DK0817626T3 - Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner - Google Patents

Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner

Info

Publication number: DK0817626T3
Authority: DK; Denmark
Prior art keywords: fumagillol; drugs; derivatives; manufacture; intestinal infections
Prior art date: 1995-03-27

Application number

DK96909200T

Other languages

English (en)

Inventor

Jean-Michel Molina

Francis Derouin

Original Assignee

Assist Publ Hopitaux De Paris

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1996-03-26

Publication date

1999-07-12

1996-03-26 Application filed by Assist Publ Hopitaux De Paris, Sanofi Synthelabo filed Critical Assist Publ Hopitaux De Paris

1999-07-12 Application granted granted Critical

1999-07-12 Publication of DK0817626T3 publication Critical patent/DK0817626T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK96909200T 1995-03-27 1996-03-26 Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner DK0817626T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9503549		1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr)	1995-03-27	1996-03-26	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (1)

Publication Number	Publication Date
DK0817626T3 true DK0817626T3 (da)	1999-07-12

Family

ID=9477436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96909200T DK0817626T3 (da)	1995-03-27	1996-03-26	Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner

Country Status (25)

Country	Link
US (1)	US5900431A (da)
EP (1)	EP0817626B1 (da)
JP (1)	JP3260378B2 (da)
KR (1)	KR100286920B1 (da)
CN (1)	CN1072485C (da)
AP (1)	AP646A (da)
AT (1)	ATE172641T1 (da)
AU (1)	AU706161B2 (da)
CA (1)	CA2216623C (da)
CZ (1)	CZ286821B6 (da)
DE (1)	DE69600879T2 (da)
DK (1)	DK0817626T3 (da)
EA (1)	EA000150B1 (da)
ES (1)	ES2128846T3 (da)
FR (1)	FR06C0014I2 (da)
HU (1)	HU224028B1 (da)
IS (1)	IS2048B (da)
NO (1)	NO315968B1 (da)
NZ (1)	NZ304906A (da)
OA (1)	OA10515A (da)
PL (1)	PL183378B1 (da)
SK (1)	SK283883B6 (da)
TR (1)	TR199701048T1 (da)
UA (1)	UA41446C2 (da)
WO (1)	WO1996030010A2 (da)

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WO1996030010A2 (fr) *	1995-03-27	1996-10-03	Sanofi	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
ATE361757T1 (de) *	1999-02-26	2007-06-15	Sanofi Aventis	Stabile fumagillin-formulierung
JP3265394B1 (ja) *	2001-03-14	2002-03-11	泰三矢野	アクリル系樹脂手袋
DE10341887A1 (de) *	2003-09-09	2005-03-31	Leopold Kostal Gmbh & Co. Kg	Elektrisches Schaltermodul
FR2886855B1 (fr) *	2005-06-08	2009-07-17	Agronomique Inst Nat Rech	Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
CN101990441A (zh) *	2007-11-28	2011-03-23	默萨那治疗学股份有限公司	生物相容的生物可降解的烟曲霉素类似物轭合物
CN102123586A (zh) *	2008-07-18	2011-07-13	法弗根股份有限公司	治疗超重或肥胖受试者的方法
WO2010065883A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Method of treating an overweight or obese subject
WO2013055385A2 (en)	2011-10-03	2013-04-18	Zafgen Corporation	Methods of treating age related disorders
US20120004162A1 (en)	2008-12-04	2012-01-05	Vath James E	Methods of Treating an Overweight or Obese Subject
AU2010303270A1 (en)	2009-10-09	2012-05-03	Zafgen Corporation	Sulphone compounds for use in the treatment of obesity
WO2011085198A1 (en)	2010-01-08	2011-07-14	Zafgen Corporation	Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
US8772333B2 (en)	2010-01-08	2014-07-08	Zafgen, Inc.	Fumigillol type compounds and methods of making and using same
US20130266578A1 (en)	2010-04-07	2013-10-10	Thomas E. Hughes	Methods of treating an overweight subject
US9266896B2 (en)	2010-07-22	2016-02-23	Zafgen, Inc.	Tricyclic compounds and methods of making and using same
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
JP2013543899A (ja)	2010-11-29	2013-12-09	ザフゲン，インコーポレイテッド	６−ｏ−（４−ジメチルアミノエトキシ）シンナモイルフマギロールの非連日投与を用いた肥満の治療
US9321740B2 (en)	2011-01-26	2016-04-26	Zafgen, Inc.	Tetrazole compounds and methods of making and using same
JP5876513B2 (ja)	2011-03-08	2016-03-02	ザフゲン，インコーポレイテッド	オキサスピロ［２．５］オクタン誘導体および類似体
US9290472B2 (en)	2011-05-06	2016-03-22	Zafgen, Inc.	Partially saturated tricyclic compounds and methods of making and using same
CA2835209A1 (en)	2011-05-06	2012-11-15	Zafgen, Inc.	Tricyclic pyrazole sulfonamide compounds and methods of making and using same
EP2705036B1 (en)	2011-05-06	2015-08-12	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
MX2014008705A (es)	2012-01-18	2015-02-05	Zafgen Inc	Compuestos tricíclicos de sulfona y métodos para elaborarlos y utilizarlos.
AU2013209723B2 (en)	2012-01-18	2016-11-24	Zafgen, Inc.	Tricyclic sulfonamide compounds and methods of making and using same
WO2013169727A1 (en)	2012-05-07	2013-11-14	Zafgen, Inc.	Polymorphic salt of the oxalate salt of 6 - o - ( 4 - dimethylaminoethoxy) cinnarnoyl fumagillol and methods of making and using same
US9839622B2 (en)	2012-05-08	2017-12-12	Zafgen, Inc.	Methods of treating hypothalamic obesity
CA2873574A1 (en)	2012-05-09	2013-11-14	Zafgen, Inc.	Fumagillol type compounds and methods of making and using same
WO2014071368A1 (en)	2012-11-05	2014-05-08	Zafgen, Inc.	Methods of treating liver diseases
BR112015010223A2 (pt)	2012-11-05	2017-07-11	Zafgen Inc	compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
CA2890342A1 (en)	2012-11-05	2014-05-08	Zafgen, Inc.	Tricyclic compounds and methods of making and using same
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
AR105671A1 (es)	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
CN106591389B (zh) *	2015-10-15	2019-10-11	中国科学院微生物研究所	一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) *	2016-02-25	2018-06-26	中国农业科学院蜜蜂研究所	一种烟曲霉素的提取方法

