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DK118791D0 - 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS - Google Patents

1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS

Info

Publication number
DK118791D0
DK118791D0 DK911187A DK118791A DK118791D0 DK 118791 D0 DK118791 D0 DK 118791D0 DK 911187 A DK911187 A DK 911187A DK 118791 A DK118791 A DK 118791A DK 118791 D0 DK118791 D0 DK 118791D0
Authority
DK
Denmark
Prior art keywords
oner
preparation
benzopyrane
benzoxazine
amino
Prior art date
Application number
DK911187A
Other languages
Danish (da)
Other versions
DK118791A (en
Inventor
Ronald B Gammill
Thomas M Judge
Joel Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK118791D0 publication Critical patent/DK118791D0/en
Publication of DK118791A publication Critical patent/DK118791A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK118791A 1988-12-21 1991-06-19 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS DK118791A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28779688A 1988-12-21 1988-12-21
PCT/US1989/005526 WO1990006921A1 (en) 1988-12-21 1989-12-15 Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Publications (2)

Publication Number Publication Date
DK118791D0 true DK118791D0 (en) 1991-06-19
DK118791A DK118791A (en) 1991-06-19

Family

ID=23104392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK118791A DK118791A (en) 1988-12-21 1991-06-19 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS

Country Status (8)

Country Link
EP (1) EP0459983A1 (en)
JP (1) JPH04502322A (en)
AU (1) AU634994B2 (en)
DK (1) DK118791A (en)
FI (1) FI912995A0 (en)
HU (2) HUT58310A (en)
RU (1) RU2118321C1 (en)
WO (1) WO1990006921A1 (en)

Families Citing this family (37)

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ES2106783T3 (en) * 1990-06-20 1997-11-16 Upjohn Co 1-BENZOPIRAN-4-ONAS AND 2-AMINO-1,3-BENZOXACIN-4-ONAS ANTIARTEROSCLEROSIS AND ANTITROMBOTICAS.
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
ES2079068T3 (en) * 1990-06-29 1996-01-01 Upjohn Co 2-AMINO-6-FENIL-4H-PIRAN-4-ONAS ANTIATEROSCLEROTICAS AND ANTITROMBOTICAS.
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
CA2182932A1 (en) * 1995-08-10 1997-02-11 Koju Watanabe Chromone derivative, process for preparing same and pharmaceutical composition
DE19850131A1 (en) 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon and chromanone derivatives
AU3704400A (en) * 1999-03-04 2000-09-21 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
WO2001053266A1 (en) 2000-01-24 2001-07-26 Kinacia Pty Ltd. Therapeutic morpholino-substituted compounds
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
MXPA04010240A (en) * 2002-04-17 2005-06-08 Cytokinetics Inc Compounds, compositions, and methods.
US6949538B2 (en) 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
CN101260104A (en) * 2002-08-16 2008-09-10 阿斯利康(瑞典)有限公司 Inhibition of phosphoinositide 3-kinase beta
CA2495661C (en) * 2002-08-16 2011-06-14 Kinacia Pty Ltd. Inhibition of phosphoinositide 3-kinase beta
CA2525383C (en) 2003-06-06 2012-03-06 Arexis Ab Use of heterocyclic compounds as scce inhibitors
CN100518740C (en) * 2003-06-06 2009-07-29 阿里克斯股份公司 Use of heterocyclic compounds as SCCE inhibitors
ATE461193T1 (en) 2003-08-13 2010-04-15 Kudos Pharm Ltd AMINOPYRONES AND THEIR USE AS ATM INHIBITORS
RU2006124421A (en) 2003-12-09 2008-01-20 ПРАВИТЕЛЬСТВО СОЕДИНЕННЫХ ШТАТОВ АМЕРИКИ, ПРЕДСТАВЛЕННОЕ СЕКРЕТАРЕМ ДЕПАРТАМЕНТА ЗДРАВООХРАНЕНИЯ И СЛУЖБЫ ДЛЯ ЛЮДЕЙ, УС Национальный Институт здравоохранени , Ведомство по передаче технологий (US) METHOD FOR SUPPRESSING AN ANSWERING IMMUNE REACTION OR TREATMENT OF A PROLIFERATIVE DISORDER
KR20070059156A (en) 2004-09-20 2007-06-11 쿠도스 파마슈티칼스 리미티드 DNA-PK inhibitor
TW200638938A (en) 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR053358A1 (en) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK
WO2009038064A1 (en) * 2007-09-19 2009-03-26 Institute Of Medicinal Molecular Design, Inc. Heterocyclic derivative having inhibitory activity on type-i 11β-hydroxysteroid dehydrogenase
CN102227420B (en) * 2008-09-29 2015-06-24 西特里斯药业公司 Quinazolinone, quinolone and related analogs as sirtuin modulators
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
UY34013A (en) 2011-04-13 2012-11-30 Astrazeneca Ab ? CHROMENONE COMPOUNDS WITH ANTI-TUMORAL ACTIVITY ?.
RU2468018C1 (en) * 2011-10-06 2012-11-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Method of producing 4-oxo-4h-chromene derivatives containing vinyl and enamine groups
EP2808322B1 (en) * 2012-01-26 2017-08-23 Daiichi Sankyo Company, Limited Chromone derivative having osteogenesis promoting effect
TW201412727A (en) * 2012-08-24 2014-04-01 Daiichi Sankyo Co Ltd Chromone derivative having linear side chain
JP6546098B2 (en) 2013-03-04 2019-07-17 アストラゼネカ アクチボラグ Combination treatment
CN108947952B (en) * 2017-05-24 2021-09-21 中国医学科学院药物研究所 2-substituted amino-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ketone compound and preparation method and application thereof
CN108929329B (en) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-Azacyclo-5-trifluoromethyl-8-nitrobenzo(thio)pyran-4-ones
AR121719A1 (en) 2020-04-03 2022-06-29 Petra Pharma Corp ALLESTERIC INHIBITORS OF CHROMENONE OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES
MX2023013080A (en) 2021-05-03 2023-11-16 Petra Pharma Corp Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease.
AU2022282380A1 (en) 2021-05-27 2023-12-07 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer
TW202329930A (en) 2021-09-30 2023-08-01 美商佩特拉製藥公司 Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2205913A1 (en) * 1972-02-08 1973-08-16 Thiemann Chem Pharm Fab 2-AMINO-3-HYDROXY-CHROMONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2555290A1 (en) * 1975-12-09 1977-06-16 Boehringer Mannheim Gmbh NEW BENZOPYRONE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
US4412071A (en) * 1982-05-17 1983-10-25 The Upjohn Company Antiatherosclerotic compositions
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
IL89840A (en) * 1988-04-06 1996-10-31 Lipha Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them

Also Published As

Publication number Publication date
EP0459983A1 (en) 1991-12-11
RU2118321C1 (en) 1998-08-27
HUT58310A (en) 1992-02-28
DK118791A (en) 1991-06-19
AU634994B2 (en) 1993-03-11
JPH04502322A (en) 1992-04-23
FI912995A0 (en) 1991-06-19
AU4807190A (en) 1990-07-10
WO1990006921A1 (en) 1990-06-28
HU211339A9 (en) 1995-11-28
HU900394D0 (en) 1991-09-30

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