DK0944631T3 - New substituted pyrazole derivatives for the treatment of cardiovascular disease - Google Patents

New substituted pyrazole derivatives for the treatment of cardiovascular disease

Info

Publication number: DK0944631T3
Authority: DK; Denmark
Prior art keywords: treatment; cardiovascular disease; pyrazole derivatives; substituted pyrazole; new substituted
Prior art date: 1996-11-26

Application number

DK97951204T

Other languages

Danish (da)

Inventor

Alexander Straub

Chantal Robyr

Thomas Jaetsch

Achim Feurer

Raimund Kast

Johannes-Peter Stasch

Elisabeth Perzborn

Joachim Huetter

Klaus Dembowsky

Original Assignee

Bayer Healthcare Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-26

Filing date

1997-11-14

Publication date

2004-06-07

1997-11-14 Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag

2004-06-07 Application granted granted Critical

2004-06-07 Publication of DK0944631T3 publication Critical patent/DK0944631T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK97951204T 1996-11-26 1997-11-14 New substituted pyrazole derivatives for the treatment of cardiovascular disease DK0944631T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19649460A DE19649460A1 (en)	1996-11-26	1996-11-26	New substituted pyrazole derivatives

Publications (1)

Publication Number	Publication Date
DK0944631T3 true DK0944631T3 (en)	2004-06-07

Family

ID=7813100

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97951204T DK0944631T3 (en)	1996-11-26	1997-11-14	New substituted pyrazole derivatives for the treatment of cardiovascular disease

Country Status (25)

Country	Link
EP (1)	EP0944631B1 (en)
JP (2)	JP4422800B2 (en)
CN (1)	CN1122032C (en)
AR (1)	AR010310A1 (en)
AT (1)	ATE259812T1 (en)
AU (1)	AU729642B2 (en)
BR (1)	BR9714363A (en)
CA (1)	CA2272584C (en)
CZ (1)	CZ185099A3 (en)
DE (2)	DE19649460A1 (en)
DK (1)	DK0944631T3 (en)
EE (1)	EE9900211A (en)
ES (1)	ES2214646T3 (en)
HU (1)	HUP0000562A3 (en)
ID (1)	ID21881A (en)
IL (1)	IL129998A0 (en)
MX (1)	MXPA99004826A (en)
NO (1)	NO992400D0 (en)
NZ (1)	NZ335890A (en)
PT (1)	PT944631E (en)
SK (1)	SK67699A3 (en)
TR (1)	TR199901172T2 (en)
TW (1)	TW403746B (en)
WO (1)	WO1998023619A1 (en)
ZA (1)	ZA9710573B (en)

