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DK0650475T3 - 4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamider, fremstilling deraf og anvendelse deraf som 5-HT2-antagonister - Google Patents

4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamider, fremstilling deraf og anvendelse deraf som 5-HT2-antagonister

Info

Publication number
DK0650475T3
DK0650475T3 DK93917661T DK93917661T DK0650475T3 DK 0650475 T3 DK0650475 T3 DK 0650475T3 DK 93917661 T DK93917661 T DK 93917661T DK 93917661 T DK93917661 T DK 93917661T DK 0650475 T3 DK0650475 T3 DK 0650475T3
Authority
DK
Denmark
Prior art keywords
pct
compounds
halo
hydrogen
formula
Prior art date
Application number
DK93917661T
Other languages
English (en)
Inventor
Daele Georges Henri Paul Van
Josepha Eduarda Maria F Leysen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0650475T3 publication Critical patent/DK0650475T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93917661T 1992-07-17 1993-07-08 4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamider, fremstilling deraf og anvendelse deraf som 5-HT2-antagonister DK0650475T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91430692A 1992-07-17 1992-07-17
PCT/EP1993/001993 WO1994002462A1 (en) 1992-07-17 1993-07-08 4-amino-n^_-(4-methyl-4-piperidinyl)-2-methoxybenzamides

Publications (1)

Publication Number Publication Date
DK0650475T3 true DK0650475T3 (da) 2000-03-20

Family

ID=25434170

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93917661T DK0650475T3 (da) 1992-07-17 1993-07-08 4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamider, fremstilling deraf og anvendelse deraf som 5-HT2-antagonister

Country Status (17)

Country Link
US (3) US5498618A (da)
EP (1) EP0650475B1 (da)
JP (1) JP3257677B2 (da)
KR (1) KR100243535B1 (da)
AT (1) ATE184001T1 (da)
AU (1) AU668208B2 (da)
CA (1) CA2138150C (da)
DE (1) DE69326245T2 (da)
DK (1) DK0650475T3 (da)
ES (1) ES2137996T3 (da)
FI (1) FI109997B (da)
GR (1) GR3031820T3 (da)
HK (1) HK1010730A1 (da)
HU (1) HUT71886A (da)
IL (1) IL106356A (da)
NO (1) NO303011B1 (da)
WO (1) WO1994002462A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents
EP0647639A1 (fr) * 1993-10-11 1995-04-12 Sanofi Hétéroarylpipéridines, procédé pour leur préparation et compositions pharmaceutiques les contenant
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
WO2001000604A1 (en) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Brain sigma-1 receptor-binding ligand
KR20010017625A (ko) * 1999-08-12 2001-03-05 윤재승 시사프라이드의 제조 방법
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
ITRM20050390A1 (it) * 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
WO2016100940A1 (en) * 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
CN110950843B (zh) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 取代的苯酰胺衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1507462A (en) * 1974-03-21 1978-04-12 Gallardo Antonio Sa N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides

Also Published As

Publication number Publication date
FI950180A0 (fi) 1995-01-16
EP0650475A1 (en) 1995-05-03
US5498618A (en) 1996-03-12
HU9500138D0 (en) 1995-03-28
IL106356A (en) 1997-06-10
EP0650475B1 (en) 1999-09-01
DE69326245T2 (de) 2000-05-18
JP3257677B2 (ja) 2002-02-18
KR950702183A (ko) 1995-06-19
NO950136L (no) 1995-02-03
DE69326245D1 (de) 1999-10-07
IL106356A0 (en) 1993-11-15
JPH07509234A (ja) 1995-10-12
KR100243535B1 (ko) 2000-03-02
CA2138150A1 (en) 1994-02-03
US5688814A (en) 1997-11-18
CA2138150C (en) 2005-04-19
ES2137996T3 (es) 2000-01-01
GR3031820T3 (en) 2000-02-29
AU4702993A (en) 1994-02-14
WO1994002462A1 (en) 1994-02-03
HUT71886A (en) 1996-02-28
ATE184001T1 (de) 1999-09-15
FI109997B (fi) 2002-11-15
US5691358A (en) 1997-11-25
FI950180L (fi) 1995-01-16
AU668208B2 (en) 1996-04-26
NO950136D0 (no) 1995-01-13
HK1010730A1 (en) 1999-06-25
NO303011B1 (no) 1998-05-18

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