[go: up one dir, main page]

DK1100912T3 - Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet - Google Patents

Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet

Info

Publication number
DK1100912T3
DK1100912T3 DK99940032T DK99940032T DK1100912T3 DK 1100912 T3 DK1100912 T3 DK 1100912T3 DK 99940032 T DK99940032 T DK 99940032T DK 99940032 T DK99940032 T DK 99940032T DK 1100912 T3 DK1100912 T3 DK 1100912T3
Authority
DK
Denmark
Prior art keywords
iii
modulators
screening
calcineurin activity
recombinant
Prior art date
Application number
DK99940032T
Other languages
English (en)
Inventor
Helge Voelkel
Original Assignee
Genopia Biomedical Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genopia Biomedical Gmbh filed Critical Genopia Biomedical Gmbh
Application granted granted Critical
Publication of DK1100912T3 publication Critical patent/DK1100912T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728Calcium binding proteins, e.g. calmodulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Burglar Alarm Systems (AREA)
  • Measuring Fluid Pressure (AREA)
  • Interface Circuits In Exchanges (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK99940032T 1998-07-22 1999-07-22 Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet DK1100912T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98113876A EP0976823A1 (de) 1998-07-22 1998-07-22 Rekombinantes Expressions System und Hoch-Durchsatz BioAssay für die therapeutische Anwendung von Calcineurin-A-Alpha, Calcineurin-A-Beta, Calcineurin-A-Gamma, Calcineurin-B und Copper/Zinc-Superoxide Dismutase bzw. zur Identifizierung von Pharmazeutika
EP99940032A EP1100912B1 (en) 1998-07-22 1999-07-22 Method for screening of modulators of calcineurin activity

Publications (1)

Publication Number Publication Date
DK1100912T3 true DK1100912T3 (da) 2004-11-15

Family

ID=8232338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99940032T DK1100912T3 (da) 1998-07-22 1999-07-22 Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet

Country Status (9)

Country Link
US (1) US6875581B1 (da)
EP (2) EP0976823A1 (da)
JP (1) JP2002522015A (da)
AT (1) ATE270709T1 (da)
AU (1) AU5412499A (da)
CA (1) CA2335278A1 (da)
DE (1) DE69918557T2 (da)
DK (1) DK1100912T3 (da)
WO (1) WO2000005363A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281756A1 (en) * 2001-07-31 2003-02-05 GENOPIA Biomedical GmbH Regulator of calcineurin
JP2005113721A (ja) * 2003-10-06 2005-04-28 Hitachi Ltd 蒸気タービン
JP5881270B2 (ja) * 2006-01-05 2016-03-09 チルドレンズ メディカル センター コーポレーション Nfatの制御因子
EP1810675A1 (en) 2006-01-18 2007-07-25 Institut Curie Method for treating Huntington's disease by inhibiting dephosphorylation of huntingtin at S421
EP2157979B1 (en) 2007-05-24 2018-07-11 Calcimedica, Inc. Calcium channel proteins and uses thereof
EP2244700A4 (en) * 2007-07-10 2011-03-02 Immune Disease Inst Inc KNOCKOUT MOUSE FOR STROMAL INTERACTION MOLECULE AND USES THEREOF
EP2183385A4 (en) 2007-08-01 2010-11-10 Univ Emory METHOD FOR DETERMINING PROTEIN PHOSPHATASE ACTIVITY AND ITS APPLICATION IN THE PROGNOSIS OF THERAPY RESULTS
US20110039789A1 (en) * 2009-08-14 2011-02-17 Institut Curie Use of Huntingtin Protein for the Diagnosis and the Treatment of Cancer
US8394778B1 (en) 2009-10-08 2013-03-12 Immune Disease Institute, Inc. Regulators of NFAT and/or store-operated calcium entry
US9567580B2 (en) 2010-10-08 2017-02-14 Anjana Rao Regulators of NFAT and/or store-operated calcium entry
EP2826079B1 (de) 2012-03-15 2021-01-20 Merck Patent GmbH Elektronische vorrichtungen
US20200256880A1 (en) * 2017-08-16 2020-08-13 The Broad Institute, Inc. Neuronal Assay Method Involving Calcineurin
EP3715406A1 (en) 2019-03-29 2020-09-30 Henkel AG & Co. KGaA Process for modifying the surface polarity of rubber substrates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3366358B2 (ja) * 1992-12-16 2003-01-14 武田薬品工業株式会社 ヒトカルシニューリンAαアイソフォーム蛋白質をコードするDNAおよびその用途
ATE228657T1 (de) 1994-03-10 2002-12-15 Fujisawa Pharmaceutical Co Verfahren zum testen von immunosuppressoren
US5723436A (en) * 1994-10-24 1998-03-03 The Board Of Trustees Of The Leland Stanford Junior University Calcineurin interacting protein compositions and methods
US5807693A (en) 1994-11-23 1998-09-15 Icos Corporation Calcineurin inhibitory compounds and anchoring protein
US5871945A (en) * 1994-11-23 1999-02-16 Icos Corporation Modulators of anchoring protein function
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them

