DK0910563T3 - Integrinreceptorantagonister - Google Patents
IntegrinreceptorantagonisterInfo
- Publication number
- DK0910563T3 DK0910563T3 DK96923553T DK96923553T DK0910563T3 DK 0910563 T3 DK0910563 T3 DK 0910563T3 DK 96923553 T DK96923553 T DK 96923553T DK 96923553 T DK96923553 T DK 96923553T DK 0910563 T3 DK0910563 T3 DK 0910563T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- cycloalkyl
- het
- cor
- opt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66595P | 1995-06-29 | 1995-06-29 | |
| US278895P | 1995-08-25 | 1995-08-25 | |
| PCT/US1996/011108 WO1997001540A1 (en) | 1995-06-29 | 1996-06-28 | Integrin receptor antagonists |
| NZ299914A NZ299914A (en) | 1995-06-29 | 1996-12-10 | Tricyclic integrin receptor antagonists, preparation and pharmaceutical compositions thereof |
| HU9603432A HU226056B1 (en) | 1995-06-29 | 1996-12-12 | Acetic acid derivatives with dibenzo[a,d]cycloheptene and dibenz[b,e]azepine skeleton, process for their preparation and pharmaceutical compositions containing them |
| CA002192764A CA2192764C (en) | 1995-06-29 | 1996-12-12 | Integrin receptor antagonists |
| AU75461/96A AU736487B2 (en) | 1995-06-29 | 1996-12-19 | Integrin receptor antagonists |
| BR9606200A BR9606200A (pt) | 1995-06-29 | 1996-12-27 | Antagonistas de receptor de integrina |
| NO965607A NO307337B1 (no) | 1995-06-29 | 1996-12-27 | Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0910563T3 true DK0910563T3 (da) | 2003-09-01 |
Family
ID=89994543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96923553T DK0910563T3 (da) | 1995-06-29 | 1996-06-28 | Integrinreceptorantagonister |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0910563B1 (da) |
| JP (1) | JP3960482B2 (da) |
| AT (1) | ATE238996T1 (da) |
| AU (1) | AU736487B2 (da) |
| BR (1) | BR9606200A (da) |
| CA (1) | CA2192764C (da) |
| CZ (1) | CZ292925B6 (da) |
| DE (1) | DE69627899T2 (da) |
| DK (1) | DK0910563T3 (da) |
| ES (1) | ES2197950T3 (da) |
| HK (1) | HK1019594A1 (da) |
| HU (1) | HU226056B1 (da) |
| NO (1) | NO307337B1 (da) |
| NZ (1) | NZ299914A (da) |
| PT (1) | PT910563E (da) |
| SI (1) | SI0910563T1 (da) |
| WO (1) | WO1997001540A1 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030125317A1 (en) | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| DE19653645A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
| US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
| US6218387B1 (en) | 1996-12-20 | 2001-04-17 | Hoechst Aktiengesellschaft | Vitronectin receptor anatagonists, their preparation and their use |
| DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
| CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
| WO1999006049A1 (en) * | 1997-08-04 | 1999-02-11 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| WO1999011626A1 (en) * | 1997-09-04 | 1999-03-11 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| US6576643B2 (en) | 1997-09-19 | 2003-06-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| PE122699A1 (es) * | 1997-09-19 | 2000-02-12 | Smithkline Beecham Corp | Antagonistas de receptores de vitronectina |
| HUP0100397A3 (en) * | 1997-12-17 | 2002-10-28 | Merck & Co Inc | Tetrahydro- or octahydrobenzonaphtyridin and quinolin derivatives, pharmaceutical compositions thereof and process for their preparation |
| JP4064059B2 (ja) | 1998-04-09 | 2008-03-19 | 明治製菓株式会社 | インテグリンαＶβ３拮抗剤としてのアミノピペリジン誘導体 |
| UA71586C2 (en) * | 1998-12-04 | 2004-12-15 | Smithkline Beecham Corp | A vitronectin receptor antagonist |
| US6339083B1 (en) | 1998-12-14 | 2002-01-15 | Bayer Aktiengesellschaft | Multiheterocyclic pharmAceuticals |
| WO2000046215A1 (en) | 1999-02-03 | 2000-08-10 | Merck & Co., Inc. | Benzazepine derivatives as alpha-v integrin receptor antagonists |
| WO2000048603A1 (en) * | 1999-02-17 | 2000-08-24 | Merck & Co., Inc. | DIBENZO-AZEPINE DERIVATIVES AS αV INTEGRIN RECEPTOR ANTAGONISTS |
| DE19916837A1 (de) * | 1999-04-14 | 2000-10-19 | Merck Patent Gmbh | Dibenzoazulenderivate |
| CA2378860A1 (en) | 1999-07-21 | 2001-02-01 | American Home Products Corporation | Bicyclic antagonists selective for the .alpha.v.beta.3 integrin |
