DK112582A - Fremgangsmaade til fremstilling af triazolonderivater - Google Patents

Fremgangsmaade til fremstilling af triazolonderivater Download PDF

Info

Publication number: DK112582A
Authority: DK; Denmark
Prior art keywords: triazolon; derivatives; procedure; preparation; triazolon derivatives
Prior art date: 1981-03-16

Application number

DK112582A

Other languages

English (en)

Other versions

DK158728B (da

DK158728C (da

Inventor

Jr D L Temple

Jr W G Lobeck

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-16

Filing date

1982-03-12

Publication date

1982-09-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22922879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK112582(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1982-03-12 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1982-09-17 Publication of DK112582A publication Critical patent/DK112582A/da

1990-07-09 Publication of DK158728B publication Critical patent/DK158728B/da

1990-12-03 Application granted granted Critical

1990-12-03 Publication of DK158728C publication Critical patent/DK158728C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK112582A 1981-03-16 1982-03-12 Analogifremgangsmaade til fremstilling af triazolon-derivater DK158728C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/244,464 US4338317A (en)	1981-03-16	1981-03-16	Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
US24446481		1981-03-16

Publications (3)

Publication Number	Publication Date
DK112582A true DK112582A (da)	1982-09-17
DK158728B DK158728B (da)	1990-07-09
DK158728C DK158728C (da)	1990-12-03

Family

ID=22922879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK112582A DK158728C (da)	1981-03-16	1982-03-12	Analogifremgangsmaade til fremstilling af triazolon-derivater

Country Status (26)

