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DK0888114T3 - Anvendelse af (+)-alfa-(2,3-dimethoxyphenyl)-1-[2-(4-flourphenyl)-ethyl]-4-piperidinmethanol til behandling af depressive lidelser og bipolare lidelser - Google Patents

Anvendelse af (+)-alfa-(2,3-dimethoxyphenyl)-1-[2-(4-flourphenyl)-ethyl]-4-piperidinmethanol til behandling af depressive lidelser og bipolare lidelser

Info

Publication number
DK0888114T3
DK0888114T3 DK97907698T DK97907698T DK0888114T3 DK 0888114 T3 DK0888114 T3 DK 0888114T3 DK 97907698 T DK97907698 T DK 97907698T DK 97907698 T DK97907698 T DK 97907698T DK 0888114 T3 DK0888114 T3 DK 0888114T3
Authority
DK
Denmark
Prior art keywords
disorders
dimethoxyphenyl
fluorophenyl
alpha
ethyl
Prior art date
Application number
DK97907698T
Other languages
English (en)
Inventor
Cesare Mondadori
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0888114T3 publication Critical patent/DK0888114T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97907698T 1996-03-21 1997-02-21 Anvendelse af (+)-alfa-(2,3-dimethoxyphenyl)-1-[2-(4-flourphenyl)-ethyl]-4-piperidinmethanol til behandling af depressive lidelser og bipolare lidelser DK0888114T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96400591A EP0796619A1 (en) 1996-03-21 1996-03-21 Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
PCT/US1997/002597 WO1997034603A1 (en) 1996-03-21 1997-02-21 USE OF (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL IN TREATING DEPRESSIVE DISORDERS AND BIPOLAR DISORDERS

Publications (1)

Publication Number Publication Date
DK0888114T3 true DK0888114T3 (da) 2002-10-07

Family

ID=8225234

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97907698T DK0888114T3 (da) 1996-03-21 1997-02-21 Anvendelse af (+)-alfa-(2,3-dimethoxyphenyl)-1-[2-(4-flourphenyl)-ethyl]-4-piperidinmethanol til behandling af depressive lidelser og bipolare lidelser

Country Status (23)

