DK0674631T3 - Substituerede pyrazoler som CRF-antogonister - Google Patents

Substituerede pyrazoler som CRF-antogonister

Info

Publication number: DK0674631T3
Authority: DK; Denmark
Prior art keywords: crf; antogonists; substituted pyrazoles; pyrazoles; substituted
Prior art date: 1992-12-17

Application number

DK93922407T

Other languages

English (en)

Inventor

Gene M Bright

Willard M Welch Jr

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-17

Filing date

1993-09-30

Publication date

2000-04-10

1993-09-30 Application filed by Pfizer filed Critical Pfizer

2000-04-10 Application granted granted Critical

2000-04-10 Publication of DK0674631T3 publication Critical patent/DK0674631T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Diabetes (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK93922407T 1992-12-17 1993-09-30 Substituerede pyrazoler som CRF-antogonister DK0674631T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99222892A	1992-12-17	1992-12-17
PCT/US1993/009170 WO1994013661A1 (en)	1992-12-17	1993-09-30	Substituted pyrazoles as crf antagonists

Publications (1)

Publication Number	Publication Date
DK0674631T3 true DK0674631T3 (da)	2000-04-10

Family

ID=25538068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93922407T DK0674631T3 (da)	1992-12-17	1993-09-30	Substituerede pyrazoler som CRF-antogonister

Country Status (26)

Country	Link
EP (2)	EP0674631B1 (da)
JP (1)	JP2781661B2 (da)
KR (1)	KR100190730B1 (da)
CN (1)	CN1045293C (da)
AT (1)	ATE187451T1 (da)
AU (1)	AU690079B2 (da)
BR (1)	BR9307664A (da)
CA (1)	CA2150703C (da)
CZ (1)	CZ287925B6 (da)
DE (1)	DE69327254T2 (da)
DK (1)	DK0674631T3 (da)
EG (1)	EG20440A (da)
ES (1)	ES2139676T3 (da)
FI (1)	FI111254B (da)
GR (1)	GR3032461T3 (da)
HU (1)	HUT65822A (da)
IL (1)	IL107947A (da)
MY (1)	MY109522A (da)
NO (1)	NO307884B1 (da)
NZ (1)	NZ256620A (da)
PL (1)	PL175982B1 (da)
PT (1)	PT674631E (da)
RU (1)	RU2130453C1 (da)
TW (1)	TW237455B (da)
WO (1)	WO1994013661A1 (da)
ZA (1)	ZA939406B (da)

