[go: up one dir, main page]

DK0688362T3 - Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå - Google Patents

Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå

Info

Publication number
DK0688362T3
DK0688362T3 DK94911550T DK94911550T DK0688362T3 DK 0688362 T3 DK0688362 T3 DK 0688362T3 DK 94911550 T DK94911550 T DK 94911550T DK 94911550 T DK94911550 T DK 94911550T DK 0688362 T3 DK0688362 T3 DK 0688362T3
Authority
DK
Denmark
Prior art keywords
phospholipase
recombinant
nucleic acids
hyaluronidase
cloning
Prior art date
Application number
DK94911550T
Other languages
English (en)
Inventor
Te Piao King
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of DK0688362T3 publication Critical patent/DK0688362T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK94911550T 1993-03-11 1994-03-10 Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå DK0688362T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3140093A 1993-03-11 1993-03-11
US08/180,209 US5593877A (en) 1993-03-11 1994-01-11 Nucleic acid and recombinant production of vespid venom hyaluronidase
PCT/US1994/002629 WO1994020623A1 (en) 1993-03-11 1994-03-10 Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon

Publications (1)

Publication Number Publication Date
DK0688362T3 true DK0688362T3 (da) 2007-04-10

Family

ID=21859247

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94911550T DK0688362T3 (da) 1993-03-11 1994-03-10 Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå
DK05017821.9T DK1650304T3 (da) 1993-03-11 1994-03-10 Kloning og rekombinant fremstilling af vespidgiftphospholipase og immunologiske terapier baseret derpå

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK05017821.9T DK1650304T3 (da) 1993-03-11 1994-03-10 Kloning og rekombinant fremstilling af vespidgiftphospholipase og immunologiske terapier baseret derpå

Country Status (10)

Country Link
US (4) US5593877A (da)
EP (2) EP0688362B1 (da)
JP (2) JP3816515B2 (da)
AT (2) ATE458817T1 (da)
AU (1) AU693785B2 (da)
CA (2) CA2654420A1 (da)
DE (2) DE69434890T2 (da)
DK (2) DK0688362T3 (da)
ES (1) ES2278379T3 (da)
WO (1) WO1994020623A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3637087B2 (ja) * 1994-11-28 2005-04-06 和男 鈴木 新規な白血球活性化因子
US5789194A (en) * 1995-05-23 1998-08-04 Heska Corporation Parasitic helminth venom allergen antigen 5-like genes and proteins
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
GB9724531D0 (en) * 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
KR20010041806A (ko) 1998-03-09 2001-05-25 에드워드 에이취. 댄스 효소 각막교정술에 사용되는 각막 경화제의 용도
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6372471B1 (en) * 1998-10-01 2002-04-16 The Rockefeller University Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
US6773695B2 (en) 2000-10-05 2004-08-10 Mannkind Corporation Modulation of allergic response
DK1499349T3 (da) 2001-03-02 2010-04-06 Univ Rockefeller Rekombinante hybrid-allergenkonstrukter med reduceret allergenitet, der bibeholder det naterulige allergens immunogenitet
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
WO2006018319A1 (en) * 2004-08-18 2006-02-23 Bayer Cropscience Gmbh Plants with increased plastidic activity of r3 starch-phosphorylating enzyme
WO2008149364A2 (en) * 2007-06-07 2008-12-11 Sarah Brenner Methods for diagnosing hypersensitivity reactions
DE102007031417A1 (de) * 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
EP2243791A1 (en) 2009-03-03 2010-10-27 PLS-Design GmbH Cloning and recombinant production of Vespula venom protease and methods of use thereof
CN103079746A (zh) * 2010-09-01 2013-05-01 三菱电机株式会社 激光加工装置及基板位置检测方法
NZ705783A (en) 2012-08-10 2017-06-30 Osio Corp D/B/A Yolia Health Contact lens use in the treatment of an ophthalmologic condition
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
AU2017362418B2 (en) 2016-11-17 2024-05-02 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
CN108950015B (zh) * 2018-08-06 2021-11-23 中国计量大学 鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469677A (en) * 1980-02-19 1984-09-04 Michael J Gabriel Polypeptide active immunosuppressant fraction
US4822608A (en) * 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
EP0495064B1 (en) 1990-08-13 2001-07-11 "BIOMAY" Produktions- und Handelsgesellschaft m.b.H. Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
BR9206131A (pt) * 1991-06-10 1995-05-02 Lucky Ltd Hepatite C: diagnóstico e vacinas
GB9204583D0 (en) * 1992-03-03 1992-04-15 Unilever Plc Recombinant plant enzyme
AU688749B2 (en) * 1992-11-30 1998-03-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Mammalian muscle NAD:arginine ADP-ribosyltransferase
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides

Also Published As

Publication number Publication date
US6270763B1 (en) 2001-08-07
EP1650304B1 (en) 2010-02-24
WO1994020623A1 (en) 1994-09-15
ES2278379T3 (es) 2007-08-01
CA2157864C (en) 2009-05-12
US6287559B1 (en) 2001-09-11
EP0688362A1 (en) 1995-12-27
US5593877A (en) 1997-01-14
EP1650304A2 (en) 2006-04-26
AU6404194A (en) 1994-09-26
US5612209A (en) 1997-03-18
DK1650304T3 (da) 2010-06-14
DE69435277D1 (de) 2010-04-08
AU693785B2 (en) 1998-07-09
JP3816515B2 (ja) 2006-08-30
JPH08508399A (ja) 1996-09-10
CA2157864A1 (en) 1994-09-15
EP1650304A3 (en) 2006-07-12
DE69434890D1 (de) 2007-01-18
EP0688362B1 (en) 2006-12-06
CA2654420A1 (en) 1994-09-15
ATE347601T1 (de) 2006-12-15
DE69434890T2 (de) 2007-10-18
ATE458817T1 (de) 2010-03-15
JP2006000119A (ja) 2006-01-05

Similar Documents

Publication Publication Date Title
DK0688362T3 (da) Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå
LV5288A3 (lv) Nukleinskabes fragments kurs kode cilveka proapolipoproteinu A-1
NZ219485A (en) Production of human endothelial cell growth factor comprising transforming a host cell with an expression vector
DE69112611D1 (de) Proteinhydrolysate.
DK0506825T3 (da) Rekombinante ekspressionsvektorer og oprensningsfremgangsmåder til Thermus thermophilus-DNA-polymerase
FR2637612B1 (fr) Sequences de nucleotides codant pour une proteine a activite ureasique
DK0535216T3 (da) DNA. der koder mammale phosphodiesteraser
ATE71632T1 (de) Cdns und gen fuer menschliches angiogenin (angiogenesis-faktor) und expression.
HUP9801638A2 (hu) Kevésbé adszorbeálódó és jobban hidrolizáló proteáz K variánsok
AU1003888A (en) Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host, process, expression vector and recombinant host therefore and pharmaceutical use thereof
ES2000255A6 (es) Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma.
AU8258591A (en) Human mk gene and protein sequence
PT851926E (pt) Variantes do interferao-gama (rhu-ifn-gama) recombinante humano com estabilidade termica melhorada
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
HUP9800767A2 (hu) Kevésbé adszorbeálódó és jobban hidrolizáló szubtilizin DY variánsok
HUT52551A (en) Process for production of neutrophil-activizating factor
ATE86662T1 (de) Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase.
NO955258L (no) Medisinsk anvendelse av enzymer
ATE134874T1 (de) Synoviale phospholipasen
EP0302838A3 (en) Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
BR9508430A (pt) Sequência nucleotídica ADN recombinante vetor de expressão com replicação autônoma e/ou integrativo célula recombinante polipeptideo processo de produção de um polipeptideo topoismorase isolada e utilização de uma topoisomeras IV
PT87332A (pt) Method of purification of product of expression of recombinant ferment
PT88098A (pt) Processo de clonacao e expressao de genes codificando para proteinas constituintes de edificios funcionais organizados
DK1528102T3 (da) Kloning og rekombinant fremstilling af Polistinae gift enzymer, såsom hyaluronidase, og immunologiske terapier baseret derpå