DK0934276T3 - Anthranilinsyrederivater som multiresistensmodulatorer - Google Patents
Anthranilinsyrederivater som multiresistensmodulatorerInfo
- Publication number
- DK0934276T3 DK0934276T3 DK97945030T DK97945030T DK0934276T3 DK 0934276 T3 DK0934276 T3 DK 0934276T3 DK 97945030 T DK97945030 T DK 97945030T DK 97945030 T DK97945030 T DK 97945030T DK 0934276 T3 DK0934276 T3 DK 0934276T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid derivatives
- anthranilic acid
- modulators
- resistance modulators
- resistance
- Prior art date
Links
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title abstract 2
- 102100031765 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Human genes 0.000 abstract 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 abstract 1
- 101000866618 Homo sapiens 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Proteins 0.000 abstract 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 abstract 1
- 239000003560 cancer drug Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9602552 | 1996-10-18 | ||
| GBGB9717576.4A GB9717576D0 (en) | 1997-08-19 | 1997-08-19 | Pharmaceutical compounds |
| PCT/GB1997/002885 WO1998017648A1 (en) | 1996-10-18 | 1997-10-17 | Anthranilic acid derivatives as multi drug resistance modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0934276T3 true DK0934276T3 (da) | 2004-04-19 |
Family
ID=10817722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97945030T DK0934276T3 (da) | 1996-10-18 | 1997-10-17 | Anthranilinsyrederivater som multiresistensmodulatorer |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6218393B1 (da) |
| EP (1) | EP0934276B1 (da) |
| JP (1) | JP4340741B2 (da) |
| KR (1) | KR100620768B1 (da) |
| AT (1) | ATE256663T1 (da) |
| AU (1) | AU741922B2 (da) |
| BG (1) | BG103327A (da) |
| BR (1) | BR9711935A (da) |
| CA (1) | CA2268403C (da) |
| CZ (1) | CZ298209B6 (da) |
| DE (1) | DE69726876T2 (da) |
| DK (1) | DK0934276T3 (da) |
| ES (1) | ES2210586T3 (da) |
| GB (2) | GB9717576D0 (da) |
| HK (1) | HK1019330A1 (da) |
| ID (1) | ID21696A (da) |
| NO (1) | NO313591B1 (da) |
| PL (1) | PL191150B1 (da) |
| PT (1) | PT934276E (da) |
| TW (1) | TW498074B (da) |
| WO (1) | WO1998017648A1 (da) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4698299A (en) * | 1998-06-30 | 2000-01-17 | Du Pont Pharmaceuticals Company | 5-HT7 receptor antagonists |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| US6982231B1 (en) | 2000-10-27 | 2006-01-03 | Kimberly-Clark Worldwide, Inc. | Elastomeric, breathable laminate with enhanced breathability upon extension |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| WO2003041128A2 (en) * | 2001-11-07 | 2003-05-15 | Pharmacia Corporation | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| EP1506188B1 (en) * | 2002-05-14 | 2009-02-25 | Xenova Limited | Process for the preparation of a hydrate of an anthranilic acid derivative |
| KR100503161B1 (ko) * | 2002-07-18 | 2005-07-25 | 한미약품 주식회사 | 신규한 ｐ-당단백질 저해제, 그의 제조방법 및 이를유효성분으로 하는 경구투여용 조성물 |
| KR100503889B1 (ko) * | 2002-07-20 | 2005-07-26 | 한국과학기술연구원 | 옥틸로늄 브로마이드를 함유하는 항암제 흡수 증진제 |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| JP2007500730A (ja) * | 2003-07-31 | 2007-01-18 | ワシントン ユニバーシティ イン セント ルイス | 固形癌の増殖状態を画像化するためのシグマ−２受容体ラジオトレーサー |
| US7659400B2 (en) | 2003-07-31 | 2010-02-09 | Washington University | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging |
| KR100557093B1 (ko) * | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| KR100580743B1 (ko) * | 2003-10-08 | 2006-05-15 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 신규한 크로몬 유도체 또는이의 약제학적으로 허용가능한 염 및 이들의 제조 방법 |
