DK0732332T3 - Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf - Google Patents
Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling derafInfo
- Publication number
- DK0732332T3 DK0732332T3 DK96103772T DK96103772T DK0732332T3 DK 0732332 T3 DK0732332 T3 DK 0732332T3 DK 96103772 T DK96103772 T DK 96103772T DK 96103772 T DK96103772 T DK 96103772T DK 0732332 T3 DK0732332 T3 DK 0732332T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- alkylcarbonyl
- hydroxy
- integer
- benzothienylpiperazines
- Prior art date
Links
- FYKGUURZJVYPQE-UHFFFAOYSA-N 1-(1-benzothiophen-2-yl)piperazine Chemical class C1CNCCN1C1=CC2=CC=CC=C2S1 FYKGUURZJVYPQE-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- -1 benzothienylcarbonyl Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41381895A | 1995-03-17 | 1995-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0732332T3 true DK0732332T3 (da) | 2002-04-15 |
Family
ID=23638775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96103772T DK0732332T3 (da) | 1995-03-17 | 1996-03-11 | Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5801176A (da) |
| EP (1) | EP0732332B1 (da) |
| JP (1) | JPH093060A (da) |
| KR (1) | KR100402510B1 (da) |
| CN (1) | CN1082959C (da) |
| AT (1) | ATE211137T1 (da) |
| AU (1) | AU700077B2 (da) |
| CA (1) | CA2171695A1 (da) |
| CZ (1) | CZ80496A3 (da) |
| DE (1) | DE69618050T2 (da) |
| DK (1) | DK0732332T3 (da) |
| ES (1) | ES2170177T3 (da) |
| HU (1) | HUP9600665A3 (da) |
| IL (1) | IL117519A (da) |
| NO (1) | NO315652B1 (da) |
| NZ (1) | NZ286186A (da) |
| PL (1) | PL182310B1 (da) |
| PT (1) | PT732332E (da) |
| RO (1) | RO117453B1 (da) |
| RU (1) | RU2157371C2 (da) |
| SG (1) | SG54269A1 (da) |
| TW (1) | TW328957B (da) |
| ZA (1) | ZA962075B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703083A (en) * | 1996-04-15 | 1997-12-30 | Neurogen Corporation | N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands |
| US6642228B1 (en) | 1999-06-24 | 2003-11-04 | Toray Industries, Inc. | α1b-adrenergic receptor antagonists |
| GB0117531D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands |
| DE60216753T2 (de) * | 2001-02-16 | 2008-01-03 | Aventis Pharmaceuticals Inc. | Heterocyclische harnstoffderivate und deren verwendung als dopamine d3 receptor liganden |
| IL157412A0 (en) * | 2001-02-16 | 2004-03-28 | Aventis Pharmaceuticals Inc Av | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
| WO2002078669A1 (fr) * | 2001-03-30 | 2002-10-10 | Takeda Chemical Industries, Ltd. | Solutions medicinales |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| TWI329641B (en) | 2005-08-31 | 2010-09-01 | Otsuka Pharma Co Ltd | (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same |
| CN105985314A (zh) * | 2015-02-05 | 2016-10-05 | 苏州旺山旺水生物医药有限公司 | 布瑞哌唑类似物的制备方法 |
| US20220213079A1 (en) * | 2019-12-24 | 2022-07-07 | Sumitomo Dainippon Pharma Co., Ltd. | Aliphatic acid amide derivative |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK169601B1 (da) * | 1983-10-17 | 1994-12-19 | Duphar Int Res | Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse |
| EP0316723B1 (en) * | 1987-11-20 | 1992-09-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments |
