DK1233784T3 - Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering - Google Patents
Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofiliseringInfo
- Publication number
- DK1233784T3 DK1233784T3 DK00992589T DK00992589T DK1233784T3 DK 1233784 T3 DK1233784 T3 DK 1233784T3 DK 00992589 T DK00992589 T DK 00992589T DK 00992589 T DK00992589 T DK 00992589T DK 1233784 T3 DK1233784 T3 DK 1233784T3
- Authority
- DK
- Denmark
- Prior art keywords
- biological molecules
- methods
- lyophilization
- preparations
- stabilizing biological
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004108 freeze drying Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 239000000872 buffer Substances 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16848699P | 1999-12-02 | 1999-12-02 | |
| PCT/US2000/042484 WO2001041800A2 (en) | 1999-12-02 | 2000-12-01 | Compositions and methods for stabilizing biological molecules upon lyophilization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1233784T3 true DK1233784T3 (da) | 2008-09-01 |
Family
ID=22611688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00992589T DK1233784T3 (da) | 1999-12-02 | 2000-12-01 | Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1233784B1 (ja) |
| JP (2) | JP4948731B2 (ja) |
| AT (1) | ATE400296T1 (ja) |
| CA (1) | CA2393298C (ja) |
| CY (1) | CY1108382T1 (ja) |
| DE (1) | DE60039450D1 (ja) |
| DK (1) | DK1233784T3 (ja) |
| ES (1) | ES2307553T3 (ja) |
| PT (1) | PT1233784E (ja) |
| WO (1) | WO2001041800A2 (ja) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4948731B2 (ja) | 1999-12-02 | 2012-06-06 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 凍結乾燥の際に生物学的分子を安定化するための組成物および方法 |
| KR100947757B1 (ko) | 2001-01-23 | 2010-03-18 | 아벤티스 파스퇴르 | 다가 수막구균 폴리사카라이드―단백질 접합체 백신 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| CA2452720C (en) * | 2001-07-26 | 2012-04-17 | Chiron S.R.L. | Vaccines comprising aluminium adjuvants and histidine |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| AU2003287980B2 (en) | 2002-11-01 | 2009-06-25 | Glaxosmithkline Biologicals S.A. | Drying process |
| ES2383175T3 (es) | 2003-01-30 | 2012-06-18 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| US20070031501A1 (en) * | 2003-08-05 | 2007-02-08 | Andries Van Es | Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions |
| JP2007509164A (ja) | 2003-10-23 | 2007-04-12 | カイロン コーポレイション | 安定化組成物 |
| GB0404586D0 (en) * | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| BRPI0612655B1 (pt) | 2005-06-27 | 2021-06-15 | Pfizer Ireland Pharmaceuticals | Composição imunogênica |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| TW201009337A (en) * | 2008-05-30 | 2010-03-01 | Intervet Int Bv | Analytical method to monitor vaccine potency and stability |
| AU2009314311B2 (en) | 2008-10-29 | 2013-01-10 | Ablynx N.V. | Methods for purification of single domain antigen binding molecules |
| AR073997A1 (es) | 2008-10-29 | 2010-12-15 | Wyeth Corp | Formulaciones de moleculas de union a antigeno de dominio unico. metodo. kit |
| PL3170508T3 (pl) | 2010-06-04 | 2020-04-30 | Wyeth Llc | Preparaty szczepionek |
| ES2994878T3 (en) | 2010-08-23 | 2025-02-03 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| CA2828844C (en) | 2011-03-02 | 2020-07-14 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| JP6048845B2 (ja) * | 2011-06-01 | 2016-12-21 | シャモン ユニヴァーシティー | ジフテリア毒素の無毒性突然変異体ｃｒｍ１９７又はその断片を含む融合タンパク質 |
| WO2013092985A1 (en) * | 2011-12-23 | 2013-06-27 | Novartis Ag | Stable compositions for immunising against staphylococcus aureus |
| IN2012MU00206A (ja) | 2012-01-20 | 2013-08-09 | ||
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| BR122016004924A2 (pt) | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
| BR112014030025A2 (pt) * | 2012-05-30 | 2017-06-27 | Brigham & Womens Hospital Inc | composições de polissacarídeo e métodos de uso |
| JP2015527310A (ja) * | 2012-06-28 | 2015-09-17 | アンサン バイオファーマ, インコーポレイテッドAnsun Biopharma, Inc. | 下気道および中枢気道への送達用微粒子製剤ならびに製造方法 |
| CN104487086B (zh) * | 2012-07-07 | 2019-08-30 | 巴拉特生物技术国际有限公司 | 无动物源的不含酒精的疫苗组合物及其制备方法 |
| CA2882619A1 (en) | 2012-09-06 | 2014-03-13 | Novartis Ag | Combination vaccines with serogroup b meningococcus and d/t/p |
| KR20150073943A (ko) | 2012-10-03 | 2015-07-01 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| BR112015014250A2 (pt) | 2012-12-18 | 2017-07-11 | Glaxosmithkline Biologicals Sa | método para imunizar um bebê, vacina de combinação e, kit |
| EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CA3117867A1 (en) | 2018-11-06 | 2020-05-14 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB202208089D0 (en) * | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| CN102416176A (zh) * | 1995-07-27 | 2012-04-18 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白质制剂 |
| JP4948731B2 (ja) | 1999-12-02 | 2012-06-06 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 凍結乾燥の際に生物学的分子を安定化するための組成物および方法 |
-
2000
- 2000-12-01 JP JP2001543144A patent/JP4948731B2/ja not_active Expired - Lifetime
- 2000-12-01 DE DE60039450T patent/DE60039450D1/de not_active Expired - Lifetime
- 2000-12-01 EP EP00992589A patent/EP1233784B1/en not_active Revoked
- 2000-12-01 PT PT00992589T patent/PT1233784E/pt unknown
- 2000-12-01 DK DK00992589T patent/DK1233784T3/da active
- 2000-12-01 AT AT00992589T patent/ATE400296T1/de active
- 2000-12-01 EP EP10180286A patent/EP2292263A3/en not_active Withdrawn
- 2000-12-01 CA CA2393298A patent/CA2393298C/en not_active Expired - Lifetime
- 2000-12-01 WO PCT/US2000/042484 patent/WO2001041800A2/en not_active Ceased
- 2000-12-01 ES ES00992589T patent/ES2307553T3/es not_active Expired - Lifetime
-
2008
- 2008-09-30 CY CY20081101074T patent/CY1108382T1/el unknown
-
2011
- 2011-04-12 JP JP2011088528A patent/JP2011137047A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003516361A (ja) | 2003-05-13 |
| CY1108382T1 (el) | 2014-02-12 |
| WO2001041800A2 (en) | 2001-06-14 |
| DE60039450D1 (de) | 2008-08-21 |
| EP2292263A3 (en) | 2011-07-27 |
| WO2001041800A3 (en) | 2002-01-03 |
| EP2292263A2 (en) | 2011-03-09 |
| PT1233784E (pt) | 2008-11-03 |
| JP2011137047A (ja) | 2011-07-14 |
| WO2001041800A9 (en) | 2002-08-01 |
| ATE400296T1 (de) | 2008-07-15 |
| ES2307553T3 (es) | 2008-12-01 |
| JP4948731B2 (ja) | 2012-06-06 |
| EP1233784A2 (en) | 2002-08-28 |
| CA2393298C (en) | 2011-02-01 |
| CA2393298A1 (en) | 2001-06-14 |
| EP1233784B1 (en) | 2008-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1233784T3 (da) | Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering | |
| NO20025450D0 (no) | Ny farmasöytisk sammensetning | |
| DK1117440T3 (da) | Farmaceutiske sammensætninger indeholdende paclitaxel | |
| LU92060I2 (fr) | Interféron beta-1a | |
| DK1887016T3 (da) | Fragmenter af humant choriongonadotropin (HCG) som immunoregulator | |
| CY1113312T1 (el) | Κυκλικοι αναστολεις κινασης τυροσινης πρωτεϊνων | |
| DK0535091T3 (da) | Knogleinducerende farmaceutiske formuleringer | |
| PT1347971E (pt) | Inibidores tiazolilicos de tirosina-cinases da familia tec | |
| EA199901031A1 (ru) | Производные бензимидазола | |
| EA200000789A1 (ru) | N-[(замещенное пятичленное ди- или триазадиненасыщенное кольцо) карбонил] гуанидиновые производные для лечения ишемии | |
| MY141641A (en) | Compositions comprising viruses and methods for concentrating virus preparations | |
| CY1110914T1 (el) | Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν | |
| FI942186A0 (fi) | Sytokiinituotantoa indusoivat uretaanit ja ureat | |
| DK0921785T3 (da) | Kombination af syreproteaseenzymer og sure puffere og anvendelser deraf | |
| DE60019458D1 (de) | Stabilisierendes verdünnungsmittel für polypeptide und antigene | |
| AU2001277961A1 (en) | Compositions comprising heat shock proteins or alpha(2)macroglobulin, antigenic molecules and saponins, and methods of use thereof | |
| TR200200821T2 (tr) | 5-Beta-sapojenin ve pseudosapojenin türevleri ve bunların bunama tedavisinde kullanımı. | |
| ES2011232A4 (es) | Compuestos farmaceuticos en piroxicam en soluciones acuosas y proceso para su preparacion | |
| DK1219301T3 (da) | Vacciner, som indeholder hybridpolypeptider, der består af mindst to forskellige allergene proteiner | |
| EA200001164A1 (ru) | КОМБИНАЦИИ ИНГИБИТОРОВ ПРОТЕИН ФАРНЕЗИЛТРАНСФЕРАЗЫ И HMG KoA РЕДУКТАЗЫ И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА | |
| ATE341339T1 (de) | Zusammensetzungen von rekombinanten papillomavirus vakzinen | |
| BR0104082A (pt) | Processo de tratamento conveniente para a deformação e/ou conformação, e isto de modo permanente, dos materiais queratìnicos e, particulamente, dos cabelos, composição cosmética redutora, e kit para tratamento | |
| NO20015398D0 (no) | Endoparasitticidisk synergistisk kombinasjon inneholdende cykliske depsipeptider og piperaziner | |
| DE60024977D1 (de) | Klonierung und expression von haemophilus somnus transferrin-bindenden proteinen | |
| DK1219299T3 (da) | Allergivacciner og fremstilling deraf |