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DK0657428T3 - Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister - Google Patents

Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister

Info

Publication number
DK0657428T3
DK0657428T3 DK94308951T DK94308951T DK0657428T3 DK 0657428 T3 DK0657428 T3 DK 0657428T3 DK 94308951 T DK94308951 T DK 94308951T DK 94308951 T DK94308951 T DK 94308951T DK 0657428 T3 DK0657428 T3 DK 0657428T3
Authority
DK
Denmark
Prior art keywords
trisubstituted
piperidinyl
alkylcarboxylates
preparation
intermediates useful
Prior art date
Application number
DK94308951T
Other languages
English (en)
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0657428T3 publication Critical patent/DK0657428T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94308951T 1993-12-08 1994-12-02 Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister DK0657428T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (1)

Publication Number Publication Date
DK0657428T3 true DK0657428T3 (da) 2001-05-07

Family

ID=22592858

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94308951T DK0657428T3 (da) 1993-12-08 1994-12-02 Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister

Country Status (31)

Country Link
US (1) US5434171A (da)
EP (3) EP1607387A3 (da)
JP (2) JP3834075B2 (da)
KR (1) KR100356239B1 (da)
CN (2) CN1057294C (da)
AT (1) ATE200279T1 (da)
AU (1) AU681198B2 (da)
BR (1) BR9404842A (da)
CA (1) CA2137221C (da)
CO (1) CO4290427A1 (da)
CZ (1) CZ290559B6 (da)
DE (1) DE69427017T2 (da)
DK (1) DK0657428T3 (da)
ES (1) ES2155844T3 (da)
FI (2) FI106455B (da)
GR (1) GR3036136T3 (da)
HK (1) HK1013826A1 (da)
HU (1) HUT71489A (da)
IL (1) IL111843A (da)
MY (1) MY121543A (da)
NO (1) NO302884B1 (da)
NZ (1) NZ270039A (da)
PE (1) PE41495A1 (da)
PL (1) PL181734B1 (da)
PT (1) PT657428E (da)
RU (1) RU2145958C1 (da)
SI (1) SI0657428T1 (da)
TW (1) TW290540B (da)
UA (1) UA52577C2 (da)
YU (2) YU49312B (da)
ZA (1) ZA949584B (da)

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GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
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US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
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US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
CN104248763A (zh) * 2005-03-07 2014-12-31 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AU2006265639A1 (en) * 2005-07-01 2007-01-11 Jenrin Discovery MAO-B inhibitors useful for treating obesity
US7914776B2 (en) * 2005-10-07 2011-03-29 Adolor Corporation Solid dispersions of opioid antagonists
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Also Published As

Publication number Publication date
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
PT657428E (pt) 2001-07-31
YU70294A (sh) 1997-07-31
IL111843A (en) 2000-02-29
CN1111239A (zh) 1995-11-08
RU2145958C1 (ru) 2000-02-27
JP3834075B2 (ja) 2006-10-18
DE69427017T2 (de) 2001-09-06
US5434171A (en) 1995-07-18
KR100356239B1 (ko) 2002-12-26
EP1607387A3 (en) 2007-01-03
CO4290427A1 (es) 1996-04-17
AU681198B2 (en) 1997-08-21
NZ270039A (en) 1996-08-27
PL181734B1 (pl) 2001-09-28
TW290540B (da) 1996-11-11
DE69427017D1 (de) 2001-05-10
EP1607387A2 (en) 2005-12-21
CA2137221C (en) 2011-02-22
YU49312B (sh) 2005-06-10
MY121543A (en) 2006-02-28
ATE200279T1 (de) 2001-04-15
CN1057294C (zh) 2000-10-11
UA52577C2 (uk) 2003-01-15
HK1013826A1 (en) 1999-09-10
CZ290559B6 (cs) 2002-08-14
CN1223257A (zh) 1999-07-21
GR3036136T3 (en) 2001-09-28
FI20000353L (fi) 2000-02-17
AU7917094A (en) 1995-06-15
HUT71489A (en) 1995-11-28
JP2006070042A (ja) 2006-03-16
PE41495A1 (es) 1995-11-28
YU82304A (sh) 2006-03-03
EP0984004A3 (en) 2003-10-15
EP0657428A1 (en) 1995-06-14
RU94042903A (ru) 1996-10-27
IL111843A0 (en) 1995-03-15
FI945703L (fi) 1995-06-09
FI106455B (fi) 2001-02-15
NO944644D0 (no) 1994-12-02
SI0657428T1 (en) 2001-08-31
CN1121387C (zh) 2003-09-17
CZ299294A3 (en) 1995-10-18
EP0984004A2 (en) 2000-03-08
JPH07215937A (ja) 1995-08-15
ES2155844T3 (es) 2001-06-01
NO302884B1 (no) 1998-05-04
FI945703A0 (fi) 1994-12-02
KR950017957A (ko) 1995-07-22
EP0657428B1 (en) 2001-04-04
ZA949584B (en) 1996-06-03
CA2137221A1 (en) 1995-06-09
PL306068A1 (en) 1995-06-12
NO944644L (no) 1995-06-09
BR9404842A (pt) 1995-08-08

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