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DK123715B - Process for the preparation of 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides. - Google Patents

Process for the preparation of 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides.

Info

Publication number
DK123715B
DK123715B DK64169AA DK64169A DK123715B DK 123715 B DK123715 B DK 123715B DK 64169A A DK64169A A DK 64169AA DK 64169 A DK64169 A DK 64169A DK 123715 B DK123715 B DK 123715B
Authority
DK
Denmark
Prior art keywords
demethylpipodophyllotoxin
glucosides
alkylidene
preparation
alkylidene glucosides
Prior art date
Application number
DK64169AA
Other languages
Danish (da)
Inventor
Wartburg A Von
Juslen C Keller
J Renz
M Kuhn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK123715B publication Critical patent/DK123715B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Saccharide Compounds (AREA)
DK64169AA 1968-02-27 1969-02-06 Process for the preparation of 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides. DK123715B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH284568A CH514578A (en) 1968-02-27 1968-02-27 Process for the production of glucosides

Publications (1)

Publication Number Publication Date
DK123715B true DK123715B (en) 1972-07-24

Family

ID=4242875

Family Applications (2)

Application Number Title Priority Date Filing Date
DK64169AA DK123715B (en) 1968-02-27 1969-02-06 Process for the preparation of 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides.
DK266771AA DK128563B (en) 1968-02-27 1971-06-01 4,6-O-Alkylidene-β-D-glucopyranoses for use as intermediates in the preparation of therapeutically valuable 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides and methods for their preparation.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK266771AA DK128563B (en) 1968-02-27 1971-06-01 4,6-O-Alkylidene-β-D-glucopyranoses for use as intermediates in the preparation of therapeutically valuable 4'-demethylpipodophyllotoxin-β-D-alkylidene glucosides and methods for their preparation.

Country Status (9)

Country Link
AT (2) AT319971B (en)
BR (1) BR6906655D0 (en)
CA (1) CA956939A (en)
CH (2) CH514578A (en)
CS (2) CS153033B2 (en)
DK (2) DK123715B (en)
FI (1) FI48924C (en)
NL (1) NL166028C (en)
SU (2) SU447886A3 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS61189230A (en) * 1985-02-19 1986-08-22 Nippon Kayaku Co Ltd Etoposide preparation
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AR074897A1 (en) 2008-12-23 2011-02-23 Pharmasset Inc NUCLEOSID PHOSPHORAMIDATES
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
PT2609923T (en) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Also Published As

Publication number Publication date
FI48924B (en) 1974-10-31
NL6901619A (en) 1969-08-29
NL166028B (en) 1981-01-15
CS153032B2 (en) 1974-02-22
CS153033B2 (en) 1974-02-22
AT303270B (en) 1972-11-27
NL166028C (en) 1981-06-15
SU406346A3 (en) 1973-11-05
CH514578A (en) 1971-10-31
CH518927A (en) 1972-02-15
CA956939A (en) 1974-10-29
DK128563B (en) 1974-05-27
FI48924C (en) 1975-02-10
SU447886A3 (en) 1974-10-25
BR6906655D0 (en) 1973-01-09
AT319971B (en) 1975-01-27

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Legal Events

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