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DK0711415T3 - Immunoassay for detection of collagen or collagen fragments - Google Patents

Immunoassay for detection of collagen or collagen fragments

Info

Publication number
DK0711415T3
DK0711415T3 DK94905104T DK94905104T DK0711415T3 DK 0711415 T3 DK0711415 T3 DK 0711415T3 DK 94905104 T DK94905104 T DK 94905104T DK 94905104 T DK94905104 T DK 94905104T DK 0711415 T3 DK0711415 T3 DK 0711415T3
Authority
DK
Denmark
Prior art keywords
collagen
immunoassay
fragments
detection
sample
Prior art date
Application number
DK94905104T
Other languages
Danish (da)
Inventor
Werner Naser
Erasmus Huber
Christoph Seidel
Ulrich Essig
Original Assignee
Roche Diagnostics Gmbh
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP1993/002010 external-priority patent/WO1994003813A1/en
Application filed by Roche Diagnostics Gmbh, Boehringer Mannheim Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of DK0711415T3 publication Critical patent/DK0711415T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

An immunoassay is disclosed for detecting collagen or collagen fragments in a sample by using an antibody that recognises a synthetic linear peptide corresponding to a sequence of non-helical C or N terminal area of collagen, said sample being preferably denatured.
DK94905104T 1993-07-28 1994-01-21 Immunoassay for detection of collagen or collagen fragments DK0711415T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1993/002010 WO1994003813A1 (en) 1992-07-29 1993-07-28 Immunoassay for detecting collagen or collagen fragments
PCT/EP1994/000164 WO1995004282A1 (en) 1993-07-28 1994-01-21 Immunoassay for detecting collagen or collagen fragments

Publications (1)

Publication Number Publication Date
DK0711415T3 true DK0711415T3 (en) 1999-04-26

Family

ID=8165750

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94905104T DK0711415T3 (en) 1993-07-28 1994-01-21 Immunoassay for detection of collagen or collagen fragments

Country Status (9)

Country Link
EP (1) EP0711415B1 (en)
JP (1) JP2703116B2 (en)
AT (1) ATE168779T1 (en)
CA (1) CA2167496A1 (en)
DE (1) DE59406512D1 (en)
DK (1) DK0711415T3 (en)
ES (1) ES2122231T3 (en)
FI (1) FI960392A0 (en)
WO (1) WO1995004282A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110689A (en) 1994-01-21 2000-08-29 Osteometer A/S Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
DE69520111T2 (en) 1994-10-17 2001-09-06 Osteometer Biotech As, Herlev Estimation of the fragmentation pattern of collagen in body fluids and diagnosis of disorders related to collagen metabolism
US5750647A (en) * 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
ES2160985T3 (en) 1996-12-09 2001-11-16 Osteometer Biotech As SANDWICH TYPE TESTS FOR COLLAGEN FRAGMENTS.
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
US6916903B2 (en) 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6348320B1 (en) 1998-06-19 2002-02-19 Washington Research Foundation Cartilage resorption assays measuring type II collagen fragments
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
ATE302949T1 (en) 1998-06-19 2005-09-15 Washington Res Found CARTILAGE RESORPTION ASSAY
PT1149111E (en) * 1999-01-06 2009-11-19 Univ Southern California Method and composition for angiogenesis inhibition
DE60042487D1 (en) 1999-07-13 2009-08-13 Univ Southern California METHOD AND COMPOSITION FOR ANGIOGENESIS INHIBITION WITH ANTAGONISTS AGAINST MMP-9 AND BETA1 INTEGRINS
US7390885B2 (en) 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7365167B2 (en) 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7488792B2 (en) 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
JP2004108914A (en) * 2002-09-18 2004-04-08 Kudo Norio Method for measuring collagen
US7781171B2 (en) 2003-10-15 2010-08-24 Daiichi Pure Chemicals Co., Ltd. Mehod of pretreating sample and immunological assay method using the same
EP1681567B1 (en) * 2003-10-15 2009-04-01 Sekisui Medical Co., Ltd. Method of pretreating sample and immunological assay method using the same
JPWO2022202876A1 (en) 2021-03-24 2022-09-29
WO2024034580A1 (en) * 2022-08-08 2024-02-15 株式会社先端生命科学研究所 Method for detecting ceacam1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3479158D1 (en) * 1983-03-04 1989-08-31 Noctech Ltd Diagnostic agent, a process for its preparation and its use in diagnostic methods
CA1339952C (en) * 1984-10-29 1998-07-14 William J. Knowles Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto
DE3714634A1 (en) * 1987-05-02 1988-11-17 Hoechst Ag METHOD FOR SELECTIVE IMMUNOLOGICAL DETERMINATION OF INTACT PROCOLLAGEN PEPTIDE (TYPE III) AND PROCOLLAGEN (TYPE III) IN BODY LIQUIDS AND MEANS TO IMPLEMENT IT
ATE115963T1 (en) * 1988-04-27 1995-01-15 Hoechst Ag MONOCLONAL ANTIBODIES FOR SELECTIVE IMMUNOLOGICAL DETERMINATION OF INTACT PROCOLLAGEN PEPTIDE (TYPE III) AND PROCOLLAGEN (TYPE III) IN BODY FLUID.
WO1990008195A1 (en) * 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
US5081031A (en) * 1989-12-14 1992-01-14 Regents Of The University Of Minnesota Synthetic polypeptide with type iv collagen activity
GB9014220D0 (en) * 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
GB9105893D0 (en) * 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
JPH07504896A (en) * 1992-01-31 1995-06-01 ベイリンク，デビッド　ジェイ． Aminoprocollagen 1 (1) peptide
DE4225038C2 (en) * 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Production and use of antibodies against collagen

Also Published As

Publication number Publication date
FI960392A (en) 1996-01-29
JPH08509294A (en) 1996-10-01
EP0711415A1 (en) 1996-05-15
JP2703116B2 (en) 1998-01-26
DE59406512D1 (en) 1998-08-27
CA2167496A1 (en) 1995-02-09
FI960392A0 (en) 1996-01-29
WO1995004282A1 (en) 1995-02-09
ES2122231T3 (en) 1998-12-16
EP0711415B1 (en) 1998-07-22
ATE168779T1 (en) 1998-08-15

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