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DK0626381T3 - Preparation of Form 1 Ranitidine Hydrochloride - Google Patents

Preparation of Form 1 Ranitidine Hydrochloride

Info

Publication number
DK0626381T3
DK0626381T3 DK93304182.4T DK93304182T DK0626381T3 DK 0626381 T3 DK0626381 T3 DK 0626381T3 DK 93304182 T DK93304182 T DK 93304182T DK 0626381 T3 DK0626381 T3 DK 0626381T3
Authority
DK
Denmark
Prior art keywords
ranitidine hydrochloride
preparation
prepared
volume
solution
Prior art date
Application number
DK93304182.4T
Other languages
Danish (da)
Inventor
Teng-Ko Ngooi
Casimir Antczak
Jeffrey David Mcgolrick
James Lorne Anthony Tindall
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Application granted granted Critical
Publication of DK0626381T3 publication Critical patent/DK0626381T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1 - 2.0 parts by volume of a C6 - C10 aromatic hydrocarbon such as toluene, and in the presence of seed crystals of pure Form 1 ranitidine hydrochloride. In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals.
DK93304182.4T 1993-04-01 1993-05-28 Preparation of Form 1 Ranitidine Hydrochloride DK0626381T3 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/041,354 US5338871A (en) 1991-12-20 1993-04-01 Preparation of form 1 ranitidine hydrochloride
EP93304182A EP0626381B1 (en) 1993-04-01 1993-05-28 Preparation of form 1 ranitidine hydrochloride
CA002099530A CA2099530C (en) 1993-04-01 1993-07-02 Preparation of form 1 ranitidine hydrochloride
AU41794/93A AU674006B2 (en) 1993-04-01 1993-07-06 Preparation of form 1 ranitidine hydrochloride
HU9301980A HU214334B (en) 1993-04-01 1993-07-08 Process for production crystall form 1 of ranitidine
ZA934995A ZA934995B (en) 1993-04-01 1993-07-12 Preparation of form 1 ranitidine hydrochloride
NZ260551A NZ260551A (en) 1993-04-01 1994-05-18 Preparation of form 1 ranitidine hcl crystals

Publications (1)

Publication Number Publication Date
DK0626381T3 true DK0626381T3 (en) 1995-10-02

Family

ID=27560579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93304182.4T DK0626381T3 (en) 1993-04-01 1993-05-28 Preparation of Form 1 Ranitidine Hydrochloride

Country Status (11)

Country Link
US (1) US5338871A (en)
EP (1) EP0626381B1 (en)
AT (1) ATE119894T1 (en)
AU (1) AU674006B2 (en)
CA (1) CA2099530C (en)
DE (1) DE69300088T2 (en)
DK (1) DK0626381T3 (en)
ES (1) ES2069446T3 (en)
HU (1) HU214334B (en)
NZ (1) NZ260551A (en)
ZA (1) ZA934995B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4341310A1 (en) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablet or capsule containing stable ranitidine hydrochloride Form 1
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
EP0754182A1 (en) * 1994-04-08 1997-01-22 Brantford Chemicals Inc. Form 1 ranitidine hydrochloride with increased density
IN181699B (en) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
NZ272054A (en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd Process for producing form 1 ranitidine hydrochloride
EP0694540B1 (en) * 1994-06-24 1998-08-19 Ranbaxy Laboratories Limited Process for the manufacture of form 1 ranitidine hydrochloride
AU1671295A (en) * 1994-12-19 1996-07-10 Lauteral Limited Combinations of ranitidine hydrochloride-form 1 and bismuth compounds
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
EP1384720A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
US20020151729A1 (en) * 1997-02-26 2002-10-17 Cheng Wen J. Novel process for the preparation of form 1 ranitidine hydrochloride
AU4055699A (en) * 1998-06-17 2000-01-05 Russinsky Limited Ranitidine adduct
IT1317858B1 (en) * 2000-02-29 2003-07-15 Pharmexcel S R L ALLOMORPH OF THE Z-ISOMER HYDROCHLORIDE OF DIKYLAMINOFURAN DERIVATE, PROCEDURE FOR ITS PRODUCTION AND COMPOSITION
DE102006015960A1 (en) * 2006-04-04 2007-10-11 Qiagen Gmbh Mixture of reversibly inhibited enzymes
EP2582671A4 (en) * 2010-06-17 2014-02-26 Reddys Lab Ltd Dr Process for the preparation of a single enantiomer of 3-aminopiperidine dihydrochloride
WO2015155297A1 (en) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1181084A (en) * 1980-01-08 1985-01-15 Glaxo Group Limited Process for the preparation of a furan derivative
GB2084580B (en) * 1980-10-01 1984-07-04 Glaxo Group Ltd Aminoalkyl furan derivative
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
DE3211127C1 (en) * 1982-03-26 1983-08-11 Degussa Ag, 6000 Frankfurt Process for the production of S- (carboxymethyl) - (R) -cysteine and S- (carboxymethyl) - (S) -cysteine
US4613688A (en) * 1982-04-02 1986-09-23 Showa Denko Kabushiki Kaisha Optical resolution process for DL-cysteine
JPH0730064B2 (en) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 Furan derivative

Also Published As

Publication number Publication date
EP0626381B1 (en) 1995-03-15
HU9301980D0 (en) 1993-09-28
ES2069446T3 (en) 1995-05-01
EP0626381A1 (en) 1994-11-30
CA2099530A1 (en) 1995-01-03
NZ260551A (en) 1995-02-24
DE69300088T2 (en) 1995-08-31
AU674006B2 (en) 1996-12-05
US5338871A (en) 1994-08-16
HUT68736A (en) 1995-04-27
ATE119894T1 (en) 1995-04-15
CA2099530C (en) 2002-10-08
ZA934995B (en) 1994-02-11
HU214334B (en) 1998-03-02
DE69300088D1 (en) 1995-04-20
AU4179493A (en) 1995-01-27

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