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GB9824310D0 (en) *	1998-11-05	1998-12-30	Univ London	Activators of soluble guanylate cyclase
DE19920352A1 (en) *	1999-05-04	2000-11-09	Bayer Ag	Substituted pyrazole derivative
DE19943634A1 (en)	1999-09-13	2001-04-12	Bayer Ag	Novel dicarboxylic acid derivatives with pharmaceutical properties
DE19943635A1 (en)	1999-09-13	2001-03-15	Bayer Ag	Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE19943636A1 (en)	1999-09-13	2001-03-15	Bayer Ag	Novel dicarboxylic acid derivatives with pharmaceutical properties
DE10021069A1 (en) *	2000-04-28	2001-10-31	Bayer Ag	Substituted pyrazole derivative
CA2429308C (en)	2000-11-22	2010-09-21	Bayer Aktiengesellschaft	Novel lactam-substituted pyrazolopyridine derivatives
AR031176A1 (en)	2000-11-22	2003-09-10	Bayer Ag	NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE
DE10057754A1 (en)	2000-11-22	2002-05-23	Bayer Ag	New cyclic sulfonamido-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation
DE10057751A1 (en)	2000-11-22	2002-05-23	Bayer Ag	New carbamate-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation
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DE10109861A1 (en)	2001-03-01	2002-09-05	Bayer Ag	Novel side chain halogenated aminodicarboxylic acid derivatives
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DE10244810A1 (en) *	2002-09-26	2004-04-08	Bayer Ag	New morpholine-bridged indazole derivatives
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DE102005050497A1 (en)	2005-10-21	2007-04-26	Bayer Healthcare Ag	Difluorophenol derivatives and their use
DE102005050376A1 (en)	2005-10-21	2007-05-31	Bayer Healthcare Ag	Dicarboxylic acid derivatives and their use
DE102005050375A1 (en)	2005-10-21	2007-04-26	Bayer Healthcare Ag	Tetrazole derivatives and their use
DE102005050377A1 (en)	2005-10-21	2007-04-26	Bayer Healthcare Ag	Heterocyclic compounds and their use
DE102005050498A1 (en)	2005-10-21	2007-06-06	Bayer Healthcare Aktiengesellschaft	Cyclopropylacetic acid derivatives and their use
DE102006020327A1 (en) *	2006-04-27	2007-12-27	Bayer Healthcare Ag	Heterocyclic substituted, fused pyrazole derivatives and their use
DE102006043443A1 (en)	2006-09-15	2008-03-27	Bayer Healthcare Ag	Novel aza-bicyclic compounds and their use
DE102007015034A1 (en)	2007-03-29	2008-10-02	Bayer Healthcare Ag	Lactam-substituted dicarboxylic acids and their use
DE102007015035A1 (en)	2007-03-29	2008-10-02	Bayer Healthcare Ag	Substituted dibenzoic acid derivatives and their use
DE102007026392A1 (en)	2007-06-06	2008-12-11	Bayer Healthcare Ag	Solutions for the perfusion and preservation of organs and tissues
DE102007028406A1 (en)	2007-06-20	2008-12-24	Bayer Healthcare Ag	Substituted oxazolidinones and their use
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DE102007028407A1 (en)	2007-06-20	2008-12-24	Bayer Healthcare Ag	Substituted oxazolidinones and their use
DK2294066T3 (en)	2008-04-28	2014-09-08	Janssen Pharmaceutica Nv	Benzoimidazoles as Prolyl Hydroxylase Inhibitors
EP2138178A1 (en)	2008-06-28	2009-12-30	Bayer Schering Pharma Aktiengesellschaft	Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
DE102008063992A1 (en)	2008-12-19	2010-09-02	Lerner, Zinoviy, Dipl.-Ing.	New aliphatic substituted pyrazolopyridines and their use
DE102009004245A1 (en)	2009-01-09	2010-07-15	Bayer Schering Pharma Aktiengesellschaft	Novel fused, heteroatom-bridged pyrazole and imidazole derivatives and their use
UY33041A (en)	2009-11-27	2011-06-30	Bayer Schering Pharma Aktienegesellschaft	PROCEDURE FOR THE PREPARATION OF {4,6-DIAMINO-2- [1- (2-FLUOROBENCIL) -1H-PIRAZOLO [3,4-B] PIRIDIN-3-IL] PIRIMIDIN-5-IL} CARBAMATO DE METTILO AND ITS PURIFICATION FOR USE AS A PHARMACEUTICAL ACTIVE PRINCIPLE
GB201004311D0 (en)	2010-03-15	2010-04-28	Proximagen Ltd	New enzyme inhibitor compounds
DK2588465T3 (en)	2010-06-30	2017-05-01	Ironwood Pharmaceuticals Inc	SGC stimulators
MX341531B (en)	2010-11-09	2016-08-22	Ironwood Pharmaceuticals Inc	Sgc stimulators.
JP6005134B2 (en) *	2011-04-21	2016-10-12	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	Fluoroalkyl-substituted pyrazolopyridines and uses thereof
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CN113712969A (en)	2015-07-23	2021-11-30	拜耳制药股份公司	Stimulators and/or activators of soluble guanylate cyclase and uses thereof
EP3389655A2 (en)	2015-12-14	2018-10-24	Ironwood Pharmaceuticals, Inc.	USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION
WO2017121700A1 (en) *	2016-01-15	2017-07-20	Bayer Pharma Aktiengesellschaft	1,3-disubstituted 1h-pyrazolo[3,4-b]pyridine derivatives and use thereof as stimulators of soluble guanylate cyclase
CA3039734A1 (en)	2016-10-11	2018-04-19	Bayer Pharma Aktiengesellschaft	Combination containing sgc stimulators and mineralocorticoid receptor antagonists
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US20190381039A1 (en)	2016-12-13	2019-12-19	Cyclerion Therapeutics, Inc.	USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS
CN108727340B (en)	2017-04-11	2020-12-29	广东东阳光药业有限公司	Fluorine substituted indazoles and use thereof
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1996
- 1996-11-26 DE DE19649460A patent/DE19649460A1/en not_active Withdrawn
1997
- 1997-11-14 AT AT97951204T patent/ATE259812T1/en active
- 1997-11-14 DK DK97951204T patent/DK0944631T3/en active
- 1997-11-14 EP EP97951204A patent/EP0944631B1/en not_active Expired - Lifetime
- 1997-11-14 IL IL12999897A patent/IL129998A0/en unknown
- 1997-11-14 TR TR1999/01172T patent/TR199901172T2/en unknown
- 1997-11-14 BR BR9714363A patent/BR9714363A/en active Search and Examination
- 1997-11-14 CA CA002272584A patent/CA2272584C/en not_active Expired - Fee Related
- 1997-11-14 ID IDW990388A patent/ID21881A/en unknown
- 1997-11-14 CN CN97180065A patent/CN1122032C/en not_active Expired - Fee Related
- 1997-11-14 CZ CZ991850A patent/CZ185099A3/en unknown
- 1997-11-14 ES ES97951204T patent/ES2214646T3/en not_active Expired - Lifetime
- 1997-11-14 DE DE59711321T patent/DE59711321D1/en not_active Expired - Lifetime
- 1997-11-14 SK SK676-99A patent/SK67699A3/en unknown
- 1997-11-14 EE EEP199900211A patent/EE9900211A/en unknown
- 1997-11-14 NZ NZ335890A patent/NZ335890A/en unknown
- 1997-11-14 MX MXPA99004826A patent/MXPA99004826A/en not_active IP Right Cessation
- 1997-11-14 JP JP52421898A patent/JP4422800B2/en not_active Expired - Fee Related
- 1997-11-14 AU AU54823/98A patent/AU729642B2/en not_active Ceased
- 1997-11-14 PT PT97951204T patent/PT944631E/en unknown
- 1997-11-14 HU HU0000562A patent/HUP0000562A3/en unknown
- 1997-11-14 WO PCT/EP1997/006366 patent/WO1998023619A1/en not_active Application Discontinuation
- 1997-11-21 TW TW086117406A patent/TW403746B/en not_active IP Right Cessation
- 1997-11-25 ZA ZA9710573A patent/ZA9710573B/en unknown
- 1997-11-26 AR ARP970105563A patent/AR010310A1/en active IP Right Grant
1999
- 1999-05-19 NO NO992400A patent/NO992400D0/en unknown
2009
- 2009-09-11 JP JP2009210476A patent/JP2010013475A/en not_active Ceased

