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DK1144428T3 - Process for preparing an aza macrolide with 4 "(R) -NH 2 - Google Patents

Process for preparing an aza macrolide with 4 "(R) -NH 2

Info

Publication number
DK1144428T3
DK1144428T3 DK00900224T DK00900224T DK1144428T3 DK 1144428 T3 DK1144428 T3 DK 1144428T3 DK 00900224 T DK00900224 T DK 00900224T DK 00900224 T DK00900224 T DK 00900224T DK 1144428 T3 DK1144428 T3 DK 1144428T3
Authority
DK
Denmark
Prior art keywords
preparing
macrolide
aza
stereoselective
compound
Prior art date
Application number
DK00900224T
Other languages
Danish (da)
Inventor
Patrick Leon
Frederic Lhermitte
Ronan Guevel
Denis Pauze
Gilles Oddon
Laurent Garel
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Application granted granted Critical
Publication of DK1144428T3 publication Critical patent/DK1144428T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4'' position in a corresponding derivative of formula II.
DK00900224T 1999-01-18 2000-01-17 Process for preparing an aza macrolide with 4 "(R) -NH 2 DK1144428T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900459A FR2788524B1 (en) 1999-01-18 1999-01-18 USEFUL PROCESS FOR TRANSFORMING THE 4 "(S) -OH FUNCTION OF THE CLADINOSIS PATTERN OF A MACROLIDE AZA INTO 4" (R) -NH2
EP00900224A EP1144428B1 (en) 1999-01-18 2000-01-17 Method for preparing an aza-macrolide with 4"(r)-nh2

Publications (1)

Publication Number Publication Date
DK1144428T3 true DK1144428T3 (en) 2005-02-14

Family

ID=9540950

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00900224T DK1144428T3 (en) 1999-01-18 2000-01-17 Process for preparing an aza macrolide with 4 "(R) -NH 2

Country Status (15)

Country Link
US (1) USRE40040E1 (en)
EP (1) EP1144428B1 (en)
JP (1) JP2003505340A (en)
AT (1) ATE279426T1 (en)
AU (1) AU768838B2 (en)
BR (1) BRPI0007593B8 (en)
CA (1) CA2359967C (en)
DE (1) DE60014849T2 (en)
DK (1) DK1144428T3 (en)
ES (1) ES2232414T3 (en)
FR (1) FR2788524B1 (en)
NZ (1) NZ513025A (en)
PT (1) PT1144428E (en)
WO (1) WO2000042056A1 (en)
ZA (1) ZA200105825B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151598A (en) * 1979-05-11 1980-11-26 Taisho Pharmaceut Co Ltd Erythromycin a derivative and its preparation
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
DE59510742D1 (en) * 1994-04-27 2003-08-14 Novartis Ag Nucleosides and oligonucleotides with 2'-ether groups
GB9806029D0 (en) * 1998-03-20 1998-05-20 Merck & Co Inc 8a-Azalides as veterinary antimicrobial agents
JP2003512290A (en) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 8a-azalide as a livestock antibacterial agent

Also Published As

Publication number Publication date
CA2359967C (en) 2011-08-30
ATE279426T1 (en) 2004-10-15
NZ513025A (en) 2003-11-28
AU1987000A (en) 2000-08-01
EP1144428B1 (en) 2004-10-13
DE60014849T2 (en) 2006-03-09
WO2000042056A1 (en) 2000-07-20
PT1144428E (en) 2005-02-28
EP1144428A1 (en) 2001-10-17
ZA200105825B (en) 2002-05-08
FR2788524A1 (en) 2000-07-21
JP2003505340A (en) 2003-02-12
AU768838B2 (en) 2004-01-08
BRPI0007593B8 (en) 2021-05-25
BR0007593A (en) 2001-11-06
BR0007593B1 (en) 2014-01-28
FR2788524B1 (en) 2002-04-26
ES2232414T3 (en) 2005-06-01
DE60014849D1 (en) 2004-11-18
CA2359967A1 (en) 2000-07-20
USRE40040E1 (en) 2008-01-29

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