Family Cites Families (9)

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Publication number	Priority date	Publication date	Assignee	Title
US2791530A (en) *	1953-08-31	1957-05-07	Abbott Lab	Stabilized fumagillin compositions
JPH0629278B2 (ja) *	1985-06-26	1994-04-20	藤沢薬品工業株式会社	オキサスピロオクタン化合物
US5135920A (en) *	1988-11-16	1992-08-04	Takeda Chemical Industries, Ltd.	Angiostatic agents
CA2082804A1 (en) *	1990-07-27	1992-01-28	Theodore Maione	Methods and compositions for treatment of angiogenic diseases
US5328930A (en) *	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
WO1996030010A2 (fr) *	1995-03-27	1996-10-03	Sanofi	Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales
EP0799616A1 (en) *	1996-04-01	1997-10-08	Takeda Chemical Industries, Ltd.	Oral composition comprising a fumagillol derivative
CA2210600A1 (en) *	1996-07-17	1998-01-17	Takashi Houkan	Inhibitor of tumor metastasis or recurrence
WO1998005293A2 (en) *	1996-08-02	1998-02-12	The Children's Medical Center Corporation	Method of regulating the female reproductive system through angiogenesis inhibitors

1996
- 1996-03-26 WO PCT/FR1996/000448 patent/WO1996030010A2/fr active IP Right Grant
- 1996-03-26 DK DK96909200T patent/DK0817626T3/da active
- 1996-03-26 AP APAP/P/1997/001092A patent/AP646A/en active
- 1996-03-26 PL PL96322470A patent/PL183378B1/pl unknown
- 1996-03-26 DE DE69600879T patent/DE69600879T2/de not_active Expired - Lifetime
- 1996-03-26 CA CA002216623A patent/CA2216623C/en not_active Expired - Lifetime
- 1996-03-26 CN CN96192923A patent/CN1072485C/zh not_active Expired - Lifetime
- 1996-03-26 CZ CZ19973049A patent/CZ286821B6/cs not_active IP Right Cessation
- 1996-03-26 NZ NZ304906A patent/NZ304906A/xx not_active IP Right Cessation
- 1996-03-26 TR TR97/01048T patent/TR199701048T1/xx unknown
- 1996-03-26 AU AU52786/96A patent/AU706161B2/en not_active Expired
- 1996-03-26 AT AT96909200T patent/ATE172641T1/de active
- 1996-03-26 HU HU9801220A patent/HU224028B1/hu active IP Right Grant
- 1996-03-26 UA UA97094765A patent/UA41446C2/uk unknown
- 1996-03-26 JP JP52900196A patent/JP3260378B2/ja not_active Expired - Lifetime
- 1996-03-26 ES ES96909200T patent/ES2128846T3/es not_active Expired - Lifetime
- 1996-03-26 EA EA199700267A patent/EA000150B1/ru not_active IP Right Cessation
- 1996-03-26 EP EP96909200A patent/EP0817626B1/fr not_active Expired - Lifetime
- 1996-03-26 SK SK1307-97A patent/SK283883B6/sk not_active IP Right Cessation
- 1996-03-26 KR KR1019970706675A patent/KR100286920B1/ko not_active IP Right Cessation
- 1996-03-26 US US08/913,360 patent/US5900431A/en not_active Expired - Lifetime
1997
- 1997-09-11 IS IS4557A patent/IS2048B/is unknown
- 1997-09-26 OA OA70088A patent/OA10515A/fr unknown
- 1997-09-26 NO NO19974466A patent/NO315968B1/no not_active IP Right Cessation
2006
- 2006-04-04 FR FR06C0014C patent/FR06C0014I2/fr active Active