Also Published As

Publication number	Publication date
HUP0000562A3 (en)	2001-12-28
JP2001505567A (en)	2001-04-24
CN1238773A (en)	1999-12-15
DE19649460A1 (en)	1998-05-28
ATE259812T1 (en)	2004-03-15
WO1998023619A1 (en)	1998-06-04
JP4422800B2 (en)	2010-02-24
NZ335890A (en)	2001-02-23
AU5482398A (en)	1998-06-22
EE9900211A (en)	1999-12-15
ES2214646T3 (en)	2004-09-16
ID21881A (en)	1999-08-05
NO992400L (en)	1999-05-19
SK67699A3 (en)	2000-02-14
CA2272584A1 (en)	1998-06-04
TR199901172T2 (en)	1999-08-23
EP0944631B1 (en)	2004-02-18
AU729642B2 (en)	2001-02-08
IL129998A0 (en)	2000-02-29
CN1122032C (en)	2003-09-24
TW403746B (en)	2000-09-01
ZA9710573B (en)	1998-06-10
BR9714363A (en)	2000-03-21
CZ185099A3 (en)	1999-08-11
PT944631E (en)	2004-06-30
JP2010013475A (en)	2010-01-21
CA2272584C (en)	2007-10-16
HK1023119A1 (en)	2000-09-01
HUP0000562A2 (en)	2000-10-28
EP0944631A1 (en)	1999-09-29
DE59711321D1 (en)	2004-03-25
NO992400D0 (en)	1999-05-19
AR010310A1 (en)	2000-06-07
MXPA99004826A (en)	2008-02-19

Publication	Publication Date	Title
DK0944631T3 (en)	2004-06-07	New substituted pyrazole derivatives for the treatment of cardiovascular disease
DK0773940T3 (en)	2003-09-15	Process for the Synthesis of Substituted Sulfoxides
DK1028954T3 (en)	2003-10-27	Substituted imidazoles suitable for the treatment of inflammatory diseases
NO995113D0 (en)	1999-10-20	Substituted benzopyran derivatives for the treatment of inflammation
DK0769947T3 (en)	2001-08-13	Indolinone compounds for the treatment of disease
DK1147083T3 (en)	2004-08-16	Arylpiperazinyl-cyclohexylindole derivatives for the treatment of depression
NO983356L (en)	1998-07-21	New 19-nor-derivative derivatives
DK0937055T3 (en)	2002-07-29	Process for the preparation of d, I-alpha-tocopherol
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