DK111787A - Aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3(2h)on-1,1-dioxid-derivater deres fremstilling og anvendelse som laegemidler - Google Patents

Aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3(2h)on-1,1-dioxid-derivater deres fremstilling og anvendelse som laegemidler

Info

Publication number: DK111787A
Authority: DK; Denmark
Prior art keywords: benzoisothiazol; aminoalkyl; aromatic; preparation; medicinal products
Prior art date: 1986-03-05

Application number

DK111787A

Other languages

Danish (da)

English (en)

Other versions

DK111787D0 (da

Inventor

Marcel Hibert

Maurice Ward Gittos

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-05

Filing date

1987-03-04

Publication date

1987-09-06

1987-03-04 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1987-03-04 Publication of DK111787D0 publication Critical patent/DK111787D0/da

1987-09-06 Publication of DK111787A publication Critical patent/DK111787A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK111787A 1986-03-05 1987-03-04 Aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3(2h)on-1,1-dioxid-derivater deres fremstilling og anvendelse som laegemidler DK111787A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/836,276 US4748182A (en)	1986-03-05	1986-03-05	Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents

Publications (2)

Publication Number	Publication Date
DK111787D0 DK111787D0 (da)	1987-03-04
DK111787A true DK111787A (da)	1987-09-06

Family

ID=25271606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK111787A DK111787A (da)	1986-03-05	1987-03-04	Aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3(2h)on-1,1-dioxid-derivater deres fremstilling og anvendelse som laegemidler

Country Status (20)

Country	Link
US (1)	US4748182A (fi)
EP (1)	EP0236930B1 (fi)
JP (1)	JPH0780861B2 (fi)
KR (1)	KR900000674B1 (fi)
CN (1)	CN1016061B (fi)
AR (1)	AR243172A1 (fi)
AT (1)	ATE57921T1 (fi)
AU (1)	AU588977B2 (fi)
CA (1)	CA1287351C (fi)
DE (1)	DE3765803D1 (fi)
DK (1)	DK111787A (fi)
ES (1)	ES2031841T3 (fi)
FI (1)	FI88390C (fi)
GR (1)	GR3001311T3 (fi)
HU (1)	HU201064B (fi)
IL (1)	IL81739A0 (fi)
NO (1)	NO167391C (fi)
NZ (1)	NZ219457A (fi)
PT (1)	PT84407B (fi)
ZA (1)	ZA871448B (fi)

Families Citing this family (32)

