DK0632033T3 - Nye benzopyranderivater - Google Patents
Nye benzopyranderivaterInfo
- Publication number
- DK0632033T3 DK0632033T3 DK93902526T DK93902526T DK0632033T3 DK 0632033 T3 DK0632033 T3 DK 0632033T3 DK 93902526 T DK93902526 T DK 93902526T DK 93902526 T DK93902526 T DK 93902526T DK 0632033 T3 DK0632033 T3 DK 0632033T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzopyran derivatives
- represent
- hydroxy
- new benzopyran
- hydrogen
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, substituted amino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1081992 | 1992-01-24 | ||
| PCT/JP1993/000086 WO1993015068A1 (en) | 1992-01-24 | 1993-01-25 | Novel benzopyran derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0632033T3 true DK0632033T3 (da) | 1999-10-18 |
Family
ID=11760967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93902526T DK0632033T3 (da) | 1992-01-24 | 1993-01-25 | Nye benzopyranderivater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5646308A (da) |
| EP (1) | EP0632033B1 (da) |
| JP (1) | JP3260458B2 (da) |
| KR (1) | KR100217167B1 (da) |
| CN (1) | CN1036918C (da) |
| AT (1) | ATE178601T1 (da) |
| AU (1) | AU3367393A (da) |
| CA (1) | CA2128603A1 (da) |
| DE (1) | DE69324354T2 (da) |
| DK (1) | DK0632033T3 (da) |
| ES (1) | ES2132217T3 (da) |
| GR (1) | GR3030581T3 (da) |
| SG (1) | SG52734A1 (da) |
| WO (1) | WO1993015068A1 (da) |
| ZA (1) | ZA93436B (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| EP0702952B1 (en) * | 1993-04-23 | 1999-12-08 | Chugai Seiyaku Kabushiki Kaisha | Benzopyran derivatives |
| WO1995013272A1 (fr) | 1993-11-10 | 1995-05-18 | Japan Tobacco Inc. | Derive de chromanne et utilisation therapeutique de ce dernier |
| SK282019B6 (sk) * | 1994-08-18 | 2001-10-08 | Merck & Co., Inc. | 2,3-dihydro-1-(2,2,2-trifluóretyl)-2-oxo-5-fenyl-1h-1,4- benzodiazepínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| WO1996040656A1 (en) * | 1995-06-07 | 1996-12-19 | Merck & Co., Inc. | Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides |
| US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
| US5700797A (en) * | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| US5631251A (en) * | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
| US5726171A (en) * | 1995-06-07 | 1998-03-10 | Merck & Co Inc | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides |
| AU3867997A (en) * | 1996-08-27 | 1998-03-19 | Shionogi & Co., Ltd. | Chromene-3-carboxylate derivatives |
| FR2756284B1 (fr) * | 1996-11-26 | 2000-04-28 | Adir | Nouveaux derives du benzopyrane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TW533073B (en) * | 1997-03-03 | 2003-05-21 | Chugai Pharmaceutical Co Ltd | Therapeutic agents for peripheral vascular disease |
| DE69832176T2 (de) * | 1997-08-08 | 2006-08-03 | Chugai Seiyaku K.K. | Arzneimittel gegen diabetes-komplikationen |
| US6455708B1 (en) * | 1998-09-30 | 2002-09-24 | Chugai Seiyaku Kabushiki Kaisha | Processes for the preparation of 4-substituted benzopyran derivatives |
| CZ20013076A3 (cs) * | 2000-08-29 | 2002-04-17 | Kuraray Co., Ltd. | Způsob výroby chromankarboxylové kyseliny |
| KR100602191B1 (ko) * | 2004-03-10 | 2006-07-19 | 한국화학연구원 | 5-라이폭시게네이즈 저해활성을 가지는2,2'-이중치환-3,4-디하이드로-7,8-이중치환-6-알킬아미노벤조피란 유도체 |
| NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
