DK1077940T3 - 4-Phenylpiperidiner til behandling af pruritiske dermatoser - Google Patents
4-Phenylpiperidiner til behandling af pruritiske dermatoserInfo
- Publication number
- DK1077940T3 DK1077940T3 DK99917038T DK99917038T DK1077940T3 DK 1077940 T3 DK1077940 T3 DK 1077940T3 DK 99917038 T DK99917038 T DK 99917038T DK 99917038 T DK99917038 T DK 99917038T DK 1077940 T3 DK1077940 T3 DK 1077940T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenylpiperidines
- treatment
- pruritic dermatoses
- pruritic
- dermatoses
- Prior art date
Links
- UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical class C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 title 1
- 230000001823 pruritic effect Effects 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810671.9A GB9810671D0 (en) | 1998-05-18 | 1998-05-18 | Anti-pruritic agents |
| EP99917038A EP1077940B1 (en) | 1998-05-18 | 1999-05-17 | 4-phenylpiperidines for the treatment of pruritic dermatoses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1077940T3 true DK1077940T3 (da) | 2004-11-01 |
Family
ID=10832267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99917038T DK1077940T3 (da) | 1998-05-18 | 1999-05-17 | 4-Phenylpiperidiner til behandling af pruritiske dermatoser |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6610711B2 (da) |
| EP (1) | EP1077940B1 (da) |
| JP (1) | JP2002515486A (da) |
| AP (1) | AP9901535A0 (da) |
| AT (1) | ATE271038T1 (da) |
| AU (1) | AU3531299A (da) |
| BR (1) | BR9910609A (da) |
| CA (1) | CA2332538C (da) |
| DE (1) | DE69918687T2 (da) |
| DK (1) | DK1077940T3 (da) |
| ES (1) | ES2230846T3 (da) |
| GB (1) | GB9810671D0 (da) |
| GT (1) | GT199900067A (da) |
| MA (1) | MA26630A1 (da) |
| PT (1) | PT1077940E (da) |
| TN (1) | TNSN99095A1 (da) |
| WO (1) | WO1999059971A1 (da) |
| ZA (1) | ZA993364B (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| JP2004536104A (ja) * | 2001-07-05 | 2004-12-02 | シナプティック・ファーマスーティカル・コーポレーション | Ｍｃｈ選択的アンタゴニストとしての置換されたアニリン−ピペリジン誘導体 |
| IL161157A0 (en) * | 2001-10-22 | 2004-08-31 | Pfizer Prod Inc | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| AU2002360403A1 (en) * | 2001-11-19 | 2003-06-10 | Elan Pharmaceuticals, Inc. | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease |
| ES2201908B1 (es) * | 2002-05-29 | 2005-02-16 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
| CA2522323C (en) * | 2003-04-14 | 2009-09-15 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands |
| FR2872416B1 (fr) * | 2004-07-01 | 2006-09-22 | Oreal | Utilisation de derives de piperidine pour lutter contre les rides |
| EP1848270B1 (en) * | 2005-02-17 | 2014-05-21 | Abbott Laboratories | Transmucosal administration of drug compositions for treating and preventing disorders in animals |
| WO2007070760A2 (en) * | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US7935715B2 (en) * | 2006-07-28 | 2011-05-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| EA200900403A1 (ru) * | 2006-09-25 | 2009-10-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединения, которые модулируют рецептор св2 |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| WO2009029257A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists |
| US7691878B2 (en) * | 2007-08-27 | 2010-04-06 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2009029252A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US8546563B2 (en) * | 2007-11-07 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| EP2326629B1 (en) * | 2008-07-10 | 2013-10-02 | Boehringer Ingelheim International GmbH | Sulfone compounds which modulate the cb2 receptor |