| AU6316900A (en) | 1999-08-05 | 2001-03-05 | Meiji Seika Kaisha Ltd. | Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism |
| EP1208101A4 (en) * | 1999-08-06 | 2003-03-19 | Smithkline Beecham Corp | VITRONECTIN RECEPTOR ANTAGONISTS USEFUL FOR THE TREATMENT OF VASCULAR ACCIDENTS |
| DE19936780A1 (de) * | 1999-08-09 | 2001-02-15 | Basf Ag | Neue Antagonisten von Integrinrezeptoren |
| US6514964B1 (en) * | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| DE10039998A1 (de) * | 2000-08-11 | 2002-02-21 | Basf Ag | Neue substituierte Diareno-azepin-Derivate als Integrin Liganden |
| EP1330430A2 (en) * | 2000-08-18 | 2003-07-30 | Genentech, Inc. | Integrin receptor inhibitors |
| WO2002085405A2 (en) | 2001-04-24 | 2002-10-31 | Merck Patent Gmbh | COMBINATION THERAPY USING ANTI-ANGIOGENIC AGENTS AND TNF$g(a) |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| WO2007084670A2 (en) | 2006-01-18 | 2007-07-26 | Merck Patent Gmbh | Specific therapy using integrin ligands for treating cancer |
| PL2101805T3 (pl) | 2007-01-18 | 2013-04-30 | Merck Patent Gmbh | Ligandy integryn do stosowania w leczeniu nowotworów |
| SG176103A1 (en) | 2009-05-25 | 2011-12-29 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
| US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794424A (fr) * | 1972-01-24 | 1973-07-23 | Science Union & Cie | Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament |
| US3972936A (en) * | 1974-02-01 | 1976-08-03 | Merck & Co., Inc. | 10,11-Dihydro-5-(3-amino-propyl-or-propylidene)-10,10,11,11-tetra-fluoro-5H-dibenzo[a,d]cycloheptenes and-5-ols |
| AU612437B2 (en) * | 1987-12-14 | 1991-07-11 | Kyowa Hakko Kogyo Co. Ltd. | Tricyclic compounds |
-
1996
- 1996-06-28 WO PCT/US1996/011108 patent/WO1997001540A1/en active IP Right Grant
- 1996-06-28 DE DE69627899T patent/DE69627899T2/de not_active Expired - Fee Related
- 1996-06-28 DK DK96923553T patent/DK0910563T3/da active
- 1996-06-28 SI SI9630616T patent/SI0910563T1/xx unknown
- 1996-06-28 ES ES96923553T patent/ES2197950T3/es not_active Expired - Lifetime
- 1996-06-28 PT PT96923553T patent/PT910563E/pt unknown
- 1996-06-28 EP EP96923553A patent/EP0910563B1/en not_active Expired - Lifetime
- 1996-06-28 JP JP50460197A patent/JP3960482B2/ja not_active Expired - Fee Related
- 1996-06-28 AT AT96923553T patent/ATE238996T1/de not_active IP Right Cessation
- 1996-12-10 NZ NZ299914A patent/NZ299914A/en unknown
- 1996-12-12 CA CA002192764A patent/CA2192764C/en not_active Expired - Fee Related
- 1996-12-12 HU HU9603432A patent/HU226056B1/hu not_active IP Right Cessation
- 1996-12-13 CZ CZ19963679A patent/CZ292925B6/cs not_active IP Right Cessation
- 1996-12-19 AU AU75461/96A patent/AU736487B2/en not_active Ceased
- 1996-12-27 BR BR9606200A patent/BR9606200A/pt not_active Application Discontinuation
- 1996-12-27 NO NO965607A patent/NO307337B1/no not_active IP Right Cessation
-
1999
- 1999-10-22 HK HK99104723A patent/HK1019594A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO965607L (no) | 1998-06-29 |
| HUP9603432A3 (en) | 1999-05-28 |
| HU226056B1 (en) | 2008-04-28 |
| HUP9603432A2 (hu) | 1998-09-28 |
| CZ292925B6 (cs) | 2004-01-14 |
| EP0910563A1 (en) | 1999-04-28 |
| HK1019594A1 (en) | 2000-02-18 |
| NZ299914A (en) | 1998-04-27 |
| JP3960482B2 (ja) | 2007-08-15 |
| PT910563E (pt) | 2003-09-30 |
| CZ367996A3 (cs) | 1998-08-12 |
| EP0910563A4 (da) | 1999-04-28 |
| SI0910563T1 (en) | 2003-10-31 |
| DE69627899T2 (de) | 2004-05-19 |
| CA2192764C (en) | 2008-03-11 |
| ES2197950T3 (es) | 2004-01-16 |
| NO965607D0 (no) | 1996-12-27 |
| AU7546196A (en) | 1998-06-25 |
| BR9606200A (pt) | 1998-11-03 |
| ATE238996T1 (de) | 2003-05-15 |
| WO1997001540A1 (en) | 1997-01-16 |
| DE69627899D1 (de) | 2003-06-05 |
| CA2192764A1 (en) | 1998-06-12 |
| JPH11508887A (ja) | 1999-08-03 |
| NO307337B1 (no) | 2000-03-20 |
| EP0910563B1 (en) | 2003-05-02 |
| HU9603432D0 (en) | 1997-01-28 |
| AU736487B2 (en) | 2001-07-26 |
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