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DK0717731T3 - Antivirale difluorstatonanaloge - Google Patents

Antivirale difluorstatonanaloge

Info

Publication number
DK0717731T3
DK0717731T3 DK94925816T DK94925816T DK0717731T3 DK 0717731 T3 DK0717731 T3 DK 0717731T3 DK 94925816 T DK94925816 T DK 94925816T DK 94925816 T DK94925816 T DK 94925816T DK 0717731 T3 DK0717731 T3 DK 0717731T3
Authority
DK
Denmark
Prior art keywords
antiviral
difluorostatone
analogues
statone
novel
Prior art date
Application number
DK94925816T
Other languages
English (en)
Inventor
Dorsselaer Viviane Van
Celine Tarnus
Daniel Schirlin
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0717731T3 publication Critical patent/DK0717731T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Epoxy Compounds (AREA)
DK94925816T 1993-09-09 1994-08-10 Antivirale difluorstatonanaloge DK0717731T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93402194 1993-09-09
PCT/US1994/009053 WO1995007257A1 (en) 1993-09-09 1994-08-10 Difluoro statone antiviral analogs

Publications (1)

Publication Number Publication Date
DK0717731T3 true DK0717731T3 (da) 1999-11-01

Family

ID=8214747

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94925816T DK0717731T3 (da) 1993-09-09 1994-08-10 Antivirale difluorstatonanaloge

Country Status (20)

Country Link
US (2) US5831094A (da)
EP (1) EP0717731B1 (da)
JP (1) JPH09502437A (da)
KR (1) KR100308839B1 (da)
CN (1) CN1130898A (da)
AT (1) ATE179167T1 (da)
AU (1) AU683927B2 (da)
CA (1) CA2170607C (da)
DE (1) DE69418050T2 (da)
DK (1) DK0717731T3 (da)
ES (1) ES2133573T3 (da)
FI (1) FI961105A0 (da)
GR (1) GR3030352T3 (da)
HU (1) HUT74569A (da)
IL (1) IL110865A (da)
NO (1) NO960849D0 (da)
NZ (1) NZ271825A (da)
TW (1) TW282449B (da)
WO (1) WO1995007257A1 (da)
ZA (1) ZA946815B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123164A (en) * 1995-08-30 2001-03-19 Searle & Co Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
CN1343219A (zh) * 1999-01-28 2002-04-03 中外制药株式会社 取代的苯乙基胺衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066643A (en) * 1985-02-19 1991-11-19 Sandoz Ltd. Fluorine and chlorine statine or statone containing peptides and method of use
CH672792A5 (da) * 1985-02-19 1989-12-29 Sandoz Ag
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
BE1002213A5 (fr) * 1987-04-23 1990-10-16 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
GB2212158A (en) * 1987-12-15 1989-07-19 Sandoz Ltd Trialkylsilymethyl-substituted peptides; renin inhibitors
WO1990000399A1 (en) * 1988-07-08 1990-01-25 Smithkline Beckman Corporation Retroviral protease binding peptides
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
US5151438A (en) * 1989-05-23 1992-09-29 Abbott Laboratories Retroviral protease inhibiting compounds
DE69122266T2 (de) * 1991-01-02 1997-03-27 Merrell Pharmaceuticals Inc. (N.D.Ges.D. Staates Delaware), Cincinnati, Ohio Antivirale verbindungen
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
BR9306138A (pt) * 1992-03-25 1998-06-23 Pfizer Peptídeos antivirais
GB9210744D0 (en) * 1992-05-20 1992-07-08 Pfizer Ltd Antiviral peptides
CA2136312A1 (en) * 1992-05-21 1993-11-25 Michael Clare Retroviral protease inhibitors
WO1995001958A1 (en) * 1993-07-08 1995-01-19 Merrell Pharmaceuticals Inc. Difluoro statone analogs
HUT76648A (en) * 1994-07-15 1997-10-28 Merrell Pharma Inc Difluorostatone, pharmaceutical compositions containing them and process for producing them

Also Published As

Publication number Publication date
IL110865A0 (en) 1994-11-28
KR960704838A (ko) 1996-10-09
AU683927B2 (en) 1997-11-27
HU9600601D0 (en) 1996-05-28
GR3030352T3 (en) 1999-09-30
ZA946815B (en) 1995-04-24
US5831094A (en) 1998-11-03
KR100308839B1 (ko) 2002-10-04
AU7560694A (en) 1995-03-27
FI961105L (fi) 1996-03-08
WO1995007257A1 (en) 1995-03-16
EP0717731B1 (en) 1999-04-21
ES2133573T3 (es) 1999-09-16
ATE179167T1 (de) 1999-05-15
NO960849L (no) 1996-03-01
NZ271825A (en) 1997-11-24
HUT74569A (en) 1997-01-28
DE69418050T2 (de) 1999-11-25
CA2170607C (en) 2000-02-22
JPH09502437A (ja) 1997-03-11
FI961105A0 (fi) 1996-03-08
US5948778A (en) 1999-09-07
IL110865A (en) 1999-07-14
TW282449B (da) 1996-08-01
EP0717731A1 (en) 1996-06-26
CN1130898A (zh) 1996-09-11
DE69418050D1 (de) 1999-05-27
NO960849D0 (no) 1996-03-01
CA2170607A1 (en) 1995-03-16

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