| AU2005278782B2 (en) | 2004-07-30 | 2011-04-21 | Torrent Pharmaceuticals Limited | Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol |
| AU2005318550B2 (en) * | 2004-12-21 | 2011-04-07 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| KR100889185B1 (ko) * | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도 |
| BRPI0516381A (pt) * | 2004-12-21 | 2008-09-02 | Hoffmann La Roche | derivados de cromano e seu uso como ligandos de receptor de 5-ht |
| CA2591810A1 (en) | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Chroman derivatives and uses thereof in the treatment of cns disorders |
| WO2006066745A1 (en) * | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| KR100704009B1 (ko) * | 2005-08-30 | 2007-04-04 | 한국화학연구원 | 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체 |
| ES2359735T3 (es) * | 2005-11-03 | 2011-05-26 | F. Hoffmann-La Roche Ag | Arilsulfonilcromanos como inhibidores de 5-ht6. |
| CN101472883A (zh) * | 2006-06-20 | 2009-07-01 | 弗·哈夫曼-拉罗切有限公司 | 芳基磺酰氨基四氢萘衍生物以及其应用 |
| WO2007147771A2 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| AU2007263076A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH619701A5 (da) * | 1975-08-07 | 1980-10-15 | Bayer Ag | |
| JPS57167981A (en) * | 1981-04-08 | 1982-10-16 | Kowa Co | Benzopyran derivative |
| GB8911280D0 (en) * | 1989-05-17 | 1989-07-05 | Beecham Group Plc | Novel compounds |
| WO1992002514A1 (en) * | 1990-07-27 | 1992-02-20 | Chugai Seiyaku Kabushiki Kaisha | Novel benzopyran derivative |
-
1993
- 1993-01-21 ZA ZA93436A patent/ZA93436B/xx unknown
- 1993-01-22 JP JP00942193A patent/JP3260458B2/ja not_active Expired - Fee Related
- 1993-01-22 CN CN93102056A patent/CN1036918C/zh not_active Expired - Fee Related
- 1993-01-25 WO PCT/JP1993/000086 patent/WO1993015068A1/ja active IP Right Grant
- 1993-01-25 DK DK93902526T patent/DK0632033T3/da active
- 1993-01-25 AU AU33673/93A patent/AU3367393A/en not_active Abandoned
- 1993-01-25 KR KR1019940702541A patent/KR100217167B1/ko not_active IP Right Cessation
- 1993-01-25 DE DE69324354T patent/DE69324354T2/de not_active Expired - Fee Related
- 1993-01-25 AT AT93902526T patent/ATE178601T1/de not_active IP Right Cessation
- 1993-01-25 EP EP93902526A patent/EP0632033B1/en not_active Expired - Lifetime
- 1993-01-25 US US08/256,580 patent/US5646308A/en not_active Expired - Fee Related
- 1993-01-25 CA CA002128603A patent/CA2128603A1/en not_active Abandoned
- 1993-01-25 SG SG1996008501A patent/SG52734A1/en unknown
- 1993-01-25 ES ES93902526T patent/ES2132217T3/es not_active Expired - Lifetime
-
1999
- 1999-06-22 GR GR990401664T patent/GR3030581T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05294954A (ja) | 1993-11-09 |
| SG52734A1 (en) | 1998-09-28 |
| KR100217167B1 (ko) | 1999-09-01 |
| DE69324354D1 (de) | 1999-05-12 |
| GR3030581T3 (en) | 1999-10-29 |
| WO1993015068A1 (en) | 1993-08-05 |
| EP0632033B1 (en) | 1999-04-07 |
| DE69324354T2 (de) | 1999-11-25 |
| ES2132217T3 (es) | 1999-08-16 |
| JP3260458B2 (ja) | 2002-02-25 |
| EP0632033A1 (en) | 1995-01-04 |
| CN1036918C (zh) | 1998-01-07 |
| CN1077954A (zh) | 1993-11-03 |
| ZA93436B (en) | 1993-08-25 |
| ATE178601T1 (de) | 1999-04-15 |
| AU3367393A (en) | 1993-09-01 |
| US5646308A (en) | 1997-07-08 |
| EP0632033A4 (da) | 1995-02-01 |
| CA2128603A1 (en) | 1993-08-05 |
| KR950700277A (ko) | 1995-01-16 |
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