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US6531475B1 (en)	1998-11-12	2003-03-11	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
ES2180338T3 (es)	1998-11-12	2003-02-01	Neurocrine Biosciences Inc	Antagonistas del receptor de crf y metodos relacionados.
JP2002529469A (ja)	1998-11-12	2002-09-10	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	Ｃｒｆレセプターアンタゴニストおよびそれに関する方法
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
US6506784B1 (en)	1999-07-01	2003-01-14	3-Dimensional Pharmaceuticals, Inc.	Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides
US6409988B1 (en)	1999-07-01	2002-06-25	3-Dimensional Pharmaceuticals, Inc.	Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
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US6638981B2 (en)	2001-08-17	2003-10-28	Epicept Corporation	Topical compositions and methods for treating pain
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KR100984085B1 (ko)	2002-10-22	2010-09-30	에자이 알앤드디 매니지먼트 가부시키가이샤	7-페닐 피라졸로피리딘 화합물
ATE479683T1 (de)	2002-11-05	2010-09-15	Glaxo Group Ltd	Antibakterielle mittel
AU2003303040B2 (en)	2002-12-13	2009-04-23	Warner-Lambert Company Llc	Pregabalin derivatives for the treatment of fibromyalgia and other disorders
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1993
- 1993-09-30 JP JP6506653A patent/JP2781661B2/ja not_active Expired - Fee Related
- 1993-09-30 BR BR9307664A patent/BR9307664A/pt not_active Application Discontinuation
- 1993-09-30 AT AT93922407T patent/ATE187451T1/de not_active IP Right Cessation
- 1993-09-30 CA CA002150703A patent/CA2150703C/en not_active Expired - Fee Related
- 1993-09-30 RU RU95113965/04A patent/RU2130453C1/ru not_active IP Right Cessation
- 1993-09-30 DK DK93922407T patent/DK0674631T3/da active
- 1993-09-30 KR KR1019950702479A patent/KR100190730B1/ko not_active Expired - Fee Related
- 1993-09-30 DE DE69327254T patent/DE69327254T2/de not_active Expired - Fee Related
- 1993-09-30 CZ CZ19951582A patent/CZ287925B6/cs not_active IP Right Cessation
- 1993-09-30 EP EP93922407A patent/EP0674631B1/en not_active Expired - Lifetime
- 1993-09-30 AU AU51413/93A patent/AU690079B2/en not_active Ceased
- 1993-09-30 WO PCT/US1993/009170 patent/WO1994013661A1/en active IP Right Grant
- 1993-09-30 NZ NZ256620A patent/NZ256620A/en unknown
- 1993-09-30 EP EP99109027A patent/EP0959074A3/en not_active Withdrawn
- 1993-09-30 ES ES93922407T patent/ES2139676T3/es not_active Expired - Lifetime
- 1993-09-30 PT PT93922407T patent/PT674631E/pt unknown
- 1993-10-02 TW TW082108104A patent/TW237455B/zh active
- 1993-12-09 IL IL10794793A patent/IL107947A/en not_active IP Right Cessation
- 1993-12-10 MY MYPI93002671A patent/MY109522A/en unknown
- 1993-12-12 EG EG78493A patent/EG20440A/xx active
- 1993-12-15 ZA ZA939406A patent/ZA939406B/xx unknown
- 1993-12-16 HU HU9303615A patent/HUT65822A/hu not_active Application Discontinuation
- 1993-12-16 FI FI935672A patent/FI111254B/fi not_active IP Right Cessation
- 1993-12-16 CN CN93120122A patent/CN1045293C/zh not_active Expired - Fee Related
1995
- 1995-05-31 PL PL93309355A patent/PL175982B1/pl not_active IP Right Cessation
- 1995-06-16 NO NO952397A patent/NO307884B1/no not_active IP Right Cessation
2000
- 2000-01-25 GR GR20000400155T patent/GR3032461T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69327254D1 (de)	2000-01-13
NO307884B1 (no)	2000-06-13
CA2150703C (en)	2002-01-08
NO952397L (no)	1995-08-14
NO952397D0 (no)	1995-06-16
IL107947A0 (en)	1994-04-12
FI935672L (fi)	1994-06-18
PL309355A1 (en)	1995-10-02
ES2139676T3 (es)	2000-02-16
ZA939406B (en)	1995-06-15
EP0674631A1 (en)	1995-10-04
TW237455B (da)	1995-01-01
DE69327254T2 (de)	2000-03-30
MY109522A (en)	1997-02-28
EG20440A (en)	1999-04-29
CZ158295A3 (en)	1995-12-13
EP0959074A2 (en)	1999-11-24
WO1994013661A1 (en)	1994-06-23
PL175982B1 (pl)	1999-03-31
EP0959074A3 (en)	2000-06-07
FI111254B (fi)	2003-06-30
PT674631E (pt)	2000-04-28
BR9307664A (pt)	1999-06-29
CA2150703A1 (en)	1994-06-23
JP2781661B2 (ja)	1998-07-30
EP0674631B1 (en)	1999-12-08
ATE187451T1 (de)	1999-12-15
AU5141393A (en)	1994-07-04
CN1045293C (zh)	1999-09-29
JPH08500121A (ja)	1996-01-09
GR3032461T3 (en)	2000-05-31
CZ287925B6 (cs)	2001-03-14
AU690079B2 (en)	1998-04-23
KR100190730B1 (ko)	1999-06-01
IL107947A (en)	1998-08-16
HUT65822A (en)	1994-07-28
CN1093363A (zh)	1994-10-12
FI935672A0 (fi)	1993-12-16
NZ256620A (en)	1996-05-28
KR950704299A (ko)	1995-11-17
RU2130453C1 (ru)	1999-05-20

Publication	Publication Date	Title
DK0674631T3 (da)	2000-04-10	Substituerede pyrazoler som CRF-antogonister
CA2192208A1 (en)	1995-12-14	Substituted pyrazoles
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
DK0675886T3 (da)	2000-09-18	Aminomethylensubstituerede ikke-aromatiske heterocykler og deres anvendelse som substance P-antagonister
DK0674625T3 (da)	1998-02-02	Aminosubstituerede pyrazoler, der har CRF-antagonistaktivitet
ATE229334T1 (de)	2002-12-15	Verwendung von crf-antagonisten
EA199900853A1 (ru)	2000-10-30	Замещенные производные бензопирана для лечения воспалительных процессов
CA2150709A1 (en)	1994-06-23	Pyrazolopyrimidines
AP1246A (en)	2004-02-07	Substituted pyrazoles as p38 Kinase inhibitors.
ATE181056T1 (de)	1999-06-15	Arylessigsäurederivate und ihre verwendung als fungizide
ATE104296T1 (de)	1994-04-15	Substituierte 1,2,4-triazindione, verfahren zu ihrer herstellung und ihre verwendung.
TR24452A (tr)	1991-11-01	Pestisidler ve bitki bueyueme duezenleyicileri olarak heterosiklik dionlar
DK0503453T3 (da)	2001-07-16	Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
ES2149202T3 (es)	2000-11-01	Nuevos arilindazoles y su uso como herbicidas.
DK0579968T3 (da)	2000-03-27	4-Iminoquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse
PT1165485E (pt)	2004-08-31	Processo para a preparacao de produtos intermediarios pesticidas
DK0556152T3 (da)	2002-04-08	Pyridiniumderivater og deres anvendelse til bestemmelse af bindevævssygdomme hos mennesker og dyr
MX9606166A (es)	1998-01-31	Pirazoles substituidos.
CA2272136A1 (en)	1994-06-23	Pyrazole derivatives having crf antagonist activity
DE59002904D1 (de)	1993-11-04	Cyclopropanthiocarbonsaeureamide.