DK1157100T3 - Oxaloacetate hydrolase-defective fungal host cells - Google Patents
Oxaloacetate hydrolase-defective fungal host cellsInfo
- Publication number
- DK1157100T3 DK1157100T3 DK00904859T DK00904859T DK1157100T3 DK 1157100 T3 DK1157100 T3 DK 1157100T3 DK 00904859 T DK00904859 T DK 00904859T DK 00904859 T DK00904859 T DK 00904859T DK 1157100 T3 DK1157100 T3 DK 1157100T3
- Authority
- DK
- Denmark
- Prior art keywords
- host cells
- defective
- fungal host
- oxaloacetate hydrolase
- nucleic acid
- Prior art date
Links
- 230000002538 fungal effect Effects 0.000 title 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 108010054497 oxaloacetase Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199900231 | 1999-02-22 | ||
| EP00904859A EP1157100B1 (en) | 1999-02-22 | 2000-02-18 | Oxaloacetate hydrolase deficient fungal host cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1157100T3 true DK1157100T3 (en) | 2006-05-29 |
Family
ID=8091215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00904859T DK1157100T3 (en) | 1999-02-22 | 2000-02-18 | Oxaloacetate hydrolase-defective fungal host cells |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1157100B1 (en) |
| JP (2) | JP4741082B2 (en) |
| CN (1) | CN1195058C (en) |
| AT (1) | ATE315638T1 (en) |
| AU (1) | AU2658200A (en) |
| DE (1) | DE60025467T2 (en) |
| DK (1) | DK1157100T3 (en) |
| WO (1) | WO2000050576A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195058C (en) * | 1999-02-22 | 2005-03-30 | 诺维信公司 | Oxaloacetae hydrolase deficient fungal host cells |
| US6544765B1 (en) | 1999-02-22 | 2003-04-08 | Novozymes, A/S | Oxaloacetate hydrolase deficient fungal host cells |
| WO2004070022A2 (en) * | 2003-02-05 | 2004-08-19 | Dsm Ip Assets B.V. | Use of oxalate deficient aspergillus niger strains for producing a polypeptide |
| CN101629204A (en) | 2003-03-31 | 2010-01-20 | 诺维信股份有限公司 | Methods for producing biological substances in enzyme-deficient mutants of aspergillus |
| PT1786908E (en) * | 2004-08-18 | 2010-04-29 | Bayer Cropscience Ag | Plants with increased plastidic activity of r3 starch-phosphorylating enzyme |
| EA015925B1 (en) | 2006-06-29 | 2011-12-30 | ДСМ АйПи АССЕТС Б.В. | A method for producing polypeptides |
| CN102741421B (en) | 2009-03-10 | 2015-03-25 | 帝斯曼知识产权资产管理有限公司 | Method for increasing polypeptide yield |
| EP2406372B1 (en) | 2009-03-10 | 2017-08-23 | DSM IP Assets B.V. | Pregastric esterase and derivatives thereof |
| WO2010121933A1 (en) | 2009-04-22 | 2010-10-28 | Dsm Ip Assets B.V. | Process for the production of a recombinant polypeptide of interest |
| EP3293264A1 (en) | 2009-07-22 | 2018-03-14 | DSM IP Assets B.V. | Improved host cell for the production of a compound of interest |
| CA2861697C (en) * | 2012-01-05 | 2022-03-15 | Novartis Ag | Protease deficient filamentous fungal cells and methods of use thereof |
| WO2014013074A1 (en) | 2012-07-19 | 2014-01-23 | Dsm Ip Assets B.V. | Agse-deficient strain |
| DK3242950T3 (en) | 2015-01-06 | 2021-12-20 | Dsm Ip Assets Bv | CRISPR-CAS SYSTEM FOR A WIRED MUSHROOM MUSHROOM HOST CELL |
| US10883131B2 (en) | 2015-02-20 | 2021-01-05 | Roal Oy | Methods for controlling protease production |
| CN110431224A (en) | 2017-03-13 | 2019-11-08 | 帝斯曼知识产权资产管理有限公司 | Zinc binuclear cluster transcription regulatory factor deficient strain |
| CN110791439B (en) * | 2019-10-10 | 2022-04-19 | 天津科技大学 | A recombinant Aspergillus niger strain for fermentative production of malic acid constructed by genetic engineering and its application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195058C (en) * | 1999-02-22 | 2005-03-30 | 诺维信公司 | Oxaloacetae hydrolase deficient fungal host cells |
-
2000
- 2000-02-18 CN CNB008041679A patent/CN1195058C/en not_active Expired - Fee Related
- 2000-02-18 WO PCT/DK2000/000067 patent/WO2000050576A1/en not_active Ceased
- 2000-02-18 JP JP2000601140A patent/JP4741082B2/en not_active Expired - Fee Related
- 2000-02-18 DE DE60025467T patent/DE60025467T2/en not_active Expired - Lifetime
- 2000-02-18 EP EP00904859A patent/EP1157100B1/en not_active Expired - Lifetime
- 2000-02-18 AU AU26582/00A patent/AU2658200A/en not_active Abandoned
- 2000-02-18 DK DK00904859T patent/DK1157100T3/en active
- 2000-02-18 AT AT00904859T patent/ATE315638T1/en not_active IP Right Cessation
-
2010
- 2010-12-24 JP JP2010287753A patent/JP2011101651A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000050576A1 (en) | 2000-08-31 |
| EP1157100B1 (en) | 2006-01-11 |
| DE60025467T2 (en) | 2006-09-21 |
| CN1341149A (en) | 2002-03-20 |
| JP4741082B2 (en) | 2011-08-03 |
| JP2011101651A (en) | 2011-05-26 |
| AU2658200A (en) | 2000-09-14 |
| EP1157100A1 (en) | 2001-11-28 |
| JP2002536993A (en) | 2002-11-05 |
| DE60025467D1 (en) | 2006-04-06 |
| ATE315638T1 (en) | 2006-02-15 |
| CN1195058C (en) | 2005-03-30 |
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