| WO2010036631A2 (en) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| US8299103B2 (en) * | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| US8383615B2 (en) | 2009-06-16 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Azetidine 2-carboxamide derivatives which modulate the CB2 receptor |
| WO2011037795A1 (en) * | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| JP5746228B2 (ja) | 2010-03-05 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節するテトラゾール化合物 |
| US8846936B2 (en) | 2010-07-22 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the CB2 receptor |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| CN106278914B (zh) * | 2016-08-19 | 2018-04-13 | 四川福思达生物技术开发有限责任公司 | 一种增产胺的合成工艺 |
| CN116440882B (zh) * | 2023-01-16 | 2024-09-20 | 浙江纽龙合成材料制造有限公司 | 一种基于端烯基活化的疏水分离层析介质及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206937A1 (es) | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
| EP0287339B1 (en) | 1987-04-16 | 1994-08-17 | Eli Lilly And Company | Piperidine opioid antagonists |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| CZ284993B6 (cs) | 1991-03-29 | 1999-04-14 | Eli Lilly And Company | Derivát piperidinu |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| EP0975614A1 (en) * | 1997-04-18 | 2000-02-02 | Smithkline Beecham Plc | A bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5ht1a, 5ht1b and 5ht1d receptor antagonistic activity |
-
1998
- 1998-05-18 GB GBGB9810671.9A patent/GB9810671D0/en not_active Ceased
-
1999
- 1999-05-13 AP APAP/P/1999/001535A patent/AP9901535A0/en unknown
- 1999-05-14 GT GT199900067A patent/GT199900067A/es unknown
- 1999-05-17 JP JP2000549590A patent/JP2002515486A/ja active Pending
- 1999-05-17 PT PT99917038T patent/PT1077940E/pt unknown
- 1999-05-17 ES ES99917038T patent/ES2230846T3/es not_active Expired - Lifetime
- 1999-05-17 US US09/646,255 patent/US6610711B2/en not_active Expired - Fee Related
- 1999-05-17 DE DE69918687T patent/DE69918687T2/de not_active Expired - Fee Related
- 1999-05-17 AT AT99917038T patent/ATE271038T1/de not_active IP Right Cessation
- 1999-05-17 BR BR9910609-4A patent/BR9910609A/pt not_active IP Right Cessation
- 1999-05-17 ZA ZA9903364A patent/ZA993364B/xx unknown
- 1999-05-17 TN TNTNSN99095A patent/TNSN99095A1/fr unknown
- 1999-05-17 AU AU35312/99A patent/AU3531299A/en not_active Abandoned
- 1999-05-17 DK DK99917038T patent/DK1077940T3/da active
- 1999-05-17 EP EP99917038A patent/EP1077940B1/en not_active Expired - Lifetime
- 1999-05-17 WO PCT/IB1999/000886 patent/WO1999059971A1/en not_active Ceased
- 1999-05-17 CA CA002332538A patent/CA2332538C/en not_active Expired - Fee Related
- 1999-05-17 MA MA25582A patent/MA26630A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030078282A1 (en) | 2003-04-24 |
| BR9910609A (pt) | 2001-01-09 |
| EP1077940A1 (en) | 2001-02-28 |
| US6610711B2 (en) | 2003-08-26 |
| JP2002515486A (ja) | 2002-05-28 |
| ES2230846T3 (es) | 2005-05-01 |
| AP9901535A0 (en) | 1999-06-30 |
| GT199900067A (es) | 2000-11-04 |
| CA2332538A1 (en) | 1999-11-25 |
| WO1999059971A1 (en) | 1999-11-25 |
| ZA993364B (en) | 2000-12-01 |
| ATE271038T1 (de) | 2004-07-15 |
| EP1077940B1 (en) | 2004-07-14 |
| TNSN99095A1 (fr) | 2005-11-10 |
| CA2332538C (en) | 2005-08-02 |
| MA26630A1 (fr) | 2004-12-20 |
| DE69918687D1 (de) | 2004-08-19 |
| DE69918687T2 (de) | 2005-07-28 |
| PT1077940E (pt) | 2004-10-29 |
| GB9810671D0 (en) | 1998-07-15 |
| AU3531299A (en) | 1999-12-06 |
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