DK0717731T3 - Antivirale difluorstatonanaloge - Google Patents
Antivirale difluorstatonanalogeInfo
- Publication number
- DK0717731T3 DK0717731T3 DK94925816T DK94925816T DK0717731T3 DK 0717731 T3 DK0717731 T3 DK 0717731T3 DK 94925816 T DK94925816 T DK 94925816T DK 94925816 T DK94925816 T DK 94925816T DK 0717731 T3 DK0717731 T3 DK 0717731T3
- Authority
- DK
- Denmark
- Prior art keywords
- antiviral
- difluorostatone
- analogues
- statone
- novel
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402194 | 1993-09-09 | ||
PCT/US1994/009053 WO1995007257A1 (en) | 1993-09-09 | 1994-08-10 | Difluoro statone antiviral analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0717731T3 true DK0717731T3 (da) | 1999-11-01 |
Family
ID=8214747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94925816T DK0717731T3 (da) | 1993-09-09 | 1994-08-10 | Antivirale difluorstatonanaloge |
Country Status (20)
Country | Link |
---|---|
US (2) | US5831094A (da) |
EP (1) | EP0717731B1 (da) |
JP (1) | JPH09502437A (da) |
KR (1) | KR100308839B1 (da) |
CN (1) | CN1130898A (da) |
AT (1) | ATE179167T1 (da) |
AU (1) | AU683927B2 (da) |
CA (1) | CA2170607C (da) |
DE (1) | DE69418050T2 (da) |
DK (1) | DK0717731T3 (da) |
ES (1) | ES2133573T3 (da) |
FI (1) | FI961105A0 (da) |
GR (1) | GR3030352T3 (da) |
HU (1) | HUT74569A (da) |
IL (1) | IL110865A (da) |
NO (1) | NO960849D0 (da) |
NZ (1) | NZ271825A (da) |
TW (1) | TW282449B (da) |
WO (1) | WO1995007257A1 (da) |
ZA (1) | ZA946815B (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
CN1343219A (zh) * | 1999-01-28 | 2002-04-03 | 中外制药株式会社 | 取代的苯乙基胺衍生物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5066643A (en) * | 1985-02-19 | 1991-11-19 | Sandoz Ltd. | Fluorine and chlorine statine or statone containing peptides and method of use |
CH672792A5 (da) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
WO1986006379A1 (en) * | 1985-04-19 | 1986-11-06 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
GB8619182D0 (en) * | 1986-08-06 | 1986-09-17 | Sandoz Ltd | Peptides & derivatives |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
BE1002213A5 (fr) * | 1987-04-23 | 1990-10-16 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments. |
GB2212158A (en) * | 1987-12-15 | 1989-07-19 | Sandoz Ltd | Trialkylsilymethyl-substituted peptides; renin inhibitors |
WO1990000399A1 (en) * | 1988-07-08 | 1990-01-25 | Smithkline Beckman Corporation | Retroviral protease binding peptides |
IL90872A0 (en) * | 1988-07-08 | 1990-02-09 | Smithkline Beckman Corp | Retroviral protease binding peptides |
CA2010531A1 (en) * | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
US5151438A (en) * | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
DE69122266T2 (de) * | 1991-01-02 | 1997-03-27 | Merrell Pharmaceuticals Inc. (N.D.Ges.D. Staates Delaware), Cincinnati, Ohio | Antivirale verbindungen |
KR100220876B1 (ko) * | 1991-01-02 | 1999-10-01 | 슈테펜엘.네스비트 | 항 바이러스 화합물 |
BR9306138A (pt) * | 1992-03-25 | 1998-06-23 | Pfizer | Peptídeos antivirais |
GB9210744D0 (en) * | 1992-05-20 | 1992-07-08 | Pfizer Ltd | Antiviral peptides |
CA2136312A1 (en) * | 1992-05-21 | 1993-11-25 | Michael Clare | Retroviral protease inhibitors |
WO1995001958A1 (en) * | 1993-07-08 | 1995-01-19 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
HUT76648A (en) * | 1994-07-15 | 1997-10-28 | Merrell Pharma Inc | Difluorostatone, pharmaceutical compositions containing them and process for producing them |
-
1994
- 1994-08-10 AU AU75606/94A patent/AU683927B2/en not_active Ceased
- 1994-08-10 HU HU9600601A patent/HUT74569A/hu unknown
- 1994-08-10 CN CN94193321A patent/CN1130898A/zh active Pending
- 1994-08-10 DE DE69418050T patent/DE69418050T2/de not_active Expired - Fee Related
- 1994-08-10 NZ NZ271825A patent/NZ271825A/en unknown
- 1994-08-10 AT AT94925816T patent/ATE179167T1/de not_active IP Right Cessation
- 1994-08-10 DK DK94925816T patent/DK0717731T3/da active
- 1994-08-10 US US08/596,336 patent/US5831094A/en not_active Expired - Fee Related
- 1994-08-10 ES ES94925816T patent/ES2133573T3/es not_active Expired - Lifetime
- 1994-08-10 JP JP7508667A patent/JPH09502437A/ja not_active Ceased
- 1994-08-10 WO PCT/US1994/009053 patent/WO1995007257A1/en active IP Right Grant
- 1994-08-10 KR KR1019960701172A patent/KR100308839B1/ko not_active Expired - Fee Related
- 1994-08-10 EP EP94925816A patent/EP0717731B1/en not_active Expired - Lifetime
- 1994-08-10 CA CA002170607A patent/CA2170607C/en not_active Expired - Fee Related
- 1994-09-05 ZA ZA946815A patent/ZA946815B/xx unknown
- 1994-09-05 IL IL11086594A patent/IL110865A/xx not_active IP Right Cessation
- 1994-09-06 TW TW083108216A patent/TW282449B/zh active
-
1996
- 1996-03-01 NO NO960849A patent/NO960849D0/no unknown
- 1996-03-08 FI FI961105A patent/FI961105A0/fi not_active IP Right Cessation
-
1998
- 1998-05-19 US US09/081,307 patent/US5948778A/en not_active Expired - Fee Related
-
1999
- 1999-05-27 GR GR990401441T patent/GR3030352T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL110865A0 (en) | 1994-11-28 |
KR960704838A (ko) | 1996-10-09 |
AU683927B2 (en) | 1997-11-27 |
HU9600601D0 (en) | 1996-05-28 |
GR3030352T3 (en) | 1999-09-30 |
ZA946815B (en) | 1995-04-24 |
US5831094A (en) | 1998-11-03 |
KR100308839B1 (ko) | 2002-10-04 |
AU7560694A (en) | 1995-03-27 |
FI961105L (fi) | 1996-03-08 |
WO1995007257A1 (en) | 1995-03-16 |
EP0717731B1 (en) | 1999-04-21 |
ES2133573T3 (es) | 1999-09-16 |
ATE179167T1 (de) | 1999-05-15 |
NO960849L (no) | 1996-03-01 |
NZ271825A (en) | 1997-11-24 |
HUT74569A (en) | 1997-01-28 |
DE69418050T2 (de) | 1999-11-25 |
CA2170607C (en) | 2000-02-22 |
JPH09502437A (ja) | 1997-03-11 |
FI961105A0 (fi) | 1996-03-08 |
US5948778A (en) | 1999-09-07 |
IL110865A (en) | 1999-07-14 |
TW282449B (da) | 1996-08-01 |
EP0717731A1 (en) | 1996-06-26 |
CN1130898A (zh) | 1996-09-11 |
DE69418050D1 (de) | 1999-05-27 |
NO960849D0 (no) | 1996-03-01 |
CA2170607A1 (en) | 1995-03-16 |
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