DK1165489T3 - Fremgangsmåde til fremstilling af gabapentin - Google Patents
Fremgangsmåde til fremstilling af gabapentinInfo
- Publication number
- DK1165489T3 DK1165489T3 DK00910850T DK00910850T DK1165489T3 DK 1165489 T3 DK1165489 T3 DK 1165489T3 DK 00910850 T DK00910850 T DK 00910850T DK 00910850 T DK00910850 T DK 00910850T DK 1165489 T3 DK1165489 T3 DK 1165489T3
- Authority
- DK
- Denmark
- Prior art keywords
- gabapentin
- retentate
- solution
- unsalified
- addition
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 12
- 229960002870 gabapentin Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000012465 retentate Substances 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 3
- XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 238000011026 diafiltration Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000625A IT1311984B1 (it) | 1999-03-26 | 1999-03-26 | Procedimento per la preparzione di gabapentin. |
| PCT/EP2000/002345 WO2000058268A1 (en) | 1999-03-26 | 2000-03-16 | A process for the preparation of gabapentin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1165489T3 true DK1165489T3 (da) | 2003-12-15 |
Family
ID=11382457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00910850T DK1165489T3 (da) | 1999-03-26 | 2000-03-16 | Fremgangsmåde til fremstilling af gabapentin |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6576790B1 (it) |
| EP (1) | EP1165489B1 (it) |
| AT (1) | ATE247628T1 (it) |
| AU (1) | AU3290400A (it) |
| CA (1) | CA2368476C (it) |
| DE (1) | DE60004652T2 (it) |
| DK (1) | DK1165489T3 (it) |
| ES (1) | ES2204533T3 (it) |
| IT (1) | IT1311984B1 (it) |
| PT (1) | PT1165489E (it) |
| WO (1) | WO2000058268A1 (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1077692T1 (en) * | 1998-05-15 | 2004-10-31 | Warner-Lambert Company Llc | Amino acid stabilized gabapentin and pregabalin preparations and process for preparing the same |
| ITMI20012750A1 (it) | 2001-12-21 | 2003-06-21 | Procos Spa | Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura |
| AU2003262383A1 (en) * | 2002-04-16 | 2003-11-03 | Taro Pharmaceutical Industries Ltd. | Process for preparing gabapentin |
| EP1727784B1 (en) | 2002-11-18 | 2008-12-24 | Nicholas Piramal India Limited | Improved process for preparation of gabapentin |
| DE60235128D1 (de) | 2002-11-20 | 2010-03-04 | Hikal Ltd | Verfahren zur herstellung von aminomethylcycloalkan-essigsäuren |
| US20070043236A1 (en) * | 2003-05-19 | 2007-02-22 | Chandiran Thakashina M | Process for preparation of gabapentin |
| ITMI20031247A1 (it) * | 2003-06-20 | 2004-12-21 | Zambon Spa | Processo per la purificazione di gabapentina |
| US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
| ITMI20040579A1 (it) | 2004-03-25 | 2004-06-25 | Zambon Spa | Processo di preparazione di gabapentina |
| ES2246159B1 (es) * | 2004-07-22 | 2007-03-16 | Menadiona, S.L. | Procedimiento para la obtencion de aminoacidos ciclicos. |
| CN116693410B (zh) * | 2023-06-08 | 2024-06-07 | 浙江竹子制药有限公司 | 一种粒径可控的加巴喷丁制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4960931A (en) * | 1988-05-02 | 1990-10-02 | Warner-Lambert Company | Gabapentin mohohydrate and a process for producing the same |
| US4894476A (en) | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| DE3928184A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
| US5491259A (en) * | 1994-09-13 | 1996-02-13 | The Dow Chemical Company | Process to produce aminocarboxylic acids containing low residual salt |
| IL119890A (en) | 1996-12-24 | 2002-03-10 | Teva Pharma | Gabapentin form iii and preparation of gabapentin form ii |
-
1999
- 1999-03-26 IT IT1999MI000625A patent/IT1311984B1/it active
-
2000
- 2000-03-16 PT PT00910850T patent/PT1165489E/pt unknown
- 2000-03-16 US US09/937,378 patent/US6576790B1/en not_active Expired - Lifetime
- 2000-03-16 CA CA002368476A patent/CA2368476C/en not_active Expired - Fee Related
- 2000-03-16 WO PCT/EP2000/002345 patent/WO2000058268A1/en active IP Right Grant
- 2000-03-16 DK DK00910850T patent/DK1165489T3/da active
- 2000-03-16 DE DE60004652T patent/DE60004652T2/de not_active Expired - Lifetime
- 2000-03-16 EP EP00910850A patent/EP1165489B1/en not_active Expired - Lifetime
- 2000-03-16 AU AU32904/00A patent/AU3290400A/en not_active Abandoned
- 2000-03-16 ES ES00910850T patent/ES2204533T3/es not_active Expired - Lifetime
- 2000-03-16 AT AT00910850T patent/ATE247628T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| IT1311984B1 (it) | 2002-03-22 |
| EP1165489B1 (en) | 2003-08-20 |
| DE60004652T2 (de) | 2004-06-24 |
| PT1165489E (pt) | 2003-12-31 |
| US6576790B1 (en) | 2003-06-10 |
| ITMI990625A1 (it) | 2000-09-26 |
| ES2204533T3 (es) | 2004-05-01 |
| AU3290400A (en) | 2000-10-16 |
| DE60004652D1 (de) | 2003-09-25 |
| CA2368476A1 (en) | 2000-10-05 |
| EP1165489A1 (en) | 2002-01-02 |
| WO2000058268A1 (en) | 2000-10-05 |
| ATE247628T1 (de) | 2003-09-15 |
| CA2368476C (en) | 2009-12-08 |
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