DK1119571T3 - Tricykliske Delta 3 piperidiner som alpha 2 antagonister. - Google Patents

Tricykliske Delta 3 piperidiner som alpha 2 antagonister.

Info

Publication number: DK1119571T3
Authority: DK; Denmark
Prior art keywords: piperidines; antagonists; alpha; tricyclic; delta
Prior art date: 1998-10-06

Application number

DK99950627T

Other languages

English (en)

Inventor

Ludo Edmond J Kennis

Den Keybus F M A Janssen P Van

Josephus C Mertens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-06

Filing date

1999-10-01

Publication date

2003-05-26

1999-10-01 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1119571T3 publication Critical patent/DK1119571T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)

DK99950627T 1998-10-06 1999-10-01 Tricykliske Delta 3 piperidiner som alpha 2 antagonister. DK1119571T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203370		1998-10-06
PCT/EP1999/007419 WO2000020421A2 (en)	1998-10-06	1999-10-01	TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS

Publications (1)

Publication Number	Publication Date
DK1119571T3 true DK1119571T3 (da)	2003-05-26

Family

ID=8234191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99950627T DK1119571T3 (da)	1998-10-06	1999-10-01	Tricykliske Delta 3 piperidiner som alpha 2 antagonister.

Country Status (31)

Country	Link
US (1)	US6495555B1 (da)
EP (1)	EP1119571B1 (da)
JP (1)	JP4590101B2 (da)
KR (1)	KR20010071843A (da)
CN (1)	CN1131230C (da)
AR (1)	AR024216A1 (da)
AT (1)	ATE232869T1 (da)
AU (1)	AU760502B2 (da)
BG (1)	BG64872B1 (da)
BR (1)	BR9913507A (da)
CA (1)	CA2345622C (da)
CZ (1)	CZ20011104A3 (da)
DE (1)	DE69905478T2 (da)
DK (1)	DK1119571T3 (da)
EE (1)	EE04770B1 (da)
ES (1)	ES2193751T3 (da)
HK (1)	HK1038010A1 (da)
HU (1)	HUP0104002A3 (da)
ID (1)	ID28032A (da)
IL (1)	IL142443A0 (da)
NO (1)	NO20011270L (da)
NZ (1)	NZ510115A (da)
PL (1)	PL347894A1 (da)
PT (1)	PT1119571E (da)
RU (1)	RU2230744C2 (da)
SI (1)	SI1119571T1 (da)
SK (1)	SK285585B6 (da)
TR (1)	TR200100952T2 (da)
TW (1)	TWI248441B (da)
UA (1)	UA69420C2 (da)
WO (1)	WO2000020421A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL142444A0 (en) *	1998-10-06	2002-03-10	Janssen Pharmaceutica Nv	TRICYCLIC δ3-PIPERIDINES AS PHARMACEUTICALS
JP2005521728A (ja) *	2002-04-03	2005-07-21	オリオンコーポレーション	ＣＮＳ関連疾患のためのα２−アドレナリン受容体アンタゴニストの使用
CN1972938B (zh)	2004-04-12	2010-09-29	大正制药株式会社	环状胺化合物
US20060035939A1 (en) *	2004-07-14	2006-02-16	Japan Tobacco Inc.	3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
AU2005260821B2 (en) *	2004-07-15	2010-02-18	Japan Tobacco Inc.	Fused benzamide compound and vanilloid receptor 1 (VR1) activity inhibitor
US7906508B2 (en)	2005-12-28	2011-03-15	Japan Tobacco Inc.	3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
MX2011012190A (es)	2009-05-14	2011-12-08	Janssen Pharmaceutica Nv	Compuestos con dos porciones de heteroarilo biciclico fusionado como moduladores de la leucotrieno a4 hidrolasa.
JOP20200052A1 (ar)	2013-12-19	2017-06-16	Bayer Pharma AG	بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
US9624198B2 (en) *	2013-12-19	2017-04-18	Bayer Pharma Aktiengesellschaft	Substituted piperidinyltetrahydroquinolines
EP3083610A1 (de)	2013-12-19	2016-10-26	Bayer Pharma Aktiengesellschaft	Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
CN114276359B (zh) *	2022-01-05	2023-05-05	浙江大学	一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3522959A1 (de)	1985-06-27	1987-01-08	Merck Patent Gmbh	Indolderivate
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
EP0339959A3 (en) *	1988-04-27	1991-03-20	Glaxo Group Limited	Lactam derivatives
US4971974A (en)	1988-06-16	1990-11-20	Neurex Corporation	Benzothiophenes as appetite suppressants
US5100891A (en) *	1991-01-18	1992-03-31	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
CN1130365C (zh) *	1996-12-06	2003-12-10	艾博特公司	α－1肾上腺素能化合物,含有该化合物的药物组合物及其应用
CN1129578C (zh) *	1997-12-25	2003-12-03	明治制果株式会社	四氢苯并吲哚衍生物
IL142444A0 (en) *	1998-10-06	2002-03-10	Janssen Pharmaceutica Nv	TRICYCLIC δ3-PIPERIDINES AS PHARMACEUTICALS