| AR048669A1 (es) * | 2004-03-03 | 2006-05-17 | Syngenta Ltd | Derivados biciclicos de bisamida |
| SE0401345D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
| DK2502911T3 (da) * | 2004-06-24 | 2017-06-06 | Vertex Pharma | Modulatorer af ATP-bindende kassettetransportere |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CA2581150A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (spirocyclylamido) aminothiophene compounds as c-kit proto- oncogene inhibitors |
| CN101223136A (zh) * | 2005-07-12 | 2008-07-16 | 拜尔农科股份有限公司 | 新苯并杂环基乙基苯甲酰胺衍生物 |
| CA2634113A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| EP2150527B1 (en) | 2007-03-19 | 2011-01-19 | Council of Scientific & Industrial Research | Anthranilic acid derivative as anticancer agent and a process for the preparation thereof |
| GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| KR100880163B1 (ko) | 2007-05-30 | 2009-02-04 | (주)바이오버드 | 신규한 다약제 내성 억제 화합물 및 이를 포함하는약제학적 조성물 |
| SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| EP2258393A4 (en) * | 2008-03-31 | 2012-02-15 | Yoshikazu Sugimoto | INHIBITOR OF ABC TRANSPORTER PROTEIN EXPRESSION |
| RU2543714C2 (ru) | 2009-03-20 | 2015-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения модуляторов регулятора трансмембранной проводимости кистозного фиброза |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
| CN110776447A (zh) * | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| JP2016501883A (ja) * | 2012-12-07 | 2016-01-21 | シガ テクノロジーズ，インコーポレーテッド | デングウイルス感染症の治療及び予防のためのチエノピリジン誘導体 |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| PL2935222T3 (pl) | 2012-12-21 | 2019-02-28 | Epizyme Inc | Inhibitory PRMT5 i ich zastosowania |
| US9221794B2 (en) | 2012-12-21 | 2015-12-29 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100695A1 (en) * | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9745291B2 (en) | 2012-12-21 | 2017-08-29 | Epizyme, Inc. | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| US20160194299A1 (en) * | 2013-05-24 | 2016-07-07 | The California Institute For Biomedical Research | Compounds for treatment of drug resistant and persistent tuberculosis |
| GB201313664D0 (en) * | 2013-07-31 | 2013-09-11 | Univ Cardiff | Bcl-3 inhibitors |
| GB201317609D0 (en) | 2013-10-04 | 2013-11-20 | Cancer Rec Tech Ltd | Inhibitor compounds |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| AU2015326506B2 (en) * | 2014-10-03 | 2021-02-25 | Divya MAHESHWARI | Novel anthranilic acid derivatives |
| RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
| GB201505658D0 (en) | 2015-04-01 | 2015-05-13 | Cancer Rec Tech Ltd | Inhibitor compounds |
| WO2016187544A1 (en) * | 2015-05-20 | 2016-11-24 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing cancer |
| KR101850607B1 (ko) * | 2015-07-23 | 2018-04-19 | 서울대학교산학협력단 | 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브 |
| US10864280B2 (en) | 2016-06-09 | 2020-12-15 | Der-Yang Tien | Nanodroplet compositions for the efficient delivery of anti-cancer agents |
| GB201617103D0 (en) | 2016-10-07 | 2016-11-23 | Cancer Research Technology Limited | Compound |
| SG11202002032SA (en) | 2017-09-22 | 2020-04-29 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| MX2020003341A (es) | 2017-10-18 | 2020-09-17 | Jubilant Epipad LLC | Compuestos de imidazo-piridina como inhibidores de pad. |
| EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| HRP20240736T1 (hr) | 2017-11-24 | 2024-11-08 | Jubilant Episcribe Llc | Heterociklički spojevi kao inhibitori prmt5 |
| BR112020018610A2 (pt) | 2018-03-13 | 2020-12-29 | Jubilant Prodel LLC | Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas |
