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DK0673255T3 - Monoklonale antistoffer, som specifikt binder til vaskulært tumorendotel, og anvendelser deraf - Google Patents

Monoklonale antistoffer, som specifikt binder til vaskulært tumorendotel, og anvendelser deraf

Info

Publication number
DK0673255T3
DK0673255T3 DK94901335T DK94901335T DK0673255T3 DK 0673255 T3 DK0673255 T3 DK 0673255T3 DK 94901335 T DK94901335 T DK 94901335T DK 94901335 T DK94901335 T DK 94901335T DK 0673255 T3 DK0673255 T3 DK 0673255T3
Authority
DK
Denmark
Prior art keywords
applications
monoclonal antibodies
glycoprotein
specifically bind
vascular tumor
Prior art date
Application number
DK94901335T
Other languages
English (en)
Inventor
Pilar Garin-Chesa
Wolfgang J Rettig
Lloyd J Old
Original Assignee
Sloan Kettering Inst Cancer
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Ludwig Inst Cancer Res filed Critical Sloan Kettering Inst Cancer
Application granted granted Critical
Publication of DK0673255T3 publication Critical patent/DK0673255T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK94901335T 1992-11-13 1993-11-09 Monoklonale antistoffer, som specifikt binder til vaskulært tumorendotel, og anvendelser deraf DK0673255T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/976,405 US5342757A (en) 1992-11-13 1992-11-13 Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
PCT/US1993/010773 WO1994011023A1 (en) 1992-11-13 1993-11-09 Monoclonal antibody which specifically binds to tumor vascular endothelium and uses thereof

Publications (1)

Publication Number Publication Date
DK0673255T3 true DK0673255T3 (da) 2001-12-10

Family

ID=25524065

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94901335T DK0673255T3 (da) 1992-11-13 1993-11-09 Monoklonale antistoffer, som specifikt binder til vaskulært tumorendotel, og anvendelser deraf

Country Status (12)

Country Link
US (2) US5342757A (da)
EP (1) EP0673255B1 (da)
JP (1) JP3541296B2 (da)
AT (1) ATE204480T1 (da)
AU (1) AU671884B2 (da)
CA (1) CA2149120C (da)
DE (1) DE69330643T2 (da)
DK (1) DK0673255T3 (da)
ES (1) ES2161751T3 (da)
GR (1) GR3036906T3 (da)
PT (1) PT673255E (da)
WO (1) WO1994011023A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
ATE239506T1 (de) * 1992-03-05 2003-05-15 Univ Texas Verwendung von immunokonjugate zur diagnose und/oder therapie der vaskularisierten tumoren
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
EP0746613B1 (en) * 1994-03-08 2006-05-24 Memorial Sloan-Kettering Cancer Center Recombinant humanized anti-fb5 antibodies
US5536641A (en) * 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
EE200000574A (et) 1998-03-31 2002-10-15 Dupont Pharmaceuticals Company Farmatseutilised ühendid angiogeensete häirete kuvamiseks
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
TR200101757T2 (tr) * 1998-12-18 2001-12-21 Dupont Pharmaceuticais Company Vitronektin reseptör antagonisti farmasötikler
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
CN1356913A (zh) 1998-12-18 2002-07-03 杜邦药品公司 玻连蛋白受体拮抗剂药物
EP1307557A2 (en) * 2000-08-02 2003-05-07 The Johns Hopkins University Endothelial cell expression patterns
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US7951061B2 (en) 2001-07-25 2011-05-31 Allan Foreman Devices for targeted delivery of thermotherapy, and methods related thereto
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
EP2365004B1 (en) * 2002-06-21 2016-01-06 Johns Hopkins University School of Medicine Membrane associated tumor endothelium markers
ATE493440T1 (de) * 2003-03-04 2011-01-15 Kirin Brewery Endothelzell-spezifische antikörper und ihre verwendung
US20060121541A1 (en) * 2004-12-03 2006-06-08 Luigi Grasso Use of endosialin binding proteins to isolate endosialin positive cells
JP2008538700A (ja) * 2005-04-22 2008-11-06 モルフォテック、インク． 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体
BRPI0809665B8 (pt) 2007-04-05 2021-05-25 Eisai Inc anticorpo monoclonal que se liga especificamente a endosialina
WO2010118203A2 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules
SE535982C2 (sv) * 2009-12-15 2013-03-19 Theravac Pharmaceuticals Ab Ett nytt vaccin som angriper tumörkärl som ett effektivt redskap i tumörterapi
EP2621946A1 (en) 2010-09-29 2013-08-07 Morphotek, Inc. Engineered human endosialin-expressing rodents
WO2013148250A1 (en) * 2012-03-30 2013-10-03 Morphotek, Inc. Tem-1 diagnostic antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0746613B1 (en) * 1994-03-08 2006-05-24 Memorial Sloan-Kettering Cancer Center Recombinant humanized anti-fb5 antibodies

Also Published As

Publication number Publication date
US5437865A (en) 1995-08-01
JPH08505764A (ja) 1996-06-25
WO1994011023A1 (en) 1994-05-26
DE69330643D1 (de) 2001-09-27
ATE204480T1 (de) 2001-09-15
AU671884B2 (en) 1996-09-12
JP3541296B2 (ja) 2004-07-07
DE69330643T2 (de) 2002-07-04
EP0673255B1 (en) 2001-08-22
CA2149120C (en) 2005-09-27
EP0673255A1 (en) 1995-09-27
US5342757A (en) 1994-08-30
EP0673255A4 (en) 1996-08-21
ES2161751T3 (es) 2001-12-16
PT673255E (pt) 2002-02-28
CA2149120A1 (en) 1994-05-26
AU5596594A (en) 1994-06-08
GR3036906T3 (en) 2002-01-31

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