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DK0870014T3 - Katalytiske antistoffer mod aldolase - Google Patents

Katalytiske antistoffer mod aldolase

Info

Publication number
DK0870014T3
DK0870014T3 DK96943772T DK96943772T DK0870014T3 DK 0870014 T3 DK0870014 T3 DK 0870014T3 DK 96943772 T DK96943772 T DK 96943772T DK 96943772 T DK96943772 T DK 96943772T DK 0870014 T3 DK0870014 T3 DK 0870014T3
Authority
DK
Denmark
Prior art keywords
aldolase
antibodies
catalytic
antibody
catalytic antibodies
Prior art date
Application number
DK96943772T
Other languages
English (en)
Inventor
Carlos F Barbas Iii
Richard A Lerner
Juergen Wagner
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0870014T3 publication Critical patent/DK0870014T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK96943772T 1995-12-15 1996-12-16 Katalytiske antistoffer mod aldolase DK0870014T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/573,415 US5733757A (en) 1995-12-15 1995-12-15 Aldolase catalytic antibody
PCT/US1996/020052 WO1997021803A1 (en) 1995-12-15 1996-12-16 Aldolase catalytic antibody

Publications (1)

Publication Number Publication Date
DK0870014T3 true DK0870014T3 (da) 2007-06-11

Family

ID=24291910

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96943772T DK0870014T3 (da) 1995-12-15 1996-12-16 Katalytiske antistoffer mod aldolase

Country Status (12)

Country Link
US (3) US5733757A (da)
EP (1) EP0870014B9 (da)
JP (1) JP3996642B2 (da)
AT (1) ATE354644T1 (da)
AU (1) AU729055B2 (da)
CA (1) CA2239167C (da)
DE (1) DE69636923T2 (da)
DK (1) DK0870014T3 (da)
ES (1) ES2283009T3 (da)
PT (1) PT870014E (da)
SI (1) SI0870014T1 (da)
WO (1) WO1997021803A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326176B1 (en) 1997-12-18 2001-12-04 The Scripps Research Institute Aldol condensations by catalytic antibodies
WO1999031263A1 (en) * 1997-12-18 1999-06-24 The Scripps Research Institute Aldol condensations by catalytic antibodies
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6294374B1 (en) * 1999-10-08 2001-09-25 The Scripps Research Institute Use of catalytic antibodies for synthesizing epothilone
US20040048312A1 (en) * 2002-04-12 2004-03-11 Ronghao Li Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
AU2006235781B2 (en) * 2004-04-27 2008-04-03 Teddy Yeung Man Lo LED illuminated glow stick
WO2006094269A2 (en) 2005-03-03 2006-09-08 Covx Technologies Ireland Limited Anti-angiogenic compounds
JP4897050B2 (ja) 2006-11-10 2012-03-14 コヴェックス・テクノロジーズ・アイルランド・リミテッド 抗血管形成化合物
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
CA2697032C (en) 2007-08-22 2021-09-14 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
US8340951B2 (en) * 2007-12-13 2012-12-25 University Of Washington Synthetic enzymes derived from computational design
JP5731827B2 (ja) 2008-03-03 2015-06-10 グライコフィ， インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
US8293714B2 (en) 2008-05-05 2012-10-23 Covx Technology Ireland, Ltd. Anti-angiogenic compounds
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
AU2010203353B2 (en) 2009-01-12 2016-06-16 Cytomx Therapeutics, Inc Modified antibody compositions, methods of making and using thereof
EP2398494A4 (en) 2009-02-23 2015-10-28 Cytomx Therapeutics Inc Proproteins and their methods of use
CA2751730A1 (en) 2009-02-25 2010-09-02 Merck Sharp & Dohme Corp. Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
KR101930961B1 (ko) 2010-02-24 2018-12-19 머크 샤프 앤드 돔 코포레이션 피키아 파스토리스에서 생산된 치료 당단백질 상의 ｎ-글리코실화 부위 점유를 증가시키는 방법
RU2012157167A (ru) 2010-07-12 2014-08-20 КовЭкс Текнолоджиз Айэлэнд Лимитед Полифункциональные антительные конъюгаты
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
CA2807343C (en) 2010-08-20 2018-05-22 Wyeth Llc Designer osteogenic proteins
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
JP2014500248A (ja) 2010-11-05 2014-01-09 コヴェックス・テクノロジーズ・アイルランド・リミテッド 抗糖尿病化合物
WO2012162561A2 (en) 2011-05-24 2012-11-29 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
WO2013093705A2 (en) 2011-12-20 2013-06-27 Pfizer Inc. Improved processes for preparing peptide conjugates and linkers
CN104066438B (zh) 2011-12-22 2015-09-23 辉瑞公司 抗糖尿病化合物
CA2861137C (en) 2012-02-03 2022-03-22 The Governors Of The University Of Alberta Method of quantifying peptide-derivative libraries using phage display
WO2014144600A2 (en) 2013-03-15 2014-09-18 Viktor Roschke Multivalent and monovalent multispecific complexes and their uses
CN113329769A (zh) * 2018-10-11 2021-08-31 斯克里普斯研究学院 具有反应性精氨酸的抗体化合物及相关的抗体药物缀合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571681A (en) * 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates

Also Published As

Publication number Publication date
SI0870014T1 (sl) 2007-08-31
US5985626A (en) 1999-11-16
JPH11510063A (ja) 1999-09-07
EP0870014B1 (en) 2007-02-21
US6368839B1 (en) 2002-04-09
DE69636923T2 (de) 2007-11-08
PT870014E (pt) 2007-05-31
DE69636923D1 (de) 2007-04-05
AU1292397A (en) 1997-07-03
ATE354644T1 (de) 2007-03-15
CA2239167C (en) 2009-09-22
US5733757A (en) 1998-03-31
JP3996642B2 (ja) 2007-10-24
EP0870014A4 (en) 2002-03-13
EP0870014B9 (en) 2007-10-10
EP0870014A1 (en) 1998-10-14
WO1997021803A1 (en) 1997-06-19
AU729055B2 (en) 2001-01-25
ES2283009T3 (es) 2007-10-16
CA2239167A1 (en) 1997-06-19

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