Country Link
US (2) US6022877A (da)
EP (2) EP0796619A1 (da)
JP (1) JP4165906B2 (da)
KR (1) KR100423018B1 (da)
CN (1) CN1114406C (da)
AR (1) AR006281A1 (da)
AT (1) ATE219672T1 (da)
AU (1) AU704435B2 (da)
BR (1) BR9708109A (da)
CA (1) CA2250077C (da)
DE (1) DE69713571T2 (da)
DK (1) DK0888114T3 (da)
ES (1) ES2175356T3 (da)
HK (1) HK1019702A1 (da)
HU (1) HU226675B1 (da)
IL (1) IL126022A (da)
NO (2) NO316788B1 (da)
NZ (1) NZ331448A (da)
PT (1) PT888114E (da)
SI (1) SI0888114T1 (da)
TW (1) TW517048B (da)
WO (1) WO1997034603A1 (da)
ZA (1) ZA972345B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796619A1 (en) * 1996-03-21 1997-09-24 Merrell Pharmaceuticals Inc. Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US6713627B2 (en) 1998-03-13 2004-03-30 Aventis Pharmaceuticals Inc. Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
TWI249526B (en) * 1998-03-13 2006-02-21 Aventis Pharma Inc Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
KR100682799B1 (ko) * 1998-08-28 2007-02-15 아벤티스 파마슈티칼스 인크. Ｒ(+)-α-(2,3-디메톡시페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올의 수면 장애 치료용 약제학적 조성물
US6277864B1 (en) 1998-08-28 2001-08-21 Aventis Pharmaceuticals Inc. Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
US6939879B2 (en) 1998-08-28 2005-09-06 Aventis Pharmaceuticals Inc. Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia
US20020099076A1 (en) 2000-05-25 2002-07-25 Richard Scheyer D. Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
US20020161026A1 (en) * 2000-11-07 2002-10-31 Paralkar Vishwas M. Combination therapies for the stimulation of bone growth
ES2248231T3 (es) * 2001-01-31 2006-03-16 Pfizer Products Inc. Derivados de eteres utiles como inhibidores de las isozimas pde4.
US8501778B2 (en) 2008-06-20 2013-08-06 Nhwa Pharma. Corporation Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783471A (en) * 1985-07-02 1988-11-08 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine methanol derivatives and the uses thereof
US5169096A (en) * 1985-07-02 1992-12-08 Merrell Dow Pharmaceuticals Inc. N-aralkyl-piperidine-methanol derivatives
US4912117A (en) * 1985-07-02 1990-03-27 Merrell Dow Pharmaceuticals Inc. Novel chemical compounds
US5021428A (en) * 1985-07-02 1991-06-04 Merrell Dow Pharmaceuticals Inc. Novel chemical compounds for the prophylactic treatment of migraine
US4762842A (en) * 1985-10-01 1988-08-09 Eli Lilly And Company Selective method for blocking 5HT2 receptors
US4877798A (en) * 1987-11-23 1989-10-31 Merrell Dow Pharmaceuticals Inc. Treatment of fibromyalgia
JPH02138214A (ja) * 1987-12-10 1990-05-28 Merrell Dow Pharmaceut Inc 不安を治療する方法
ATE102482T1 (de) * 1988-01-21 1994-03-15 Merrell Dow Pharma Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit.
US5064838A (en) * 1988-01-21 1991-11-12 Merrell Dow Pharmaceuticals 1,4-disubstituted-piperidinyl compounds as pain relievers
ZA891901B (en) * 1988-03-17 1989-11-29 Merrell Dow Pharma Method for the treatment of the extrapyramidal side effects associated with neuroleptic therapy
US4902691A (en) * 1988-12-19 1990-02-20 Eli Lilly And Company Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
US5106855A (en) * 1989-12-20 1992-04-21 Merrell Dow Pharmaceuticals Inc. Method for the treatment of glaucoma
DK0531410T3 (da) * 1990-06-01 1995-01-30 Merrell Dow Pharma (+)-alfa-(2,3-Demethoxyphenyl)-1-(2-(4-fluorphenyl)ethyl)-4-piperidinmethanol
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
AU705834B2 (en) * 1995-12-22 1999-06-03 Eli Lilly And Company Method for treating depression
EP0796619A1 (en) * 1996-03-21 1997-09-24 Merrell Pharmaceuticals Inc. Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders

Also Published As

Publication number Publication date
US6380216B1 (en) 2002-04-30
CA2250077C (en) 2003-10-07
IL126022A0 (en) 1999-05-09
AU704435B2 (en) 1999-04-22
SI0888114T1 (en) 2002-10-31
HUP9902135A3 (en) 2001-05-28
EP0888114B1 (en) 2002-06-26
NO984348D0 (no) 1998-09-18
AU1963197A (en) 1997-10-10
CA2250077A1 (en) 1997-09-25
NO20033184L (no) 1998-09-18
WO1997034603A1 (en) 1997-09-25
NZ331448A (en) 2000-06-23
EP0796619A1 (en) 1997-09-24
HK1019702A1 (en) 2000-02-25
DE69713571D1 (de) 2002-08-01
CN1114406C (zh) 2003-07-16
HU226675B1 (en) 2009-06-29
JP4165906B2 (ja) 2008-10-15
DE69713571T2 (de) 2003-02-20
BR9708109A (pt) 1999-07-27
ATE219672T1 (de) 2002-07-15
ZA972345B (en) 1997-09-25
AR006281A1 (es) 1999-08-11
KR20000064711A (ko) 2000-11-06
HUP9902135A2 (hu) 1999-11-29
EP0888114A1 (en) 1999-01-07
IL126022A (en) 2003-11-23
CN1213968A (zh) 1999-04-14
NO984348L (no) 1998-09-18
NO316788B1 (no) 2004-05-10
TW517048B (en) 2003-01-11
KR100423018B1 (ko) 2004-05-17
JP2000506887A (ja) 2000-06-06
NO20033184D0 (no) 2003-07-11
US6022877A (en) 2000-02-08
ES2175356T3 (es) 2002-11-16
PT888114E (pt) 2002-11-29

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