DK0989858T3 - CD28/CTLA-4-inhiberende peptidomimetika og farmaceutiske præparater deraf - Google Patents
CD28/CTLA-4-inhiberende peptidomimetika og farmaceutiske præparater derafInfo
- Publication number
- DK0989858T3 DK0989858T3 DK98929048T DK98929048T DK0989858T3 DK 0989858 T3 DK0989858 T3 DK 0989858T3 DK 98929048 T DK98929048 T DK 98929048T DK 98929048 T DK98929048 T DK 98929048T DK 0989858 T3 DK0989858 T3 DK 0989858T3
- Authority
- DK
- Denmark
- Prior art keywords
- ctla
- pharmaceutical compositions
- peptidomimetics
- inhibitory
- interaction
- Prior art date
Links
- 108010021064 CTLA-4 Antigen Proteins 0.000 title abstract 3
- 229940045513 CTLA4 antagonist Drugs 0.000 title abstract 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 title abstract 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 title abstract 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000816 peptidomimetic Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4947097P | 1997-06-12 | 1997-06-12 | |
| PCT/US1998/012312 WO1998056401A1 (en) | 1997-06-12 | 1998-06-11 | Cd28/ctla-4 inhibiting peptidomimetics, pharmaceutical compositions thereof, and method of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0989858T3 true DK0989858T3 (da) | 2004-08-09 |
Family
ID=21959997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98929048T DK0989858T3 (da) | 1997-06-12 | 1998-06-11 | CD28/CTLA-4-inhiberende peptidomimetika og farmaceutiske præparater deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6337316B1 (da) |
| EP (1) | EP0989858B1 (da) |
| JP (2) | JP2002505673A (da) |
| AT (1) | ATE264688T1 (da) |
| AU (1) | AU743939B2 (da) |
| CA (1) | CA2293666A1 (da) |
| DE (1) | DE69823352T2 (da) |
| DK (1) | DK0989858T3 (da) |
| ES (1) | ES2215306T3 (da) |
| IL (2) | IL133467A0 (da) |
| PT (1) | PT989858E (da) |
| WO (1) | WO1998056401A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047558A2 (en) * | 1998-03-19 | 1999-09-23 | Heska Corporation | T cell costimulatory proteins, sequences and uses thereof |
| JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途 |
| US7531168B2 (en) | 2001-02-16 | 2009-05-12 | Genetics Institute Llc | Method for downmodulating immune response in type I diabetes |
| IL148993A0 (en) * | 2002-04-04 | 2002-11-10 | Yissum Res Dev Co | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof |
| US8535672B2 (en) * | 2002-04-04 | 2013-09-17 | Yissum Research Development Of The Hebrew University Of Jerusalem | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof |
| WO2004087754A1 (en) * | 2003-04-03 | 2004-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof |
| AU2004220036A1 (en) * | 2003-03-12 | 2004-09-23 | Duke University | Oligonucleotide mimetics |
| US20060075968A1 (en) * | 2004-10-12 | 2006-04-13 | Applied Materials, Inc. | Leak detector and process gas monitor |
| EP1814988A2 (en) | 2004-11-26 | 2007-08-08 | Pieris AG | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
| US8440185B2 (en) | 2006-12-26 | 2013-05-14 | The Johns Hopkins University | Compositions and methods for the treatment of immunologic disorders |
| US20090007853A1 (en) * | 2007-07-03 | 2009-01-08 | Tyson Foods, Inc. | Stackable tray system and method to load, transport, stun and singulate poultry |
| EP2646552B1 (en) | 2010-12-02 | 2017-07-05 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for ctla-4 |
| AU2014265142A1 (en) | 2013-05-17 | 2015-12-24 | Medimmune, Llc | Receptors for B7-H4 |
| WO2015104406A2 (en) | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| US20170355755A1 (en) | 2014-11-21 | 2017-12-14 | Yale University | Compositions and methods for modulating salm5 and hvem |
| WO2018083080A2 (en) | 2016-11-04 | 2018-05-11 | Innate Pharma | Nkp46 ligand |
| IT201800004853A1 (it) | 2018-04-24 | 2019-10-24 | Metodi per trattare il cancro | |
| JP7498889B2 (ja) | 2020-01-30 | 2024-06-13 | 東亞合成株式会社 | Ｃｔｌａ４とｂ７タンパク質との結合を抑制するペプチドおよびその利用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| CA2110518C (en) * | 1991-06-27 | 2007-05-22 | Peter S. Linsley | Ctla4 receptor, fusion proteins containing it and uses thereof |
| US5773253A (en) * | 1993-01-22 | 1998-06-30 | Bristol-Myers Squibb Company | MYPPPY variants of CTL A4 and uses thereof |
| US5888763A (en) * | 1994-12-30 | 1999-03-30 | The Rockefeller University | Peptides specific for the first Crk-SH3 domain |
| WO1996031229A1 (en) * | 1995-04-05 | 1996-10-10 | Beth Israel Hospital Association | Inhibiting rejection of a graft |
-
1998
- 1998-06-11 AU AU80706/98A patent/AU743939B2/en not_active Ceased
- 1998-06-11 PT PT98929048T patent/PT989858E/pt unknown
- 1998-06-11 IL IL13346798A patent/IL133467A0/xx active IP Right Grant
- 1998-06-11 AT AT98929048T patent/ATE264688T1/de not_active IP Right Cessation
- 1998-06-11 DE DE69823352T patent/DE69823352T2/de not_active Expired - Fee Related
- 1998-06-11 WO PCT/US1998/012312 patent/WO1998056401A1/en active IP Right Grant
- 1998-06-11 ES ES98929048T patent/ES2215306T3/es not_active Expired - Lifetime
- 1998-06-11 EP EP98929048A patent/EP0989858B1/en not_active Expired - Lifetime
- 1998-06-11 DK DK98929048T patent/DK0989858T3/da active
- 1998-06-11 CA CA002293666A patent/CA2293666A1/en not_active Abandoned
- 1998-06-11 JP JP50328699A patent/JP2002505673A/ja not_active Withdrawn
-
1999
- 1999-12-10 IL IL133467A patent/IL133467A/en not_active IP Right Cessation
- 1999-12-13 US US09/460,384 patent/US6337316B1/en not_active Expired - Fee Related
-
2008
- 2008-09-29 JP JP2008250706A patent/JP2009029833A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002505673A (ja) | 2002-02-19 |
| ES2215306T3 (es) | 2004-10-01 |
| WO1998056401A1 (en) | 1998-12-17 |
| IL133467A (en) | 2006-12-31 |
| ATE264688T1 (de) | 2004-05-15 |
| PT989858E (pt) | 2004-07-30 |
| CA2293666A1 (en) | 1998-12-17 |
| JP2009029833A (ja) | 2009-02-12 |
| US6337316B1 (en) | 2002-01-08 |
| EP0989858B1 (en) | 2004-04-21 |
| DE69823352T2 (de) | 2004-09-02 |
| IL133467A0 (en) | 2001-04-30 |
| DE69823352D1 (de) | 2004-05-27 |
| EP0989858A1 (en) | 2000-04-05 |
| EP0989858A4 (en) | 2001-03-21 |
| AU743939B2 (en) | 2002-02-07 |
| AU8070698A (en) | 1998-12-30 |
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