1999
- 1999-01-10 UA UA2001031999A patent/UA69420C2/uk unknown
- 1999-10-01 JP JP2000574533A patent/JP4590101B2/ja not_active Expired - Fee Related
- 1999-10-01 NZ NZ510115A patent/NZ510115A/xx unknown
- 1999-10-01 RU RU2001111812/04A patent/RU2230744C2/ru not_active IP Right Cessation
- 1999-10-01 SK SK432-2001A patent/SK285585B6/sk unknown
- 1999-10-01 EE EEP200100209A patent/EE04770B1/xx not_active IP Right Cessation
- 1999-10-01 AU AU63341/99A patent/AU760502B2/en not_active Ceased
- 1999-10-01 ES ES99950627T patent/ES2193751T3/es not_active Expired - Lifetime
- 1999-10-01 TW TW088116898A patent/TWI248441B/zh not_active IP Right Cessation
- 1999-10-01 DK DK99950627T patent/DK1119571T3/da active
- 1999-10-01 BR BR9913507-8A patent/BR9913507A/pt not_active IP Right Cessation
- 1999-10-01 IL IL14244399A patent/IL142443A0/xx not_active IP Right Cessation
- 1999-10-01 AT AT99950627T patent/ATE232869T1/de not_active IP Right Cessation
- 1999-10-01 CN CN99811682A patent/CN1131230C/zh not_active Expired - Fee Related
- 1999-10-01 TR TR2001/00952T patent/TR200100952T2/xx unknown
- 1999-10-01 DE DE69905478T patent/DE69905478T2/de not_active Expired - Lifetime
- 1999-10-01 WO PCT/EP1999/007419 patent/WO2000020421A2/en not_active Application Discontinuation
- 1999-10-01 PL PL99347894A patent/PL347894A1/xx not_active Application Discontinuation
- 1999-10-01 KR KR1020017000442A patent/KR20010071843A/ko active Search and Examination
- 1999-10-01 EP EP99950627A patent/EP1119571B1/en not_active Expired - Lifetime
- 1999-10-01 CA CA002345622A patent/CA2345622C/en not_active Expired - Fee Related
- 1999-10-01 PT PT99950627T patent/PT1119571E/pt unknown
- 1999-10-01 SI SI9930264T patent/SI1119571T1/xx unknown
- 1999-10-01 CZ CZ20011104A patent/CZ20011104A3/cs unknown
- 1999-10-01 ID IDW20010780A patent/ID28032A/id unknown
- 1999-10-01 HU HU0104002A patent/HUP0104002A3/hu unknown
- 1999-10-01 US US09/806,547 patent/US6495555B1/en not_active Expired - Lifetime
- 1999-10-05 AR ARP990105038A patent/AR024216A1/es not_active Application Discontinuation
2001
- 2001-03-12 BG BG105332A patent/BG64872B1/bg unknown
- 2001-03-13 NO NO20011270A patent/NO20011270L/no not_active Application Discontinuation
- 2001-12-10 HK HK01108631A patent/HK1038010A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ20011104A3 (cs)	2001-12-12
DE69905478T2 (de)	2004-03-18
AU760502B2 (en)	2003-05-15
HUP0104002A2 (hu)	2002-03-28
PL347894A1 (en)	2002-04-22
WO2000020421A2 (en)	2000-04-13
ID28032A (id)	2001-05-03
SK285585B6 (sk)	2007-04-05
CN1131230C (zh)	2003-12-17
SK4322001A3 (en)	2002-01-07
EE200100209A (et)	2002-06-17
PT1119571E (pt)	2003-06-30
EP1119571A2 (en)	2001-08-01
AU6334199A (en)	2000-04-26
DE69905478D1 (de)	2003-03-27
ATE232869T1 (de)	2003-03-15
US6495555B1 (en)	2002-12-17
BG64872B1 (bg)	2006-07-31
UA69420C2 (uk)	2004-09-15
SI1119571T1 (en)	2003-08-31
BG105332A (en)	2001-11-30
EE04770B1 (et)	2007-02-15
EP1119571B1 (en)	2003-02-19
ES2193751T3 (es)	2003-11-01
NO20011270D0 (no)	2001-03-13
NZ510115A (en)	2002-11-26
IL142443A0 (en)	2002-03-10
AR024216A1 (es)	2002-09-25
TR200100952T2 (tr)	2001-10-22
HUP0104002A3 (en)	2003-12-29
JP4590101B2 (ja)	2010-12-01
HK1038010A1 (en)	2002-03-01
CA2345622C (en)	2007-12-04
NO20011270L (no)	2001-03-13
RU2230744C2 (ru)	2004-06-20
JP2002526545A (ja)	2002-08-20
CA2345622A1 (en)	2000-04-13
BR9913507A (pt)	2001-06-05
KR20010071843A (ko)	2001-07-31
WO2000020421A3 (en)	2000-08-03
TWI248441B (en)	2006-02-01
CN1332744A (zh)	2002-01-23

