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DK118791A - 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler - Google Patents

1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler Download PDF

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Publication number
DK118791A
DK118791A DK118791A DK118791A DK118791A DK 118791 A DK118791 A DK 118791A DK 118791 A DK118791 A DK 118791A DK 118791 A DK118791 A DK 118791A DK 118791 A DK118791 A DK 118791A
Authority
DK
Denmark
Prior art keywords
oner
preparation
benzopyrane
benzoxazine
amino
Prior art date
Application number
DK118791A
Other languages
English (en)
Other versions
DK118791D0 (da
Inventor
Ronald B Gammill
Thomas M Judge
Joel Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK118791A publication Critical patent/DK118791A/da
Publication of DK118791D0 publication Critical patent/DK118791D0/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
DK911187A 1988-12-21 1991-06-19 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler DK118791D0 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28779688A 1988-12-21 1988-12-21
PCT/US1989/005526 WO1990006921A1 (en) 1988-12-21 1989-12-15 Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Publications (2)

Publication Number Publication Date
DK118791A true DK118791A (da) 1991-06-19
DK118791D0 DK118791D0 (da) 1991-06-19

Family

ID=23104392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK911187A DK118791D0 (da) 1988-12-21 1991-06-19 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler

Country Status (8)

Country Link
EP (1) EP0459983A1 (da)
JP (1) JPH04502322A (da)
AU (1) AU634994B2 (da)
DK (1) DK118791D0 (da)
FI (1) FI912995A0 (da)
HU (2) HUT58310A (da)
RU (1) RU2118321C1 (da)
WO (1) WO1990006921A1 (da)

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* Cited by examiner, † Cited by third party
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CA2081577A1 (en) * 1990-06-20 1991-12-21 Ronald B. Gammill Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1, 3-benzoxazine-4-ones
CA2064796A1 (en) * 1990-06-29 1991-12-30 Joel Morris Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
CA2182932A1 (en) * 1995-08-10 1997-02-11 Koju Watanabe Chromone derivative, process for preparing same and pharmaceutical composition
DE19850131A1 (de) 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate
AU3704400A (en) * 1999-03-04 2000-09-21 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
GB9920910D0 (en) * 1999-09-03 1999-11-10 Indena Spa Novel chalcones
WO2001053266A1 (en) 2000-01-24 2001-07-26 Kinacia Pty Ltd. Therapeutic morpholino-substituted compounds
DE10044091A1 (de) * 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
DE60333094D1 (de) 2002-04-17 2010-08-05 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
US6949538B2 (en) 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
EP1537102A4 (en) * 2002-08-16 2010-12-08 Astrazeneca Ab INHIBITORS OF PHOSPHOINOSITIDE-3-KINASE BETA
CN101260104A (zh) * 2002-08-16 2008-09-10 阿斯利康(瑞典)有限公司 抑制磷酸肌醇3-激酶β
CN100518740C (zh) * 2003-06-06 2009-07-29 阿里克斯股份公司 杂环化合物作为scce抑制剂的制药用途
JP5044214B2 (ja) * 2003-06-06 2012-10-10 アレクシス・アクチボラゲット 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用
CA2534300A1 (en) 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
AU2004296868B2 (en) * 2003-12-09 2010-11-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for suppressing an immune response or treating a proliferative disorder
UA88329C2 (en) 2004-09-20 2009-10-12 Кудос Фармасьютикалз Лимитед Dna-pk inhibitors
US7642254B2 (en) 2005-02-09 2010-01-05 Kudos Pharmaceuticals Limited ATM inhibitors
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US20100234363A1 (en) * 2007-09-19 2010-09-16 Institute Of Medicinal Molecular Design, Inc. Heterocyclic derivative having inhibitory activity on type-i 11 data-hydroxysteroid dehydrogenase
BRPI0919390A8 (pt) 2008-09-29 2018-03-13 Sirtris Pharmaceuticals Inc quinazolinone, quinolone e análogos relacionados como muduladores sirtuinais.
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
US8530470B2 (en) 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
RU2468018C1 (ru) * 2011-10-06 2012-11-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Способ получения производных 4-оксо-4h-хроменов, содержащих винильную и енаминную группировки
JP6000986B2 (ja) * 2012-01-26 2016-10-05 第一三共株式会社 骨形成促進作用を有するクロモン誘導体
TW201412727A (zh) * 2012-08-24 2014-04-01 Daiichi Sankyo Co Ltd 具有鏈狀側鏈之色酮衍生物
RU2666999C2 (ru) 2013-03-04 2018-09-13 Астразенека Аб Комбинированное лечение
CN108947952B (zh) * 2017-05-24 2021-09-21 中国医学科学院药物研究所 2-取代氨基-5-三氟甲基-8-硝基苯并（硫代）吡喃-4-酮类化合物及其制备方法和用途
CN108929329B (zh) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
WO2022235574A1 (en) 2021-05-03 2022-11-10 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
WO2022251482A1 (en) 2021-05-27 2022-12-01 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑

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* Cited by examiner, † Cited by third party
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DE2205913A1 (de) * 1972-02-08 1973-08-16 Thiemann Chem Pharm Fab 2-amino-3-hydroxy-chromon-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2555290A1 (de) * 1975-12-09 1977-06-16 Boehringer Mannheim Gmbh Neue benzopyron-derivate und verfahren zu ihrer herstellung
US4412071A (en) * 1982-05-17 1983-10-25 The Upjohn Company Antiatherosclerotic compositions
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
MA21528A1 (fr) * 1988-04-06 1989-12-31 Lipha Composants substituants du flavonoide, leurs sels, leurs manufactures et produits contenant ces matieres .

Also Published As

Publication number Publication date
JPH04502322A (ja) 1992-04-23
HUT58310A (en) 1992-02-28
AU634994B2 (en) 1993-03-11
FI912995A7 (fi) 1991-06-19
HU211339A9 (en) 1995-11-28
AU4807190A (en) 1990-07-10
WO1990006921A1 (en) 1990-06-28
DK118791D0 (da) 1991-06-19
RU2118321C1 (ru) 1998-08-27
EP0459983A1 (en) 1991-12-11
HU900394D0 (en) 1991-09-30
FI912995A0 (fi) 1991-06-19

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