Country	Link
US (1)	US4338317A (da)
JP (1)	JPS57159774A (da)
KR (1)	KR880001374B1 (da)
AT (1)	AT384022B (da)
BE (1)	BE892503A (da)
CA (1)	CA1198436A (da)
CH (1)	CH649539A5 (da)
CY (1)	CY1373A (da)
DE (1)	DE3209557A1 (da)
DK (1)	DK158728C (da)
ES (1)	ES510449A0 (da)
FI (1)	FI73670C (da)
FR (1)	FR2501690B1 (da)
GB (1)	GB2096137B (da)
GR (1)	GR76076B (da)
HK (1)	HK4788A (da)
IE (1)	IE52788B1 (da)
IT (1)	IT1148137B (da)
KE (1)	KE3711A (da)
LU (1)	LU84011A1 (da)
MX (1)	MX9203176A (da)
NL (2)	NL190757C (da)
SE (1)	SE447256B (da)
SG (1)	SG30287G (da)
YU (1)	YU43256B (da)
ZA (1)	ZA821359B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4487773A (en) *	1981-03-16	1984-12-11	Mead Johnson & Company	1,2,4-Triazol-3-one antidepressants
US4386091A (en) *	1982-02-24	1983-05-31	Mead Johnson & Company	2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
US4575555A (en) *	1983-06-29	1986-03-11	Mead Johnson & Company	4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
AT388555B (de) *	1983-06-29	1989-07-25	Bristol Myers Co	Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten
US4613600A (en) *	1983-09-30	1986-09-23	Mead Johnson & Company	Antidepressant 1,2,4-triazolone compounds
YU44721B (en) *	1983-11-30	1990-12-31	Bristol Myers Co	Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids
US4784998A (en) *	1987-04-06	1988-11-15	Bristol-Myers Company	1,3,4-oxadiazole pyschotropic compounds
US5116852A (en) *	1990-12-03	1992-05-26	Bristol-Myers Squibb Co.	Treatment of sleep disorders
US5266571A (en) *	1992-01-09	1993-11-30	Amer Moh Samir	Treatment of hemorrhoids with 5-HT2 antagonists
US5256664A (en) *	1992-04-28	1993-10-26	Bristol-Myers Squibb Company	Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
IT1256387B (it) *	1992-11-13	1995-12-04	Acraf	Procedimento per preparare triazoloni
CA2160423A1 (en) *	1994-11-02	1996-05-03	Hemant N. Joshi	Salts of nefazodone having improved dissolution rates
CA2187989A1 (en)	1995-10-17	1997-04-18	Ronald N. Marcus	Nefazodone: treatment of panic attack
CA2182241C (en) *	1996-07-29	2002-09-17	Bo Lei	Methods for the manufacture of nefazodone
US5854248A (en) *	1996-07-31	1998-12-29	Bristol-Myers Squibb Company	Nefazodone: use in migraine prophylaxis
US5852020A (en) *	1996-11-22	1998-12-22	Bristol-Myers Squibb Company	Nefazodone: use in treating post traumatic stress disorder
US5735873A (en) *	1996-12-19	1998-04-07	Maclean; David S.	Surgical tool handle
US5917050A (en) *	1998-02-11	1999-06-29	Bayer Corporation	Process for preparing alkoxytriazolinones
ES2152860B1 (es)	1998-10-23	2001-08-16	Finaf 92 Sa	Forma cristalina de la nefazodona y procedimiento para su preparacion.
US6706282B1 (en)	1998-11-02	2004-03-16	Evangeline Cruz	Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
CA2369732A1 (en) *	1999-04-09	2000-10-19	Sepracor Inc.	R-hydroxynefazodone
US6469008B2 (en)	1999-04-09	2002-10-22	Sepracor Inc.	(R)-hydroxynefazodone antipsychotic therapy
JP2002541192A (ja)	1999-04-09	2002-12-03	セプラコール，インク．	Ｓ−ヒドロキシネファゾドン
US6586437B2 (en)	1999-04-09	2003-07-01	Sepracor Inc.	(S)-hydroxynefazodone antipsychotic therapy
CA2356450C (en)	2001-09-10	2003-11-25	Brantford Chemicals Inc.	An improved process for the preparation of nefazodone hydrochloride
WO2003099265A2 (de) *	2002-05-24	2003-12-04	Coester Carl-Fr	Pharmazeutische wirkstoffkombination sowie deren verwendung
GB0306604D0 (en) *	2003-03-21	2003-04-30	Curidium Ltd	Second medical use
BRPI0409684A (pt) *	2003-04-30	2006-04-18	Fmc Corp	derivados de dihidrobenzofurano e dihidrobenzopirano (dihalopropenil) fenilalquila substituìdos inseticidas
JP4864719B2 (ja) *	2003-11-26	2012-02-01	ファイザー・プロダクツ・インク	Ｇｓｋ−３インヒビターとしてのアミノピラゾール誘導体
WO2005102366A2 (en) *	2004-04-19	2005-11-03	Philip Maxwell Satow	Lithium combinations, and uses related thereto
TW200612961A (en) *	2004-05-18	2006-05-01	Fmc Corp	Substituted cyclic urea derivatives
CA2614289A1 (en)	2005-07-08	2007-01-18	Braincells, Inc.	Methods for identifying agents and conditions that modulate neurogenesis
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
CA2651813A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
US7858611B2 (en) *	2006-05-09	2010-12-28	Braincells Inc.	Neurogenesis by modulating angiotensin
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2068872A1 (en)	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2008083204A2 (en) *	2006-12-28	2008-07-10	Braincells, Inc.	Modulation of neurogenesis by melatoninergic ligands
WO2008086483A2 (en) *	2007-01-11	2008-07-17	Braincells, Inc.	Modulation of neurogenesis with use of modafinil
GB2454290B (en) *	2007-08-07	2009-09-30	Prosarix Ltd	Novel serotonergic modulators
US9339500B2 (en)	2008-03-04	2016-05-17	Intra-Cellular Therapies, Inc.	Methods of treating vasomotor symptoms
WO2009128058A1 (en)	2008-04-18	2009-10-22	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al	Psycho-pharmaceuticals
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
TWI368512B (en) *	2009-04-30	2012-07-21	Univ Kaohsiung Medical	Pharmaceutical compositions comprising chlorophenyl piperazine derived compounds and use of the compounds in producing medicaments
WO2012072665A1 (en)	2010-11-30	2012-06-07	Pharmaneuroboost N.V.	Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
CN104402842A (zh) *	2014-11-19	2015-03-11	苏州乔纳森新材料科技有限公司	一种哌嗪类药物中间体的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1066857B (it) *	1965-12-15	1985-03-12	Acraf	Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) *	1972-10-16	1981-06-20	Sigma Tau Ind Farmaceuti	Derivati del triazolinone e procedimento per la loro preparazione