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Publication number	Priority date	Publication date	Assignee	Title
DE3718317A1 (de) *	1986-12-10	1988-06-16	Bayer Ag	Substituierte basische 2-aminotetraline
DE3901814A1 (de) *	1988-07-28	1990-02-01	Bayer Ag	Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
US5300523A (en) *	1988-07-28	1994-04-05	Bayer Aktiengesellschaft	Substituted aminomethyltetralins and their heterocyclic analogues
US5202572A (en) *	1988-09-21	1993-04-13	Fuji Xerox Co., Ltd.	Thin film transistor
GB8907865D0 (en) *	1989-04-07	1989-05-24	Wyeth John & Brother Ltd	Tetrahydroquinoline derivatives
SG48298A1 (en) *	1989-05-04	1998-04-17	Sterling Winthorp Inc	Saccharin deriatives useful as proteolytic enzymeinhibitors and preparation of
US5236917A (en) *	1989-05-04	1993-08-17	Sterling Winthrop Inc.	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
IE903410A1 (en) *	1989-10-09	1991-04-10	Novo Nordisk As	Indole derivatives, their preparation and use
US5177096A (en) *	1989-10-25	1993-01-05	Smithkline Beecham Corporation	Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
DE4003541C1 (fi) *	1990-02-06	1991-08-08	Alter S.A., Madrid, Es
DK37790A (da) *	1990-02-13	1991-08-14	Novo Nordisk As	Indolderivater, deres fremstilling og anvendelse
US5194439A (en) *	1990-04-06	1993-03-16	John Wyeth & Brother Limited	N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes
FR2661177A1 (fr) *	1990-04-23	1991-10-25	Rhone Poulenc Sante	Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
EP0492021A1 (en) *	1990-12-24	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania
WO1992011011A1 (en) *	1990-12-24	1992-07-09	Merrell Dow Pharmaceuticals Inc.	Use of certain glutarimide derivatives in the treatment of depression and mania
DE4120322A1 (de) *	1991-06-20	1992-12-24	Bayer Ag	Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5182292A (en) *	1991-06-21	1993-01-26	American Home Products Corporation	Psychotropic piperidinylmethyl benzodioxans
US5134140A (en) *	1991-06-21	1992-07-28	American Home Products Corporation	Psychotropic benzofuran derivatives
US5189171A (en) *	1991-06-21	1993-02-23	American Home Products Corporation	Antipsychotic benzodioxan derivatives
US5166367A (en) *	1991-06-21	1992-11-24	American Home Products Corporation	Antipsychotic benzodioxan derivatives
US5126366A (en) *	1991-06-21	1992-06-30	American Home Products Corporation	Aminophenoxyalkyl derivatives of benzodioxan
US5212170A (en) *	1991-06-21	1993-05-18	American Home Products Corporation	Psychotropic piperidinylmethyl benzodioxans
US5126367A (en) *	1991-06-21	1992-06-30	American Home Products Corporation	Psychotropic benzodioxan derivatives
US5221745A (en) *	1991-06-21	1993-06-22	American Home Products Corp.	Psychotropic piperidinylmethyl benzodioxans
CA2090767A1 (en) *	1992-03-06	1993-09-07	Gerald Guillaumet	1,4-dioxino[2,3-b]pyridine derivatives
US5235055A (en) *	1992-09-02	1993-08-10	American Home Products Corporation	Antipsychotic quinoline derivatives of benzodioxanmethylamine
US5245051A (en) *	1992-09-03	1993-09-14	American Home Products Corporation	Antipsychotic chroman derivatives of benzodioxanmethylamine
RU2118322C1 (ru) *	1993-07-05	1998-08-27	Дюфар Интернэшнл Рисерч Б.В.	2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
DE19522088A1 (de) *	1995-06-19	1997-01-02	Bayer Ag	Benzisothiazolyl-substituierte Aminomethylchromane
CN1187342C (zh) *	2000-05-25	2005-02-02	弗·哈夫曼-拉罗切有限公司	取代的1－氨基烷基内酰胺化合物及其作为毒蕈碱受体拮抗剂的用途
DE10254596A1 (de) *	2002-11-22	2004-06-03	Merck Patent Gmbh	Indolderivate
US7297704B2 (en)	2005-02-17	2007-11-20	Wyeth	Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2751392A (en) *	1953-11-23	1956-06-19	Geschickter Fund Med Res	Tertiary amine derivatives of nu-and omicron-saccharin
US3711474A (en) *	1969-07-31	1973-01-16	Procter & Gamble	Heterocyclic nitrogen-and sulfur-containing optical brightener compounds and detergents and bleach compositions containing same
US4104387A (en) *	1977-05-23	1978-08-01	E. R. Squibb & Sons, Inc.	3-(Arylcycloiminoalkyl)benzisothiazole 1,1-dioxides
US4110449A (en) *	1977-05-23	1978-08-29	E. R. Squibb & Sons, Inc.	2-substituted benzisothiazol-3-ones
CA1117533A (en) *	1978-02-03	1982-02-02	Peter C. Wade	Benzisothiazole-1,1-dioxides
US4337250A (en) *	1979-07-30	1982-06-29	Pfizer Inc.	Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4405622A (en) *	1980-10-16	1983-09-20	Syntex (U.S.A.) Inc.	[1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ZA855563B (en) *	1984-07-30	1986-05-28	Merrell Dow Pharma	Glutarimide antianxiety and antihypertensive agents

1986
- 1986-03-05 US US06/836,276 patent/US4748182A/en not_active Expired - Lifetime
1987
- 1987-02-27 ZA ZA871448A patent/ZA871448B/xx unknown
- 1987-03-02 AU AU69606/87A patent/AU588977B2/en not_active Ceased
- 1987-03-02 NZ NZ219457A patent/NZ219457A/xx unknown
- 1987-03-03 FI FI870926A patent/FI88390C/fi not_active IP Right Cessation
- 1987-03-03 HU HU87867A patent/HU201064B/hu not_active IP Right Cessation
- 1987-03-03 IL IL81739A patent/IL81739A0/xx not_active IP Right Cessation
- 1987-03-03 AR AR87306891A patent/AR243172A1/es active
- 1987-03-04 CA CA000531105A patent/CA1287351C/en not_active Expired - Fee Related
- 1987-03-04 AT AT87103077T patent/ATE57921T1/de not_active IP Right Cessation
- 1987-03-04 EP EP87103077A patent/EP0236930B1/en not_active Expired - Lifetime
- 1987-03-04 DK DK111787A patent/DK111787A/da unknown
- 1987-03-04 ES ES198787103077T patent/ES2031841T3/es not_active Expired - Lifetime
- 1987-03-04 NO NO870890A patent/NO167391C/no unknown
- 1987-03-04 DE DE8787103077T patent/DE3765803D1/de not_active Expired - Fee Related
- 1987-03-04 PT PT84407A patent/PT84407B/pt not_active IP Right Cessation
- 1987-03-05 JP JP62048997A patent/JPH0780861B2/ja not_active Expired - Lifetime
- 1987-03-05 KR KR1019870001951A patent/KR900000674B1/ko not_active IP Right Cessation
- 1987-03-05 CN CN87101689A patent/CN1016061B/zh not_active Expired
1991
- 1991-01-10 GR GR91400020T patent/GR3001311T3/el unknown