Also Published As

Publication number	Publication date
CN1072485C (zh)	2001-10-10
TR199701048T1 (xx)	1998-01-21
WO1996030010A2 (fr)	1996-10-03
NO315968B1 (no)	2003-11-24
CA2216623A1 (en)	1996-10-03
EP0817626A2 (fr)	1998-01-14
SK283883B6 (sk)	2004-04-06
FR06C0014I1 (da)	2006-11-17
KR19980703271A (ko)	1998-10-15
ES2128846T3 (es)	1999-05-16
EA199700267A1 (ru)	1998-04-30
AU5278696A (en)	1996-10-16
AP9701092A0 (en)	1997-10-31
CZ286821B6 (en)	2000-07-12
AU706161B2 (en)	1999-06-10
UA41446C2 (uk)	2001-09-17
AP646A (en)	1998-04-27
CA2216623C (en)	2005-05-31
JP3260378B2 (ja)	2002-02-25
OA10515A (fr)	2002-04-24
IS4557A (is)	1997-09-11
HUP9801220A3 (en)	2001-10-29
MX9707150A (es)	1998-07-31
DE69600879D1 (de)	1998-12-03
NZ304906A (en)	1999-06-29
PL322470A1 (en)	1998-02-02
EA000150B1 (ru)	1998-10-29
HUP9801220A2 (hu)	1999-09-28
CN1179715A (zh)	1998-04-22
DE69600879T2 (de)	1999-06-02
HU224028B1 (hu)	2005-05-30
EP0817626B1 (fr)	1998-10-28
CZ304997A3 (en)	1997-12-17
ATE172641T1 (de)	1998-11-15
WO1996030010A3 (fr)	1996-11-28
NO974466D0 (no)	1997-09-26
US5900431A (en)	1999-05-04
IS2048B (is)	2005-09-15
PL183378B1 (pl)	2002-06-28
JPH11506421A (ja)	1999-06-08
SK130797A3 (en)	1998-03-04
NO974466L (no)	1997-09-26
FR06C0014I2 (da)	2006-12-29
KR100286920B1 (ko)	2001-04-16

Publication	Publication Date	Title
DK0817626T3 (da)	1999-07-12	Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner
DK1167364T3 (da)	2003-08-11	Benzopyranholdige forbindelser og promedikamentformer af disse
ATE187063T1 (de)	1999-12-15	Arzneimittel
NO305833B1 (no)	1999-08-02	Naftylforbindelser, mellomprodukter og anvendelse av forbindelsene
DK0876392T3 (da)	2000-11-06	Lacton-derivater af 17.beta.-carboxy, carbothio og amidandrostanforbindelser
NO962606L (no)	1996-12-23	Farmasöytisk sammensetning
PT892640E (pt)	2004-06-30	Composicoes farmaceuticas de micofenolato entericamente revestidas
FI973243A0 (fi)	1997-08-06	Uusi farmaseuttinen yhdistelmä
ATE367150T1 (de)	2007-08-15	Arzneimittel
NO20011157L (no)	2001-04-25	Benzenderivater og farmasöytisk anvendelse derav
ATE223707T1 (de)	2002-09-15	Mehrphasige weichgelatine darreichungsform
NO962231D0 (no)	1996-05-31	Prolegemidler av paclitaxelderivater
NO983678D0 (no)	1998-08-11	Nye cefemforbindelser og farmasöytiske anvendelser derav
NO992724D0 (no)	1999-06-04	Farmas°ytiske blandinger inneholdende N-sulfonyl-indolin-derivater
DE69529848D1 (de)	2003-04-10	Elektronisches medizinalthermometer
PT850048E (pt)	2004-09-30	Granulos farmaceuticos
FI921877L (fi)	1992-10-30	Farmaceutiska foereningar
MX9204370A (es)	1993-03-01	Derivados de pirazol.
NO980471D0 (no)	1998-02-03	Benzensulfonamidderivater, fremstilling derav og terapautiske anvendelser derav
BR9609723A (pt)	1999-03-16	Derivados da tricetona
DK0869952T3 (da)	2002-01-21	Derivater af 5-naphthalen-1-yl-1,3-dioxaner, fremstilling og terapeutisk anvendelse heraf
NO965448L (no)	1997-06-20	Farmasöytiske forbindelser
BR9605777A (pt)	1998-08-25	Composição farmacêutica
NO911298L (no)	1991-10-04	Farmasoeytisk preparat og anvendelse derav.
NO964309D0 (no)	1996-10-10	Farmasöytisk sammensetning