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DK0673370T3 - Troponsubstituerede phenyloxazolidinoner som antibakterielle midler - Google Patents

Troponsubstituerede phenyloxazolidinoner som antibakterielle midler

Info

Publication number
DK0673370T3
DK0673370T3 DK93923304T DK93923304T DK0673370T3 DK 0673370 T3 DK0673370 T3 DK 0673370T3 DK 93923304 T DK93923304 T DK 93923304T DK 93923304 T DK93923304 T DK 93923304T DK 0673370 T3 DK0673370 T3 DK 0673370T3
Authority
DK
Denmark
Prior art keywords
antibacterial agents
tropon
substituted
substituted phenyloxazolidinones
phenyloxazolidinones
Prior art date
Application number
DK93923304T
Other languages
English (en)
Inventor
Michael Robert Barbachyn
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0673370T3 publication Critical patent/DK0673370T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93923304T 1992-12-08 1993-10-14 Troponsubstituerede phenyloxazolidinoner som antibakterielle midler DK0673370T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98858992A 1992-12-08 1992-12-08
US377893A 1993-01-13 1993-01-13
US6635693A 1993-05-21 1993-05-21
PCT/US1993/009589 WO1994013649A1 (en) 1992-12-08 1993-10-14 Tropone-substituted phenyloxazolidinone antibacterial agents

Publications (1)

Publication Number Publication Date
DK0673370T3 true DK0673370T3 (da) 1998-09-07

Family

ID=27357482

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93923304T DK0673370T3 (da) 1992-12-08 1993-10-14 Troponsubstituerede phenyloxazolidinoner som antibakterielle midler

Country Status (20)

Country Link
US (1) US5523403A (da)
EP (1) EP0673370B1 (da)
JP (1) JP3558088B2 (da)
KR (1) KR100276382B1 (da)
AT (1) ATE161833T1 (da)
AU (1) AU670842B2 (da)
CA (1) CA2147753C (da)
CZ (1) CZ288788B6 (da)
DE (1) DE69316240T2 (da)
DK (1) DK0673370T3 (da)
ES (1) ES2111188T3 (da)
FI (1) FI952798A7 (da)
GR (1) GR3026228T3 (da)
HU (1) HUT74099A (da)
NO (1) NO952253L (da)
NZ (1) NZ257031A (da)
PL (1) PL175782B1 (da)
RU (1) RU2119484C1 (da)
SK (1) SK282453B6 (da)
WO (1) WO1994013649A1 (da)

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GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
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GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
HUP0004388A3 (en) * 1997-11-07 2001-10-29 Upjohn Co Process for the preparation of oxazolidinones, intermediates and preparation thereof
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6083967A (en) * 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
NZ505902A (en) * 1998-01-23 2003-08-29 Upjohn Co Oxazolidinone compounds useful as antimicrobial agents and combinatorial libraries
PL345162A1 (en) 1998-06-05 2001-12-03 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
WO2000045177A1 (en) 1999-01-27 2000-08-03 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
US6689769B2 (en) 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
AU2002360238B2 (en) * 2001-04-17 2007-11-15 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
AU2003209241A1 (en) 2002-02-05 2003-09-02 Pharmacia & Upjohn Company Antimicrobial thiadiazinone derivatives useful in treatment of bacterial infections
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
MXPA04009356A (es) * 2002-03-29 2005-01-25 Pharmacia & Upjohn Co Llc Administracion parenteral, intravenosa y oral de oxazolidinonas para tratar infecciones de pie diabetico.
EP1539745B1 (en) * 2002-08-12 2006-03-29 Pharmacia & Upjohn Company LLC N-aryl-2-oxazolidinones and their derivatives
MXPA05005472A (es) * 2002-11-21 2005-07-25 Pharmacia & Upjohn Co Llc Derivados de n-(4-piparazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
US8813142B2 (en) * 2003-01-31 2014-08-19 Qwest Communications International Inc. Methods, systems and apparatus for providing video transmissions over multiple media
US8050281B2 (en) * 2003-01-31 2011-11-01 Qwest Communications International Inc. Alert gateway, systems and methods
US7474742B2 (en) * 2003-01-31 2009-01-06 Qwest Communications International Inc. Environmentally-controlled network interface device and methods
MXPA05007724A (es) * 2003-02-07 2005-09-30 Warner Lambert Co Agentes antibacterianos.
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR045690A1 (es) 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
RU2348628C2 (ru) * 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
US20060247286A1 (en) * 2003-07-02 2006-11-02 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
EP1654259A1 (en) * 2003-07-02 2006-05-10 Merck & Co., Inc. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
CA2536480A1 (en) * 2003-08-25 2005-03-03 Warner-Lambert Company Llc Novel antimicrobial aryloxazolidinone compounds
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2006133397A2 (en) 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
TW200804358A (en) 2006-03-31 2008-01-16 Res Found Itsuu Lab Novel compound having heterocycle
JPWO2007116960A1 (ja) * 2006-04-06 2009-08-20 財団法人乙卯研究所 炭素環を有するオキサゾリジノン誘導体
EP2208729A4 (en) 2007-10-02 2011-04-27 Res Found Itsuu Lab OXAZOLIDINONE DERIVATIVE WITH 7-CHAIN HETEROCYCLE
SG195544A1 (en) 2008-10-10 2013-12-30 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
USRE29607E (en) * 1969-03-18 1978-04-11 Delalande S. A. Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
DE3149608A1 (de) * 1981-12-15 1983-08-04 Dr. Madaus & Co, 5000 Köln Substituierte tropolone, verfahren zur herstellung derselben und diese enthaltende pharmazeutische zubereitungen
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
DE3884563T2 (de) * 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones

Also Published As

Publication number Publication date
DE69316240D1 (de) 1998-02-12
SK74695A3 (en) 1995-10-11
US5523403A (en) 1996-06-04
ATE161833T1 (de) 1998-01-15
EP0673370B1 (en) 1998-01-07
NO952253L (no) 1995-08-08
ES2111188T3 (es) 1998-03-01
PL175782B1 (pl) 1999-02-26
WO1994013649A1 (en) 1994-06-23
HUT74099A (en) 1996-11-28
HU9501670D0 (en) 1995-08-28
AU5323994A (en) 1994-07-04
RU95114378A (ru) 1997-06-10
PL309283A1 (en) 1995-10-02
SK282453B6 (sk) 2002-02-05
FI952798L (fi) 1995-06-07
NZ257031A (en) 1996-07-26
CA2147753A1 (en) 1994-06-23
FI952798A0 (fi) 1995-06-07
NO952253D0 (no) 1995-06-07
RU2119484C1 (ru) 1998-09-27
GR3026228T3 (en) 1998-05-29
AU670842B2 (en) 1996-08-01
CZ136695A3 (en) 1995-10-18
KR100276382B1 (ko) 2000-12-15
EP0673370A1 (en) 1995-09-27
DE69316240T2 (de) 1998-05-20
CA2147753C (en) 2004-08-03
FI952798A7 (fi) 1995-06-07
CZ288788B6 (cs) 2001-09-12
JP3558088B2 (ja) 2004-08-25
JPH08504205A (ja) 1996-05-07

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