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DK1204650T3 - Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler - Google Patents

Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler

Info

Publication number
DK1204650T3
DK1204650T3 DK00954726T DK00954726T DK1204650T3 DK 1204650 T3 DK1204650 T3 DK 1204650T3 DK 00954726 T DK00954726 T DK 00954726T DK 00954726 T DK00954726 T DK 00954726T DK 1204650 T3 DK1204650 T3 DK 1204650T3
Authority
DK
Denmark
Prior art keywords
substituted
compounds
antitumor agents
amino acid
substituent
Prior art date
Application number
DK00954726T
Other languages
English (en)
Inventor
Malcolm Francis Graham Stevens
Tracey Dawn Poole
Andrew David Westwell
Ian Paul Hutchinson
Mei-Sze Chua
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of DK1204650T3 publication Critical patent/DK1204650T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK00954726T 1999-08-20 2000-08-21 Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler DK1204650T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9919673.5A GB9919673D0 (en) 1999-08-20 1999-08-20 2-Arlybenzazole compounds

Publications (1)

Publication Number Publication Date
DK1204650T3 true DK1204650T3 (da) 2006-08-21

Family

ID=10859458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00954726T DK1204650T3 (da) 1999-08-20 2000-08-21 Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler

Country Status (13)

Country Link
US (1) US6858633B1 (da)
EP (1) EP1204650B1 (da)
JP (1) JP2003507462A (da)
AT (1) ATE323686T1 (da)
AU (1) AU783360B2 (da)
CA (1) CA2382406C (da)
CY (1) CY1105091T1 (da)
DE (1) DE60027435T2 (da)
DK (1) DK1204650T3 (da)
ES (1) ES2263483T3 (da)
GB (1) GB9919673D0 (da)
PT (1) PT1204650E (da)
WO (1) WO2001014354A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5022554B2 (ja) * 2000-08-24 2012-09-12 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
JP2005523903A (ja) * 2002-02-13 2005-08-11 アメルシャム・パブリック・リミテッド・カンパニー アミロイド斑の生体内撮像用のベンゾチアゾール誘導体
KR20050033052A (ko) * 2002-07-01 2005-04-08 메르크 파텐트 게엠베하 중합가능한 발광성 화합물 및 혼합물, 발광성 중합체 물질및 이들의 용도
CN101413143B (zh) 2002-12-19 2013-09-18 斯克里普斯研究学院 稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
EP1611115B1 (en) * 2003-03-14 2012-08-22 University of Pittsburgh - of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
BRPI0510033A (pt) 2004-05-20 2007-10-02 Scripps Res Insittute estabilização de transtiretina
AU2006325294B2 (en) 2005-10-31 2012-10-11 Merck Sharp & Dohme Corp. CETP inhibitors
US8703096B2 (en) * 2006-04-21 2014-04-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Beta-amyloid PET imaging agents
AU2008266957A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
EP2170059B1 (en) 2007-06-20 2014-11-19 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
AU2008266954A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
WO2009027452A2 (en) * 2007-08-30 2009-03-05 Ge Healthcare Limited Radiopharmaceutical composition
EP2627361B1 (en) 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US8592603B2 (en) * 2011-02-22 2013-11-26 Kaohsiung Medical University Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
US9249112B2 (en) 2011-09-16 2016-02-02 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
US20150157744A1 (en) 2012-06-27 2015-06-11 Geoffrey B. Johnson Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
CN104884424B (zh) * 2012-12-25 2016-08-24 日本曹达株式会社 卤代苯胺及其制造方法
WO2015127548A1 (en) * 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
WO2016180274A1 (zh) * 2015-05-09 2016-11-17 江苏新元素医药科技有限公司 用于治疗或预防乳腺癌的化合物
CN111166744B (zh) * 2018-11-12 2024-06-25 诺丁汉大学 4-(苯并噻唑-2-基)芳胺类化合物治疗胃癌的用途
CN111170963B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗胃癌的用途
CN111170962B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗肠癌的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE581862A (da) 1958-08-22
US3401048A (en) * 1964-06-22 1968-09-10 Mitsui Kagaku Kogyo Kabushiki 2-styrylazole optical brightener
DE2333378A1 (de) * 1973-06-30 1975-01-23 Basf Ag Neue verbindungen der benzoxazol- und der benzthiazolreihe und farbbildner fuer kopierverfahren
GB9317949D0 (en) * 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
JPH1160573A (ja) 1997-08-22 1999-03-02 Nippon Kayaku Co Ltd トリアジン誘導体及びテロメラーゼ阻害剤

Also Published As

Publication number Publication date
DE60027435D1 (de) 2006-05-24
CY1105091T1 (el) 2009-11-04
GB9919673D0 (en) 1999-10-20
PT1204650E (pt) 2006-08-31
DE60027435T2 (de) 2007-04-19
ES2263483T3 (es) 2006-12-16
US6858633B1 (en) 2005-02-22
JP2003507462A (ja) 2003-02-25
ATE323686T1 (de) 2006-05-15
CA2382406C (en) 2009-05-19
EP1204650B1 (en) 2006-04-19
AU783360B2 (en) 2005-10-20
WO2001014354A1 (en) 2001-03-01
AU6708500A (en) 2001-03-19
CA2382406A1 (en) 2001-03-01
EP1204650A1 (en) 2002-05-15

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