chimiques a activite bronchospasmolytique et antitussive, et procede pour leur obtention
US4130646A (en) *	1975-07-25	1978-12-19	E. R. Squibb & Sons, Inc.	1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
FI60479C (fi) *	1977-12-22	1982-02-10	Serlachius Oy	Planteringsanordning
US4684651A (en) *	1981-03-17	1987-08-04	Mitsubishi Chemical Industries Limited	Alkylenedioxybenzene and acid addition salts thereof useful as hypotensives
US4891375A (en) *	1988-01-13	1990-01-02	Pfizer Inc.	Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
AU6517196A (en) *	1995-07-13	1997-02-10	Knoll Aktiengesellschaft	Piperazine derivatives as therapeutic agents
FR2737724B1 (fr) *	1995-08-09	1997-09-05	Synthelabo	Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique
US20070219213A1 (en) *	2004-05-20	2007-09-20	Soares Romeiro Luiz A	Use of Adrenergic N-Phenylpiperazine Antagonists, Pahrmaceutical Compositions Containning Them, and Methods of Preparing Them

0
- NL NL132357D patent/NL132357C/xx active
1967
- 1967-08-01 DE DE19671670254 patent/DE1670254A1/de active Pending
- 1967-08-10 CH CH292670A patent/CH505841A/de not_active IP Right Cessation
- 1967-08-10 CH CH292270A patent/CH505838A/de not_active IP Right Cessation
- 1967-08-10 CH CH292070A patent/CH507964A/de not_active IP Right Cessation
- 1967-08-10 CH CH292570A patent/CH517751A/de not_active IP Right Cessation
- 1967-08-10 CH CH292170A patent/CH505837A/de not_active IP Right Cessation
- 1967-08-10 CH CH1127167A patent/CH506532A/de not_active IP Right Cessation
- 1967-08-10 CH CH292470A patent/CH505840A/de not_active IP Right Cessation
- 1967-08-10 CH CH292370A patent/CH505839A/de not_active IP Right Cessation
- 1967-08-31 AT AT477569A patent/AT280301B/de not_active IP Right Cessation
- 1967-08-31 AT AT477869A patent/AT280304B/de not_active IP Right Cessation
- 1967-08-31 AT AT478169A patent/AT280307B/de not_active IP Right Cessation
- 1967-08-31 AT AT477669A patent/AT280302B/de not_active IP Right Cessation
- 1967-08-31 AT AT478069A patent/AT280306B/de not_active IP Right Cessation
- 1967-08-31 AT AT801367A patent/AT280289B/de active
- 1967-08-31 AT AT477769A patent/AT280303B/de not_active IP Right Cessation
- 1967-09-01 DK DK441867AA patent/DK124081B/da unknown
- 1967-09-01 SE SE12167/67A patent/SE350260B/xx unknown
- 1967-09-01 FR FR1550188D patent/FR1550188A/fr not_active Expired
- 1967-09-01 IL IL28589A patent/IL28589A/en unknown
- 1967-09-01 FI FI672361A patent/FI49969C/fi active
- 1967-09-01 ES ES344693A patent/ES344693A1/es not_active Expired
- 1967-09-01 YU YU1724/67A patent/YU33749B/xx unknown
- 1967-09-01 NL NL6712054A patent/NL6712054A/xx unknown
- 1967-09-01 BE BE703407D patent/BE703407A/xx not_active IP Right Cessation
- 1967-09-04 GB GB40403/67A patent/GB1176672A/en not_active Expired
- 1967-12-01 FR FR130682A patent/FR7515M/fr not_active Expired
1968
- 1968-10-15 ES ES359162A patent/ES359162A1/es not_active Expired
- 1968-10-15 ES ES359158A patent/ES359158A1/es not_active Expired
- 1968-10-15 ES ES359161A patent/ES359161A1/es not_active Expired
- 1968-10-15 ES ES359156A patent/ES359156A1/es not_active Expired
- 1968-10-15 ES ES359160A patent/ES359160A1/es not_active Expired
- 1968-10-15 ES ES359157A patent/ES359157A1/es not_active Expired
- 1968-10-15 ES ES359159A patent/ES359159A1/es not_active Expired
1971
- 1971-01-28 US US00110766A patent/US3729474A/en not_active Expired - Lifetime
1975
- 1975-05-14 YU YU1234/75A patent/YU37322B/xx unknown
- 1975-05-14 YU YU1233/75A patent/YU37321B/xx unknown
- 1975-05-14 YU YU1232/75A patent/YU37320B/xx unknown
- 1975-05-14 YU YU1235/75A patent/YU37323B/xx unknown
- 1975-05-14 YU YU1237/75A patent/YU37325B/xx unknown
- 1975-05-14 YU YU1236/75A patent/YU37324B/xx unknown
- 1975-05-14 YU YU1238/75A patent/YU37326B/xx unknown
- 1975-05-14 YU YU1239/75A patent/YU37327B/xx unknown

