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DK0687259T3 - Fremgangsmåde til fremstilling af taxoider - Google Patents

Fremgangsmåde til fremstilling af taxoider

Info

Publication number
DK0687259T3
DK0687259T3 DK94908385.1T DK94908385T DK0687259T3 DK 0687259 T3 DK0687259 T3 DK 0687259T3 DK 94908385 T DK94908385 T DK 94908385T DK 0687259 T3 DK0687259 T3 DK 0687259T3
Authority
DK
Denmark
Prior art keywords
radical
general formula
taxoids
preparation
bicycloalkyl
Prior art date
Application number
DK94908385.1T
Other languages
English (en)
Inventor
Alain Commercon
Jean-Dominique Bourzat
Herve Bouchard
Jean-Pierre Pulicani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0687259T3 publication Critical patent/DK0687259T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94908385.1T 1993-03-02 1994-02-28 Fremgangsmåde til fremstilling af taxoider DK0687259T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9302370A FR2702212B1 (fr) 1993-03-02 1993-03-02 Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
DK0687259T3 true DK0687259T3 (da) 1997-05-26

Family

ID=9444565

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94908385.1T DK0687259T3 (da) 1993-03-02 1994-02-28 Fremgangsmåde til fremstilling af taxoider

Country Status (19)

Country Link
US (2) US5556877A (da)
EP (1) EP0687259B1 (da)
JP (1) JP3782443B2 (da)
KR (1) KR960701034A (da)
AT (1) ATE151763T1 (da)
AU (1) AU683449B2 (da)
CZ (1) CZ223795A3 (da)
DE (1) DE69402694T2 (da)
DK (1) DK0687259T3 (da)
ES (1) ES2101513T3 (da)
FI (1) FI954111L (da)
FR (1) FR2702212B1 (da)
GR (1) GR3023162T3 (da)
NO (1) NO953452D0 (da)
NZ (1) NZ262137A (da)
PL (1) PL310441A1 (da)
SK (1) SK107295A3 (da)
WO (1) WO1994020484A1 (da)
ZA (1) ZA941387B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
EP0914102B8 (en) 1996-05-24 2005-11-02 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
KR100225535B1 (ko) 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US20030157187A1 (en) * 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
KR100648125B1 (ko) 1999-05-17 2006-11-24 브리스톨-마이어스스퀴브컴파니 파클리탁셀 (탁솔 (Ｔａｘｏｌ, 등록상표)) 및 파클리탁셀유사체 제조에서 실릴 에테르의 절단을 위한 신규 반응조건
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2003521514A (ja) 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０ヘテロ置換アセテートタキサン
UA75038C2 (en) 2000-02-02 2006-03-15 Univ Florida State Res Found Taxanes having a carbonate substituent at c(10), pharmaceutical compositions based thereon and methods for inhibiting tumors growth
EP1562927B1 (en) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analogues of paclitaxel and intermediates thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
PE20050693A1 (es) 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
EP2276755A4 (en) 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
US10550093B2 (en) 2015-07-01 2020-02-04 The Research Foundation For The State University Of New York Third generation taxoids and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
EP0639186B1 (en) * 1992-04-17 1999-06-23 Abbott Laboratories Taxol derivatives
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2101513T3 (es) 1997-07-01
WO1994020484A1 (fr) 1994-09-15
KR960701034A (ko) 1996-02-24
AU683449B2 (en) 1997-11-13
JPH08509959A (ja) 1996-10-22
DE69402694T2 (de) 1997-10-16
US5556877A (en) 1996-09-17
JP3782443B2 (ja) 2006-06-07
FI954111A0 (fi) 1995-09-01
US5654449A (en) 1997-08-05
NO953452L (no) 1995-09-01
PL310441A1 (en) 1995-12-11
NO953452D0 (no) 1995-09-01
FI954111A7 (fi) 1995-09-01
SK107295A3 (en) 1996-06-05
AU6144694A (en) 1994-09-26
FR2702212A1 (fr) 1994-09-09
ZA941387B (en) 1994-09-29
FI954111L (fi) 1995-09-01
DE69402694D1 (de) 1997-05-22
FR2702212B1 (fr) 1995-04-07
ATE151763T1 (de) 1997-05-15
NZ262137A (en) 1997-11-24
EP0687259B1 (fr) 1997-04-16
GR3023162T3 (en) 1997-07-30
EP0687259A1 (fr) 1995-12-20
CZ223795A3 (en) 1995-12-13

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