1981
- 1981-03-16 US US06/244,464 patent/US4338317A/en not_active Expired - Lifetime
1982
- 1982-03-02 ZA ZA821359A patent/ZA821359B/xx unknown
- 1982-03-08 CA CA000397793A patent/CA1198436A/en not_active Expired
- 1982-03-09 GR GR67529A patent/GR76076B/el unknown
- 1982-03-11 NL NL8201021A patent/NL190757C/xx not_active IP Right Cessation
- 1982-03-11 YU YU525/82A patent/YU43256B/xx unknown
- 1982-03-12 FI FI820856A patent/FI73670C/fi not_active IP Right Cessation
- 1982-03-12 DK DK112582A patent/DK158728C/da not_active IP Right Cessation
- 1982-03-12 IT IT47978/82A patent/IT1148137B/it active Protection Beyond IP Right Term
- 1982-03-15 FR FR8204325A patent/FR2501690B1/fr not_active Expired
- 1982-03-15 IE IE589/82A patent/IE52788B1/en active Protection Beyond IP Right Term
- 1982-03-15 BE BE0/207574A patent/BE892503A/fr not_active IP Right Cessation
- 1982-03-15 CH CH1615/82A patent/CH649539A5/de not_active IP Right Cessation
- 1982-03-15 ES ES510449A patent/ES510449A0/es active Granted
- 1982-03-15 LU LU84011A patent/LU84011A1/fr unknown
- 1982-03-15 SE SE8201631A patent/SE447256B/sv not_active IP Right Cessation
- 1982-03-15 GB GB8207539A patent/GB2096137B/en not_active Expired
- 1982-03-15 CY CY137382A patent/CY1373A/xx unknown
- 1982-03-16 JP JP57040315A patent/JPS57159774A/ja active Granted
- 1982-03-16 AT AT0104582A patent/AT384022B/de not_active IP Right Cessation
- 1982-03-16 DE DE19823209557 patent/DE3209557A1/de active Granted
- 1982-03-16 KR KR8201129A patent/KR880001374B1/ko active
1987
- 1987-03-27 SG SG302/87A patent/SG30287G/en unknown
- 1987-03-31 KE KE3711A patent/KE3711A/xx unknown
1988
- 1988-01-21 HK HK47/88A patent/HK4788A/xx not_active IP Right Cessation
1992
- 1992-06-23 MX MX9203176A patent/MX9203176A/es unknown
1997
- 1997-03-17 NL NL970014C patent/NL970014I2/nl unknown

Also Published As

Publication number	Publication date
NL970014I2 (nl)	1997-09-01
LU84011A1 (fr)	1983-02-22
GR76076B (da)	1984-08-03
NL8201021A (nl)	1982-10-18
AT384022B (de)	1987-09-25
ZA821359B (en)	1983-01-26
HK4788A (en)	1988-01-29
FR2501690A1 (fr)	1982-09-17
BE892503A (fr)	1982-09-15
AU555888B2 (en)	1986-10-16
IT8247978A0 (it)	1982-03-12
JPS57159774A (en)	1982-10-01
NL970014I1 (nl)	1997-06-02
FI820856L (fi)	1982-09-17
SG30287G (en)	1987-07-17
IE820589L (en)	1982-09-16
FR2501690B1 (fr)	1985-07-05
IE52788B1 (en)	1988-03-02
SE8201631L (sv)	1982-09-17
NL190757C (nl)	1994-08-01
MX9203176A (es)	1992-07-01
ES8305756A1 (es)	1983-04-16
YU43256B (en)	1989-06-30
CH649539A5 (de)	1985-05-31
JPH0237353B2 (da)	1990-08-23
ATA104582A (de)	1987-02-15
FI73670C (fi)	1987-11-09
CA1198436A (en)	1985-12-24
DE3209557C2 (da)	1993-07-15
AU8117082A (en)	1982-09-23
GB2096137B (en)	1985-01-03
YU52582A (en)	1985-06-30
DK158728B (da)	1990-07-09
KE3711A (en)	1987-04-30
KR880001374B1 (ko)	1988-07-29
DK158728C (da)	1990-12-03
FI73670B (fi)	1987-07-31
GB2096137A (en)	1982-10-13
DE3209557A1 (de)	1982-12-09
ES510449A0 (es)	1983-04-16
KR830009089A (ko)	1983-12-17
US4338317A (en)	1982-07-06
CY1373A (en)	1987-08-07
NL190757B (nl)	1994-03-01
IT1148137B (it)	1986-11-26
SE447256B (sv)	1986-11-03