| US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US4968792A (en) * | 1989-09-25 | 1990-11-06 | American Home Products Corporation | Psychotropic benzisothiazole derivatives |
| US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
| GB9302622D0 (en) * | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
| GB9410031D0 (en) * | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1996
- 1996-03-11 EP EP96103772A patent/EP0732332B1/en not_active Expired - Lifetime
- 1996-03-11 ES ES96103772T patent/ES2170177T3/es not_active Expired - Lifetime
- 1996-03-11 DE DE69618050T patent/DE69618050T2/de not_active Expired - Fee Related
- 1996-03-11 AT AT96103772T patent/ATE211137T1/de not_active IP Right Cessation
- 1996-03-11 PT PT96103772T patent/PT732332E/pt unknown
- 1996-03-11 DK DK96103772T patent/DK0732332T3/da active
- 1996-03-12 SG SG1996006846A patent/SG54269A1/en unknown
- 1996-03-13 CA CA002171695A patent/CA2171695A1/en not_active Abandoned
- 1996-03-14 HU HU9600665A patent/HUP9600665A3/hu unknown
- 1996-03-14 PL PL96313251A patent/PL182310B1/pl unknown
- 1996-03-14 AU AU48113/96A patent/AU700077B2/en not_active Ceased
- 1996-03-14 ZA ZA9602075A patent/ZA962075B/xx unknown
- 1996-03-15 NZ NZ286186A patent/NZ286186A/en unknown
- 1996-03-15 CN CN96103608A patent/CN1082959C/zh not_active Expired - Fee Related
- 1996-03-15 RU RU96104547/04A patent/RU2157371C2/ru not_active IP Right Cessation
- 1996-03-15 JP JP8058707A patent/JPH093060A/ja not_active Abandoned
- 1996-03-15 NO NO19961077A patent/NO315652B1/no not_active IP Right Cessation
- 1996-03-15 RO RO96-00568A patent/RO117453B1/ro unknown
- 1996-03-15 CZ CZ96804A patent/CZ80496A3/cs unknown
- 1996-03-16 KR KR1019960007100A patent/KR100402510B1/ko not_active IP Right Cessation
- 1996-03-17 IL IL11751996A patent/IL117519A/xx not_active IP Right Cessation
- 1996-05-15 TW TW085105712A patent/TW328957B/zh active
-
1997
- 1997-06-06 US US08/870,988 patent/US5801176A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL117519A0 (en) | 1996-07-23 |
| NO961077D0 (no) | 1996-03-15 |
| NZ286186A (en) | 1997-07-27 |
| PL313251A1 (en) | 1996-09-30 |
| PL182310B1 (pl) | 2001-12-31 |
| AU4811396A (en) | 1996-09-26 |
| HUP9600665A2 (en) | 1997-10-28 |
| TW328957B (en) | 1998-04-01 |
| CA2171695A1 (en) | 1996-09-18 |
| KR960034201A (ko) | 1996-10-22 |
| EP0732332A1 (en) | 1996-09-18 |
| RO117453B1 (ro) | 2002-03-29 |
| RU2157371C2 (ru) | 2000-10-10 |
| PT732332E (pt) | 2002-06-28 |
| IL117519A (en) | 2000-08-31 |
| AU700077B2 (en) | 1998-12-17 |
| CN1139108A (zh) | 1997-01-01 |
| DE69618050D1 (de) | 2002-01-31 |
| DE69618050T2 (de) | 2002-07-11 |
| SG54269A1 (en) | 1998-11-16 |
| JPH093060A (ja) | 1997-01-07 |
| ZA962075B (en) | 1997-12-31 |
| HUP9600665A3 (en) | 1998-08-28 |
| ES2170177T3 (es) | 2002-08-01 |
| NO961077L (no) | 1996-09-18 |
| KR100402510B1 (ko) | 2004-03-18 |
| EP0732332B1 (en) | 2001-12-19 |
| CZ80496A3 (en) | 1996-10-16 |
| CN1082959C (zh) | 2002-04-17 |
| NO315652B1 (no) | 2003-10-06 |
| US5801176A (en) | 1998-09-01 |
| ATE211137T1 (de) | 2002-01-15 |
| HU9600665D0 (en) | 1996-05-28 |
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