[go: up one dir, main page]

DK0805790T3 - Forbedret syntese af cyclopropylacetylen - Google Patents

Forbedret syntese af cyclopropylacetylen

Info

Publication number
DK0805790T3
DK0805790T3 DK96902153T DK96902153T DK0805790T3 DK 0805790 T3 DK0805790 T3 DK 0805790T3 DK 96902153 T DK96902153 T DK 96902153T DK 96902153 T DK96902153 T DK 96902153T DK 0805790 T3 DK0805790 T3 DK 0805790T3
Authority
DK
Denmark
Prior art keywords
cyclopropylacetylene
improved synthesis
synthesis
improved
Prior art date
Application number
DK96902153T
Other languages
English (en)
Inventor
Andrew S Thompson
Edward G Corley
Martha Huntington
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0805790T3 publication Critical patent/DK0805790T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK96902153T 1995-01-23 1996-01-19 Forbedret syntese af cyclopropylacetylen DK0805790T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/376,611 US5663467A (en) 1995-01-23 1995-01-23 Synthesis of cyclopropylacetylene
PCT/US1996/000628 WO1996022955A1 (en) 1995-01-23 1996-01-19 Improved synthesis of cyclopropylacetylene

Publications (1)

Publication Number Publication Date
DK0805790T3 true DK0805790T3 (da) 2000-05-01

Family

ID=23485719

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96902153T DK0805790T3 (da) 1995-01-23 1996-01-19 Forbedret syntese af cyclopropylacetylen

Country Status (23)

Country Link
US (1) US5663467A (da)
EP (1) EP0805790B1 (da)
JP (1) JP3107829B2 (da)
KR (1) KR19980701577A (da)
CN (1) CN1056824C (da)
AR (1) AR000771A1 (da)
AT (1) ATE186903T1 (da)
AU (1) AU692674B2 (da)
BR (1) BR9606782A (da)
CA (1) CA2210577A1 (da)
CZ (1) CZ234997A3 (da)
DE (1) DE69605282T2 (da)
DK (1) DK0805790T3 (da)
EA (1) EA000074B1 (da)
ES (1) ES2140062T3 (da)
FI (1) FI973086A0 (da)
GR (1) GR3032200T3 (da)
HR (1) HRP960029B1 (da)
HU (1) HUP9800849A3 (da)
NZ (1) NZ301206A (da)
SK (1) SK99997A3 (da)
WO (1) WO1996022955A1 (da)
YU (1) YU3696A (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3736197A (en) * 1996-07-26 1998-02-20 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
US6028237A (en) * 1996-12-16 2000-02-22 Dupont Pharmaceuticals Company Synthesis of cyclopropylacetylene
ZA9711256B (en) 1996-12-16 1999-06-15 Du Pont Merck Pharma Asymmetric synthesis of benzoxazinones
US5955627A (en) * 1996-12-16 1999-09-21 Kuraray Co., Ltd. Process for the preparation of cyclopropylacetylene derivatives
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
EP0975609B1 (en) * 1997-02-05 2010-10-27 Merck Sharp & Dohme Corp. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
JP2001514636A (ja) 1997-03-07 2001-09-11 ビーエーエスエフ アクチェンゲゼルシャフト シクロプロピルアセチレンを製造するための改善法
JP2001519810A (ja) * 1997-04-07 2001-10-23 デュポン ファーマシューティカルズ カンパニー 新規中間体を経由するベンゾオキサジノン類の不斉合成
AR011731A1 (es) * 1997-05-16 2000-08-30 Merck & Co Inc Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc.
PL338455A1 (en) * 1997-07-31 2000-11-06 Du Pont Pharm Co Metho dof obtaining cyclopropyl acetylene
AU738790B2 (en) * 1997-08-06 2001-09-27 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
US6072094A (en) * 1997-08-06 2000-06-06 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
ATE212961T1 (de) * 1997-12-10 2002-02-15 Lonza Ag Verfahren zur herstellung von ethinylcyclopropan
KR100350752B1 (ko) * 1998-02-06 2002-08-28 가부시키가이샤 구라레 시클로프로필아세틸렌 유도체의 제조방법
US5952537A (en) 1998-03-13 1999-09-14 Wiley Organics, Inc. Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium
UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
AU6281199A (en) 1998-10-01 2000-04-17 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
GB2355988A (en) 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
GB2355724A (en) * 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU578293A1 (ru) * 1972-02-04 1977-10-30 Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср Способ получени циклопропилацетилена
SU555079A1 (ru) * 1976-01-30 1977-04-25 Институт органической химии им.Н.Д.Зелинского АН СССР Способ получени циклопропилацетилена
SU572445A1 (ru) * 1976-04-05 1977-09-15 Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср Способ получени циклопропилацетилена