Publication	Publication Date	Title
DK112582A (da)	1982-09-17	Fremgangsmaade til fremstilling af triazolonderivater
DK66582A (da)	1982-08-18	Fremgangsmaade til fremstilling af carbostyrilderivater
DK534481A (da)	1982-06-06	Fremgangsmaade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK99781A (da)	1981-09-07	Fremgangsmaade til fremstilling af carboxtyrilderivater
DK2281A (da)	1981-07-08	Fremgangsmaade til fremstilling af tiazolinderivater
DK65882A (da)	1982-08-18	Fremgangsmaade til fremstilling af substituerede phosphonamider
DK300981A (da)	1982-02-22	Fremgangsmaade til fremstilling af imidazolderivater
DK161581A (da)	1981-12-07	Fremgangsmaade til fremstilling af imidazolderivater
DK491582A (da)	1983-05-10	Fremgangsmaade til fremstilling af morphinanderivater
DK352082A (da)	1983-02-08	Fremgangsmaade til fremstilling af ergopeptinderivater
DK100281A (da)	1981-09-09	Fremgangsmaade til fremstilling af imidazolderivater
DK153282A (da)	1982-10-07	Fremgangsmaade til fremstilling af bismethinisoindoliner
DK239382A (da)	1982-11-29	Fremgangsmaade til fremstilling af anthracyclinglycosider
DK160555C (da)	1991-09-16	Fremgangsmaade til fremstilling af eburnamoninderivater
DK305982A (da)	1983-01-09	Fremgangsmaade til fremstilling af amidobenzamider
DK116982A (da)	1982-09-18	Fremgangsmaade til fremstilling af alkylendioxybenzenderivater
DK564781A (da)	1982-06-27	Fremgangsmaade til fremstilling af pyrazoloindazolderivater
DK554581A (da)	1982-06-16	Fremgangsmaade til fremstilling af alkylendioxybenzenderivater
DK172181A (da)	1981-10-18	Fremgangsmaade til fremstilling af 9-carbamoyl-9-aminoalkylfluoren-derivater
DK565281A (da)	1982-06-20	Fremgangsmaade til fremstilling af quinolon-derivater
DK162230C (da)	1992-03-02	Fremgangsmaade til fremstilling af 2-thiacephemderivater
DK448981A (da)	1982-04-12	Fremgangsmaade til fremstilling af 4-chinolinmethanderivater
DK424781A (da)	1982-03-27	Fremgangsmaade til fremstilling af quinolonderivater
DK85281A (da)	1981-08-26	Fremgangsmaade til fremstilling af phenoxyderivater
DK375882A (da)	1983-02-27	Fremgangsmaade til fremstilling af benzisoxazolderivater

Legal Events

Date	Code	Title	Description
1997-09-15	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1997 00025, 970708
1998-05-25	CTFG	Supplementary protection certificate (spc) issued	Free format text: CA 1997 00025, 970708, EXPIRES: 20070312
2002-03-25	PUP	Patent expired