DK0626377T3 - Fremgangsmåde til fremstilling af benzylidenderivater - Google Patents
Fremgangsmåde til fremstilling af benzylidenderivaterInfo
- Publication number
- DK0626377T3 DK0626377T3 DK94303687T DK94303687T DK0626377T3 DK 0626377 T3 DK0626377 T3 DK 0626377T3 DK 94303687 T DK94303687 T DK 94303687T DK 94303687 T DK94303687 T DK 94303687T DK 0626377 T3 DK0626377 T3 DK 0626377T3
- Authority
- DK
- Denmark
- Prior art keywords
- optionally substituted
- chem
- formula
- lower alkoxy
- halogen
- Prior art date
Links
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/06—Six-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12390993 | 1993-05-26 | ||
| JP08443894A JP3507124B2 (ja) | 1993-05-26 | 1994-04-22 | ベンジリデン誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0626377T3 true DK0626377T3 (da) | 2000-02-21 |
Family
ID=26425484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94303687T DK0626377T3 (da) | 1993-05-26 | 1994-05-23 | Fremgangsmåde til fremstilling af benzylidenderivater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5463052A (da) |
| EP (1) | EP0626377B1 (da) |
| JP (1) | JP3507124B2 (da) |
| KR (1) | KR100326788B1 (da) |
| CN (1) | CN1044238C (da) |
| AT (1) | ATE182589T1 (da) |
| AU (1) | AU674739B2 (da) |
| CA (1) | CA2124136C (da) |
| DE (1) | DE69419662T2 (da) |
| DK (1) | DK0626377T3 (da) |
| ES (1) | ES2137323T3 (da) |
| GR (1) | GR3031470T3 (da) |
| HU (1) | HU217088B (da) |
| NO (1) | NO303117B1 (da) |
| TW (1) | TW290539B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| PE20011083A1 (es) * | 2000-02-15 | 2001-10-26 | Sugen Inc | 2-indolinas sustituidas con pirroles inhibidoras de proteinquinasas |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| JP2005508953A (ja) | 2001-10-10 | 2005-04-07 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 |
| SI1928454T1 (sl) | 2005-05-10 | 2015-01-30 | Intermune, Inc. | Piridonski derivati za moduliranje s stresom aktiviranega protein kinaznega sistema |
| DE102007052891A1 (de) * | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Stabilisierung von olefinisch ungesättigten Monomeren |
| WO2009149188A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| DE102013204950A1 (de) | 2013-03-20 | 2014-09-25 | Evonik Industries Ag | Verfahren und Zusammensetzung zur Inhibierung der Polymerisation von Cyclopentadienverbindungen |
| MX2016012808A (es) | 2014-04-02 | 2017-01-05 | Intermune Inc | Piridinonas anti-fibroticas. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892870A (en) * | 1988-08-01 | 1990-01-09 | Biofor, Ltd. | Oxaza heterocycles and pharmaceutical compositions containing same |
| US5093363A (en) * | 1989-08-22 | 1992-03-03 | Shionogi & Co., Ltd. | 2,4,6-substituted phenol derivatives |
| TW224461B (da) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag | |
| ES2106855T3 (es) * | 1991-01-21 | 1997-11-16 | Shionogi & Co | Analogos de 3-benciliden-1-carbamoil-2-pirrolidona. |
| DE69301894T2 (de) * | 1992-10-28 | 1996-11-07 | Shionogi & Co | Benzylidenderivate |
-
1994
- 1994-04-22 JP JP08443894A patent/JP3507124B2/ja not_active Expired - Fee Related
- 1994-05-19 TW TW083104536A patent/TW290539B/zh active
- 1994-05-20 US US08/246,494 patent/US5463052A/en not_active Expired - Fee Related
- 1994-05-23 AT AT94303687T patent/ATE182589T1/de not_active IP Right Cessation
- 1994-05-23 ES ES94303687T patent/ES2137323T3/es not_active Expired - Lifetime
- 1994-05-23 DE DE69419662T patent/DE69419662T2/de not_active Expired - Fee Related
- 1994-05-23 DK DK94303687T patent/DK0626377T3/da active
- 1994-05-23 EP EP94303687A patent/EP0626377B1/en not_active Expired - Lifetime
- 1994-05-24 CA CA002124136A patent/CA2124136C/en not_active Expired - Fee Related
- 1994-05-25 HU HU9401569A patent/HU217088B/hu not_active IP Right Cessation
- 1994-05-25 NO NO941934A patent/NO303117B1/no unknown
- 1994-05-25 KR KR1019940011338A patent/KR100326788B1/ko not_active IP Right Cessation
- 1994-05-26 AU AU63351/94A patent/AU674739B2/en not_active Ceased
- 1994-05-26 CN CN94105933A patent/CN1044238C/zh not_active Expired - Fee Related
-
1999
- 1999-10-08 GR GR990402561T patent/GR3031470T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2124136C (en) | 2004-07-27 |
| EP0626377A1 (en) | 1994-11-30 |
| GR3031470T3 (en) | 2000-01-31 |
| JPH0741470A (ja) | 1995-02-10 |
| JP3507124B2 (ja) | 2004-03-15 |
| NO941934L (no) | 1994-11-28 |
| EP0626377B1 (en) | 1999-07-28 |
| DE69419662T2 (de) | 2000-01-27 |
| AU6335194A (en) | 1994-12-01 |
| TW290539B (da) | 1996-11-11 |
| HU9401569D0 (en) | 1994-08-29 |
| DE69419662D1 (de) | 1999-09-02 |
| CN1099751A (zh) | 1995-03-08 |
| ES2137323T3 (es) | 1999-12-16 |
| US5463052A (en) | 1995-10-31 |
| CN1044238C (zh) | 1999-07-21 |
| CA2124136A1 (en) | 1994-11-27 |
| NO303117B1 (no) | 1998-06-02 |
| HU217088B (hu) | 1999-11-29 |
| HUT70841A (en) | 1995-11-28 |
| ATE182589T1 (de) | 1999-08-15 |
| NO941934D0 (no) | 1994-05-25 |
| KR100326788B1 (ko) | 2002-06-20 |
| AU674739B2 (en) | 1997-01-09 |
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