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DK0830376T3 - Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner - Google Patents

Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner

Info

Publication number
DK0830376T3
DK0830376T3 DK96919753T DK96919753T DK0830376T3 DK 0830376 T3 DK0830376 T3 DK 0830376T3 DK 96919753 T DK96919753 T DK 96919753T DK 96919753 T DK96919753 T DK 96919753T DK 0830376 T3 DK0830376 T3 DK 0830376T3
Authority
DK
Denmark
Prior art keywords
free
host cell
animal proteins
protein
producing erythropoietin
Prior art date
Application number
DK96919753T
Other languages
English (en)
Inventor
Josef Burg
Walter Schneider
Alexander Wrba
Werner Fuerst
Karl-Heinz Sellinger
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of DK0830376T3 publication Critical patent/DK0830376T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96919753T 1995-05-11 1996-05-10 Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner DK0830376T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95107165 1995-05-11
DE19522461 1995-06-21
PCT/EP1996/001988 WO1996035718A1 (de) 1995-05-11 1996-05-10 Verfahren zur herstellung von erythropoietin frei von tierischen proteinen

Publications (1)

Publication Number Publication Date
DK0830376T3 true DK0830376T3 (da) 2004-05-24

Family

ID=26016131

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96919753T DK0830376T3 (da) 1995-05-11 1996-05-10 Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner
DK03016548T DK1394179T3 (da) 1995-05-11 1996-05-10 Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03016548T DK1394179T3 (da) 1995-05-11 1996-05-10 Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner

Country Status (12)

Country Link
US (2) US6399333B1 (da)
EP (2) EP0830376B1 (da)
JP (1) JP3061200B2 (da)
AT (2) ATE334146T1 (da)
AU (1) AU5817496A (da)
CA (1) CA2220515C (da)
DE (2) DE59611371D1 (da)
DK (2) DK0830376T3 (da)
ES (2) ES2268232T3 (da)
IL (2) IL118201A (da)
PT (2) PT830376E (da)
WO (1) WO1996035718A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US6005081A (en) * 1996-11-15 1999-12-21 Genentech, Inc. Purification of recombinant human neurotrophins
TR200000175T2 (tr) * 1997-07-23 2001-01-22 Roche Diagnostics Gmbh Endogenik gen aktivasyonu ile eritropoietinin hazırlanması.
US6548296B1 (en) * 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
AR022358A1 (es) 1997-12-03 2002-09-04 Roche Olivier Una composicion de epo, un procedimiento para su obtencion, un preparado farmaceutico que la contiene y un procedimiento para aumentar la actividadespecifica de una composicion de epo
CN103641885A (zh) 1998-05-06 2014-03-19 基因技术股份有限公司 用离子交换层析纯化蛋白质
BR9917606A (pt) * 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
BR9905868A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
PE20010288A1 (es) 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
BR0116381A (pt) 2000-12-20 2004-02-25 Hoffmann La Roche Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina
AU2002358047A1 (en) * 2001-11-28 2003-06-10 Sandoz Ag Method for producing a recombinant polypeptide
US20050153879A1 (en) * 2002-03-26 2005-07-14 Monica Svetina Process for the preparation of a desired erythropoietin glyco-isoform profile
ATE405644T1 (de) * 2002-12-13 2008-09-15 Bioceuticals Arzneimittel Ag Verfahren zur herstellung und reinigung von erythropoietin
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
AU2003271194A1 (en) * 2003-10-09 2005-04-21 Daewoong Co., Ltd. Process for purifying human thrombopoietin with high content of sialic acid
DE102004027816A1 (de) * 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
US7598356B2 (en) * 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily
CN101061137A (zh) * 2004-11-09 2007-10-24 Usv有限公司 用于纯化人生长激素的新方法
CN1930186A (zh) * 2005-03-03 2007-03-14 阿勒根公司 为获得梭菌毒素的梭菌细菌培养基及方法
SI1957630T2 (sl) 2005-12-08 2023-07-31 Amgen Inc. Izboljšana proizvodnja glikoproteinov z uporabo mangana
KR101304081B1 (ko) 2006-08-04 2013-09-05 프로롱 파마슈티컬스, 엘엘씨 수식된 에리스로포이에틴
WO2008068879A1 (en) * 2006-12-06 2008-06-12 Jcr Pharmaceuticals Co., Ltd. Method for production of human erythropoietin
KR100988706B1 (ko) 2007-03-07 2010-10-18 한미홀딩스 주식회사 재조합 에리트로포이에틴의 신규한 정제방법
AR067536A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
KR100900033B1 (ko) 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
US9938333B2 (en) 2008-02-08 2018-04-10 Ambrx, Inc. Modified leptin polypeptides and their uses
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
JP5632376B2 (ja) 2008-09-23 2014-11-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ エリスロポエチンの精製
NZ601659A (en) 2008-09-26 2014-02-28 Ambrx Inc Modified animal erythropoietin polypeptides and their uses
DE102008054716A1 (de) 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
KR101498772B1 (ko) 2009-07-24 2015-03-04 에프. 호프만-라 로슈 아게 항체 생성의 최적화 방법
AU2010297530B2 (en) 2009-09-23 2013-12-19 Ratiopharm Gmbh Process for the purification of recombinant human erythropoietin (EPO), EPO thus purified and pharmaceutical compositions comprising same
KR101443257B1 (ko) * 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
US10066001B2 (en) 2013-03-15 2018-09-04 Apotex Inc. Enhanced liquid formulation stability of erythropoietin alpha through purification processing
WO2016116966A1 (en) 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
EP3613486B1 (de) * 2018-08-24 2020-10-07 UGA Biopharma GmbH Verfahren und anlage zur reinigung von epo und/oder einem epo-derivat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
IL79176A (en) * 1985-06-20 1992-06-21 Kirin Amgen Inc Process for the recovery of erythropoietin from a fluid
US4954437A (en) * 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
AU4104889A (en) 1988-09-07 1990-03-15 Bioclones (Pty) Ltd Purification of erythropoietin
DE4115722A1 (de) * 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen

Also Published As

Publication number Publication date
PT830376E (pt) 2004-05-31
DE59610898D1 (de) 2004-02-26
PT1394179E (pt) 2006-11-30
AU5817496A (en) 1996-11-29
EP1394179B1 (de) 2006-07-26
ES2268232T3 (es) 2007-03-16
US20020146771A1 (en) 2002-10-10
EP0830376B1 (de) 2004-01-21
ATE334146T1 (de) 2006-08-15
ATE258189T1 (de) 2004-02-15
DK1394179T3 (da) 2006-11-20
EP1394179A1 (de) 2004-03-03
ES2211961T3 (es) 2004-07-16
JP3061200B2 (ja) 2000-07-10
WO1996035718A1 (de) 1996-11-14
CA2220515A1 (en) 1996-11-14
DE59611371D1 (de) 2006-09-07
US6471500B1 (en) 2002-10-29
IL118201A (en) 2004-12-15
IL118201A0 (en) 1996-09-12
EP0830376A1 (de) 1998-03-25
US6399333B1 (en) 2002-06-04
IL157644A0 (en) 2004-03-28
JPH10506924A (ja) 1998-07-07
CA2220515C (en) 2003-07-22

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