Also Published As

Publication number	Publication date
EP0236930B1 (en)	1990-10-31
EP0236930A1 (en)	1987-09-16
FI88390B (fi)	1993-01-29
FI870926A (fi)	1987-09-06
NO167391C (no)	1991-10-30
JPS62221678A (ja)	1987-09-29
DK111787D0 (da)	1987-03-04
CA1287351C (en)	1991-08-06
ES2031841T3 (es)	1993-01-01
ZA871448B (en)	1987-08-20
AU588977B2 (en)	1989-09-28
PT84407B (pt)	1989-10-04
DE3765803D1 (de)	1990-12-06
NO870890L (no)	1987-09-07
HUT47104A (en)	1989-01-30
GR3001311T3 (en)	1992-08-31
IL81739A0 (en)	1987-10-20
ATE57921T1 (de)	1990-11-15
NO870890D0 (no)	1987-03-04
CN87101689A (zh)	1987-10-28
NO167391B (no)	1991-07-22
FI88390C (fi)	1993-05-10
NZ219457A (en)	1989-09-27
PT84407A (en)	1987-04-01
CN1016061B (zh)	1992-04-01
AR243172A1 (es)	1993-07-30
US4748182A (en)	1988-05-31
HU201064B (en)	1990-09-28
FI870926A0 (fi)	1987-03-03
KR900000674B1 (ko)	1990-02-02
AU6960687A (en)	1987-09-10
JPH0780861B2 (ja)	1995-08-30
KR870008880A (ko)	1987-10-21

Publication	Publication Date	Title
DK111787D0 (da)	1987-03-04	Aromatiske 2-aminoalkyl-1,2-benzoisothiazol-3(2h)on-1,1-dioxid-derivater deres fremstilling og anvendelse som laegemidler
DK267489D0 (da)	1989-06-01	1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler
NO874632D0 (no)	1987-11-06	Cyclodextrinclathrater av carbacyclinderivater og deres anvendelse som legemiddel.
DK658688A (da)	1989-05-28	1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK143588D0 (da)	1988-03-16	Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK131887A (da)	1987-09-15	1,2,3,4-tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og deres anvendelse som laegemidler
DK55088D0 (da)	1988-02-03	3,4-dihydro-2h-benzo(b)pyraner, deres fremstilling og anvendelse som laegemidler
DK166590D0 (da)	1990-07-10	Substituerede allylaminderivater, deres fremstilling og anvendelse som laegemidler
DK219685A (da)	1985-11-19	Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK366888D0 (da)	1988-07-01	Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK284688D0 (da)	1988-05-25	Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler
DK144885A (da)	1985-10-01	Substituerede 4-hydroxybenzopyraner eller farmaceutisk acceptable additionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK208886A (da)	1986-11-08	(1,4)-benzodioxin- og (1,4)-benzoxazinderivater deres fremstilling og anvendelse som laegemidler
DK648389A (da)	1990-06-21	Anthracylin-derivater, deres fremstilling og anvendelse som laegemidler
DK614186A (da)	1987-06-20	Substituerede piperazin-1,4-naphtalendioner, deres fremstilling og anvendelse som laegemidler
DK501888D0 (da)	1988-09-09	6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
DK42888A (da)	1988-07-30	Arylthiadiazolylsulfonamider og derivater deraf, deres fremstilling og anvendelse som laegemiddel
DK111887D0 (da)	1987-03-04	Aromatiske omega-alkylimino-tetrahydro-6h-1,3-thiazin-6-on-derivater, deres fremstilling og anvendelse som laegemidler
DK37787D0 (da)	1987-01-23	2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
DK111987D0 (da)	1987-03-04	4-(2-pyrimidinyl)-1-piperazinyl-hererocycliske carbonylderivater, deres fremstilling og anvendelse som laegemidler
DK116787A (da)	1987-09-09	Diarylsulfidderivater, deres fremstilling og anvendelse som laegemidler
DK602184D0 (da)	1984-12-14	Imidazoquinoliner, deres fremstilling og anvendelse som laegemidler
DK454588D0 (da)	1988-08-12	Substituerede thienoimidazolderivater, deres fremstilling, farmaceutiske praeparater deraf og deres anvendelse som mavesyresekretionshaemmende midler
DK288989D0 (da)	1989-06-13	Cholestadienderivater, deres fremstilling og anvendelse som laegemidler
DK14885A (da)	1985-07-13	1,4-dihydropyrazin, deres fremstilling og anvendelse som laegemidler