Also Published As

Publication number Publication date
WO2000005363A1 (en) 2000-02-03
JP2002522015A (ja) 2002-07-23
US6875581B1 (en) 2005-04-05
EP1100912B1 (en) 2004-07-07
DE69918557D1 (de) 2004-08-12
EP0976823A1 (de) 2000-02-02
AU5412499A (en) 2000-02-14
CA2335278A1 (en) 2000-02-03
EP1100912A1 (en) 2001-05-23
DE69918557T2 (de) 2005-07-28
ATE270709T1 (de) 2004-07-15

Similar Documents

Publication Publication Date Title
DK1100912T3 (da) Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet
ATE201793T1 (de) Stromabnehmer-anordnung für eine elektrochemische zelle
DE4491386T1 (de) Festes Elektrolyt-Elektroden-System für eine elektrochemische Zelle
EP1533380A3 (en) Recombinant protein production in a human cell comprising at least one E1 protein of adenovirus
NO905556D0 (no) Flerkomponentmembran og anvendelse av denne.
AU7034398A (en) Fuel cell with pulsed anode potential
DE69729055D1 (de) Kathodenmaterial für nichtwaessrige elektrolytische zelle und zelle, die dieses verwendet
DK0963615T3 (da) Brændselscelle og anvendelse af jern-baserede legeringer til konstruktion af brændselsceller
BR0313145A (pt) Sistema de célula eletroquìmica, célula metal-ar e método de operar um sistema de célula eletroquìmica
DE69432392D1 (de) Elektrochemische Zelle mit hoher Zuverlässigkeit und Elektrodenanordnung hierfür
NO910982L (no) Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller.
ATE324614T1 (de) Elektrochrome einheit
DE59807012D1 (de) Flip-gen und flip-protein
DE3673591D1 (de) Anodenscheibe fuer thermalzelle.
CA2306449A1 (en) Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
DK0952223T3 (da) Regulatorisk sekvens for cellulase cbh1-gener fra Trichoderma viride og system til masseproduktion af proteiner eller peptider under anvendelse af en sådan sekvens
AU2085195A (en) Gene coding for igg-fc-binding protein
AU1814995A (en) Galanin receptor, nucleic acids, transformed cells and uses thereof
GB9308094D0 (en) Improved catalyst material
DK0658626T3 (da) Fremgangsmåder til produktion af protein C
DE69830594D1 (de) Dna expression in transfizierten zellen und testverfahren in transfiziereen zellen
MY139948A (en) Enhanced transfection system
WO1997037028A3 (de) Ribose-5-phosphat isomerase (d-ribose-5-phosphat ketol isomerase, ec 5.3.1.6)
WO1998048020A3 (en) Mammalian ubiquitin-isopeptidases that control cell proliferation
NO20015821D0 (no) Nye humane androgenreseptorvarianter