| US20190343827A1 (en) * | 2018-05-08 | 2019-11-14 | Izumi Technology, Llc | Deuterated analogs of tariquidar |
| CN116964044A (zh) | 2020-10-07 | 2023-10-27 | 希华医药有限公司 | 乙酰胺基-苯基四唑衍生物及其使用方法 |
| KR20230104614A (ko) * | 2020-10-07 | 2023-07-10 | 아테넥스, 인크. | 아세트아미도-페닐벤즈아미드 유도체 및 그의 사용 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2074061A1 (en) | 1991-08-26 | 1993-02-27 | Ivo Monkovic | Benzamide multidrug resistance reversing agents |
| DK0649410T3 (da) * | 1992-07-10 | 1997-09-15 | Glaxo Lab Sa | Anilidderivater. |
| AU5813394A (en) | 1992-12-23 | 1994-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
| WO1994022842A1 (en) * | 1993-03-29 | 1994-10-13 | Basf Aktiengesellschaft | 1-amino-3-phenoxy propane derivatives as modulators of multi-drug resistance |
| GB9402809D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9426224D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
-
1997
- 1997-08-19 GB GBGB9717576.4A patent/GB9717576D0/en active Pending
- 1997-10-17 WO PCT/GB1997/002885 patent/WO1998017648A1/en active IP Right Grant
- 1997-10-17 CZ CZ0135399A patent/CZ298209B6/cs not_active IP Right Cessation
- 1997-10-17 AT AT97945030T patent/ATE256663T1/de active
- 1997-10-17 BR BR9711935A patent/BR9711935A/pt not_active Application Discontinuation
- 1997-10-17 CA CA2268403A patent/CA2268403C/en not_active Expired - Fee Related
- 1997-10-17 AU AU46339/97A patent/AU741922B2/en not_active Ceased
- 1997-10-17 ID IDW990197A patent/ID21696A/id unknown
- 1997-10-17 GB GB9908193A patent/GB2334521B/en not_active Expired - Fee Related
- 1997-10-17 ES ES97945030T patent/ES2210586T3/es not_active Expired - Lifetime
- 1997-10-17 KR KR1019997003389A patent/KR100620768B1/ko not_active IP Right Cessation
- 1997-10-17 PT PT97945030T patent/PT934276E/pt unknown
- 1997-10-17 DE DE69726876T patent/DE69726876T2/de not_active Expired - Lifetime
- 1997-10-17 EP EP97945030A patent/EP0934276B1/en not_active Expired - Lifetime
- 1997-10-17 JP JP51910898A patent/JP4340741B2/ja not_active Expired - Fee Related
- 1997-10-17 US US09/284,642 patent/US6218393B1/en not_active Expired - Lifetime
- 1997-10-17 DK DK97945030T patent/DK0934276T3/da active
- 1997-10-18 TW TW086115402A patent/TW498074B/zh not_active IP Right Cessation
-
1999
- 1999-04-09 PL PL332725A patent/PL191150B1/pl not_active IP Right Cessation
- 1999-04-13 BG BG103327A patent/BG103327A/bg unknown
- 1999-04-16 NO NO19991836A patent/NO313591B1/no not_active IP Right Cessation
- 1999-09-01 HK HK99103773A patent/HK1019330A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001502683A (ja) | 2001-02-27 |
| CA2268403A1 (en) | 1998-04-30 |
| ES2210586T3 (es) | 2004-07-01 |
| GB2334521A (en) | 1999-08-25 |
| JP4340741B2 (ja) | 2009-10-07 |
| BG103327A (bg) | 2000-11-30 |
| PT934276E (pt) | 2004-05-31 |
| KR20000049278A (ko) | 2000-07-25 |
| HK1019330A1 (en) | 2000-02-03 |
| BR9711935A (pt) | 1999-08-24 |
| AU4633997A (en) | 1998-05-15 |
| KR100620768B1 (ko) | 2006-09-06 |
| GB9908193D0 (en) | 1999-06-02 |
| CZ135399A3 (cs) | 1999-09-15 |
| AU741922B2 (en) | 2001-12-13 |
| ATE256663T1 (de) | 2004-01-15 |
| EP0934276B1 (en) | 2003-12-17 |
| PL332725A1 (en) | 1999-10-11 |
| US6218393B1 (en) | 2001-04-17 |
| GB2334521B (en) | 2000-10-04 |
| WO1998017648A1 (en) | 1998-04-30 |
| CZ298209B6 (cs) | 2007-07-25 |
| EP0934276A1 (en) | 1999-08-11 |
| GB9717576D0 (en) | 1997-10-22 |
| DE69726876D1 (de) | 2004-01-29 |
| ID21696A (id) | 1999-07-15 |
| DE69726876T2 (de) | 2004-10-14 |
| TW498074B (en) | 2002-08-11 |
| NO313591B1 (no) | 2002-10-28 |
| PL191150B1 (pl) | 2006-03-31 |
| NO991836D0 (no) | 1999-04-16 |
| NO991836L (no) | 1999-06-17 |
| CA2268403C (en) | 2010-02-09 |
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