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DK1161239T3 - 3- cyclopropylmethoxy-4-difluormethoxy-N-(3,5-dichlorpyrid-4-yl)benzamid til behandling af dissemineret sklerose - Google Patents

3- cyclopropylmethoxy-4-difluormethoxy-N-(3,5-dichlorpyrid-4-yl)benzamid til behandling af dissemineret sklerose

Info

Publication number
DK1161239T3
DK1161239T3 DK00910736T DK00910736T DK1161239T3 DK 1161239 T3 DK1161239 T3 DK 1161239T3 DK 00910736 T DK00910736 T DK 00910736T DK 00910736 T DK00910736 T DK 00910736T DK 1161239 T3 DK1161239 T3 DK 1161239T3
Authority
DK
Denmark
Prior art keywords
dichloropyrid
cyclopropylmethoxy
difluoromethoxy
benzamide
treatment
Prior art date
Application number
DK00910736T
Other languages
English (en)
Inventor
Hans-Peter Kley
Armin Hatzelmann
Christian Schudt
Karl Sanders
Hermann Amschler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK1161239T3 publication Critical patent/DK1161239T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK00910736T 1999-03-10 2000-03-01 3- cyclopropylmethoxy-4-difluormethoxy-N-(3,5-dichlorpyrid-4-yl)benzamid til behandling af dissemineret sklerose DK1161239T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99104793 1999-03-10
EP00910736A EP1161239B1 (en) 1999-03-10 2000-03-01 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis
PCT/EP2000/001703 WO2000053182A2 (en) 1999-03-10 2000-03-01 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis

Publications (1)

Publication Number Publication Date
DK1161239T3 true DK1161239T3 (da) 2005-02-14

Family

ID=8237737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00910736T DK1161239T3 (da) 1999-03-10 2000-03-01 3- cyclopropylmethoxy-4-difluormethoxy-N-(3,5-dichlorpyrid-4-yl)benzamid til behandling af dissemineret sklerose

Country Status (12)

Country Link
US (1) US6531493B1 (da)
EP (1) EP1161239B1 (da)
JP (1) JP2002538207A (da)
AT (1) ATE279924T1 (da)
AU (1) AU3284000A (da)
CA (1) CA2364258C (da)
DE (1) DE60015098T2 (da)
DK (1) DK1161239T3 (da)
ES (1) ES2231162T3 (da)
PT (1) PT1161239E (da)
SI (1) SI1161239T1 (da)
WO (1) WO2000053182A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
WO2002088079A2 (en) * 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
US20030092706A1 (en) * 2001-11-09 2003-05-15 Johannes Barsig Combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CN101491520B (zh) 2002-05-28 2011-03-16 尼科梅德有限责任公司 局部应用的药物制剂
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
DK1606261T3 (da) 2003-03-10 2010-01-18 Nycomed Gmbh Hidtil ukendt fremgangsmåde til fremstilling af roflumilast
DE102004046235A1 (de) 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
EP2258350B1 (en) * 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3775684B2 (ja) * 1992-07-28 2006-05-17 ローン−プーラン・ロレ・リミテツド 脂肪族−またはヘテロ原子−含有連結基によりアリールまたはヘテロアリールに連結されたフェニル含有化合物
SK283263B6 (sk) * 1993-07-02 2003-04-01 Altana Pharma Ag Fluóralkoxysubstituované benzamidy, spôsob ich výroby a ich použitie ako inhibítorov fosfodiesterázy cyklických nukleotidov
ATE255413T1 (de) * 1994-04-21 2003-12-15 Schering Ag Pde iv-inhibitoren zur behandlung der multiplen sklerose

Also Published As

Publication number Publication date
ES2231162T3 (es) 2005-05-16
SI1161239T1 (en) 2005-06-30
CA2364258A1 (en) 2000-09-14
DE60015098D1 (de) 2004-11-25
DE60015098T2 (de) 2006-02-02
US6531493B1 (en) 2003-03-11
AU3284000A (en) 2000-09-28
JP2002538207A (ja) 2002-11-12
PT1161239E (pt) 2005-02-28
WO2000053182A3 (en) 2001-04-12
EP1161239A2 (en) 2001-12-12
ATE279924T1 (de) 2004-11-15
EP1161239B1 (en) 2004-10-20
WO2000053182A2 (en) 2000-09-14
CA2364258C (en) 2008-12-30

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