Also Published As

Publication number	Publication date
NL132357C (fr)
DE1670254A1 (de)	1971-01-28
YU37320B (en)	1984-08-31
ES359159A1 (es)	1970-05-16
CH505840A (de)	1971-04-15
SE350260B (fr)	1972-10-23
YU123775A (en)	1983-04-27
YU37326B (en)	1984-08-31
YU123375A (en)	1983-04-27
ES359161A1 (es)	1970-05-16
CH507964A (de)	1971-05-31
YU123675A (en)	1983-04-27
YU37325B (en)	1984-08-31
AT280306B (de)	1970-04-10
YU123875A (en)	1983-04-27
IL28589A (en)	1972-02-29
ES359160A1 (es)	1970-05-16
CH505841A (de)	1971-04-15
AT280289B (de)	1970-04-10
FI49969B (fr)	1975-07-31
YU123975A (en)	1983-04-27
GB1176672A (en)	1970-01-07
CH505838A (de)	1971-04-15
CH506532A (de)	1971-04-30
ES359158A1 (es)	1970-05-16
ES344693A1 (es)	1969-01-01
ES359156A1 (es)	1970-05-16
YU123575A (en)	1983-04-27
AT280302B (de)	1970-04-10
ES359157A1 (es)	1970-05-16
CH505837A (de)	1971-04-15
BE703407A (fr)	1968-03-01
YU37321B (en)	1984-08-31
US3729474A (en)	1973-04-24
YU37323B (en)	1984-08-31
FI49969C (fi)	1975-11-10
YU123475A (en)	1983-04-27
YU123275A (en)	1983-04-27
CH517751A (de)	1972-01-15
FR7515M (fr)	1969-12-15
ES359162A1 (es)	1970-05-16
FR1550188A (fr)	1968-12-20
YU33749B (en)	1978-05-15
YU172467A (en)	1977-10-31
AT280307B (de)	1970-04-10
NL6712054A (fr)	1968-03-04
YU37324B (en)	1984-08-31
YU37327B (en)	1984-08-31
AT280301B (de)	1970-04-10
AT280303B (de)	1970-04-10
CH505839A (de)	1971-04-15
AT280304B (de)	1970-04-10
YU37322B (en)	1984-08-31

Publication	Publication Date	Title
DK124824B (da)	1972-11-27	Analogifremgangsmåde til fremstilling af piperazinderivater eller syreadditionssalte deraf.
DK104409C (da)	1966-05-16	Fremgangsmåde til fremstilling af quinazolonderivater eller syreadditionssalte deraf.
DK131029B (da)	1975-05-20	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-alkylaminopropaner eller syreadditionssalte deraf.
DK129447B (da)	1974-10-14	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-sek.-alkylaminopropaner eller syreadditionssalte heraf.
DK120756B (da)	1971-07-12	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive norscopolaminderivater eller syreadditionssalte eller kvaternære salte heraf.
DK136527B (da)	1977-10-24	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive p-alkoxyfenoxypropanolaminer eller syreadditionssalte deraf.
DK140281B (da)	1979-07-23	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-cycloalkylaminopropaner eller syreadditionssalte heraf.
DK132411B (da)	1975-12-01	Analogifremgangsmåde til fremstilling af pyrrylaminoketonderivater eller syreadditionssalte deraf.
DK122133B (da)	1972-01-24	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive substituerede 3-alkoxythianaphthen-2-carboxamider eller syreadditionssalte eller kvaternære ammoniumsalte deraf.
DK124081B (da)	1972-09-11	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf.
DK121512B (da)	1971-10-25	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive substituerede 5-phenyl-6,7-benzomorphaner eller syreadditionssalte deraf.
DK118187B (da)	1970-07-20	Fremgangsmåde til fremstilling af indolderivater eller syreadditionssalte deraf.
DK120597B (da)	1971-06-21	Analogifremgangsmåde til frematilling af racemiske eller optisk aktive 10b-substituerede hexahydro-eller octahydrophenanthridinderivater eller salte deraf.
DK125639B (da)	1973-03-19	Analogifremgangsmåde til fremstilling af racemisk eller optisk aktivt 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylaminopropan eller syreadditionssalte heraf.
DK131988B (da)	1975-10-06	Analogifremgangsmåde til fremstilling af optisk aktive eller racemiske 1-aryloxy-2-hydroxy-3-isopropylamino-propaner eller syreadditionssalte heraf.
DK139582B (da)	1979-03-12	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive benzocycloheptaisoquinolin-forbindelser eller syreadditionssalte deraf.
DK129235B (da)	1974-09-16	Fremgangsmåde til fremstilling af racemiske eller optisk aktive quinolinderivater eller syreadditionssalte deraf.
DK129924B (da)	1974-12-02	Analogifremgangsmåde til fremstilling af aminoalkylaminobenzophenonderivater eller syreadditionssalte deraf.
DK120998B (da)	1971-08-16	Analogifremgangsmåde til fremstilling af piperazinderivater eller syreadditionssalte deraf.
DK120133B (da)	1971-04-13	Analogifremgangsmåde til fremstilling af piperazinderivater eller syreadditionssalte deraf.
DK103831C (da)	1966-02-28	Fremgangsmåde til fremstilling af 4-azathioxanthenderivater eller syreadditionssalte deraf.
DK121513B (da)	1971-10-25	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive N-substituerede noratropiniumsalte.
DK131470B (da)	1975-07-21	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive thiazolino-pyrimidin-5-on derivater eller syreadditionssalte deraf.
DK132551B (da)	1975-12-29	Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive carbamoylalkoxyphenoxyisopropanolaminderivater eller syreadditionssalte deraf.
DK129416B (da)	1974-10-07	Fremgangsmåde til fremstilling af γ-lactonen af racemiske eller optisk aktive derivater af 6H,7H-cis-7-aminodesacetylcephalosporansyre.