Also Published As

Publication number Publication date
HRP960029B1 (en) 2000-12-31
FI973086L (fi) 1997-07-22
EA000074B1 (ru) 1998-06-25
EP0805790B1 (en) 1999-11-24
CN1169137A (zh) 1997-12-31
CZ234997A3 (cs) 1998-02-18
MX9705562A (es) 1997-10-31
HUP9800849A2 (hu) 1999-01-28
FI973086A0 (fi) 1997-07-22
HUP9800849A3 (en) 2001-01-29
EP0805790A1 (en) 1997-11-12
SK99997A3 (en) 1998-05-06
GR3032200T3 (en) 2000-04-27
AU692674B2 (en) 1998-06-11
AR000771A1 (es) 1997-08-06
KR19980701577A (ko) 1998-05-15
ATE186903T1 (de) 1999-12-15
DE69605282D1 (en) 1999-12-30
CA2210577A1 (en) 1996-08-01
AU4657496A (en) 1996-08-14
YU3696A (sh) 1998-11-05
HRP960029A2 (en) 1997-08-31
JPH10512880A (ja) 1998-12-08
JP3107829B2 (ja) 2000-11-13
NZ301206A (en) 1998-11-25
US5663467A (en) 1997-09-02
DE69605282T2 (de) 2000-07-13
WO1996022955A1 (en) 1996-08-01
BR9606782A (pt) 1997-12-30
EA199700139A1 (ru) 1997-12-30
ES2140062T3 (es) 2000-02-16
CN1056824C (zh) 2000-09-27

Similar Documents

Publication Publication Date Title
DK0805790T3 (da) Forbedret syntese af cyclopropylacetylen
NO20001950D0 (no) Syntese av SAPO-44
NO982850D0 (no) Ny syntese
LV11178A (lv) 3-Ú4-(2-aminoetoksi) benzoil¾-2-aril-6-hidroksibenzoÚb¾tiofenu sintezes panemiens
DK0882071T3 (da) Syntese af forgrenede polymerer
DE69620399D1 (de) Sprachsynthese
NO974701D0 (no) Syntese av tale-bölgeformer
DK1445259T3 (da) Anvendelse af krystalformer for 2-methyl-thieno-benzodiazepin
MX199501B (es) Sintesis asimetrica de (-)6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona
FI973591A0 (fi) Nya syntetiserade kryptofysiner
NO20005187L (no) Én-sats syntese av 2-oksazolidinonderivater
FI945705L (fi) Bisindolyylimaleimidien parannettu synteesi
NO990832D0 (no) Syntese av bisendolylmalimider
DE69603578D1 (de) Synthese von tetrafluorethylen
BR9708718A (pt) Sínteses de aminas substituídas
DK0996646T3 (da) Syntese af forgrenet polyolefin
FI953319A0 (fi) Dimetyylinaftaleenin valmistus
EP0901495A4 (en) SYNTHESIS OF FLUOROPHENYL-BORANES
DE69613921D1 (de) Herstellung von Methylaminen
FI98053B (fi) Sekoitus
DK89195A (da) Fremstilling af trommestik
PT761766E (pt) Compostos assimetricos de trifenilenodioxazina
KR970041939U (ko) 부품의 방진체결구조
KR970011853U (ko) 새로운 형태의 메리야스
KR970014177U (ko) 스냅링의 구조