Publication	Publication Date	Title
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
ID30132A (id)	2001-11-08	Turunan-turunan pirazol trisiklik
ID17259A (id)	1997-12-11	Fluorina mengandung turunan piperidina 1,4-disubtitusikan
DE60214428D1 (de)	2006-10-12	1, 4-dihydro-1, 4-diphenylpyridin-derivate
DK1218359T3 (da)	2004-10-18	Piperazinforbindelser som tachykininantagonister
NO20023485L (no)	2002-09-03	1,3-disubstituerte pyrrolidiner som alfa-2- adrenoceptorantagonister
MXPA03006991A (es)	2003-11-18	Derivados de piperidina como antagonistas de neurocinina 1.
NO20001609L (no)	2000-03-28	Aminoterminert trunkerte RANTES som kjemokinantagonister
DK0871623T3 (da)	2003-03-31	3-Azetinidylalkylpiperidiner eller -pyrrolidiner som tachykininantagonister
NO20010873D0 (no)	2001-02-21	Mikropartikkel-blanding
DK1119571T3 (da)	2003-05-26	Tricykliske Delta 3 piperidiner som alpha 2 antagonister.
ID26909A (id)	2001-02-15	Turunan-turunan 1,3,4-oksadiazolon
DK0964863T3 (da)	2003-08-04	Oxazolidinoner som 5-HT2A-antagonister
DE60025958D1 (de)	2006-04-20	14,15-beta-methylen substituierte androgene
ID27845A (id)	2001-04-26	Turunan tetrahidrokuilina sebagai antagonis glisilina
DK1075471T3 (da)	2005-01-17	Idolylderivater som serotonerge midler
NO992066D0 (no)	1999-04-29	Piperazinoderivater som neurokininantagonister
ATE234839T1 (de)	2003-04-15	4,5-azolo-oxindole
NO20000434D0 (no)	2000-01-27	Lyksofuranosyl benzimidazoler som antivirale midler
ITTO970975A0 (it)	1997-11-07	Composizioni organiche.
NO20011402L (no)	2001-03-20	Tricykliske <delta>3-piperidiner som farmasöytiske midler
DK1315700T3 (da)	2007-02-19	Substituerede 4-phenyl-1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridiner
NO20002575D0 (no)	2000-05-19	Substituerte oksimer som neurokininantagonister
NO20005756L (no)	2001-01-12	Karboksysubstituerte karboksamidderivater som tachykininantagonister
DK0882044T3 (da)	2002-09-02	1,4-dihydropyridinforbindelser som bradykinin-antagonister